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| 1 | Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps显示文摘AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.METHODS:This is a single-center comparative effectiveness pilot study.Polyps(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center.Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology.We determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous polyps.Histopathologic diagnosis was the gold standard comparison.RESULTS:One hundred and three small polyps,detected from forty-three patients,were included in the analysis.The average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include 'lymphoid aggregates','non-specific colitis,' and 'no pathologic diagnosis.' Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging modality.Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study.Though endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B decreased accuracy using i-SCAN from 100%(95%CI:80.5%-100.0%) in the first half to 84.6%(95%CI:54.6%-98.1%) in the second half,neither of these differences were statistically significant.CONCLUSION:i-SCAN and high-definition white light had similar efficacy predicting polyp histology.Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. | Johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 2 | Treatment of painful osteopo- rotic compression and burst fractures using kyphoplasty : a prospec- tive observational design 显示文摘 | Stoffel M Wolf I Ringel F | 2007 | J Neurosurg Spine2007，6，4： | 1 |
| 3 | Comparison and evaluation of methods for liver segmentation from CT datasets显示文摘 | Heimann T van Ginneken B Styner MA Arzhaeva Y Aurich V Bauer C Beck A Becket C Beichel R Bekes G Bello F Binnig G Bischof H Bornik A Cashman PM Chi Y Cordova A Dawant BM Fidrich M Furst JD Furukawa D Grenacher L Hornegger J Kainmuller D Kitney RI Kobatake H Lamecker H Lange T Lee J Lennon B Li R Li S Meinzer HP Nemeth G Raicu DS Rau AM van Rikxoort EM Rousson M Rusko L Saddi KA Schmidt G Seghers D Shimizu A Slagmolen P Sorantin E Soza G Susomboon R Waite JM Wimmer A Wolf I | 2009 | IEEE Transactions on Medical Imaging2009，28，8： | 1 |
| 4 | Magnesium deficiency inhibits primary tumor growth but favors metastasis in mice显示文摘 | NASULEWICZ A WIETRZYK J WOLF F I | 2004 | Biochimica et Biophysica Acta2004，1739，1： | 1 |
| 5 | An instrumentation system applied to formation flight显示文摘 | WALTON R MAMOUN F RHEE I SONG E WOLFE J | | 0，，01： | 1 |
| 6 | Mechanical and chemical compaction model for sedimentary basin simulators显示文摘 | Schneider F Potdevin JL Wolf S Faille I | 1996 | Tectonophysics1996，263，1： | 1 |
| 7 | Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements显示文摘 | Schoffer A A Aravind L Madden T L Shavirin S Spouge J L Wolf Y I Koonin E V Altschul S F | 2001 | Nucleic Acids Res2001，29，： | 1 |
| 8 | Immunolocalization of the hyaluronan receptor CD44 in the reproductive tract of the mare显示文摘 | RODRIGUEZ HURTADO I STEWART A J WOLFE D F | 2010 | Theriogenology2010，75，： | 1 |
| 9 | Resveratrol,a naturl phenolic compound,inhibits cell proliferation and prevents oxidative DNA damage显示文摘 | Ardito R Faraglia B Boninseqna A Wolf F I Ciftadini A | 2001 | Mutat Res2001，496，： | 1 |
| 10 | Kiljmmvalgia criteriaand severity scales for clinical and epidemiological studies: amodification of the ACR preliminary diagnostic criteria forfihromyalgia显示文摘 | Wolfe F Clauw I)J Fitzcharles MA | 2011 | J Rheumatol2011，38，6： | 1 |
| 11 | Treatment ofpainful osteoporotic compression and burst fracturesusing kyphoplasty:A prospective observationaldesign显示文摘 | Stoffel M Wolf I Ringel F | 2007 | Neurosurg Spine2007，6，4： | 1 |
| 12 | Fetal growth retardation and the ma- ternal arterial supply of the human placenta in the absence of sus- tained hypertension 显示文摘 | De Wolf F Bosens I Renaer M | 1980 | B''r J Obstet Gynaecul1980，87，8： | 1 |
| 13 | Improving the Accuracy of PSI - BLAST Protein Database Searches with Composition - Based Statistics and Other Refinements显示文摘 | Schaffer A Aravind L Madden T L Shavarin S Spouge J L Wolf Y I Koonin E V Altschul S F | 2001 | Nucleic Acids Research2001，29，： | 1 |
| 14 | Cell physiology of magnesium 显示文摘 | Wolf F I Torsello A Fasanella S | 2003 | Molecular Aspects of Medicine2003，24，13： | 1 |
| 15 | AIDS prognosis based on HIV-1 RNA,CD4+ T-cell count and function:markers with reciprocal predictive value over time after seroconversion显示文摘 | De Wolf F Spijkerman I Schellekens PT | 1997 | AIDS1997，11，： | 1 |
| 16 | Use of the Bro mine Isotope Ratio in HPLC ICP-MS and HPLC ESI-MS Analysis of a New Drug in Development显示文摘 | Cuyckens F Balcaen L I L Wolf K D | 2008 | Analytical and Bioanalytical Chemistry2008，390，7： | 1 |
| 17 | Fetal growth retardation and the maternal arterial supply of the human placenta in the ab- sence of sustained hypertension 显示文摘 | De Wolf F Brosens I Renaer M | 1980 | Br J Obstet Gynaecol1980，87，8： | 1 |
| 18 | Magnesium deficiency and endothelial dysfunction:is oxidative stress involved?显示文摘 | WOLF F I TRAPANI V SIMONACCI M | 2008 | Magnesium Research:Official Organ of the International Society for the Development of Research on Magnesium2008，21，1： | 1 |
| 19 | Magnesium andneoplasia : from carcinogenesis to tumor growth and progression ortreatment 显示文摘 | WOLF F I MAIER J A NASULEWICZ A | 2007 | Arch Biochem Biophys2007，458，1： | 1 |
| 20 | Increased lability of estuarine dissolved organic nitrogen from urbanized watersheds显示文摘 | WOLFE F L KROEGER K D VALIELA I | 1999 | Biol Bull1999，197，2： | 1 |
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