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| 1 | Facile Synthesis of Porous Carbon Nitride Spheres with Hierarchical Three-Dimensional Mesostructures for CO_(2) Capture显示文摘Porous carbon nitride(CN)spheres with partially crystalline frameworks have been successfully synthesized via a nanocasting approach by using spherical mesoporous cellular silica foams(MCFs)as a hard template,and ethylenediamine and carbon tetrachloride as precursors.The resulting spherical CN materials have uniform diameters of ca.4μm,hierarchical three-dimensional(3-D)mesostructures with small and large mesopores with pore diameters centered at ca.4.0 and 43 nm,respectively,a relatively high BET surface area of~550 m^(2)/g,and a pore volume of 0.90 cm^(3)/g.High-resolution transmission electron microscope(HRTEM)images,wide-angle X-ray diffraction(XRD)patterns,and Raman spectra demonstrate that the porous CN material has a partly graphitized structure.In addition,elemental analyses,X-ray photoelectron spectra(XPS),Fourier transform infrared spectra(FT-IR),and CO_(2) temperature-programmed desorption(CO_(2)-TPD)show that the material has a high nitrogen content(17.8 wt%)with nitrogen-containing groups and abundant basic sites.The hierarchical porous CN spheres have excellent CO_(2) capture properties with a capacity of 2.90 mmol/g at 25℃and 0.97 mmol/g at 75℃,superior to those of the pure carbon materials with analogous mesostructures.This can be mainly attributed to the abundant nitrogen-containing basic groups,hierarchical mesostructure,relatively high BET surface area and stable framework.Furthermore,the presence of a large number of micropores and small mesopores also enhance the CO_(2) capture performance,owing to the capillary condensation effect. | Qiang Li Jianping Yang Dan Feng Zhangxiong Wu Qingling Wu Sung Soo Park Chang-Sik Ha Dongyuan Zhao | 2010 | Nano Research2010，3，9： | 24 |
| 2 | Therapeutic angiogenesis induced by human hepatocyte growth factor gene in hindlimb ischemia of dogs显示文摘A preclinical study of treating peripheral ar-tery occlusive disease (PAD) was performed by using ahepatocyte growth factor (HGF) gene-expressing vector,plasmid pUDKH, in a dog model with complete ischemia of one hindlimb. After ligation of femoral artery of onehindlimb, pUDKH was transferred directly into the ischemic limb muscles. The angiogenic activity of the plasmid pUDKH was evaluated. On D 30 after injecting once of pUDKH at different doses into local muscles immediately after opera-tion, the degree of augmentation of collateral vessel forma-tion was significantly greater than that treated by blankvector. In addition, the blood flow rate of femoral artery in dogs treated with pUDKH was recovered on D 90, while the flow rate was only 1/5 to 1/3 in control dogs. The pulse am-plitude of pUDKH-treated dogs was recovered on D 90, but it was hardly detectable in most of the control dogs. The sideeffects of intramuscular transfection of pUDKH were alsoinvestigated, and no significant positive change was found. It is suggested that angiogenesis induced by HGF gene has the potential for clinical use in the treatment of peripheral arte-rial diseases. | HA Xiaoqin, REN Jianping, BI Jianjin, ZHANG Jinhui & WU Zuze (Wu Chu-tse) Beijing Institute of Radiation Medicine, Beijing 100850, China | 2003 | Chinese Science Bulletin2003，48，7： | 13 |
| 3 | Keratinocyte growth factor gene therapy ameliorates ulcerative colitis in rats显示文摘AIM:To investigate the effect of keratinocyte growth factor(KGF) gene therapy in acetic acid-induced ulcerative colitis in rat model.METHODS:The colitis of Sprague-Dawley rats was induced by intrarectal infusion of 1 mL 5%(v/v) acetic acid.Twenty-four hours after exposed to acetic acid,rats were divided into three experimental groups:control group,attenuated Salmonella typhimurium Ty21a strain(SP) group and SP strain carrying human KGF gene(SPK) group,and they were separately administered orally with 10% NaHCO3,SP or SPK.Animals were sacrificed and colonic tissues were harvested respectively on day 3,5,7 and 10 after administration.Weights of rats,colonic weight/length ratio and stool score were evaluated.Histological changes of colonic tissues were examined by hematoxylin and eosin(HE) staining method.The expression of KGF,KGF receptor(KGFR) and TNF-α were measured either by enzyme-linked immunosorbent assay or Western blotting.Immunohistochemistry was used to detect the cellular localization of KGFR and Ki67.In addition,superoxide dismutase(SOD) activity and malondialdehyde(MDA) contents in the homogenate were measured.RESULTS:Body weight and colonic weight/length ratio were declined in SPK group compared with SP and control groups(body weight:272.78 ± 17.92 g vs 243.72 ± 14.02 g and 240.68 ± 12.63 g,P < 0.01;colonic weight/length ratio:115.76 ± 7.47 vs 150.32 ± 5.99 and 153.67 ± 5.50 mg/cm,P < 0.01).Moreover,pathological changes of damaged colon were improved in SPK group as well.After administration of SPK strain,KGF expression increased markedly from the 3rd d,and remained at a high level till the 10th d.Furthermore,KGFR expression and Ki67 expression elevated,whereas TNF-α expression was inhibited in SPK group.In the group administered with SPK,SOD activity increased significantly(d 5:26.18 ± 5.84 vs 18.12 ± 3.30 and 18.79 ± 4.74 U/mg,P < 0.01;d 7:35.48 ± 3.35 vs 22.57 ± 3.44 and 21.69 ± 3.94 U/mg,P < 0.01;d 10:46.10 ± 6.23 vs 25.35 ± 4.76 and 27.82 ± 6.42 U/mg,P < 0.01) and MDA contents decreased accordingly(d 7:7.40 ± 0.88 vs 9.81 ± 1.21 and 10.45 ± 1.40 nmol/mg,P < 0.01;d 10:4.36 ± 0.62 vs 8.41 ± 0.92 and 8.71 ± 1.27 nmol/mg,P < 0.01),compared with SP and control groups.CONCLUSION:KGF gene therapy mediated by attenuated Salmonella ameliorates ulcerative colitis induced by acetic acids,and it may be a safe and effective treatment for ulcerative colitis. | Chun-Jie Liu Ji-De Jin Tong-De Lv Zu-Ze Wu Xiao-Qin Ha | 2011 | World Journal of Gastroenterology2011，17，21： | 11 |
| 4 | Graft-verse-host disease after liver transplantation:A report of two cases and review of literature显示文摘Graft-verse-host disease (GVHD) is an uncommon fatal complication following liver transplantation (LTx). In China's Mainland, only six cases have been reported with a morbidity rate up to 1%-2%. Definitive diagnosis was achieved by molecular techniques (HLA typing or PCR-STR) in only two cases and the remaining cases were diagnosed based on typical clinical features with exclusion of other possible causes. All patients died of septic shock or multiple organ failure even after administration of increased corticosteroids and supportive therapy, and reduced immunosuppressive agents. In our center, two cases of GVHD were found among 128 (1.56%) patients. One case was diagnosed by detecting lymphocyte macrochimerism through DNA-STR. Both of them died even after aggressive treatment. In China, the incidence of GVHD is similar to that reported by foreign centers except for an extremely bad prognosis. Rapid diagnosis is crucial for a better prognosis. In China, only 37.5% of cases are diagnosed by molecular methods. We recommend detecting lymphocyte macrochimerism through DNA-STR to get a rapid diagnosis, and interleukin 2-receptor antibody (basiliximab or daclizumab) therapy seems to be a good choice for the disease. | Zhi-Yong Guo Xiao-Shun He Lin-Wei Wu Xiao-Feng Zhu Wei-Qiang Ju Dong-Ping Wang Shen You Yi Ha Guo-Dong Wang Jie-Fu Huang | 2008 | World Journal of Gastroenterology2008，14，6： | 8 |
| 5 | An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel显示文摘金 nanoparticles (AuNPs ) 的 biodistribution 是仔细与毒物学的效果有关并且因为他们的潜在的申请,担心大。与为液体运输的新奇解剖、组织学的结构的发现,然而,内在的机制包含了在在里面 AuNPs 的 vivo 运输和 biodistribution 要求进一步深入的调查。在当前的学习,在腱,容器,和神经纤维的一个焦点的点可以最佳地与另外的遥远的结缔组织连接的地方,我们在跗骨的隧道在 intervaginal 空间注射(ISI ) 以后在老鼠调查了 10-nm AuNPs 的 biodistribution。AuNPs 的静脉内的注射(IVI ) 用作控制。血和机关与诱导地联合的血浆团 spectrometry (ICPMS ) 为 Au 分发的定量分析在注射以后在 5, 15,和 30 min 并且在 1, 4, 12,和 24 h 被收集。IVI 和 ISI 产出显著地不同的结果:在在 ISI 以后的血的 AuNP 内容在 IVI 以后是比那低得多的;在肺,心,和肠是类似的;并且在皮和肌肉是更高的。这些调查结果被 AuNP 内容和相对机关 AuNP 分发比例的比率支持。我们表明的结果一快,直接并且发行量无关的 AuNP 器官运输小径,它可以改进我们生理、病理学的 biodistribution 的理解在生物系统处理。而且,这些结果提供新奇卓见进在里面 vivo 运输和 AuNPs 的 biodistribution,它可以导致新奇、有效治疗学并且管理策略。 | Xiaoli Shi Yuting Zhu Wenda Hua Yinglu Ji Qing Ha Xinxiao Han Yang Liu Jingwei Gao Qiang Zhang Sidi Liu Keli Ren Xiaochun Wu Hongyi Li Dong Han | 2016 | Nano Research2016，9，7： | 7 |
| 6 | FGFR2 mutation in a Chinese family with unusual Crouzon syndrome显示文摘AIM:To describe the clinical characteristics with genetic lesions in a Chinese family with Crouzon syndrome. METHODS: All five patients from this family were included and received comprehensive ophthalmic and systemic examinations.Direct sequencing of the FGFR2 gene was employed for mutation identification.Crystal structure analysis was applied to analyze the structural changes associated with the substitution. RESULTS: All patients presented typical Crouzon features,including short stature,craniosynostosis,mandibular prognathism,shallow orbits with proptosis,and exotropia.Intrafamilial phenotypic diversities were observed.Atrophic optic nerves were exclusively detected in the proband and her son.Cranial magnetic resonance imaging implied a cystic lesion in her sellar and third ventricular regions.A missense mutation,FGFR2 p.Cys342 Trp,was found as disease causative.This substitution would generate conformational changes in the extracellular Ig-III domain of the FGFR-2 protein,thus altering its physical and biological properties.CONCLUSION: We describe the clinical presentations and genotypic lesions in a Chinese family with Crouzon syndrome.The intrafamilial phenotypic varieties in this family suggest that other genetic modifiers may also play a role in the pathogenesis of Crouzon syndrome. | Zi-Li Li Xue Chen Wen-Juan Zhuang Wei Zhao Ya-Ni Liu Fang-Xia Zhang Ruo-Shui Ha Jin-Hua Wu Chen Zhao Xun-Lun Sheng | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 4 |
| 7 | Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway显示文摘Consumption of kava(Piper methysticum Forst) has been linked to reduced cancer risk in the South Pacific Islands.Kavalactones are major bioactive components in kava root extracts, which have recently demonstrated anti-cancer activities. However, molecular mechanisms of kavalactones' anti-cancer action remain largely unknown. We have identified two kavalactones, yangonin and 5' 6'-dehydrokawain, as potent inducers of autophagic cell death in bladder cancer cells. The effect of yangonin inducing autophagy is associated with increased expression of beclin and ATG5.In addition, yangonin increases the expression of LKB1 and decreases the phosphorylation of Akt, PRAS40, rpS6,p70S6 K and 4E-BP1, leading to increased binding of 4E-BP1 to m7 GTP. The growth inhibitory effects of yangonin were attenuated in TSC1 or LKB1 knockout mouse embryonic fibroblasts, suggesting that TSC1 and LKB1 expression may contribute to optimal growth inhibition by yangonin. Furthermore, yangonin reduces the viability of bladder cancer cell lines derived from different stages of human bladder cancer, and acts synergistically with apoptosis-inducing agents such as docetaxel and flavokawain A. Our results support a novel anti-bladder cancer mechanism by yangonin and further studies are needed to assess the potential use of yangonin for bladder cancer prevention and | Zhongbo Liu U-Syn Ha Ke Yu Chunli Wu Noriko Yokoyama Xiaolin Zi | 2017 | The Journal of Biomedical Research2017，31，5： | 4 |
| 8 | Late Cenozoic Sedimentary Evolution of Pagri-Duoqing Co graben, Southern End of Yadong-Gulu Rift, Southern Tibet显示文摘The north trending rifts in southern Tibet represent the E-W extension of the plateau and confirming the initial rifting age is key to the study of mechanics of these rifts. Pagri-Duoqing Co graben is located at southern end of Yadong-Gulu rift, where the late Cenozoic sediments is predominately composed of fluvio-lacustrine and moraine. Based on the sedimentary composition and structures, the fluviolacustrine could be divided into three facies, namely, lacustrine, lacustrine fan delta and alluvial fan. The presence of paleo-currents and conglomerate components and the provenance of the strata around the graben indicate that it was Tethys Himalaya and High Himalaya. Electron spin resonance(ESR) dating and paleo-magnetic dating suggest that the age of the strata ranges from ca. 1.2 Ma to ca. 8 Ma. Optically stimulated luminescence(OSL) dating showed that moraine in the graben mainly developed from around181-109 ka(late Middle Pleistocene). Combining previous data about the Late Cenozoic strata in other basins, it is suggested that 8-15 Ma may be the initial rifting time. Together with sediment distribution and drainage system, the sedimentary evolution of Pagri could be divided into four stages. The graben rifted at around 15-8 Ma due to the eastern graben-boundary fault resulting in the appearance of a paleolake.Following by a geologically quiet period about 8-2.5 Ma, the paleolake expanded from east to west at around 8-6 Ma reaching its maximum at ca. 6 Ma. Then, the graben was broken at about 2.5 Ma. At last,the development of the glacier separated the graben into two parts that were Pagri and Duoqing Co since the later stages of the Middle Pleistocene. The evolution process suggested that the former three stages were related to the tectonic movement, which determined the basement of the graben, while the last stage may have been influenced by glacial activity caused by climate change. | HA Guanghao WU Zhonghai HE Lin WANG Shubing | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 3 |
| 9 | Porous Carbon Architecture Assembled by Cross-Linked Carbon Leaves with Implanted Atomic Cobalt for High-Performance Li-S Batteries显示文摘The practical application of lithium-sulfur batteries is severely hampered by the poor conductivity,polysulfide shuttle effect and sluggish reaction kinetics of sulfur cathodes.Herein,a hierarchi-cally porous three-dimension(3D)carbon architecture assembled by cross-linked carbon leaves with implanted atomic Co-N4 has been deli-cately developed as an advanced sulfur host through a SiO_(2)-mediated zeolitic imidazolate framework-L(ZIF-L)strategy.The unique 3D architectures not only provide a highly conductive network for fast electron transfer and buffer the volume change upon lithiation-delithi-ation process but also endow rich interface with full exposure of Co-N4 active sites to boost the lithium polysulfides adsorption and conversion.Owing to the accelerated kinetics and suppressed shuttle effect,the as-prepared sulfur cathode exhibits a superior electrochemical perfor-mance with a high reversible specific capacity of 695 mAh g^(−1) at 5 C and a low capacity fading rate of 0.053%per cycle over 500 cycles at 1 C.This work may provide a promising solution for the design of an advanced sulfur-based cathode toward high-performance Li-S batteries. | Ruirui Wang Renbing Wu Chaofan Ding Ziliang Chen Hongbin Xu Yongfeng Liu Jichao Zhang Yuan Ha Ben Fei Hongge Pan | 2021 | Nano-Micro Letters2021，13，10： | 3 |
| 10 | Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival显示文摘 | Berna C. ?zdemir Tsvetelina Pentcheva-Hoang Julienne L. Carstens Xiaofeng Zheng Chia-Chin Wu Tyler R. Simpson Hanane Laklai Hikaru Sugimoto Christoph Kahlert Sergey V. Novitskiy Ana De Jesus-Acosta Padmanee Sharma Pedram Heidari Umar Mahmood Lynda Chin Ha | 2014 | Cancer Cell2014，，： | 2 |
| 11 | Removal of ammonium from greywater using natural zeolite显示文摘 | Nurul Widiastuti Hongwei Wu Ha Ming Ang Dongke Zhang | 2011 | Desalination2011，，1： | 2 |
| 12 | Spatiotemporal patterns and influencing factors of human migration networks in China during COVID-19显示文摘The social lockdowns and strict control measures initiated to combat the COVID-19 pandemic have had an impact on human migration.In this study,big data was used to analyze spatial patterns of population migration in 369 Chinese cities during the COVID-19 outbreak and to identify determinants of population migration.We found that the overall migration intensity decreased by 39.87%compared to the same period in 2019 prior to the COVID-19 outbreak.COVID-19 severely affected human migration.The public holidays and weekends have impacted human migration from the perspective of time scale.The spatial pattern of China’s population distribution presents a diamond structure that is dense in the east and sparse in the west,which is bounded by the Hu line and the cities such as Beijing,Shanghai,Guangzhou and Chengdu as nodes to connect.There is a strong consistency between the population distribution center and the level of urban development.The urban human migration network is centered on provincial capitals or municipalities at the regional scale,showing a prominent'center-periphery'structure.COVID-19 dispersed the forces of human migration in time and changed the direction of human migration in space.But it did not change the pattern of national migration.The most critical factors influencing mass migration are income levels and traditional culture.This study reveals the impacts of major public health emergencies on conventional migration patterns and provides a scientific theoretical reference for COVID-19 prevention and control. | Debin Lu Wu Xiao Guoyu Xu Lin Ha Dongyang Yang | 2021 | Geography and Sustainability2021，2，4： | 2 |
| 13 | Initial Rifting Age of the Nearly N–S Rifts in Southern Tibetan Plateau:New Evidence from the Age limit of the Early Sediments显示文摘Objective The nearly parallel N–S-trending rifts in southern Tibet represent the E–W extension of the Tibet Plateau.Most data which constrained the age of the extensional deformation come from isotopic dating of the dikes probably related to the activity of the nearly N–S faulting and micas from hydrothermal activity and the lowtemperature thermochronology of plateau uplift. | HA Guanghao WU Zhonghai HE Lin WANG Shubing | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 2 |
| 14 | Long-term fertilizer effects on organic carbon and total nitrogen and coupling relationships of C and N in paddy soils in subtropical China显示文摘 | Tong CL Xiao HA Tang GY Wang HQ Huang TP Xia HA Keith S J Li Y Liu SL Wu JS | 2009 | Soil and Tillage Research2009，106，1： | 1 |
| 15 | The perception ofmenopause among women in Taiwan 显示文摘 | Pan HA Wu MH Hsu CC | 2002 | Maturitas2002，41，4： | 1 |
| 16 | Completion of a fuzzy measure显示文摘 | WU C X HA M H | 1993 | J Fuzzy Math1993，，1： | 1 |
| 17 | Theperception of menopause a- mong women in Taiwan 显示文摘 | Pan HA Wu MH Hsu C C et ai | 2002 | Maturitas2002，41，4： | 1 |
| 18 | Theinfluence of reaction conditions on SO2 oxidation in adischarge plasma reactor 显示文摘 | Hyun Ha Kim Chunxi Wu Youhei Kinoshita | 2001 | IEEE Transactions onIndustry Applications2001，37，2： | 1 |
| 19 | P T EN sig na ling pat hways in melanoma显示文摘 | Wu H G oel V Ha luska F G | | 0，，20： | 1 |
| 20 | Nonlinear optical changes in 1-D photonic bandgaps of cholesteric liquid crystal显示文摘 | Wu J W Hwang Jisoo Ha N Y | 2002 | Proceedings of SPIE2002，4655，： | 1 |
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