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| 1 | Perspectives of pluripotent stem cells in livestock显示文摘The recent progress in derivation of pluripotent stem cells(PSCs)from farm animals opens new approaches not only for reproduction,genetic engineering,treatment and conservation of these species,but also for screening novel drugs for their efficacy and toxicity,and modelling of human diseases.Initial attempts to derive PSCs from the inner cell mass of blastocyst stages in farm animals were largely unsuccessful as either the cells survived for only a few passages,or lost their cellular potency;indicating that the protocols which allowed the derivation of murine or human embryonic stem(ES)cells were not sufficient to support the maintenance of ES cells from farm animals.This scenario changed by the innovation of induced pluripotency and by the development of the 3 inhibitor culture conditions to support naïve pluripotency in ES cells from livestock species.However,the long-term culture of livestock PSCs while maintaining the full pluripotency is still challenging,and requires further refinements.Here,we review the current achievements in the derivation of PSCs from farm animals,and discuss the potential application areas. | Dharmendra Kumar Thirumala R Talluri Naresh L Selokar Iqbal Hyder Wilfried A Ku | 2021 | World Journal of Stem Cells2021，13，1： | 4 |
| 2 | Complex 3D-tailored facets for optimal lighting of facades and public places显示文摘 | WILFRIED P CHRISTIAN A CHRISTIAN A K | 2003 | SPIE2003，5186，： | 1 |
| 3 | Kues application of transgenesis in livestock for agriculture and biomedicine 显示文摘 | Heiner Niemann Wilfried A | 2003 | Animal Reproduction Science2003，79，： | 1 |
| 4 | The role of germacrene D as a precursor in sesquiterpene biosynthesis: investigations of acid catalyzed, photochemically and thermally induced rearrangements显示文摘 | Nils Bulow Wilfried A Konig | 2000 | Phytochemistry2000，55，： | 1 |
| 5 | Indigenous bacteria and bacterial metabolic products in the gastrointestinal tract of broiler chickens显示文摘 | Habib Ur R Wilfried V Wageha A A Prof J Z | 2007 | Archives of Animal Nutrition2007，61，5： | 1 |
| 6 | CCNU -dependent potentiation of TRAIL/APO2L- induced apoptosis in human glioma cells is P53 independent but may involve enhanced cytochrome C release 显示文摘 | Till A Rohn Bettina Wagenknecht Wilfried Roth | 2001 | Oncogene2001，20，： | 1 |
| 7 | Porcine model characterizing various parameters assessing the outcome after acetaminophen intoxication induced acute liver failure显示文摘AIM To investigate the changes of hemodynamic and laboratory parameters during the course of acute liver failure following acetaminophen overdose.METHODS Eight pigs underwent a midline laparotomy following jejunal catheter placement for further acetaminophen intoxication and positioning of a portal vein Doppler flow-probe. Acute liver failure was realized by intrajejunal acetaminophen administration in six animals, two animals were sham operated. All animals were invasively monitored and received standardized intensive care support throughout the study. Portal blood flow, hemodynamic and ventilation parameters were continuously recorded. Laboratory parameters were analysed every eight hours. Liver biopsies were sampled every 24 h following intoxication and upon autopsy.RESULTS Acute liver failure (ALF) occurred after 28 ± 5 h resulted in multiple organ failure and death despite maximal support after further 21 ± 1 h (study end). Portal blood flow (baseline 1100 ± 156 m L/min) increased to a maximum flow of 1873 ± 175 m L/min at manifestation of ALF, which was significantly elevated(P < 0.01). Immediately after peaking, portal flow declined rapidly to 283 ± 135 m L/min at study end. Thrombocyte values (baseline 307 × 103/μL± 34 × 103/μL) of intoxicated animals declined slowly to values of 145 × 103/μL± 46 × 103/μL when liver failure occurred. Subsequent appearance of severe thrombocytopenia in liver failure resulted in values of 11 × 103/μL± 3 × 103/μL preceding fatality within few hours which was significant(P > 0.01).CONCLUSION Declining portal blood flow and subsequent severe thrombocytopenia after acetaminophen intoxication precede fatality in a porcine acute liver failure model. | Karolin Thiel Wilfried Klingert Kathrin Klingert Matthias H Morgalla Martin U Schuhmann Pamela Leckie Yalda Sharifi Nathan A Davies Rajiv Jalan Andreas Peter Christian Grasshoff Alfred Konigsrainer Martin Schenk Christian Thiel | 2017 | World Journal of Gastroenterology2017，23，9： | 1 |
| 8 | Reactive compawtibilization of polypropylene terphthalate blends显示文摘 | Michel F Champapne Michel A Huneault Claudine Roux Wilfried Peyrel | 1999 | Polym Eng Sci1999，396，： | 1 |
| 9 | An attempt to rationalize stretching frequencies of lattice hydroxyl groups in hydrogen 显示文摘 | Peter A Jacobs Wilfried J Mortier | 1982 | Zeollitees1982，2，3： | 1 |
| 10 | Analytical separation and detection methods for flavonoids显示文摘 | Rijke Eva de Out Pieter Niessen Wilfried M A Gooijer Cees Brinkman Udo A Th | 2006 | Journal of Chromatography A2006，，2： | 1 |
| 11 | The role of germacrene D as a precursor in sesquiterpene biosynthesis:investigations of acid catalyzed,photochemically and thermally induced rearrangements显示文摘 | Nils Bülow Wilfried A Konig | 2000 | Phytochemistry2000，55，2： | 1 |
| 12 | Modifizerte cyclodextrine neue hochenantioselektive trennphasen fur die gaschromatographic显示文摘 | Konig Sabine Lutz | 1988 | Angew Chem1988，，： | 1 |
| 13 | Ophiocordin,an Antifungal Antibiotic of Cordyceps ophioglossoides显示文摘 | Helmut K Wilfried A K Wolfgang L | 1997 | Archives of Microbiology1997，113，： | 1 |
| 14 | Steroids from the fungus Fomitopsis pinicola显示文摘 | Joachim R Wilfried A K | 1999 | Phytochemistry1999，52，： | 1 |
| 15 | Analytic path planning algorithms for bipedal robots without a trunk显示文摘 | AMOS A WILFRIED G | 2003 | Journal of Intelligent and Robotic Systems2003，36，2： | 1 |
| 16 | Physical limits of hyperthermia using magnetite fine pa rtjcles显示文摘 | RUDOLF H WILFRIED A CARL G d’A | 1998 | Transactions on Magnetics1998，34，5： | 1 |
| 17 | The role of germacrene D as a precursor in sesquiterpene biosynthesis: investigations of acid catalyzed, photochemically and thermally induced re- arrangements 显示文摘 | Nils B Wilfried A K | 2000 | Phytochemistry2000，155，： | 1 |
| 18 | The Role Germacrene D as a Precursor in Sesquiterpene Biosynthesis: Investigations of Acid Aatalyzed, Photochemically and Thermally Induced Rearrangements 显示文摘 | Nils Bulow Wilfried A Konig | 2000 | Phytochemistry2000，2，55： | 1 |
| 19 | Ksnig, Steroids from the fungus Fomitopsis pinicola显示文摘 | Joachim Rssecke Wilfried A | 1999 | Phytochemistry1999，52，： | 1 |
| 20 | Konig, Chemical study of the essential oil of Cyperus rotundus 显示文摘 | Mesmin Mekem Sonwa Wilfried A | 2001 | Phytochemistry2001，58，5： | 1 |
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