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| 1 | Intravenous fluid selection rationales in acute clinical management显示文摘BACKGROUND: Intravenous fluid(IVF) is commonly used in acute clinical management. This study aimed to review the choice and primary considerations in IVF prescriptions and to evaluate the adequacy of guidelines and trainings on it in the New Territories West Cluster(NTWC) of Hong Kong.METHODS: This is a descriptive study based on data collected from an online survey. Data were processed by SPSS for statistical analysis. This study focused on a general description and doctor-nurse between group comparison. Participants were asked the choice of IVF for nine acute clinical scenarios and provide reason. A 1–10 scale was used to assess the sufficiency of guideline, training and information, and time for revision on IVF prescription.RESULTS: 0.9% sodium chloride was the most familiar IVF(36%), followed by 5% Dextrose solution(26%). In the nine scenarios, the most chosen IVF was 0.9% sodium chloride(37%–61%). There was significant difference in the choice of IVF between doctors and nurses in 7 cases. The second most chosen IVF for doctors was Plasma-Lyte A while that for nurses was Gelofusine. Departmental practice was the most chosen reason to account for the prescription. The adequacy of guideline, information and training, and time for revision was rated 5. Doctors had significantly more time at work than nurses to update knowledge in IVF prescription(5.41 versus 4.57).CONCLUSION: 0.9% sodium chloride was mostly chosen. The choice of IVF was mainly based on departmental practice. Adequacy of guideline, information and training, and time for revision on IVF prescription were average, indicating significant training deficit. | Wing Yan Shirley Cheung Wai Kwan Cheung Chun Ho Lam Yeuk Wai Chan Hau Ching Chow Ka Lok Cheng Yau Hang Wong Chak Wah Kam | 2018 | World Journal of Emergency Medicine2018，9，1： | 3 |
| 2 | Impact of small-for-size liver grafts on medium-term and long-term graft survival in living donor liver transplantation: A meta-analysis显示文摘BACKGROUND Small-for-size grafts (SFSGs) in living donor liver transplantation (LDLT) could optimize donor postoperative outcomes and also expand the potential donor pool. Evidence on whether SFSGs would affect medium-term and long-term recipient graft survival is lacking. AIM To evaluate the impact of small-for-size liver grafts on medium-term and longterm graft survival in adult to adult LDLT. METHODS A systematic review and meta-analysis were performed by searching eligible studies published before January 24, 2019 on PubMed, EMBASE, and Web of Science databases. The primary outcomes were 3-year and 5-year graft survival. Incidence of small-for-size syndrome and short term mortality were also extracted. RESULTS This meta-analysis is reported according to the guidelines of the PRISMA 2009 Statement. Seven retrospective observational studies with a total of 1821 LDLT recipients were included in the meta-analysis. SFSG is associated with significantly poorer medium-term graft survival. The pooled odds ratio for 3-year graft survival was 1.58 [95% confidence interval 1.10-2.29, P = 0.014]. On the other hand, pooled results of the studies showed that SFSG had no significant discriminatory effect on 5-year graft survival with an odds ratio of 1.31 (95% confidence interval 0.87-1.97, P = 0.199). Furthermore, incidence of small-for-size syndrome detected in recipients of SFSG ranged from 0-11.4% in the included studies. CONCLUSION SFSG is associated with inferior medium-term but not long-term graft survival. Comparable long-term graft survival based on liver graft size shows that smaller grafts could be accepted for LDLT with appropriate flow modulatory measures. Close follow-up for graft function is warranted within 3 years after liver transplantation. | Ka Wing Ma Kelly Hiu Ching Wong Albert Chi Yan Chan Tan To Cheung Wing Chiu Dai James Yan Yue Fung Wong Hoi She Chung Mau Lo Kenneth Siu Ho Chok | 2019 | World Journal of Gastroenterology2019，25，36： | 3 |
| 3 | Kinetics and Risk of De Novo Hepatitis B Infection in HBsAg–Negative Patients Undergoing Cytotoxic Chemotherapy显示文摘 | Chee–Kin Hui Winnie W.W. Cheung Hai–Ying Zhang Wing–Yan Au Yui–Hung Yueng Anskar Y.H. Leung Nancy Leung John M. Luk Albert K.W. Lie Yok–Lam Kwong Raymond Liang George K.K. Lau | 2006 | Gastroenterology2006，，1： | 2 |
| 4 | Liver transplantation:would it be the best and last chance of cure for hepatocellular carcinoma with major venous invasion?显示文摘Background:Hepatocellular carcinoma(HCC)with portal vein tumour thrombus(PVTT)signifies advanced disease,whether LT confers any survival superiority over resection remains uncertain.Methods:A propensity score matched(PSM)analysis of liver transplantation(LT)and liver resection(LR)for HCC with PVTT was performed.Results:A consecutive series of 88 patients who received either LT(10 DDLTs and 3 LDLTs)or LR(n=75)respectively were recruited.Before PSM,the LT group has a higher MELD score(17.3 vs.7.8,P<0.001),lower serum AFP levels(96 vs.2,164 ng/mL,P=0.017)and smaller tumour size(4 vs.10 cm,P<0.001).The 5-year overall survival for LT and LR were 55.4%and 15.9%respectively(P=0.007).After matching for serum AFP levels and tumour size,1-,3-and 5-year overall survival for LT were 81 ng/mL,3.9 cm,80%,70%and 70%and the corresponding rates for LR were 1,417 ng/mL,5.3 cm,51.8%,19,6%and 9.8%(P value=0.12,0.27 and 0.009 respectively).Conclusions:LT is associated with significantly better oncological outcomes in HCC patients with PVTT involving the lobar or segmental level.A modest expansion of selection criteria to include small HCC with segmental PVTT should be considered. | Ka Wing Ma Albert Chi Yan Chan Kenneth Siu Ho Chok Wong Hoi She Tan To Cheung Wing Chiu Dai James Yan Yue Fung Chung Mau Lo | 2021 | Hepatobiliary Surgery and Nutrition2021，10，3： | 2 |
| 5 | Validated model for prediction of recurrent hepatocellular carcinoma after liver transplantation in Asian population显示文摘BACKGROUND Liver transplantation(LT) is regarded as the best treatment for both primary and recurrent hepatocellular carcinoma(HCC). Post-transplant HCC recurrence rate is relatively low but significant, ranging from 10%-30% according to different series. When recurrence happens, it is usually extrahepatic and associated with poor prognosis. A predictive model that allows patient stratification according to recurrence risk can help to individualize post-transplant surveillance protocol and guidance of the use of anti-tumor immunosuppressive agents.AIM To develop a scoring system to predict HCC recurrence after LT in an Asian population.METHODS Consecutive patients having LT for HCC from 1995 to 2016 at our hospital were recruited. They were randomized into the training set and the validation set in a60:40 ratio. Multivariable Cox regression model was used to identity factors associated with HCC recurrence. A risk score was assigned to each factor according to the odds ratio. Accuracy of the score was assessed by the area under the receiver operating characteristic curve.RESULTS In total, 330 patients were eligible for analysis(183 in training and 147 invalidation). Recurrent HCC developed in 14.2% of them. The median follow-up duration was 65.6 mo. The 5-year disease-free and overall survival rates were78% and 80%, respectively. On multivariate analysis, alpha-fetoprotein > 400 ng/mL [P = 0.012, hazard ratio(HR) 2.92], sum of maximum tumor size and number(P = 0.013, HR 1.15), and salvage LT(P = 0.033, HR 2.08) were found to be independent factors for disease-free survival. A risk score was calculated for each patient with good discriminatory power(c-stat 0.748 and 0.85, respectively,in the training and validation sets). With the derived scores, patients were classified into low-(0–9), moderate-(> 9–14), and high-risk groups(> 14), and the risk of HCC recurrence in the training and validation sets was 10%, 20%, 54%(cstat 0.67) and 4%, 22%, 62%(c-stat 0.811), accordingly. The risk stratification model was validated with chi-squared goodness-of-fit test(P = 0.425).CONCLUSION A validated predictive model featuring alpha-fetoprotein, salvage LT, and the sum of largest tumor diameter and total number of tumor nodule provides simple and reliable guidance for individualizing postoperative surveillance strategy. | Ka Wing Ma Wong Hoi She Albert Chi Yan Chan Tan To Cheung James Yan Yue Fung Wing Chiu Dai Chung Mau Lo Kenneth Siu Ho Chok | 2019 | World Journal of Gastrointestinal Oncology2019，11，4： | 2 |
| 6 | Targeted hepatitis C screening among ex‐injection drug users in the community显示文摘 | Vincent Wai‐Sun Wong Grace Lai‐Hung Wong Angel Mei‐Ling Chim Tsz‐Fai Cheng Shirley Wing‐Yan Cheung Carol Man‐Sze Lai Kylie Joan‐Yi Szeto Sharon Tsang Stephen Ho‐Chun Wu Kenneth Kar‐Lung Yan Alex Yui Hui Desmond Chi‐Him Yiu Brian Bing‐Ying Wu David Cheung | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 7 | Developing a trust inventory for construction contracting显示文摘 | Sai On Cheung Wei Kei Wong Tak Wing Yiu Hoi Yan Pang | 2010 | International Journal of Project Management2010，，2： | 1 |
| 8 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era显示文摘Hepatitis due to hepatitis B virus(HBV)reactivation can be serious and potentially fatal,but is preventable.HBV reactivation is most commonly reported in patients receiving chemotherapy,especially rituximab-containing therapy for hematological malignancies and those receiving stem cell transplantation.Patients with inactive and even resolved HBV infection still have persistence of HBV genomes in the liver.The expression of these silent genomes is controlled by the immune system.Suppression or ablation of immune cells,most importantly B cells,may lead to reactivation of seemingly resolved HBV infection.Thus,all patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBsAg)and antibody to hepatitis B core antigen.Patients found to be positive for HBsAg should be given prophylactic antiviral therapy.For patients with resolved HBV infection,there are two approaches.The first is pre-emptive therapy guided by serial HBV DNA monitoring,and treatment with antiviral therapy as soon as HBV DNA becomes detectable.The second approach is prophy-lactic antiviral therapy,particularly for patients receiving high-risk therapy,especially anti-CD20 monoclonal antibody or hematopoietic stem cell transplantation.Entecavir and tenofovir are the preferred antiviral choices.Many new effective therapies for hematological malignancies have been introduced in the past decade,for example,chimeric antigen receptor(CAR)-T cell therapy,novel monoclonal antibodies,bispecific antibody drug conjugates,and small molecule inhibitors,which may be associated with HBV reactivation.Although there is limited evidence to guide the optimal preventive measures,we recommend antivi-ral prophylaxis in HBsAg-positive patients receiving novel treatments,including Bruton’s tyrosine kinase inhibitors,B-cell lymphoma 2 inhibitors,and CAR-T cell therapy.Further studies are needed to determine the risk of HBV reactivation with these agents and the best prophylactic strategy. | Joyce Wing Yan Mak Alvin Wing Hin Law Kimmy Wan Tung Law Rita Ho Carmen Ka Man Cheung Man Fai Law | 2023 | World Journal of Gastroenterology2023，29，33： | 1 |
| 9 | Kinetics and Risk of De Novo Hepatitis B Infection in HBsAg–Negative Patients Undergoing Cytotoxic Chemotherapy显示文摘 | Chee–Kin Hui Winnie W.W. Cheung Hai–Ying Zhang Wing–Yan Au Yui–Hung Yueng Anskar Y.H. Leung Nancy Leung John M. Luk Albert K.W. Lie Yok–Lam Kwong Raymond Liang George K.K. Lau | 2006 | Gastroenterology2006，，1： | 1 |
| 10 | A framework for trust in construc- tion contracting显示文摘 | Wong Wei Kei Cheung Sai On Yiu Tak Wing Pang Hoi Yan | 2008 | International Journal of Pro- ject Management2008，26，8： | 1 |
| 11 | Developing a trust inventory for construction contracting 显示文摘 | Cheung Sai On Wong Wei Kei Yiu Tak Wing Pang Hoi Yan | 2011 | International Journal of Project Management2011，29，2： | 1 |
| 12 | Application of biomarkers in sentinel lymph node biopsy for the management of breast cancer显示文摘Objective Sentinel lymph node in breast cancer is a predictor of the tumor's metastatic potential.Cytokines emerging from antitumor immune response might also target sentinel lymph node (SLN).In this study,we evaluated the cytokine profile including interleukin-8 (IL-8),interleukin-12 (IL-12),interferon-gamma (IFN-γ),and tumor necrosis factor alpha (TNF-α) for the T-cell response.Methods From January 2008 to August 2010,35 patients with breast mass underwent SLN biopsy in UNIMED Medical Institute.The specimens were formalin-fixed and paraffin-embedded for hematoxylin and eosin staining and immunohistochemistry with following markers:IL-8,IL-12,IFN-γ and TNF-α.The staining intensity was scored according to four grades:negative (-),weak expression (+),moderately positive expression (+ +),strong positive expression (+ + +).The correlation between the expression of cytokines and pathological characteristics were also analyzed using the Spearman Rank Correlation test.Results Out of 35 patients,SLN metastases were observed in 20 patients and among them,75% (15 /20) were strongly stained (+ + +) with IL-8 and moderately stained (+ +) with IL-12,but only 25% (5 /20) were strongly stained (+ + +) with IFN-γ and TNF-α.The expression of IL-8 was significantly associated with all tumor grades (r=0.639,P=0.00),estrogen receptor (r=0.778,P=0.01),progesterone receptor (r=0.759 P=0.00) and HER-2 /neu receptor (r=0.863 P=0.00).Conclusion The strong association between IL-8 expression and SLN metastases might highlight the prognostic significance of IL-8 in SLN. | Qing Liu Wings Tjing Yung Loo Adrian Yun San Yip Louis Wing Cheong Chow Elizabeth Lam Yan Ng Mary Ngan Bing Cheung | 2012 | 中华乳腺病杂志(电子版)2012，6，6： | 1 |
| 13 | Kinetics and Risk of De Novo Hepatitis B Infection in HBsAg–Negative Patients Undergoing Cytotoxic Chemotherapy显示文摘 | Chee–Kin Hui Winnie W.W. Cheung Hai–Ying Zhang Wing–Yan Au Yui–Hung Yueng Anskar Y.H. Leung Nancy Leung John M. Luk Albert K.W. Lie Yok–Lam Kwong Raymond Liang George K.K. Lau | 2006 | Gastroenterology2006，，1： | 1 |
| 14 | Kinetics and Risk of De Novo Hepatitis B Infection in HBsAg–Negative Patients Undergoing Cytotoxic Chemotherapy显示文摘 | Chee–Kin Hui Winnie W.W. Cheung Hai–Ying Zhang Wing–Yan Au Yui–Hung Yueng Anskar Y.H. Leung Nancy Leung John M. Luk Albert K.W. Lie Yok–Lam Kwong Raymond Liang George K.K. Lau | 2006 | Gastroenterology2006，，1： | 1 |
| 15 | A machine learning model for colorectal liver metastasis post-hepatectomy prognostications显示文摘Background:Currently,surgical resection is the mainstay for colorectal liver metastases(CRLM)management and the only potentially curative treatment modality.Prognostication tools can support patient selection for surgical resection to maximize therapeutic benefit.This study aimed to develop a survival prediction model using machine learning based on a multicenter patient sample in Hong Kong.Methods:Patients who underwent hepatectomy for CRLM between 1 January 2009 and 31 December 2018 in four hospitals in Hong Kong were included in the study.Survival analysis was performed using Cox proportional hazards(CPH).A stepwise selection on Cox multivariable models with Least Absolute Shrinkage and Selection Operator(LASSO)regression was applied to a multiply-imputed dataset to build a prediction model.The model was validated in the validation set,and its performance was compared with that of Fong Clinical Risk Score(CRS)using concordance index.Results:A total of 572 patients were included with a median follow-up of 3.6 years.The full models for overall survival(OS)and recurrence-free survival(RFS)consist of the same 8 established and novel variables,namely colorectal cancer nodal stage,CRLM neoadjuvant treatment,Charlson Comorbidity Score,pre-hepatectomy bilirubin and carcinoembryonic antigen(CEA)levels,CRLM largest tumor diameter,extrahepatic metastasis detected on positron emission-tomography(PET)-scan as well as KRAS status.Our CRLM Machine-learning Algorithm Prognostication model(CMAP)demonstrated better ability to predict OS(C-index=0.651),compared with the Fong CRS for 1-year(C-index=0.571)and 5-year OS(C-index=0.574).It also achieved a C-index of 0.651 for RFS.Conclusions:We present a promising machine learning algorithm to individualize prognostications for patients following resection of CRLM with good discriminative ability. | Cynthia Sin Nga Lam Alina Ashok Bharwani Evelyn Hui Yi Chan Vernice Hui Yan Chan Howard Lai Ho Au Margaret Kay Ho Shireen Rashed Bernard Ming Hong Kwong Wentao Fang Ka Wing Ma Chung Mau Lo Tan To Cheung | 2023 | Hepatobiliary Surgery and Nutrition2023，12，4： | 0 |
| 16 | Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties显示文摘A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC 16872.Heterologous production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 VrcB.Intriguingly,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic window.Our study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities. | Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 17 | Erratum:Defining the role of laparoscopic liver resection in elderly HCC patients:a propensity score matched analysis显示文摘This is an Erratum of the publsihed paper:Defining the role of laparoscopic liver resection in elderly HCC patients:a propensity score matched analysis.The ethical approval and consent to participation information were missing in the DECLARATIONS section due to the production issue.The original article has been updated. | Phoenix Wai Yan Wong Ka Wing Ma Tan To Cheung Wong Hoi She Wing Chiu Dai Albert Chi YanChan Kenneth Siu Ho Chok Chung Mau Lo | 2022 | Hepatoma Research2022，8，1： | 0 |
| 18 | In-Home Drug Storage by Older Adults显示文摘Globally,in-home drug-storage compliance is often unsatisfactory,especially among older adults,and can lead to negative health outcomes.This study used a cross-sectional and descriptive design to examine inhome drug-storage compliance among older adults.Convenience sampling was used to recruit 117 older adults in Hong Kong.An in-home drugstorage checklist was used to assess the in-home drug-storage environments(light,temperature,and humidity)and drug-storage methods(drug safety,packaging,information,and expiration)of each older adult.The findings showed that Hong Kong older adults’overall compliance rate in drug storage was 87.25%,and their compliance rate for drug-storage methods(84.59%)was lower than that for drug-storage environments(97.02%).Older adults who were of advanced age,who were less educated or who lived alone demonstrated lower in-home drug-storage compliance.This indicates the need to revise existing health-education strategies to encourage in-home drug-storage compliance.Healthcare professionals should assess older adults’drug-storage compliance to identify less compliant subgroups and deliver specific drug-storage support as required.Family members should also be involved in this process. | Lori Suet Hang Lo Linda Yin King Lee Irene Yuen Fung Wong Yuen Yan Lai Hoi Tong Au Tsz Ying Wong Chui Ping Chueng Wai Lam Shek Choi Yi Wong Hoi Lam Chan Hon Sze Cheuk Nga Hing Mark Shu Ching Wong Wing Yan Cheung | 2020 | Journal of Geriatric Medicine2020，2，3： | 0 |
| 19 | 胃癌及其淋巴结转移的诊断学分子标志物的鉴定显示文摘背景与目的:分子标志物是肿瘤快速诊断的重要工具。本研究旨在鉴定可用于临床诊断胃癌及其淋巴结转移的分子标记物。方法:前瞻性收集2014年12月1日至2015年12月31日期间的胃癌手术标本和相应的癌旁正常胃黏膜,以及胃周转移性和非转移性淋巴结标本,采用实时定量PCR方法对9个目标基因进行定量检测。采用相对表达量来计算目标基因的mRNA表达水平。采用单因素方差分析(ANOVA)和Tukey多重比较检验来进行统计学比较,采用GraphPad Prism软件绘制统计分析图。结果:在9个受检基因中,INHBA和SPP1在胃癌组织中稳定高表达,其mRNA表达水平分别是相应癌旁胃黏膜的15.4和15.6倍(P<0.001);前者诊断胃癌的敏感性和特异性分别为91.3%和95.7%(ROC曲线下面积0.974),后者的敏感性和特异性分别为82.6%和87.0%(ROC曲线下面积0.924)。进一步分析转移性与非转移性淋巴结组织中上述两个基因的表达差异,结果显示,SPP1 mRNA表达水平两者差异无统计学意义(P=0.470),而转移性淋巴结中INHBA mRNA表达水平上调了4.1倍(P<0.001),其诊断淋巴结转移的敏感性和特异性分别为80.0%和81.5%(ROC曲线下面积0.857),而且能有效区别更严重的肿瘤进展,如T3与T4(P=0.003)、M0与M1(P=0.043),以及不同的组织学类型,如肠型与弥漫型(P=0.019)。结论:INHBA是用于诊断胃癌及其淋巴结转移的一种理想的分子标志物。 | Sharvesh Raj Seeruttun Wing Yan Cheung Wei Wang Cheng Fang Zhi-Min Liu Jin-Qing Li Ting Wu Jun Wang Chun Liang Zhi-Wei Zhou | 2019 | Gastroenterology Report2019，7，1： | 0 |
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