|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Integrated Pipe- line for Mass Spectrometry-Based Discovery and Confirmation of Biomarkers Demonstrated in a Mouse Model of Breast Cancer显示文摘 | Whiteaker J Zhang H Zhao L | 2007 | J Proteome Res2007，6，： | 1 |
| 2 | ^125I-α-Conotoxin MII identifies a novel nicotinic acetylcholine receptor population in mouse brain显示文摘 | Whiteaker P McIntosh J M Luo S | 2000 | Mol Pharmacol2000，57，： | 1 |
| 3 | Antibody-based enrichment of peptides on magnetic beads for mass-spectrometry-based quantification of serum biomarkers显示文摘 | Whiteaker J Zhao L Zhang HY | 2007 | Anal Biochem2007，362，： | 1 |
| 4 | Integrated pipeline for mass spectrometry-based discovery and confirmation of biomarkers demonstrated in a mouse model of breast cancer显示文摘 | Whiteaker J R Zhang H Zhao L | 2007 | J Proteome Res2007，6，10： | 1 |
| 5 | A targeted proteomics-based pipeline for verification of biomarkers in plasma显示文摘 | Whiteaker JR Lin C Kennedy J | 2011 | Nat Biotechnol2011，29，7： | 1 |
| 6 | A first approach to Web services for the national water information system显示文摘 | GOODALL J L HORSBURGH J S WHITEAKER T L | 2008 | Environmental Modelling & Software2008，23，4： | 1 |
| 7 | Explaining packet de- lays under virtualization 显示文摘 | Whiteaker J Schneider F Teixeira R | 2011 | Computer Communication Re-view2011，41，1： | 1 |
| 8 | Effects ofmeteorological conditions on aerosol composition and mixing statein bakersfield,CA 显示文摘 | Whiteaker J R Suess D T Prather K A | 2002 | Environmental Science Technology2002，36，11： | 1 |
| 9 | Antibody-based enrichment of peptides on magnetic beads for mass-spectrometry-based quantification of serum biomarkers显示文摘 | WHITEAKER J R ZHAO L ZHANG H Y | 2007 | Anal Biochem2007，362，1： | 1 |
| 10 | Pharmacological and immunochemical characterization of α2* nicotinic acetylcholine receptors (nAChRs) in mouse brain显示文摘 | Paul WHITEAKER Jennifer A WILKING Robert WB BROWN Robert J BRENNAN Allan C COLLINS Jon M LINDSTROM Jim BOULTER | 2009 | Acta Pharmacologica Sinica2009，30，6： | 1 |
| 11 | Antibody-based enrichment of peptides on magnetic beads for mass-spectrometry- based quantification of serum biomarkers 显示文摘 | WHITEAKER J R ZHAO L ZHANG H Y | 2007 | Anal Biochem2007，362，1： | 1 |
| 12 | Explaining Packet I)e- lays under Virtualization 显示文摘 | Whiteaker J Schneider F Teixeira R | 2011 | Computer Communication Re- view2011，41，1： | 1 |
| 13 | Pharmacological and functional comparisons of α6/ α31β2β3-nAChRs and (α4β2-nAChRs heterologously expressed in the human epithelial SH-EP1 cell line显示文摘 | De-jie CHEN Fen-fei GAO Xiao-kuang MA Gang-gang SHI Yuan-bing HUANG Quang-xi SU Sterling SUD- WEEKS Ming GAO Turner DHARSHAUN Jason Brek EATON Yong-chang CHANG J Michael MClNTOSH Ronald J LUKAS Paul WHITEAKER Scott C STEFFENSEN Jie WU | 2018 | Acta Pharmacologica Sinica2018，39，10： | 1 |
| 14 | A first approach to web services for the National Water Information System显示文摘 | Goodall J L Horsburgh J S Whiteaker T L | 2008 | Environmental Modelling & Software2008，，： | 1 |
| 15 | A first approach to Web services for the national water information system显示文摘 | GOODALL J L HORSBURGII J S WHITEAKER T L | 2008 | Environmental Modelling & Software2008，23，4： | 1 |
| 16 | A targeted proteomics-based pipeline for verification of biomarkers in plasma显示文摘 | Whiteaker J R Lin C Kennedy J | 2011 | Nat Biotechnol2011，29，7： | 1 |
| 17 | Nicotinic acetylcholine receptor α7 subunits with a C2 cytoplasmic loop yellow fluorescent protein insertion form functional receptors显示文摘 | Teresa A MURRAY Qiang LIU Paul WHITEAKER Jie WU Ronald J LUKAS | 2009 | Acta Pharmacologica Sinica2009，30，6： | 0 |
| 18 | Cocaine potently blocks neuronal α_(3)β_(4) nicotinic acetylcholine receptors in SH-SY5Y cells显示文摘Cocaine is one of the most abused illicit drugs worldwide.It is well known that the dopamine(DA)transporter is its major target;but cocaine also acts on other targets including nicotinic acetylcholine receptors(nAChRs).In this study,we investigated the effects of cocaine on a special subtype of neuronal nAChR,α3β4-nAChR expressed in native SH-SY5Y cells.α3β4-nAChR-mediated currents were recorded using whole-cell recordings.Drugs were applied using a computer-controlled U-tube drug perfusion system.We showed that bath application of nicotine induced inward currents in a concentration-dependent manner with an EC50 value of 20μM.Pre-treatment with cocaine concentration-dependently inhibited nicotine-induced current with an IC50 of 1.5μM.Kinetic analysis showed that cocaine acceleratedα3β4-nAChR desensitization,which caused a reduction of the amplitude of nicotine-induced currents.Co-application of nicotine and cocaine(1.5μM)depressed the maximum response on the nicotine concentration-response curve without changing the EC50 value,suggesting a non-competitive mechanism.The cocaine-induced inhibition of nicotine response exhibited both voltage-and use-dependence,suggesting an open-channel blocking mechanism.Furthermore,intracellular application of GDP-βS(via recording electrode)did not affect cocaine-induced inhibition,suggesting that cocaine did not alter receptor internalization.Moreover,intracellular application of cocaine(30μM)failed to alter the nicotine response.Finally,cocaine(1.5μM)was unable to inhibit the nicotine-induced inward current in heterologous expressedα6/α3β2β3-nAChRs andα4β2-nAChRs expressed in human SH-EP1 cells.Collectively,our results suggest that cocaine is a potent blocker for nativeα3β4-nAChRs expressed in SH-SY5Y cells. | Ze-gang Ma Nan Jiang Yuan-bing Huang Xiao-kuang Ma Jason Brek Eaton Ming Gao Yong-chang Chang Ronald J Lukas Paul Whiteaker Janet Neisewander Jie Wu | 2020 | Acta Pharmacologica Sinica2020，41，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员