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| 1 | Effect of metabolic structures and energy requirements on curdlan production by Alcaligenes faecalis显示文摘 | Zheng, ZY Lee, AW Zhan, XB Shi, Z Wang, L Zhu, L Wu, JR Lin, CC | 2007 | 中国生物学文摘2007，21，10： | 13 |
| 2 | Acute antibody-mediated rejection after intestinal transplantation显示文摘AIM To investigate the incidence, risk factors and clinical outcomes of acute antibody-mediated rejection(ABMR) after intestinal transplantation(ITx).METHODS A retrospective single-center analysis was performed to identify cases of acute ABMR after ITx, based on the presence of donor-specific antibody(DSA), acute tissue damage, C4 d deposition, and allograft dysfunction.RESULTS Acute ABMR was identified in 18(10.3%) out of 175 intestinal allografts with an average occurrence of 10 d(range, 4-162) after ITx. All acute ABMR cases were presensitized to donor human leukocyte antigens class Ⅰand/or Ⅱ antigens with a detectable DSA. A positive cross-match was seen in 14(77.8%) cases and twelve of 18 patients(66.7%) produced newly-formed DSA following ITx. Histological characteristics of acute ABMR include endothelial C4 d deposits, interstitial hemorrhage, and severe congestion with focal fibrin thrombin in the lamina propria capillaries. Multivariate analysis identified a liver-free graft and high level of panel reactive antibodyas a significant independent risk factor. Despite initial improvement after therapy, eleven recipients(61.1%) lost transplant secondary to rejection. Of those, 9(50%) underwent graft removal and 4(22.2%) received second transplantation following acute ABMR. At an average follow-up of 32.3 mo(range, 13.3-76.4), 8(44.4%) recipients died.CONCLUSION Our results indicate that acute ABMR is an important cause of intestine graft dysfunction, particularly in a liver-exclusive graft and survivors are at an increased risk of developing refractory acute rejection and chronic rejection. More effective strategies to prevent and manage acute ABMR are needed to improve outcomes. | Guo-Sheng Wu Ruy J Cruz Jr Jun-Chao Cai | 2016 | World Journal of Transplantation2016，6，4： | 5 |
| 3 | Hypertrophic adenoids in patients with nasopharyngeal carcinoma:appearance at magnetic resonance imaging before and after treatment显示文摘Introduction:Patients with nasopharyngeal carcinoma(NPC) sporadically develop abnormal adenoids.Nasopharyngeal adenoids are usually included in the gross tumor volume(GTV) but may have different therapeutic responses than tumor tissue.Therefore,distinguishing adenoids from tumor tissue may be required for precise and efficient chemoradiotherapy and radiotherapy.We characterized nasopharyngeal adenoids and investigated the therapeutic responses of NPC and nasopharyngeal adenoids using magnetic resonance imaging(MRI).Methods:MRI data from 40 NPC patients with a coexisting adenoid mass before and after treatment were analyzed.The features of the adenoid masses,including location,striped appearance,size,interface,symmetry/asymmetry,and cysts,were evaluated.Treatment response were scored according to the World Health Organization guidelines.Results:A striped appearance was observed in 36 cases before treatment and in all cases after treatment.In these 36 cases,the average GTVs including and excluding the uninvolved adenoids were 19.8 cm^3 and 14.8 cm^3,respectively.The average percentage change after excluding the uninvolved adenoids from the GTV was 31.0%.Stable disease in the adenoids was identified in 27(96.4%) of 28 patients after neoadjuvant chemotherapy,while NPC clearly regressed.Partial adenoid responses were identified in 33(82.5%) of 40 patients at 3 months after chemoradiotherapy or radiotherapy,whereas complete tumor responses were achieved in all patients.Six months after treatment,the adenoids continued to atrophy but did not disappear,and tumor recurrence was not found.Conclusions:Nasopharyngeal adenoids and carcinoma tissue in NPC patients can be distinguished by using MRI and have different responses to chemoradiotherapy and radiotherapy.These findings contribute to better delineating the GTV of NPC,based on which spatially optimized strategies can be developed to render precise and efficient chemoradiotherapy and radiotherapy.Additionally,we observed a clear difference in the responses of these two tissue types to current therapies.This finding may reduce or avoid unnecessary biopsies or overtreatment. | Yao-Pan Wu Pei-Qiang Cai Li Tian Jie-Hua Xu Richard Alan Mitteer Jr Yi Fan Zhenfeng Zhang | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 4 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 5 | miRNA profiling of naive, effeetor and memory CD8 T cells显示文摘 | Wu H Neilson JR Manjunath N | 2007 | PLoS ONE2007，2，10： | 1 |
| 6 | Arginine metabolism: nitric oxide and beyond 显示文摘 | Wu G Morris Jr SM | 1998 | Biochem J1998，336，： | 1 |
| 7 | Chorioamnionitis as a risk factor for cerebral palsy:a meta-analysis显示文摘 | Wu YW Colford JM Jr | 2000 | JAMA2000，284，： | 1 |
| 8 | Uptake of apoptotic DC co/averts immature DC into toleregenic DC that induce differentiation of Foxp3^+ Treg显示文摘 | Kushwah R Wu J Oliver JR | 2010 | Eur J Immunol2010，40，4： | 1 |
| 9 | Proteomic analysis of two functional states of the Golgi complex in mammary epithelial cells显示文摘 | Wu CC Yates JR 3rd Neville MC | | 0，，： | 1 |
| 10 | Lercanidipine inhibits vascular smooth muscle cell proliferation and neointimal formation via reducing intracellular reactive oxygen species and inactivating Ras-ERK1/2 signaling显示文摘 | Wu JR Liou SF Lin SW | | 0，，： | 1 |
| 11 | FANCJ helicase operates in the Fanconi anemia DNA repair pathway and the response to replicational stress 显示文摘 | WU Y BROSH RM JR | 2009 | Curr Mol Med2009，9，4： | 1 |
| 12 | Arginine metabolism:nitric oxide and beyond显示文摘 | Wu G Morris SM Jr | 1998 | Biochem J1998，336，1： | 1 |
| 13 | Transcellular and lipophilic complex-enhanced intestinal absorption of human growth hormone显示文摘 | Robinson JR | 1999 | Pharm Res1999，16，8： | 1 |
| 14 | Design and hydrodynamic evaluation of a novel pulsatile bioreactor for biologically active heart valves 显示文摘 | Hildebrand DK Wu ZJ Mayer JE Jr | 2004 | Ann BME2004，32，8： | 1 |
| 15 | Surveillance and control of post-transmission schistosomiasis in Jiaxing Prefecture, Zhejiang Province, China显示文摘 | Wu WL Wang JR Wen LY | 2005 | Acta Trop2005，96，23： | 1 |
| 16 | Preoperative mediastinal and hilar nodal staging with diffusion-weighted magnetic res onance imaging and fluorodeoxyglucose positron emission tomography/computed tomography in patients with non small-cell lung cancer: which is better? 显示文摘 | Wu LM1 Xu JR Gu HY | 2012 | J Surg Res2012，178，1： | 1 |
| 17 | Induction of apoptotic death in cells via bad gene expression by infectious pancreatic necrosis virus infection 显示文摘 | Hong JR Wu JL | 2002 | Cell Death Differ2002，9，2： | 1 |
| 18 | Distinct lineages of Th1cells have differential capacities for memory cell generation in vivo显示文摘 | Wu CY Kirman JR Rotte MJ | 2002 | Nat Immunol2002，3，9： | 1 |
| 19 | Usefulness of diffusion-weighted magnetic resonance imaging in the diagnosis of prostate cancer显示文摘 | Wu LM Xu JR Gu HY | 2012 | Acad Radiol2012，19，： | 1 |
| 20 | Is ureteroscopy first line treatment for pediatric stone disease?显示文摘 | Smaldone MC Cannon GM Jr Wu HY | 2007 | J Urol2007，178，5： | 1 |
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