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| 1 | Preservation solutions used during abdominal transplantation:Current status and outcomes显示文摘Organ preservation remains an important contributing factor to graft and patient outcomes. During donor organ procurement and transportation, cellular injury is mitigated through the use of preservation solutions in conjunction with hypothermia. Various preservation solutions and protocols exist with widespread variability among transplant centers. In this review of abdominal organ preservation solutions, evolution of transplantation and graft preservation are discussed followed by classification of preservation solutions according to the composition of electrolytes, impermeants, buffers, antioxidants, and energy precursors. Lastly, pertinent clinical studies in the setting of hepatic, renal, pancreas, and intestinal transplantation are reviewed for patient and graft survival as well as financial considerations. In liver transplants there may be some benefit with the use of histidine-tryptophan-ketoglutarate(HTK) over University of Wisconsin solution in terms of biliary complications and potential cost savings. Renal grafts may experience increased initial graft dysfunction with the use of Euro-Collins thereby dissuading its use in support of HTK which can lead to substantial cost savings. University of Wisconsin solution and Celsior are favored in pancreas transplants given the concern for pancreatitis and graft thrombosis associated with HTK. No difference was observed with preservation solutions with respect to graft and patient survival in liver, renal, and pancreas transplants. Studies involving intestinal transplants are sparse but University of Wisconsin solution infused intraluminally in combination with an intra-vascular washout is a reasonable option until further evidence can be generated. Available literature can be used to ameliorate extensive variation across centers while potentially minimizing graft dysfunction and improving associated costs. | Nicholas Latchana Joshua R Peck Bryan A Whitson Mitchell L Henry Elmahdi A Elkhammas Sylvester M Black | 2015 | World Journal of Transplantation2015，5，4： | 5 |
| 2 | Animal models of ex vivo lung perfusion as a platform for transplantation research显示文摘Ex vivo lung perfusion(EVLP) is a powerful experimental model for isolated lung research. EVLP allows for the lungs to be manipulated and characterized in an external environment so that the effect of specific ventilation/perfusion variables can be studied independent of other confounding physiologic contributions. At the same time,EVLP allows for normal organ level function and real-time monitoring of pulmonary physiology and mechanics. As a result,this technique provides uniqueadvantages over in vivo and in vitro models. Small and large animal models of EVLP have been developed and each of these models has their strengths and weaknesses. In this manuscript,we provide insight into the relative strengths of each model and describe how the development of advanced EVLP protocols is leading to a novel experimental platform that can be used to answer critical questions in pulmonary physiology and transplant medicine. | Kevin Nelson Christopher Bobba Samir Ghadiali Don Hayes Jr Sylvester M Black Bryan A Whitson | 2014 | World Journal of Experimental Medicine2014，4，2： | 2 |
| 3 | Melatonin and cortisoI assessment of circadian shifts in astronauts be- fore flight 显示文摘 | Whitson P A Putcha L Chen Y M | 1995 | Journal of Pineal Research1995，18，3： | 1 |
| 4 | Children's coping with marital conflict and their adjustment and physical health:Vulnerability and protective functions显示文摘 | Nicolotti L El-Sheikh M Whitson SM | | 0，，： | 1 |
| 5 | Surgical assessment and intraoperative management of mediastinal lymph nodes in non small cell lung cancer显示文摘 | Whitson B A Groth S S Maddaus M A | 2007 | Ann Thorac Surg2007，84，3： | 1 |
| 6 | Double stranded- RNA-mediated activation of P21 gene induced apoptosis and cell cycle arrest in renal cell carcinoma显示文摘 | Whitson J M Noonan E J Pookot D | 2009 | Int J Cancer2009，125，2： | 1 |
| 7 | Intravenous therapy in the older adult: Special needs and considerations显示文摘 | Whitson M | 1996 | J Intraven Nurs1996，19，5： | 1 |
| 8 | Application of a General Material Balance for High-Pressure Gas Reservoirs显示文摘 | FETKOVICH M J REESE D E WHITSON C H | 1991 | SPE J1991，3，1： | 1 |
| 9 | Application of a general material balance for high pressure gas reservoirs显示文摘 | Fetkovich M J Reese D E Whitson C H | 1998 | SPE Journal1998，3，1： | 1 |
| 10 | Laparoscopic resection of periaortic paragangliomas显示文摘 | Whitson B A Tuttle T M | 2005 | Am Surg2005，71，： | 1 |
| 11 | Resolving factor analysis显示文摘 | Mason C Maeder M Whitson A | 2001 | Anal Chem2001，73，7： | 1 |
| 12 | Detection of carbonic anhydrase-9 gene expression in peripheral blood ceils predicts risk of disease recurrence in patients with renal cortical tumors显示文摘 | Gilbert S M Whitson J M Mansukhani M | 2006 | Urology2006，67，5： | 1 |
| 13 | Se- quential intravesial gemcitabine and mitomycin C chemotherapy regimen in patients with non-muscle in- vasive bladder cancer显示文摘 | Breyer B N Whitson J M Carroll P R | 2010 | Urol Oneol2010，28，5： | 1 |
| 14 | The RDH bandage:Hemostasis and survival in a lethal aortotomy hemorrhage model显示文摘 | Vournakis JN Demcheva M Whitson AB | | 0，，01： | 1 |
| 15 | The negative flash显示文摘 | Whitson C H Michelsen M L | 1989 | Fluid Phase Equilibria1989，53，： | 1 |
| 16 | Application of a general material balance for high-pressure gas reservoirs显示文摘 | Fetkovich M J Reese D E Whitson C H | 1998 | SPE Journal1998，3，1： | 1 |
| 17 | Sensorycharacterization of chemical components responsible for cardboard flavor in whey protein 显示文摘 | Whitson M E Miracle R E Drake M A | 2010 | Journal of Sensory Studies2010，25，4： | 1 |
| 18 | Comparison of travoprost and with timolol in patients with ele- vated intraocular pressure: a 6-month, masked, multieenter trial 显示文摘 | Fellman RL Sullivan EK Ratliff M Silver LH Whitson | 2002 | Ophthalmology2002，109，5： | 1 |
| 19 | Organ assessment and repair centers: The future of transplantation is near显示文摘Solid organ transplantation is limited by suitable donor organ availability and the geographic limitations that lead to prolonged ischemic times. Ex vivo organ perfusion is an evolving technology that enables assessment of organ function prior to transplantation. As a byproduct, overall out of body organ times are able to be extended. The future implications organ assessment and repair centers utilizing this technology are discussed. | Bryan A Whitson Sylvester M Black | 2014 | World Journal of Transplantation2014，4，2： | 1 |
| 20 | Sequen- tial intravesical gemcitabine and mitomycin C chemo- therapy regimen in patients with non-muscle invasive bladder cancer显示文摘 | Breyer B N Whitson J M Carroll P R | 2010 | Urol Oncol2010，28，5： | 1 |
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