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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | Influence of non‐alcoholic fatty liver disease on the development of diabetes mellitus显示文摘 | Anuradhani Kasturiratne Sanjaya Weerasinghe Anuradha S Dassanayake Shaman Rajindrajith Arjuna P Silva Norihiro Kato A Rajitha Wickremasinghe H Janaka Silva | 2012 | J Gastroenterol Hepatol2012，，1： | 2 |
| 3 | Biochemical andgenetic control of apoptpsis: relevance to normalhematopoiesis and hematological malignancies 显示文摘 | Wickremasinghe R G Hoffbrand A V | 1999 | Blood1999，93，11： | 1 |
| 4 | Enteral feeding during indomethacin and ibuprofen treatment of a patent ductus arteriosus显示文摘 | Clyman R Wickremasinghe A Jhaveri N | 2013 | J Pediatr2013，163，2： | 1 |
| 5 | p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies显示文摘 | Wickremasinghe R G Prentice A G Steele A J | 2011 | Leukemia2011，25，9： | 1 |
| 6 | Biochemical and genetic control of apoptosis: relevance to normal hematological control of apoptosis 显示文摘 | Wickremasinghe R G Hofffbrand A V | 1997 | Immunol Today1997，18，： | 1 |
| 7 | The global burden of snake bite: a literature analysis and modelling based on regional estimates of envenoming and deaths显示文摘 | Kasturiratne A Wickremasinghe AR de Sliva N | 2008 | PloS Medicine2008，5，11： | 1 |
| 8 | The global burden of snakebite:a literature analysis and modelling based on re-gional estimates of envenoming and deaths显示文摘 | Kasturiratne A Wickremasinghe A R Silva N | 2008 | PLOS Medicine2008，5，11： | 1 |
| 9 | Accumulation of free proline in bark and latex of Hevea brasiliensis affected by brow bast显示文摘 | Wickremasinghe S I Yapa P A J De-Soyza-T V W | 1987 | J Rubber Res Inst SL1987，，： | 1 |
| 10 | Effectof ethephon, pure tea seed saponin, and partially purified tearoot saponin on the growth of tea in the nursery and the field显示文摘 | Wickremasinghe RL Perera KP WC Munasinghe T A | 1974 | TeaQ1974，，44： | 1 |
| 11 | Effect of ethephon, pure tea seed saponin, and partially purifiedtea root saponin on the growth of tea in the nursery and the field显示文摘 | Wickremasinghe R L Perera K P W C & Munasinghe T A | 1974 | Tea Q1974，44，： | 1 |
| 12 | Effect of ethephon, pure tea seed saponin, and partially purified tea root saponin on the growth of tea in the nursery and the field 显示文摘 | WICKREMASINGHE R L PERERA K P W C MUNAS- INGHE T A | 1974 | Tea Q1974，44，： | 1 |
| 13 | Toxicity due to organophosphorus compounds: What about chronic exposure 显示文摘 | De Silva H J Samarawickrema N A Wickremasinghe A R | 2006 | Transactions of the Royal Society of Tropical Medicine and Hygiene2006，100，9： | 1 |
| 14 | The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths显示文摘 | Kasturiratne A Wickremasinghe AR de Silva N | 2008 | PLoS Med2008，5，11： | 1 |
| 15 | Prevalence and predictors of osteoporosis in an urban Sri Lankan population显示文摘 | Karunanayake A L Pinidiyapathirage M J Wickremasinghe A R | 2010 | lnt J Rheum Dis2010，13，4： | 1 |
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