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| 1 | Assessment of contrast-enhanced ultrasonography in diagnosis and preoperative localization of insulinoma显示文摘 | Lichun An Wenxiu Li Ke-chun Yao Rong Liu Faqin Lv Jie Tang Sunxin Zhang | 2010 | European Journal of Radiology2010，，3： | 1 |
| 2 | Prognostic influence of metformin as first-line chemotherapy for advanced nonsmall cell lung Cancer in patients with type 2 diabetes显示文摘 | Tan Benxu Yao Wenxiu Ge Jun | | 0，，22： | 1 |
| 3 | Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study显示文摘Background:Lipusu is the first commercialized liposomal formulation of pacli-taxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma(LSCC)in a small-scale study.Here,we conducted a multicenter,randomized,phase 3 study to compare the efficacy and safety of cis-platin plus Lipusu(LP)versus cisplatin plus gemcitabine(GP)as first-line treat-ment in locally advanced or metastatic LSCC.Methods:Patients enrolled were aged between 18 to 75 years,had locally advanced(clinical stage IIIB,ineligible for concurrent chemoradiation or surgery)or metastatic(Stage IV)LSCC,had no previous systemic chemother-apy and at least one measurable lesion as per the Response Evaluation Criteria in Solid Tumors(version 1.1)before administration of the trial drug.The primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),overall survival(OS),and safety profiles.To explore the possible predictive value of plasma cytokines for LP treatment,plasma samples were collected from the LP group at baseline and first efficacy evaluation time and were then subjected to analysis by 45-Plex ProcartaPlex Panel 1 to detect the presence of 45 cytokines using the Luminex xMAP technology.The correlation between treatment outcomes and dynamic changes in the levels of cytokines were evaluated in preliminary analyses.Results:The median duration of follow-up was 15.4 months.237 patients in the LP group and 253 patients in the GP group were included in the per protocol set(PPS).In the PPS,the median PFS was 5.2 months versus 5.5 months in the LP and GP group(hazard rtio[HR]:1.03,P=0.742)respectively.The median OS was 14.6 months versus 12.5 months in the LP and GP group(HR:0.83,P=0.215).The ORR(41.8%versus 45.9%,P=0.412)and DCR(90.3%versus 88.1%,P=0.443)were also similar between the LP and GP group.A significantly lower proportion of patients in the LP group experienced adverse events(AEs)leading to treatment interruptions(10.9%versus 26.4%,P<0.001)or treatment termination(14.3%versus 23.1%,P=0.011).The analysis of cytokine levels in the LP group showed that low baseline levels of 27 cytokines were associated with an increased ORR,and 15 cytokines were associated with improved PFS,with 14 cytokines,including TNF-a,IFN-y,IL-6,and IL-8,demonstrating an overlapping trend.Conclusion:The LP regimen demonstrated similar PFS,OS,ORR and DCR as the GP regimen for patients with locally advanced or metastatic LSCC but had more favorable toxicity profiles.The study also identified a spectrum of different cytokines that could be potentially associated with the clinical benefit in patients who received the LP regimen. | Jie Zhang Yueyin Pan Qin Shi Guojun Zhang Liyan Jiang Xiaorong Dong Kangsheng Gu Huijuan Wang Xiaochun Zhang Nong Yang Yuping Li Jianping Xiong Tienan Yi Min Peng Yong Song Yun Fan Jiuwei Cui Gongyan Chen Wei Tan Aimin Zang Qisen Guo Guangqiang Zhao Ziping Wang Jianxing He Wenxiu Yao Xiaohong Wu Kai Chen Xiaohua Hu Chunhong Hu Lu Yue Da Jiang Guangfa Wang Junfeng Liu Guohua Yu Junling Li Jianling Bai Wenmin Xie Weihong Zhao Lihong Wu Caicun Zhou | 2022 | Cancer Communications2022，42，1： | 1 |
| 4 | Assessment of contrast-enhanced ultrasonography in diagnosis and preoperative localization of insulinoma显示文摘 | Lichun An Wenxiu Li Ke-chun Yao Rong Liu Faqin Lv Jie Tang Sunxin Zhang | 2010 | European Journal of Radiology2010，，3： | 1 |
| 5 | Arabidopsis cryptochrome 1 promotes stomatal development through repression of AGB1 inhibition of SPEECHLESS DNA-binding activity显示文摘Cryptochromes are blue light photoreceptors that mediate various light responses in plants and mammals. The heterotrimeric G-protein is known to regulate various physiological processes in plants and mammals. In Arabidopsis, cryptochrome 1(CRY1) and the G-protein β subunit AGB1 act antagonistically to regulate stomatal development.The molecular mechanism by which CRY1 and AGB1 regulate this process remains unknown.Here, we show that Arabidopsis CRY1 acts partially through AGB1, and AGB1 acts through SPEECHLESS(SPCH), a master transcription factor that drives stomatal initiation and proliferation, to regulate stomatal development. We demonstrate that AGB1 physically interacts with SPCH to block the b HLH DNA-binding domain of SPCH and inhibit its DNA-binding activity. Moreover, we demonstrate that photoexcited CRY1 represses the interaction of AGB1 with SPCH to release AGB1 inhibition of SPCH DNA-binding activity, leading to the expression of SPCH-target genes promoting stomatal development. Taken together, our results suggest that the mechanism by which CRY1 promotes stomatal development involves positive regulation of the DNA-binding activity of SPCH mediated by CRY1 inhibition of the AGB1-SPCH interaction. We propose that the antagonistic regulation of SPCH DNA-binding activity by CRY1 and AGB1 may allow plants to balance light and G-protein signaling and optimize stomatal density and pattern. | Xiaoli Cao Pengbo Xu Yao Liu Guangqiong Yang Minqing Liu Li Chen Yingyu Cheng Peng Xu Langxi Miao Zhilei Mao Wenxiu Wang Shuang Kou Tongtong Guo Hong‐Quan Yang | 2021 | Journal of Integrative Plant Biology2021，63，11： | 1 |
| 6 | Chemotherapy with or without irinotecan in patients with advanced or recurrent gastric cancer: a meta-analysis of randomized controlled trials显示文摘 | Zeng Chao Zhou Hang Wei Yang Wang Liyang Xie Hua Yao Wenxiu | 2014 | Chinese Medical Journal2014，，5： | 0 |
| 7 | STUDY ON BEHAVIOR OF TRAPPED HYDROGEN IN 18Ni MARAGING STEEL BY THERMAL HYDROGEN EVOLUTION TECHNIQUE显示文摘The interaction of hydrogen with interface between the precipitates and the martensitie matrixin 18Ni maraging steel has been studied by means of thermal evolution hydrogen technique us-ing gas chromatograph as hydrogen detector.An evolution rate peak has been observed at 451K.The height of the peak relates to the amount and distribution of the precipitates.Theactivation energy for hydrogen escaping from the trap sites is 23.2 kJ/mol. | YAO Daping CHEN Wenxiu Institute of Metal Research,Academia Sinica,Shenyang,China Institute of Metal Research,Academia Sinica,Shenyang,China | 1989 | Acta Metallurgica Sinica(English Letters)1989，2，4： | 0 |
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