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| 1 | Lushan M_S7.0 earthquake:A blind reserve-fault event显示文摘In the epicenter of the Lushan MS7.0 earthquake there are several imbricate active reverse faults lying from northwest to southeast,namely the Gengda-Longdong,Yanjing-Wulong,Shuangshi-Dachuan and Dayi faults.Emergency field investigations have indicated that no apparent earthquake surface rupture zones were located along these active faults or their adjacent areas.Only brittle compressive ruptures in the cement-covered pavements can be seen in Shuangshi,Taiping,Longxing and Longmen Townships,and these ruptures show that a local crustal shortening occurred in the region during the earthquake.Combining spatial distribution of the relocated aftershocks and focal mechanism solutions,it is inferred that the Lushan earthquake is classified as a typical blind reverse-fault earthquake,and it is advised that the relevant departments should pay great attention to other historically un-ruptured segments along the Longmenshan thrust belt and throughout its adjacent areas. | XU XiWei WEN XueZe HAN ZhuJun CHEN GuiHua LI ChuanYou ZHENG WenJun ZHNAG ShiMin REN ZhiQun XU Chong TAN XiBin WEI ZhanYu WANG MingMing REN JunJie HE ZhongTai LIANG MingJian | 2013 | Chinese Science Bulletin2013，58，28： | 35 |
| 2 | Parameterizing soil organic carbon's impacts on soil porosity and thermal parameters for Eastern Tibet grasslands显示文摘This study investigates the stratification of soil thermal properties induced by soil organic carbon (SOC) and its impacts on the parameterization of the thermal properties. Soil parameters were measured for alpine grassland stations and North China flux stations, with a total of 34 stations and 77 soil profiles. Measured data indicate that the topsoils of alpine grasslands contain high SOC contents than underlying soil layers, which leads to higher soil porosity values and lower thermal conductivity and bulk density values in the topsoils. However, this stratification is not evident at the lowland stations due to low SOC contents. Evaluations against measured data show that three thermal conductivity schemes used in land surface models severely overestimate the values for soils with high SOC content (i.e. topsoils of alpine grassland), but they are better for soils with low SOC content. A new parameterization is then developed to take the impacts of SOC into account. The new one can well estimate the soil thermal conductivity values in both low and high SOC content cases, and therefore, it is a potential candidate of thermal conductivity scheme to be used in land surface models. | CHEN YingYing YANG Kun TANG WenJun QIN Jun ZHAO Long | 2012 | Science China Earth Sciences2012，55，6： | 31 |
| 3 | Improvement of tree-like network constructal method for heat conduction optimization显示文摘The analysis of the “tree-like network” construct method has been repeated. The high effective conduction channel distribution has been optimized again, without the premise that the new order assembly construct must be assembled by the optimized last order construct. It is proved that the “tree-like network” construct method is faultiness. A more optimal construct is obtained, and when the thermal conductivity and the proportion of the two heat conduction materials are constant, the limit of the minimum heat resistance is derived. All these conclusions can be used to guide the engineering application. | WU Wenjun CHEN Lingen SUN Fengrui | 2006 | Science China(Technological Sciences)2006，49，3： | 25 |
| 4 | The role of high mobility group box 1(HMGB1)in the pathogenesis of kidney diseases显示文摘High mobility group box 1(HMGB1) is a nuclear protein that can bind to DNA and act as a co-factor for gene transcription. When released into extracellular fluid, it plays a proinflammatory role by acting as a damage-associated molecular pattern molecule(DAMP)(also known as an alarmin) to initiate innate immune responses by activating multiple cell surface receptors such as the receptor for advanced glycation end-products(RAGE) and toll-like receptors(TLRs), TLR2, TLR4 or TLR9. This proinflammatory role is now considered to be important in the pathogenesis of a wide range of kidney diseases whether they result from hemodynamic changes, renal tubular epithelial cell apoptosis, kidney tissue fibrosis or inflammation. This review summarizes our current understanding of the role of HMGB1 in kidney diseases and how the HMGB1-mediated signaling pathway may constitute a new strategy for the treatment of kidney diseases. | Qingjie Chen Xiaofeng Guan Xiaocong Zuo Jianglin Wang Wenjun Yin | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 26 |
| 5 | Mineralization episode of porphyry copper deposits in the Jinshajiang-Red River mineralization belt: Re-Os dating显示文摘Re-Os isotopic dating for the molybdenites from the porphyry copper deposits of the Jinshajiang-Red River mineralization belt in Yunnan Province yields isochron ages of 33.9±1.1 Ma for the Machangqing deposit and 34.4±0.5 Ma for the Tongchang deposit. This result shows that both the Machangqing and the Tongchang porphyry Cu-Mo deposits from two different ore-fields formed simultaneously. This new data and the published Re-Os model ages of molybdenite (35.4 Ma, 35.9 Ma, 36.2 Ma) of the Yulong porphyry copper deposit in Tibet, which is located in the same Jinshajiang-Red River mineralization belt as the Machangqing deposit and the Tongchang deposit, suggest that these three Cenozoic porphyry copper deposits in the Jinshajiang-Red River mineralization belt were contemporary for their mineralization episode. That is to say, even their present locality is far away and nearly iso-distantly distributed, these three porphyry Cu(Mo) deposits belong to the same mineralization episode at the end of Eocene. | WANG Denghong, QU Wenjun, LI Zhiwei, YIN Hanlong4 & CHEN Yuchuan Institute of Mineral Resources, Chinese Academy of Geological Sciences, Beijing 100037, China National Center of Rock and Mineral Analysis, Chinese Academy of Geological Sciences, Beijing 100037, China Resource Assessment Center of Yunnan, Kunming 650011, China Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100101, China Chinese Academy of Geological Sciences, Beijing 100037, China | 2005 | Science China Earth Sciences2005，48，2： | 21 |
| 6 | Review on photocatalytic and electrocatalytic artificial nitrogen fixation for ammonia synthesis at mild conditions: Advances,challenges and perspectives显示文摘The ammonia synthesis from nitrogen and water under ambient conditions is one of the most inviting but challenging reaction routes.Although nitrogen is abundant in the atmosphere and the ammonia synthesis reaction is exothermic on the thermodynamics,the conversion of N2 to ammonia is actually hard to proceed owing to the chemical inertness and stability of N2 molecules.In industry,ammonia synthesis is carried out by the Haber-Bosch process under harsh conditions (300-500 ℃,20-30 MPa) associated with the requirement of substantial energy input and the enormous emission of greenhouse gases (e.g.,CO2).Recently,a growing number of studies on photo(electro)catalytic and electrocatalytic nitrogen reduction reaction (NRR) in aqueous solution have attracted extensive attention,which holds great promise for nitrogen fixation under room temperature and atmospheric pressure.However,the very low efficiency and ambiguous mechanism still remain as the major hurdles for the development of photochemical and electrochemical NRR systems.Here we provide an overview of the latest progresses,remaining challenges and future prospects in photocatalytic and electrocatalytic nitrogen fixation.Moreover,this review offers a helpful guidance for the reasonable design of photocatalysts and electrocatalysts towards NRR by combining theory predictions and experiment results.We hope this review can stimulate more research interests in the relatively understudied but highly promising research field of NRR. | Xiaolan Xue Renpeng Chen Changzeng Yan Peiyang Zhao Yi Hu Wenjun Zhang Songyuan Yang Zhong Jin | 2019 | Nano Research2019，12，6： | 20 |
| 7 | A review of ecological restoration techniques in fluvial rivers显示文摘Rivers play an important role in people's living and agricultural production,however,intense human activities have broken the original ecological balance,and affected structures and functions of the river ecosystem.To restore the damaged river ecosystem back to a healthy status,effective ecological restoration measures need to be implemented.The main problems that the damaged rivers face are either the locally altered hydrological processes affected by construction of hydraulic facilities,or the deterioration of water quality resulted from pollution emissions,or both.In this study,ecological restoration techniques of the rivers affected by engineering control or pollution are reviewed respectively.In addition,three kinds of methods,i.e.physical,chemical and biological-ecological methods are introduced in details for the rivers affected by water pollution.At present,the development of river restoration techniques shows the following trends:1) the scale of ecological restoration is becoming larger;2) ecological restoration measures are required to meet multiple objectives;and 3) the management of water environment is changing from water quality management to aquatic ecosystem management. | Baozhu Pan Jianping Yuan Xinhua Zhang Zhaoyin Wang Jiao Chen Jinyou Lu Wenjun Yang Zhiwei Li Na Zhao Mengzhen Xu | 2016 | International Journal of Sediment Research2016，31，2： | 18 |
| 8 | Isotopic Chronological Study of the Huangsha-Tieshanlong Quartz Vein-Type Tungsten Deposit and Timescale of Molybdenum Mineralization in Southern Jiangxi Province,China显示文摘Huangsha-Tieshanlong 石英静脉钨 polymetallic 矿石沉积物,在勘探 Yushan metallogenic 带的区域的东方 Ganxian-Yudu 在北 Pangushan-Tieshanlong 钨矿石地里定位了,是在南部的江西省的著名的钨沉积物,中国。从 Tieshanlong 花岗石的锆石的虾坚定的标明日期产出 168.1 | HUANG Fan FENG Chengyou CHEN Yuchuan YING Lijuan CHEN Zhenghui1 ZENG Zailin QU Wenjun | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 18 |
| 9 | Comparisons between centrifuge and numerical modeling results for slope toppling failure显示文摘This paper presents series studies on the toppling mechanism by centrifuge tests and numerical simulations. Two different discrete element methods, i.e., the continuum-based discrete element method(CDEM) and the discontinuous deformation analysis(DDA), are adopted. The modeling results show that both the methods can accurately capture the failure modes of the centrifuge tests, including three distinct zones and two failure surfaces. Comparisons are made between the physical test and numerical simulation results. The critical inclination angle of the tilting table where the slope models are fixed on can be moderately predicted by the two methods, with different degrees of precision. The error between the test results and the simulated results is within 1% for the slope models without rock-bridges by both CDEM and DDA. However, it is amplified for the staggered-joint models that simulate the rock-bridges. With DDA, the average error is about 5%, and the maximum error is up to 17%. While with CDEM, the errors for the aligned-joint models are ranged from 1% to 6%, and it is from 10% to 29% for the staggered-joint models. The two numerical methods show the capability in simulating toppling failure of blocky rock mass with and without rock-bridges. The model with rock-bridges which provides a certain bending resistance is more stable than the one without any rock-bridge. In addition, the two failure surfaces were observed, which is different from the common understanding that only one failure surface appears. | CHEN ZuYu GONG WenJun MA GuoWei WANG Jie HE Lei XING YiChuan XING JianYing | 2015 | Science China(Technological Sciences)2015，58，9： | 18 |
| 10 | Re-Os dating of gold-bearing arsenopyrite of the Maoling gold deposit,Liaoning Province,Northeast China and its geological significance显示文摘The Maoling gold deposit, one of the large gold deposits in eastern Liaoning Province, NE China, is an ar- senopyrite-disseminated gold deposit with a resource of ap- proximately 25 t Au and an average Au grade of 3.2 g/t. Six arsenopyrites closely related to Au mineralization of the Maoling gold deposit are dated by Re-Os technique and de- fine a Re-Os isochron with an age of 2316±140 Ma, which suggests that the deposit was formed in the Paleoproterozoic era rather than in the Indosinian period as some early re- searchers suggested. High initial 187Os/188Os ratio of 1.32±0.48 indicates a crustal derivation of the ore-forming material of the deposit, which may be derived from rocks of the Gaixian formation of the Liaohe Group. Furthermore, the result also implies that the age of the Gaixian Formation in the Maoling district is older than 2316±140 Ma. | YU Gang YANG Gang CHEN Jiangfeng QU Wenjun DU Andao HE Wei | 2005 | Chinese Science Bulletin2005，50，14： | 12 |
| 11 | Salusins protect myocardium against ischemic injury by alleviating endoplasmic reticulum stress显示文摘Salusins are regulatory peptides that affect cardiovascular function. We previously reported that salusin-α and -β protected cultured cardiomyocytes from serum deprivation-induced cell death through upregulating glucose-regulated protein 78 (GRP78), an endoplasmic reticulum (ER) resident protein whose overexpression acts as a marker and suppressor of ER stress. The present study examined whether salusin-α and -β inhibit ER stress in ischemic myocardium. In a rat model of myocardial infarction created by ligating the left anterior descending coronary artery (LAD), salusin-α or -β was intravenously injected at 5 or 15 nmol kg 1 15 min prior to 2 h of LAD occlusion. The high dose of salusin-α and -β significantly improved heart function and hemodynamics in LAD-occluded rats, but had no effects in sham-operated rats. The arrhythmias caused by LAD occlusion were markedly attenuated by salusin-α and -β. The apoptotic rate in ischemic myocardium was reduced from 31.5%±3.7% to 19.8%±2.2% and 12.3%±2.2%, and the infarct size was reduced from 53.4%±4.0% of the risk area to 26.5%±9.7% and 23.7%±8.9% by 15 nmol kg 1 salusin-α and -β, respectively. Furthermore, salusin-α and -β prevented the activation of GRP78 and ER stress-specific apoptotic effectors caspase-12 and CHOP (C/EBP homologous protein), and attenuated the reduction of an ER stress-associated antiapoptotic protein Bcl-2 in ischemic cardiac tissue. The salusins also inhibited the ER stress induced by tunicamycin in cultured rat H9c2 cardiomyocytes. These results indicate that salusins protect myocardium against ischemic injury by inhibiting ER stress and ER stress-associated apoptosis. | WANG JianFei WANG Yin SHAN ShiFu HU TianTian CHEN HuYan TIAN Jing REN AnJing ZHOU Xu YUAN WenJun LIN Li | 2012 | Science China(Life Sciences)2012，55，4： | 11 |
| 12 | Inhibition of lung cancer cell proliferation mediated by human mesenchymal stem cells显示文摘人的间充质的干细胞(hMSCs ) 主要为他们的潜在的临床的使用被学习。最近,癌症研究的领域里的许多注意对 hMSCs 被给予了。在这研究,我们由使用一个合作文化系统和调节 hMSCs 的媒介在 vitro 并且在 vivo 在肺癌症房间线 SK-MES-1 和 A549 的增长上调查了 hMSCs 的影响。我们的结果证明 hMSCs 能禁止 SK-MES-1 和 A549 房间的增长,并且经由一些可溶的因素在 vitro 导致肿瘤房间的 apoptosis。动物学习证明从 hMSCs 的这些可溶的因素能由 preliminarily 与调节 hMSCs 的媒介对待肿瘤细胞压制 tumorigenesis 和肿瘤 angiogenesis。在肿瘤房间的脉管的 endothelial 生长因素的 downregulated 表示可能是在肿瘤 angiogenesis 的干扰的机制,它被西方的污点分析和 immunohistochemistry 试金验证。一起拿,我们的结果建议 hMSCs 能由 secreting 一些禁止肿瘤细胞生长可溶的因素。 | Lin Li Hui Tian Zhitao Chen Weiming Yue Shuhai Li Wenjun Li | 2011 | Acta Biochimica et Biophysica Sinica2011，43，2： | 11 |
| 13 | Re-Os geochronology of Cu and W-Mo deposits in the Balkhash metallogenic belt,Kazakhstan and its geological significance显示文摘<正>The Central Asian metallogenic domain(CAMD) is a multi-core metallogenic system controlled by boundary strike-slip fault systems.The Balkhash metallogenic belt in Kazakhstan,in which occur many large and super-large porphyritic Cu—Mo deposits and some quartz vein- and greisen-type W—Mo deposits,is a well-known porphyritic Cu—Mo metallogenic belt in the CAMD.In this paper 11 molybdenite samples from the western segment of the Balkhash metallogenic belt are selected for Re—Os compositional analyses and Re—Os isotopic dating.Molybdenites from the Borly porphyry Cu deposit and the three quartz vein-greisen W—Mo deposits—East Kounrad.Akshatau and Zhanet—all have relatively high Re contents(2712—2772μg/g for Borly and 2.267—31.50μg/g for the other three W—Mo deposits),and lower common Os contents(0.670—2.696 ng/g for Borly and 0.0051—0.056 ng/g for the other three).The molybdenites from the Borly porphyry Cu—Mo deposit and the East Kounrad,Zhanet,and Akshatau quartz vein- and greisen-type W—Mo deposits give average model Re—Os ages of 315.9 Ma,298.0 Ma,295.0 Ma,and 289.3 Ma respectively.Meanwhile,molybdenites from the East Kounrad,Zhanet,and Akshatau W—Mo deposits give a Re—Os isochron age of 297.9 Ma,with an MSWD value of 0.97.Re-Os dating of the molybdenites indicates that Cu—W—Mo metallogenesis in the western Balkhash metallogenic belt occurred during Late Carboniferous to Early Permian(315.9—289.3 Ma),while the porphyry Cu—Mo deposits formed at—316 Ma,and the quartz vein-greisen W—Mo deposits formed at ~298 Ma.The Re—Os model and isochron ages thus suggest that Late Carboniferous porphyry granitoid and pegmatite magmatism took place during the late Hercynian movement.Compared to the Junggar-East Tianshan porphyry Cu metallogenic belt in northwestern China,the formation of the Cu—Mo metallogenesis in the Balkhash metallogenic belt occurred between that of the Tuwu-Yandong in East Tianshan and the Baogutu porphyry Cu deposits in West Junggar. Collectively,the large-scale Late Carboniferous porphyry Cu—Mo metallogenesis in the Central Asian metallogenic domain is related to Hercynian tectono-magmatic activities. | Xuanhua Chen Wenjun Qu Shuqin Han Seitmuratova Eleonora Nong Yang Zhengle Chen Fagang Zeng Andao Du Zhihong Wang | 2010 | Geoscience Frontiers2010，1，1： | 10 |
| 14 | Coupling behavior between adhesive and abrasive wear mechanism of aero-hydraulic spool valves显示文摘Leakage due to wear is one of the main failure modes of aero-hydraulic spool valves.This paper established a practical coupling wear model for aero-hydraulic spool valves based on dynamic system modelling theory. Firstly, the experiment for wear mechanism verification proved that adhesive wear and abrasive wear did coexist during the working process of spool valves. Secondly coupling behavior of each wear mechanism was characterized by analyzing actual timevariation of model parameters during wear evolution process. Meanwhile, Archard model and three-body abrasive wear model were utilized for adhesive wear and abrasive wear, respectively.Furthermore, their coupling wear model was established by calculating the actual wear volume.Finally, from the result of formal test, all the required parameters for our model were obtained.The relative error between model prediction and data of pre-test was also presented to verify the accuracy of model, which demonstrated that our model was useful for providing accurate prediction of spool valve's wear life. | Chen Yunxia Gong Wenjun Kang Rui | 2016 | Chinese Journal of Aeronautics2016，29，4： | 10 |
| 15 | Structure of the receptor-activated human TRPC6 and TRPC3 ion channels显示文摘TRPC6 和 TRPC3 是属于正规短暂受体潜力(TRPC ) 的家庭的激活受体的 nonselective 阳离子隧道隧道。他们被 diacylglycerol 激活,一个类脂化合物秒送信人。TRPC6 和 TRPC3 涉及许多生理的过程并且在人的基因疾病含有。这里我们在场在有最新识别的高亲密关系的禁止者 BTDM 的建筑群的人的 TRPC6 homotetramer 的结构由单个粒子的 cryo 电子显微镜学解决了到 3.8?分辨率。我们也在 4.4 点介绍人的 TRPC3 的结构吗?分辨率。这些结构显示出塑造钟的 cytosolic 层在保持 transmembrane 层的二层的体系结构。包括 N 终端 ankyrin 重复和 C 终端卷卷, cytosolic 领域的广泛的内部子单元的相互作用贡献 tetramer 集会。高亲密关系的禁止者 BTDM 在 S5-S6 毛孔领域和电压之间挤像传感器的领域禁止隧道开。我们的结构揭开 TRPC 隧道的分子的建筑学并且为理解这些隧道的机制提供一个结构的基础。 | Qinglin Tang Wenjun Guo Li Zheng Jing-Xiang Wu Meng Liu Xindi Zhou Xiaolin Zhang Lei Chen | 2018 | Cell Research2018，28，7： | 10 |
| 16 | Geochemistry of Platinum Group and Rare Earth Elements of the Polymetallic Layer in the Lower Cambrian,Weng'an,Guizhou Province显示文摘在华南的 Yangtze 站台上,在 Weng'an 的更低的寒武纪的 Niutitang 形成的黑页岩包含多卷的 polymetallic 硫化物存款。踪迹,稀土元素,和铂组元素(PGE ) 的全面 geochemical 调查被承担了以便讨论它有 tectono-depositional 背景的矿石开始和关联。忍受矿石的层充实铝(瞬间) ,镍(Ni ) ,钒(V) ,铅(Pb ) ,锶(Sr ) ,钡(Ba ) ,铀(U) ,砷(作为) ,并且在丰富的稀土元素元素(REE ) 。高铀 / 钍(U/Th ) 比率(U/Th>1 ) 显示那个矿化作用被热水的过程主要影响。δU 价值超过 1.9 是沉积状况,显示出减少。REE 模式在轻稀土元素元素(LREE ) 显示出高丰富(重稀土元素元素(HREE )(LREE/HREE=5 17 ) ,稍微否定的铕(Eu ) 和铈(Ce ) 异例(δEu=0.81 0.93 ) ,并且积极 Ce 异例(δCe=0.76 1.12 ) 。PGE 丰富被 PGE 类型分发模式描绘,充实铂(磅) ,钯(Pd ) ,钌(Ru ) 和锇(O ) 。Pt/Pd 比率是 0.8,它接近海水和 ultramafic 岩石的比率。这些, geochemical 展示的所有建议矿化作用被热水的活动在前触发在 Rodinian 超级大陆的分散的上下文的紧张的背景。 | FU Yong WU Chaodong GUAN Ping QU Wenjun CHEN Jiafu | 2009 | Acta Geologica Sinica(English Edition)2009，83，3： | 10 |
| 17 | Model-driven degradation modeling approaches:Investigation and review显示文摘The second law of thermodynamics implies that any animate and inanimate systems degrade and inevitably stops functioning.It is irreversible over time that can be labeled as‘‘the degradation arrow of time'.From perspective of products’reliability design,it is essential to build appropriate models of describing the degradation arrow of time.The current modeling approaches mainly include the model-driven(having assumed forms based on cognitive experience of mankind)and data-driven(using data learning techniques without form hypothesis)approaches.In this paper,we just investigate and review the model-driven degradation approaches,hoping to provide suggestions of the model construction or selection for scholars or engineers.First,for the single mechanism,degradation law models and stochastic process models are classified as separately depicting the tendency and fluctuation of degradation.For the degradation law model,we propose the concept of meta-models as original types for various personal models.For the stochastic process model,two main types including the non-monotonic and monotonical types are presented.Then,four multi-mechanism degradation types are discussed,that are competitive degradation,multi-stage degradation,coexistence of degradation and impact,and coexistence of degradation and failure.Besides,for the multi-performance degradation,independent and coupling models are introduced.The forms,connotations,applicability and insufficiency of these models are described with a series of examples from the literature and our own experiences.The final explicit suggestions about the potential future work are provided for the development of new degradation models. | Rui KANG Wenjun GONG Yunxia CHEN | 2020 | Chinese Journal of Aeronautics2020，33，4： | 9 |
| 18 | Land Use-Related Changes in Soils of Hainan Island During the Past Half Century显示文摘During the past half century, the land utilization of Hainan Island has undergone a rapid development,but in the meanwhile, soil degradation occurs. Analysis on some basic data of the soil series collected frommore than 100 soil profiles at the end of the 1990s and beginning of this century, in combination with dataavailable, showed that soils there suffered significant decline in organic matter, experienced P and K deficiencywith soil K going on losing and undergone acidification with continuing trend. The current situation calls forstrategies to build up Hainan into an important province of sound ecology by restoring forests, to improvefood quality by implementing K supplement projects, to combat soil acidification by ameliorating the soils andgrowing leguminous crops and to ensure health of the people by developing dairy production and increasingthe daily Ca uptake by the people. | GONG ZITONG, ZHANG GANLIN, ZHAO WENJUN, ZHAO YUGUO and CHEN ZHICHENGInstitute of Soil Science, the Chinese Academy of Sciences, Nanjing 210008 (China) | 2003 | Pedosphere2003，13，1： | 9 |
| 19 | Inhibitory effects of chitosan on superoxide anion radicals and lipid free radicals显示文摘With the electron spin resonance (ESR) technique, the inhibitory effects of chitosan on superoxide anion radicals and linoleic acid lipid radicals were found. The inhibitory ratio E for these two kinds of radicals is in proportion to the concentration of chitosan. It was also observed that E for linoleic acid lipid radicals increased with the increase of the degree of deacetylation and decreased with the increase of the molecular weight of chitosan. | Wenjun Li Xuan Jiang Peihua Xue Shiming Chen | 2002 | Chinese Science Bulletin2002，47，11： | 9 |
| 20 | Aerosolized STAT1 Antisense Oligodeoxynucleotides Decrease the Concentrations of Inflammatory Mediators in Bronchoalveolar Lavage Fluid in Bleomycin-Induced Rat Pulmonary Fibrosis显示文摘It has been demonstrated that alveolar macrophages (AMs) play a key role in the pathogenesis of pulmonary fibrosis by releasing a variety of cytokines and inflammatory mediators. In addition, abnormal signal transducer and activator of transcription-1 (STAT1) activation in AMs may play a pivotal role in the process of alveolitis and pulmonary fibrosis. In this study, we transfected STAT1 antisense oligodeoxynucleotide (ASON) into rats by aerosolization, and then investigated the effect of STAT1 ASON on inflammatory mediators such as TGF-β, PDGF and TNF-α in bronchoalveolar lavage fluid (BALF) from rats with bleomycin (BLM)-induced rat pulmonary fibrosis. Our results showed that STAT1 ASON by aerosolization could enter into lung tissues and AMs. STAT1 ASON could inhibit mRNA and protein expressions of STAT1 and ICAM-1 in AMs of rat with pulmonary fibrosis, and had no toxic side effect on liver and kidney. Aerosolized STAT1 ASON could ameliorate the alveolitis through inhibiting the secretion of inflammatory mediators in BLM-induced rat pulmonary fibrosis. These results suggest that aerosolized STAT1 ASON might be considered as a promising new strategy in the treatment of pulmonary fibrosis. | Ming Zeng Bin Liao Chen Zhu Wenjun Wang Xiaoqin Zhan Xianming Fan | 2008 | Cellular & Molecular Immunology2008，5，3： | 8 |
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