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| 1 | Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth显示文摘 | Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang | 2014 | Cell Research2014，24，10： | 33 |
| 2 | YTH Domain: A Family of N^6-methyladenosine (m^6A) Readers显示文摘Like protein and DNA, different types of RNA molecules undergo various modifications. Accumulating evidence suggests that these RNA modifications serve as sophisticated codes to mediate RNA behaviors and many important biological functions. N^6-methyladenosine(m^6 A)is the most abundant internal RNA modification found in a variety of eukaryotic RNAs, including but not limited to m RNAs, t RNAs, r RNAs, and long non-coding RNAs(lnc RNAs). In mammalian cells, m^6 A can be incorporated by a methyltransferase complex and removed by demethylases, which ensures that the m^6 A modification is reversible and dynamic. Moreover, m^6 A is recognized by the YT521-B homology(YTH) domain-containing proteins, which subsequently direct different complexes to regulate RNA signaling pathways, such as RNA metabolism, RNA splicing, RNA folding, and protein translation. Herein, we summarize the recent progresses made in understanding the molecular mechanisms underlying the m^6 A recognition by YTH domaincontaining proteins, which would shed new light on m^6 A-specific recognition and provide clues to the future identification of reader proteins of many other RNA modifications. | Shanhui Liao Hongbin Sun Chao Xu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，2： | 29 |
| 3 | Current developments in pharmacological therapeutics for chronic constipation显示文摘Chronic constipation is a common gastrointestinal disease severely affecting the patient's quality of life. The traditional treatment of constipation is the use of laxatives. Recently, several new drugs including lubiprostone, linaclotide and prucalopride have been approved for treatment of chronic constipation. However, a significant unmet medical need still remains, particularly among those patients achieving poor results by current therapies. The 5-HT4 receptor modulators velusetrag and naronapride,the guanylate cyclase C agonist plecanatide and the ileal bile acid transporter inhibitor elobixibat are recognized as the most promising drugs under investigation. Herein, we give a comprehensive review on the pharmacological therapeutics for the treatment of chronic constipation, with the purpose of reflecting the drug development trends in this field. | Chunhuan Jiang Qinglong Xu Xiaoan Wen Hongbin Sun | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 23 |
| 4 | Responses of grassland vegetation to climatic variations on different temporal scales in Hulun Buir Grassland in the past 30 years显示文摘全球温暖特别在过去的 20 年里导致了重要植被变化。在内部蒙古的 Hulun Buir 草地,世界之一三个大草原,正在经历突出的温暖并且弄干的一个过程。为气候的变化的更好的理解在植被动力学上调查气候的变化(温度和降水) 的效果是必要的。NDVI (规范的差别植被索引) ,植物生长的思考特征,植被范围和生物资源,被用作指示物监视植被变化。从 1981 ~ 2006 的 GIMMS NDVI 和从 2000 ~ 2009 的 MODIS NDVI 被采用并且集成于到植被的时间系列特征在 Hulun Buir 改变的摘录的这研究草地。到每年、季节、每月的规模上的气候的变化的植被范围的回答被分析与温度和七个气象学的地点的降水数据结合了。在过去的 30 年里,植被范围是更多与气候的因素相关,并且关联依赖于时间规模。在内部年度的规模上,植被变化更好与降水被相关,建议降雨是为驾驶植被变化的主要因素。在 seasonal-interannual 规模上,在植被范围变化和气候的因素之间的关联证明到水、热的条件变化的植被生长的敏感在不同季节是不同的。当它到在夏天和秋天的降雨的敏感更高时,到在夏天的温度的植被生长的敏感比在另外的季节高,特别在夏天。在 monthly-interannual 规模上,在植被范围变化和气候的因素之间的关联在生长季节期间证明在 4 月和 5 月的温度的植被变化的反应更强壮。这显示温度效果发生在植被生长的早阶段。在植被生长和在当前的月前的月的降水之间的关联,从 5 月更好到 8 月,显示出植被生长的磁滞现象回答到降雨。草变得绿并且开始在草生长上在温度的 4 月,和影响成长是明显的。在 4 月的 NDVI 的增加可能由于气候的温暖那导致一个先进生长季节。在摘要,在植被范围和气候的因素的 monthly-interannual 变化之间的关系大部分在草生长上代表温度和降水的时间的节奏控制。 | ZHANG Geli XU Xingliang ZHOU Caiping ZHANG Hongbin OUYANG Hua | 2011 | Journal of Geographical Sciences2011，21，4： | 20 |
| 5 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 6 | Influence of plant architecture on maize physiology and yield in the Heilonggang River valley显示文摘The size and distribution of leaf area determine light interception in a crop canopy and influence overall photosynthesis and yield. Optimized plant architecture renders modern maize hybrids(Zea mays L.) more productive, owing to their tolerance of high plant densities. To determine physiological and yield response to maize plant architecture, a field experiment was conducted in 2010 and 2011. With the modern maize hybrid ZD958, three plant architectures, namely triangle, diamond and original plants, were included at two plant densities, 60,000 and 90,000 plants ha-1. Triangle and diamond plants were derived from the original plant by spraying the chemical regulator Jindele(active ingredients,ethephon, and cycocel) at different vegetative stages. To assess the effects of plant architecture, a light interception model was developed. Plant height, ear height, leaf size,and leaf orientation of the two regulated plant architectures were significantly reduced or altered compared with those of the original plants. On average across both plant densities and years, the original plants showed higher yield than the triangle and diamond plants,probably because of larger leaf area. The two-year mean grain yield of the original and diamond plants were almost the same at 90,000 plants ha-1(8714 vs. 8798 kg ha-1). The yield increase(up to 5%) of the diamonds plant at high plant densities was a result of increased kernel number per ear, which was likely a consequence of improved plant architecture in the top and middle canopy layers. The optimized light distribution within the canopy can delay leaf senescence, especially for triangle plants. The fraction of incident radiation simulated by the interception model successfully reflected plant architecture traits. Integration of canopy openness is expected to increase the simulation accuracy of the present model. Maize plant architecture with increased tolerance of high densities is probably dependent on the smaller but flatter leaves around the ear. | Shoubing Huang Yingbo Gao Yebei Li Lina Xu Hongbin Tao Pu Wang | 2017 | The Crop Journal2017，5，1： | 11 |
| 7 | Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer显示文摘MicroRNAs (miRNAs ) 玩在在各种各样的癌症的发展和前进的关键角色。不正常的 miR-9 表示仍然保持模糊,并且卵巢的癌症的变形前进上的一致都没被到达。在这研究,从生物信息学分析的结果证明 E-cadherin mRNA 的 3-UTR 被 miR-9 直接调整。酶记者试金结果证实 miR-9 能直接指向这 3-UTR。在卵巢的癌症织物的 miR-9 和 E-cadherin 表示被 qRT-PCR 确定。移植和侵略被在 SKOV3 和 A2780 愈合弯屈和 Transwell 系统试金检测。qRT-PCR 和西方的污点被执行检测上皮 ? 间充质的联系转变的 mRNA 和蛋白质。Immunofluorescence 技术被用来分析表示和 E-cadherin, N-cadherin,和 vimentin 的 subcellular 本地化。结果证明 miR-9 经常与配对的主要的相比是在变形浆液的卵巢的癌症织物的 upregulated。miR-9 的 Upregulation 能 downregulate E-cadherin 的表示但是 upregulate 间充质的标记(N-cadherin 和 vimentin ) 的表示。miR-9 的 Overexpression 能在卵巢的癌症支持房间移植和侵略,并且这些进程能有效地经由 miR-9 禁止者被禁止。因此,我们的学习证明 miR-9 可以经由指向 E-cadherin 和一条新奇潜在的治疗学的途径控制卵巢的癌症的转移支持卵巢的癌症转移。 | Bo Zhou Hongbin Xu Meng Xia Chaoyang Sun Na Li Ensong Guo Lili Guo Wanying Shan Hao Lu Yifan Wu Yuan Li Degui Yang Danhui Weng Li Meng Junbo Hu Ding Ma Gang Chen Kezhen Li | 2017 | Frontiers of Medicine2017，11，2： | 10 |
| 8 | MicroRNA-4661 inhibits antiviral innate immune response by targeting interferon-alpha显示文摘 | Yingke Li Xiaohua Fan Xingying He Haijing Sun Zui Zou Hongbin Yuan Haitao Xu Chengcai Wang Xueyin Shi | 2012 | Cellular & Molecular Immunology2012，9，6： | 8 |
| 9 | The effect of low-molecular-weight organic-acids(LMWOAs)on treatment of chromium-contaminated soils by compost-phytoremediation: Kinetics of the chromium release and fractionation显示文摘A soil–plant biological system was developed from chromium(Cr) polluted soil treated by the compost-phytoremediation method. The transformation and migration of the Cr in this system is comprehensively studied in this research. The results illustrated that the co-composting treatment can reduce the Cr availability from 39%(F1 was about 31% of total, F2 was about 8% of total) to less than 2% by stabilizing the Cr. However, herbaceous plants can accumulate the concentrations of Cr from 113.8 to 265.2 mg/kg in the two crops,even though the concentration of soluble Cr in the substrate soil was below 0.1 mg/L.Cr can be assimilated and easily transferred in the tissues of plants because the lowmolecular-weight organic-acids(LMWOAs) derived from the plant root increase the bioavailability of Cr. The amount of extracted Cr dramatically increased when the organic acids were substituted in this order: citric acid > malic acid > tartaric acid > oxalic acid >acetic acid. On average the maximum(147.4 mg/kg) and the minimum(78.75 mg/kg) Cr were extracted by 20 mmol/L citric acid and acetic acid, respectively. The desorption of Cr in different acid solutions can be predicted by the pseudo second-order kinetics. The exchangeable Cr, carbonate-bound Cr, and residual Cr decreased, while Fe–Mn oxide bound Cr and organic bound Cr increased in the soil solid phase. According to the experimental results, the organic acids will promote the desorption and chelation processes of Cr, leading to the remobilization of Cr in the soil. | Huixia Chen Junfeng Dou Hongbin Xu | 2018 | Journal of Environmental Sciences2018，30，8： | 8 |
| 10 | Advances in the Studies of the Middle and Upper Atmosphere in 2004 - 2006显示文摘This paper summarizes the research results obtained by Chinese scientists and/or through international collaborations during 2004 to 2006. Within the context of COSPAR, the progresses in the studies of the middle and upper atmosphere in China in the past two years are introduced with focusing the developments in facilities and instruments, and the advancements in scientific issues, e.g., dynamics related processes, atmospheric constituents, and the coupling with the lower atmosphere. | CHEN Zeyu LIU Renqiang CHEN Hongbin CHEN Wen LU Daren XU Jiyao HU Xiong | 2006 | 空间科学学报2006，26，z1： | 6 |
| 11 | Investigation on the fabrication of lightweight aggregate with acid-leaching tailings of vanadium-bearing stone coal minerals and red mud显示文摘Proper treatment of acidleaching tailings(ALTs)of vanadiumbearing stone coal minerals is of great urgency.One approach is adding it into the raw materials during the preparation of lightweight aggregate(LWA).But clay is always needed.In this paper,another solid waste,red mud,was mixed with ALTs as a source of flux components instead of clay.Evaluation of the physical characteristics,morphological structures,as well as crystal phases during the sintering process were investigated.When their mixtures with a proper ratio were sintered at 1080℃,a glassy phase with certain viscosity was formed,and the gases generated simultaneously were encapsulated by the melt.Finally,LWA with a onehour water absorption as low as 1.46%,a bulk density as low as 728.76 kgm 3 and a compressive strength as high as 10.77 MPa was fabricated. | Chunguang Song Hongling Zhang Yuming Dong Lili Pei Honghui Liu Junsheng Jiang Hongbin Xu | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 6 |
| 12 | Rational synthesis of carbon shell coated polyaniline/ MoS2 monolayer composites for high-performance supercapacitors显示文摘进行的聚合物通常显示出高特定的电容,但是受不了差的率能力和快速的电容腐烂,它极大地在 supercapacitor 电极限制他们的实际应用。到这个目的,许多研究在由综合改进全面电容的表演上集中了进行聚合物的 nanostructured 或由扔涂层的一个范围增加,活跃表面区域暴露了到电解质并且提高费用运输效率和结构的稳定性。尽管有这,同时完成高特定的电容,好率表演,和长周期生活仍然是可观的挑战。在之中各种各样二维(2D ) 分层的材料,八面(1T ) 分阶段执行铝二硫化物(瞬间 2) nanosheets 有高电的电导率,大特定的表面区域,和唯一的表面化学药品特征,为进行聚合物的 nanostructured 的控制生长使他们成为有趣的底层。这份报纸报导碳的合理合成在 1T 瞬间 2 单层上种的壳涂的 polyaniline (PANI )( 瞬间 2/PANI@C) 。合成电极与 3 nm 碳壳展出了的 ~ 瞬间包括了 2/PANI@C 多达 678 F 耶尙洜暗囊桓鱿灾囟ǖ牡缛萋穑浚? | Chao Yang Zhongxin Chen Imran Shakir Yuxi Xu Hongbin Lu | 2016 | Nano Research2016，9，4： | 5 |
| 13 | Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome显示文摘 | Guowei Lei Mingkuan Chen Hua Li Jun-Ling Niu Shuxian Wu Liming Mao Ailing Lu Hongbin Wang Wei Chen Bin Xu Qibin-Leng Cunshuan Xu Guiwen Yang Liguo An Li-Ping Zhu Guangxun Meng | 2013 | Cell Research2013，23，7： | 5 |
| 14 | Internal failure of anode materials for lithium batteriesd——A critical review显示文摘Prevention of mechanical and finally electrochemical failures of lithium batteries is a critical aspect to be considered during their design and performance, especially for those with high specific capacities. Internal failure is observed as one of the most serious factors, including loss of electrode materials, structure deformation and dendrite growth. It usually incubates from atomic/molecular level and progressively aggravates along with lithiation. Understanding the internal failure is of great importance for developing solutions of failure prevention and advanced anode materials. In this research, different internal failure processes of anode materials for lithium batteries are discussed. The progress on observation technologies of the anode failure is further summarized in order to understand their mechanisms of internal failure. On top of them, this review aims to summarize innovative methods to investigate the anode failure mechanisms and to gain new insights to develop advanced and stable anodes for lithium batteries. | Xiangqi Meng Yaolin Xu Hongbin Cao Xiao Lin Pengge Ning Yi Zhang Yaiza Gonzalez Garcia Zhi Sun | 2020 | Green Energy & Environment2020，5，1： | 5 |
| 15 | Numerical and Experimental Investigations on Tunable Low-frequency Locally Resonant Metamaterials显示文摘In this paper,a tunable locally resonant metamaterial is proposed for low-frequency band gaps.The local resonator composed of two pairs of folded slender beams and a proof mass is designed based on the theory of compliant mechanism.The design optimization on geometric parameters is carried out to fulfil the quasi-zero-stiffness property.The locally resonant metamaterial is formed by periodically arranged unit cells,and the transmittance of longitudinal wave is studied through three aspects:numerical predictions,finite element simulations and experimental tests.The variation trends revealed by these three methods match well with one another:the band gap moves to lower frequency and both its depth and width get smaller and smaller with the increase of pre-compression(Δ).The band gap overlays the frequency range of 73.10–92.38 Hz and 16.78–19.49 Hz atΔ=0mm andΔ=10mm,respectively,providing a wide range of tunability.Besides,the ultralow-frequency band gap can be achieved asΔapproaches 10 mm.This study may provide an avenue for achieving the tunable ultralow-frequency locally resonant band gap. | Qida Lin Jiaxi Zhou Hongbin Pan Daolin Xu Guilin Wen | 2021 | Acta Mechanica Solida Sinica2021，34，5： | 4 |
| 16 | Non-equilibrium Plasma Assisted Combustion of Low Heating Value Fuels显示文摘This paper describes the effects of non-equilibrium air plasma generated by a dielectric barrier discharge (DBD) on the combustion of low heating value fuels. The experimental results indicate that addition of a very small amount of energy to the air flow in the form of DBD significantly improves the flame stability. Moreover, main combustion characteristics such as flame propagation speed, combustion intensity and lean blow-off limits are also enhanced by the effect of plasma. Some active radicals such as excited O atom and excited N2 molecule are observed by spectrograph in the discharge area. Based on the results of numerical investigation we can conclude that these active radicals generated in discharge area can accelerate the production rate of active OH radical which plays a key role in the oxidation process of low heating value fuel, and thus the whole combustion process is accelerated. | Hongbin Hu Quanbin Song Yanji Xu Gang Li Chaoqun Nie | 2013 | Journal of Thermal Science2013，22，3： | 4 |
| 17 | Engineering an enthesis-like graft for rotator cuff repair:An approach to fabricate highly biomimetic scaffold capable of zone-specifically releasing stem cell differentiation inducers显示文摘Rotator cuff(RC)attaches to humerus across a triphasic yet continuous tissue zones(bone-fibrocartilage-tendon),termed“enthesis”.Regrettably,rapid and functional enthesis regeneration is challenging after RC tear.The existing grafts bioengineered for RC repair are insufficient,as they were engineered by a scaffold that did not mimic normal enthesis in morphology,composition,and tensile property,meanwhile cannot simultaneously stimulate the formation of bone-fibrocartilage-tendon tissues.Herein,an optimized decellularization approach based on a vacuum aspiration device(VAD)was developed to fabricate a book-shaped decellularized enthesis matrix(O-BDEM).Then,three recombinant growth factors(CBP-GFs)capable of binding collagen were synthesized by fusing a collagen-binding peptide(CBP)into the N-terminal of BMP-2,TGF-β3,or GDF-7,and zone-specifically tethered to the collagen of O-BDEM to fabricate a novel scaffold(CBP-GFs/O-BDEM)satisfying the above-mentioned requirements.After ensuring the low immunogenicity of CBP-GFs/O-BDEM by a novel single-cell mass cytometry in a mouse model,we interleaved urine-derived stem cell-sheets into this CBP-GFs/O-BDEM to bioengineer an enthesis-like graft.Its high-performance on regenerating enthesis was determined in a canine model.These findings indicate this CBP-GFs/O-BDEM may be an excellent scaffold for constructing enthesis-like graft to patch large/massive RC tears,and provide breakthroughs in fabricating graded interfacial tissue. | Can Chen Qiang Shi Muzhi Li Yang Chen Tao Zhang Yan Xu Yunjie Liao Shulin Ding Zhanwen Wang Xing Li Chunfeng Zhao Lunquan Sun Jianzhong Hu Hongbin Lu | 2022 | Bioactive Materials2022，7，10： | 4 |
| 18 | OPTIMAL COMBINATIONAL OF QUOTA-SHARE AND STOP-LOSS REINSURANCE CONTRACTS UNDER VAR AND CTE WITH A CONSTRAINED REINSURANCE PREMIUM显示文摘这份报纸考虑最小化 VaR 和 CTE 的问题一保险公司由控制 combinational 限额份额和站损失再保险策略保留了风险。与抑制再保险奖赏,作者分别地在站损失再保险和站损失 after-quota-share 再保险的盒子以后在限额份额的情况中给保留的风险的明确的再保险形式和最小的 VaR 和 CTE。最后,作者断定在站损失以后的限额份额比在限额份额以后的站损失是更好的再保险策略与一样的抑制再保险奖赏最小化 VaR 和 CTE。并且纯站损失再保险与一个高级规章的要求为一个保险公司被比较喜欢。 | Ming ZHOU Hongbin DONG Jingfeng XU | 2011 | Journal of Systems Science & Complexity2011，24，1： | 4 |
| 19 | Extended Range(10–30 Days) Heavy Rain Forecasting Study Based on a Nonlinear Cross-Prediction Error Model显示文摘Extended range(10–30 d) heavy rain forecasting is difficult but performs an important function in disaster prevention and mitigation. In this paper,a nonlinear cross prediction error(NCPE) algorithm that combines nonlinear dynamics and statistical methods is proposed. The method is based on phase space reconstruction of chaotic single-variable time series of precipitable water and is tested in 100 global cases of heavy rain. First,nonlinear relative dynamic error for local attractor pairs is calculated at different stages of the heavy rain process,after which the local change characteristics of the attractors are analyzed. Second,the eigen-peak is defined as a prediction indicator based on an error threshold of about 1.5,and is then used to analyze the forecasting validity period. The results reveal that the prediction indicator features regarded as eigenpeaks for heavy rain extreme weather are all reflected consistently,without failure,based on the NCPE model; the prediction validity periods for 1–2 d,3–9 d and 10–30 d are 4,22 and 74 cases,respectively,without false alarm or omission. The NCPE model developed allows accurate forecasting of heavy rain over an extended range of 10–30 d and has the potential to be used to explore the mechanisms involved in the development of heavy rain according to a segmentation scale. This novel method provides new insights into extended range forecasting and atmospheric predictability,and also allows the creation of multi-variable chaotic extreme weather prediction models based on high spatiotemporal resolution data. | XIA Zhiye CHEN Hongbin XU Lisheng WANG Yongqian | 2015 | Advances in Atmospheric Sciences2015，32，12： | 4 |
| 20 | PhaseⅡstudy of induction chemotherapy followed by concurrent chemoradiotherapy with raltitrexed and cisplatin in locally advanced nasopharyngeal carcinoma显示文摘Objective:For locally advanced nasopharyngeal carcinoma(LA-NPC)patients,high incidences of distant metastases and severe treatment related toxicities are the main obstacles needed to be overcome.Raltitrexed,a specific thymidylate synthase inhibitor with a convenient administration schedule,has an acceptable and manageable toxicity,and possesses radio-sensitizing properties.To investigate the efficacy and safety of raltitrexed and cisplatin induction chemotherapy and concurrent chemoradiotherapy(IC+CCRT)in patients with LA-NPC,a phaseⅡclinical study was conducted.Methods:Sixty eligible patients with LA-NPC were enrolled into this study.A raltitrexed-cisplatin combination was used as part of an IC+CCRT regimen.Raltitrexed-cisplatin IC was given once every 3 weeks(q3 w)for two cycles,followed by raltitrexed-cisplatin based CCRT q3 w for two cycles.Intensity-modulated radiotherapy(IMRT)was given for all enrolled patients.Results:All patients were included in survival analysis according to the intent-to-treat principle.The objective response rate(ORR)3 months after treatment was 98%.The 2-year overall survival(OS)rate was 92%.The median relapse-free survival(RFS)time was 30.5[95%confidence interval(95%CI),28.4-32.3]months.The 2-year RFS rate was 85%.The 2-year local failure-free survival(LFFS)rate was 97%and the 2-year distant metastasis-free survival(DMFS)rate was 88%.Acute toxicities were mostly grade 2 and 3 reactions in bone marrow suppression,gastrointestinal side effect and oropharyngeal mucositis.Only two patients occurred grade 4 acute toxicities,one was bone marrow suppression and the other was dermatitis radiation.Conclusions:The combination of raltitrexed and cisplatin has a comparable efficacy to those in standard firstline therapy. | Yuan Wu Xueyan Wei Zilong Yuan Hongbin Xu Yanping Li Ying Li Liu Hu Guang Han Yu Qian Desheng Hu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 4 |
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