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| 1 | Voxel-based magnetic resonance imaging investigation of poor and preserved clinical insight in people with schizophrenia显示文摘AIM To define regional grey-matter abnormalities in schizophrenia patients with poor insight(Insight-),relative to patients with preserved clinical insight(Insight+),and healthy controls.METHODS Forty stable schizophrenia outpatients(20 Insight-and 20 Insight+) and 20 healthy controls underwent whole brain magnetic resonance imaging(MRI).Insight in all patients was assessed using the Birchwood Insight Scale(BIS;a self-report measure).The two patient groups were preselected to match on most clinical and demographic parameters but,by design,they had markedly distinct BIS scores.Voxel-based morphometry employed in SPM8 was used to examine group differences in grey matter volumes across the whole brain.RESULTS The three participant groups were comparable in age [F(2,57) = 0.34,P = 0.71] and the patient groups did not differ in age at illness onset [t(38) = 0.87,P = 0.39].Insight-and Insight+ patient groups also did not differ in symptoms on the Positive and Negative Syndromes scale(PANSS):Positive symptoms [t(38) = 0.58,P = 0.57],negative symptoms [t(38) = 0.61,P = 0.55],general psychopathology [t(38) = 1.30,P = 0.20] and total PANSS scores [t(38) = 0.21,P = 0.84].The two patient groups,as expected,varied significantly in the level of BIS-assessed insight [t(38) = 12.11,P < 0.001].MRI results revealed lower fronto-temporal,parahippocampal,occipital and cerebellar grey matter volumes in Insightpatients,relative to Insight+ patients and healthy controls(for all clusters,family-wise error corrected P < 0.05).Insight+ patient and healthy controls did not differ significantly(P > 0.20) from each other.CONCLUSION Our findings demonstrate a clear association between poor clinical insight and smaller fronto-temporal,occipital and cerebellar grey matter volumes in stable long-term schizophrenia patients. | Adegboyega Sapara Dominic H Ffytche Michael A Cooke Steven CR Williams Veena Kumari | 2016 | World Journal of Psychiatry2016，6，3： | 3 |
| 2 | 雨养农业:中国半干旱地区雨水灌溉土地上的水资源综合管理系统显示文摘雨养农业(RHA)最早是由甘肃省科学家在十几年前开发的,它是适用于半干旱地区靠雨水灌溉土地的一种水资源综合管理系统。这个系统由三个主要部分组成:雨水收集系统、节水灌溉系统和高效农作物生产系统。它的主要功能是为农民们提供一种能够在用水受限制的环境下获得满足家庭生活和农业所需要的水的途径。在甘肃省和中国西北地区的其他省份,RHA的最初设置表明RHA有能力改进靠雨水灌溉的农业系统的表现,并且能够致力于解决土壤侵蚀等一些环境问题。RHA系统规模小、成本低,很客易在农民家庭推广应用。但是,为了能够取得成功,需要把RHA系统纳入到一个综合农业管理系统之中:即RHA管理必须与其他农业技术与管理实践结合在一起运用。此外,在大范围内推广使用RHA需要考虑一系列技术、农业水文、生态、社会、文化、经济和政治因素。特别是需要向农民提供培训和技术指导,以开发和传播更为有效和廉价的RHA技术方式来更新换代并设计开发出替代性的政策工具和社会规则以便于RHA在实践中的应用。 | Li Fengrui Seth Cook Gordon T. Geballe William R. Burch | 2000 | AMBIO-人类环境杂志2000，29，8： | 3 |
| 3 | An approach for greenway suitability analysis显示文摘 | William Miller Michael G. Collins Frederick R. Steiner Edward Cook | 1998 | Landscape and Urban Planning1998，，2： | 2 |
| 4 | Dissecting anxiety-related QTLs in mice by univariate and multivariate mapping显示文摘To detect genes underlying anxiety-related traits in mice,we performed univariate and multivariate QTL mapping analyses of phenotypes obtained from 71 mice of the BXD recombinant inbred (RI) strains (n=528 mice) and their parental strains (C57BL/6J and DBA/2J).Separate and joint mapping analyses were carried out using a linkage map composed of 506 simple sequence repeats (SSRs).The main QTL effects,interactions between pairs of QTLs (epistasis),and their environmental interactions were estimated.The results showed that anxiety-related traits were influenced by multiple QTLs (five main effect QTLs and three epistatic QTLs).Ten potential anxiety-related candidate genes within the QTL intervals on chromosomes 5,13 and 15 were identified.Some of these genes have been reported previously to be associated with the anxiety response.Based on our results,it is suggested that the multivariate QTL mapping approach improves the statistical power for detecting QTL and the precision of parameter estimation.Moreover,multivariate mapping can also detect pleiotropic QTL effects. | ZHU ZhiHong ZHANG ChenHao WANG XuSheng COOK Melloni N WILLIAMS Robert LU Lu ZHU Jun | 2012 | Chinese Science Bulletin2012，57，21： | 2 |
| 5 | Shock Tube Studies of Methane and Ethane Oxidation 显示文摘 | Cooke D F Williams A | 1975 | Combustion and Flame1975，24，： | 1 |
| 6 | Trace and minor elements in sphalerite: A LA-ICPMS study显示文摘 | Nigel J. Cook Cristiana L. Ciobanu Allan Pring William Skinner Masaaki Shimizu Leonid Danyushevsky Bernhardt Saini-Eidukat Frank Melcher | 2009 | Geochimica et Cosmochimica Acta2009，，16： | 1 |
| 7 | Multiple Organ Dysfunction Score: A reliable descriptor of a complex clinical outcome显示文摘 | John C. Marshall Deborah J. Cook Nicolas V. Christou Gordon R. Bernard Charles L. Sprung William J. Sibbald | 1995 | Critical Care Medicine1995，，10： | 1 |
| 8 | The impact of antibioticimpregnated catheters on shunt infection in children and neonates 显示文摘 | Hayhurst C Cooke R Williams D | 2008 | Childs New Syst2008，24，5： | 1 |
| 9 | Mechanisms of esophagopha- ryngeal acid regurgitation in human subjects显示文摘 | Szczesniak MM Williams RB Cook IJ | 2011 | PLoS One2011，6，7： | 1 |
| 10 | [43] Antioxidant effects of nitric oxide显示文摘 | David A. Wink Yoram Vodovotz Matthew B. Grisham William DeGraff John C. Cook Roberto Pacelli Murali Krishna James B. Mitchell | 1999 | Methods in Enzymology1999，，： | 1 |
| 11 | The Chemokine, CCL3, and Its Receptor, CCR1, Mediate Thoracic Radiation-Induced Pulmonary Fibrosis显示文摘 | Yang Xuebin Walton William Cook Donald N Hua Xiaoyang Tilley Stephen Haskell Christopher A Horuk Richard Blackstock A William Kirby Suzanne L | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，： | 1 |
| 12 | New thyristor assisted diverter switch for on load transformer tap changers显示文摘 | Cooke G H Williams K T | 1992 | IEE Proceedings-B1992，139，6： | 1 |
| 13 | New thyristor assisted diverter switch for on load transformer tap changers显示文摘 | Cooke G H Williams K T | 1992 | IEEE Proceedings B: Electric Power Applications1992，139，6： | 1 |
| 14 | Cerebral blood flow during cardiac operations: Comparison of Kety-Schmidt and xenon-133 clearance methods显示文摘 | David J. Cook Robert E. Anderson John D. Michenfelder William C. Oliver Thomas A. Orszulak Richard C. Daly Rex D. Bryce | 1995 | The Annals of Thoracic Surgery1995，，3： | 1 |
| 15 | Testing reckless drivers for cocaine and marijuana显示文摘 | Brooko D Cook C S Williams C | 1995 | The New England Journal of Medicine1995，26，3： | 1 |
| 16 | Seismic response of steel beams coupling concrete walls 显示文摘 | Kent A Harries Denis Mitchell William D Cook | 1993 | Journal of Structural Engineering1993，119，12： | 1 |
| 17 | A- merican Medical Education I00 years after the flexner re- port显示文摘 | Molly Cooke David M Irby William Sullivan | 2006 | New England J Med2006，355，： | 1 |
| 18 | Oropharyngeal scintigraphy:a reliable technique for the quantitative evaluation of oralpharyngeal swallowing显示文摘 | Shaw DW Williams RB Cook IJ | 2004 | Dysphagia2004，19，1： | 1 |
| 19 | Mechanisms of esophago-pharyngeal acid regurgitation in human subjects显示文摘 | Szczesniak MM Williams RB Cook IJ | | 0，，07： | 1 |
| 20 | A Computational Study of the Job-Shop Scheduling Problem显示文摘 | David Applegate William Cook | 1991 | ORSA Journal on Computing1991，，2： | 1 |
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