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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | RT-PCR detection and identification of three species of Cucumoviruses with a genus-specific single pair of primers显示文摘 | Seung K C Jang K C Won M P | 1999 | Journal of Virological Methods1999，83，1： | 1 |
| 3 | 查看详情显示文摘 | Kim A Won Y Woo K Hu P Wang Z Zhang M Shi L | | 0，，02： | 1 |
| 4 | Kinetics and mechanism of the deearboxylation of anthranilic acid in aqueous solution 显示文摘 | Willi A V Won C M Vilk P | 1968 | The Journal of Physical Chemistry1968，72，9： | 1 |
| 5 | RT-PCR detection and identification of three species of Cucumo viruses with a genus specific single pair of primers显示文摘 | SEUNG K C JANG K C WON M P | 1999 | Journal of Virological Methods1999，83，1： | 1 |
| 6 | Extraeellular ATP and P2Yz receptors mediate intercellular Ca(z+ )waves induced by mechanical stimulation in submandibular gland cells:role of mitochondrial regulation of store operated Ca(2 +)entry显示文摘 | RYU S Y PEIXOTO P M WON J H | 2010 | Cell Calcium2010，47，1： | 1 |
| 7 | Spatially-resolved heat transfer and flow structure in a rectangular channel with pin fins显示文摘 | Won S Y Mahmood G I Ligrani P M | | 0，，8： | 1 |
| 8 | Epidermal electronics显示文摘 | Kim D H Lu N Ma R Kim Y S Kim R H Wang S Wu J Won M S Tao H Islam A Yu J Kim T I Chowdhury R Ying M Xu L Li M Chung H J Ke- um H McCormick M Liu P Zhang Y Omenetto F G Huang Y G Coleman Todd Rogers J A | 2011 | Science2011，333，6044： | 1 |
| 9 | Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy显示文摘 | Kim D H Lu N Ghaffari R Kim Y S Lee S P Xu L Wu J Kim R H Song J Liu Z Viventi J Graff B D Elolampi B Mansour M Slepian M J Hwang S Moss J D Won S M Huang Y Rogers J A | 2011 | Nature Materials2011，10，4： | 1 |
| 10 | Numerical predictions of flow structure and local nusselt number ratios along and above dimpled surfaces with different dimple depths in a channel显示文摘 | Won S Y Ligrani P M | 2004 | Numerical Heat Transfer Part A:Applications2004，46，6： | 1 |
| 11 | Miscibility and rheological properties of poly (vinyl chloride) /styrene- acrylonitrile blends prepared by melt extrusion 显示文摘 | HYUN S M WON M C MUN H K O-OK P | 2007 | J Appl Polym Sci2007，104，： | 1 |
| 12 | Recyclable Wood- plastic Siding Sports 50-year Guarantee显示文摘 | Sang M L Donghwan C Won H P | 2005 | Composites Science and Technology2005，65，： | 1 |
| 13 | Recombinant expression,isotope labeling, refolding, and purification of an antimicrobial peptide,piscidin显示文摘 | Won J M Dong K H Eu J P | 2007 | Protein Expression and Purification2007，51，： | 1 |
| 14 | Epidermal Electronics显示文摘 | Kim D H Lu N Ma R Kim Y S Kim R H Wang S Wu J Won S M Tao H Islam A Yu K J Kim T I Chowdhury R Ying M Xu L Li M Chung H J Keum H McCormick M Liu P Zhang Y W Omenetto F G Huang Y Coleman T Rogers J A | 2011 | Science2011，，： | 1 |
| 15 | Estrogen modulates Bcl-2 family proteins in ischemic brain injury显示文摘 | Won C K Kim M O Koh P O | 2006 | J Vet Med Sci2006，68，： | 1 |
| 16 | Electrochemical detection of CIO3-, BrO3- and 1O3 at a phosphomilybdic acid linked 3-aminopropyl-trimethoxysilane modified electrode 显示文摘 | Rahman M A Won M S Wei P H | 2006 | Electro- analysis2006，18，10： | 1 |
| 17 | Observation of cascade complete chaos synchronization with zero time lag in laser diodes显示文摘 | WON L M JON P CRISTINA M | 2006 | J Opt Soc Am B2006，23，5： | 1 |
| 18 | Effects of operating parameters on the performance of a CO2 air conditioning system for vehicles显示文摘 | KIM S C WON J P KIM M S | 2009 | Applied Thermal Engineering2009，29，1112： | 1 |
| 19 | Characteristic evaluation on the cooling performance of an electrical air conditioning system using R744 for a fuel cell electric vehicle显示文摘 | LEE M Y LEE H S WON H P | 2012 | Energies2012，，5： | 1 |
| 20 | Electrochemical detection of CIO3- , BrO3^- , and IO3^- at a phosphomolybdic acid linked 3-aminopropyl-trimethoxysilane modified electrode 显示文摘 | Rahman M A Won M S Wei P H | 2006 | Electroanalysis2006，18，0： | 1 |
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