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| 1 | Retardant effect of dihydroartemisinin on ulcerative colitis in a JAK2/STAT3-dependent manner显示文摘Dihydroartemisinin(DHA)is a semi-synthetic derivative and the main active metabolite of artemisinin.The purpose of this study was to investigate the effect of DHA on the ulcerative colitis(UC)in both in vivo and in vitro models.Weight,survival rate,colon length,and Disease Activity Index score were used to evaluate the severity of colitis.Reverse transcription quantitative polymerase chain reaction and enzyme-linked immunosorbent assay were used to detect the expressions of cytokines interleukin(IL)-1,IL-1β,IL-4,IL-6,IL-10,IL-12,and tumor necrosis factor-α(TNF-α).The expressions of Janus kinase 2(JAK2)and signal transducer and activator of transcription 3(STAT3),and the phosphorylation of JAK2(p-JAK2)and STAT3(p-STAT3),were measured by western blot analysis.Western blot analysis and immunohistochemistry were used to detect the expressions of tight junction proteins.We found that the weights and colon lengths of mice in dextran sodium sulfate(DSS)+DHA group were significantly lower and longer than those in the DSS group,respectively.Compared with those in the DSS group,the expressions of IL-1β,IL-6,IL-17,and TNF-αin the DSS+DHA and DSS+5-aminosalicylic acid(5-ASA)groups were decreased,while the expressions of IL-4 and IL-10 were significantly upregulated.DHA largely increased the expressions of zonula occludens-1 and occludin.Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2,STAT3,p-JAK2,and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.DHA has a specific therapeutic effect on UC.The anti-inflammatory mechanism of DHA is related to the blockage of the JAK2/STAT3 signaling pathway.These findings provide evidence that DHA may be a useful drug and is expected to become a promising new treatment for human UC. | Mingrui Jiang Guangjun Zhong Yichao Zhu Liuhua Wang Yuzhe He Qiannan Sun Xiaoqing Wu Xiaolan You Sujun Gao Dong Tang Daorong Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 6 |
| 2 | Virtual population pharmacokinetic using physiologically based pharmacokinetic model for evaluating bioequivalence of oral lacidipine formulations in dogs显示文摘The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic(PBPK) model for evaluating bioequivalence of oral lacidipine formulations in dogs. The dissolution behaviors of three lacidipine formulations including one commercial product and two self-made amorphous solid dispersions(ASDs)capsules were determined in 0.07% Tween 80 media. A randomized 3-period crossover design in 6 healthy beagle dogs after oral administration of the three formulations at a single dose of 4 mg was conducted. The PBPK modeling was utilized for the virtual bioequivalence study.In vitro dissolution experiment showed that the dissolution behaviors of lacidipine amorphous solid dispersions(ASDs) capsules, which was respectively prepared by HPMC-E5 or Soluplus, as polymer displayed similar curves compared with the reference formulation in 0.07% Tween 80 media. In vivo pharmacokinetics experiments showed that three formulations had comparable maximum plasma drug concentration(Cmax), and the time(Tmax) to reach Cmax of lacidipine tablet, which was prepared by Soluplus, as polymer was slower than other two formulations in consistency with the in vitro dissolution rate. The 90% confidence interval(CI) for the Cmax, AUC0–24 h and AUC0–∞ of the ratio of the test drug to the reference drug exceeded the acceptable bioequivalence(BE) limits(0.80–1.25). However, the 90% CI of the AUC0–24 h, AUC0–∞ and Cmax of the ratio of test to reference drug were within the BE limit,calculated using PBPK modeling when the virtual subjects reached 24 dogs. The results all demonstrated that virtual bioequivalence study can overcome the inequivalence caused by inter-subject variability of the 6 beagle dogs involved in in vivo experiments. | Bin Yang Chunnuan Wu Bin Ji Mingrui Wu Zhonggui He Lei Shang Jin Sun | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，1： | 5 |
| 3 | Hydrogel-based composites beyond the porous architectures for electromagnetic interference shielding显示文摘With the rapid development of the electronic industry and wireless communication technology,electromagnetic interference(EMI)or pollution has been increasingly serious.This not only severely endangers the normal operation of electronic equipment but also threatens human health.Therefore,it is urgent to develop high-performance EMI shielding materials.The advent of hydrogel-based materials has given EMI shields a novel option.Hydrogels combined with conductive functional materials have good mechanical flexibility,fatigue durability,and even high stretchability,which are beneficial for a wide range of applications,especially in EMI shielding and some flexible functional devices.Herein,the current progress of hydrogel-based EMI shields was reviewed,in the meanwhile,some novel studies about pore structure design that we believe will help advance the development of hydrogel-based EMI shielding materials were also included.In the outlook,we suggested some promising development directions for the hydrogel-based EMI shields,by which we hope to provide a reference for designing hydrogels with excellent EMI shielding performance and multifunctionalities. | Yunfei Yang Mingrui Han Wei Liu Na Wu Jiurong Liu | 2022 | Nano Research2022，15，10： | 5 |
| 4 | Quasi-two-dimensionalβ-Ga2O3 field effect transistors with large drain current density and low contact resistance via controlled formation of interfacial oxygen vacancies显示文摘Quasi-two-dimensi on al(2D)β-Ga2O3 is a rediscovered metal-oxide semiconductor with an ultra-wide bandgap of 4.6-4.9eV.It has been reported to be a promising material for next-generation power and radio frequency electronics.Field effect transistors(FETs)that can switch at high voltage are key compone nts in power and radio frequency devices,and reliable Ohmic con tacts are essential for high FET performance.However,obtaining low contact resistance onβ-Ga2O3 FETs is difficult since reactions betweenβ-Ga2O3 and metal contacts are not fully understood.Herein,we experimentally demonstrate the importanee of reactions at the metal/β-Ga2O3 interface and the corresponding effects of these reactions on FET performance.When Ti is employed as the metal contact,annealing ofβ-Ga2O3 FETs in argon can effectively transform Schottky contacts into Ohmic contacts and permit a large drain current density of-3.1 mA//μm.The contact resistance(Rcontact)between the Ti electrodes andβ-Ga2O3 decreased from^430 to^0.387Ω·mm after annealing.X-ray photoelectron spectroscopy(XPS)confirmed the formation of oxygen vacancies at the Ti/β-Ga2O3 interface after annealing,which is believed to cause the improved FET performance.The results of this study pave the way for greater application ofβ-Ga2O3 in electronics. | Zhen Li Yihang Liu Anyi Zhang Qingzhou Liu Chenfei Shen Fanqi Wu Chi Xu Mingrui Chen Hongyu Fu Chongwu Zhou | 2019 | Nano Research2019，12，1： | 2 |
| 5 | Spinning from Nature:Engineered Preparation and Application of High-Performance Bio-Based Fibers显示文摘Many natural fibers are lightweight and display remarkable strength and toughness.These properties originate from the fibers’hierarchical structures,assembled from the molecular to macroscopic scale.The natural spinning systems that produce such fibers are highly energy efficient,inspiring researchers to mimic these processes to realize robust artificial spinning.Significant developments have been achieved in recent years toward the preparation of high-performance bio-based fibers.Beyond excellent mechanical properties,bio-based fibers can be functionalized with a series of new features,thus expanding their sophisticated applications in smart textiles,electronic sensors,and biomedical engineering.Here,recent progress in the construction of bio-based fibers is outlined.Various bioinspired spinning methods,strengthening strategies for mechanically strong fibers,and the diverse applications of these fibers are discussed.Moreover,challenges in reproducing the mechanical performance of natural systems and understanding their dynamic spinning process are presented.Finally,a perspective on the development of biological fibers is given. | Zongpu Xu Mingrui Wu Qi Ye Dong Chen Kai Liu Hao Bai | 2022 | Engineering2022，8，7： | 2 |
| 6 | Author Correction:Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing显示文摘Correction to:Cell Research http://gffzzd3cc09b8251d45dfscc6koxnp0nko6bbw.ffgz.tsg.suse.edu.cn/10.1038/s41422-022-00635-9,published online 10 March 2022 We found that the information in the original Supplementary Figs.S2–S4 was not fully displayed due to an error in the image upload.The correct images are shown below for better display.These corrections do not affect the description of the results or the conclusion of this work.No change of the original figure legends is needed.We apologize for the mistake.The original article has been corrected. | Ziqi Zhao Dan Zhang Fuqiang Yang Mingrui Xu Shaoli Zhao Taotao Pan Chuanyu Liu Yongjie Liu Qingfeng Wu Qiang Tu Ping Zhou Rong Li Jia Kang Lan Zhu Fei Gao Yaqing Wang Zhiheng Xu | 2023 | Cell Research2023，33，7： | 1 |
| 7 | A Small Sphere and Large Margin Approach for Novelty Detection Using Training Data with Outliers显示文摘 | Wu Mingrui Ye Jieping | | 0，，11： | 1 |
| 8 | A small sphere and large margin approach for novelty detection using training data with outliers显示文摘 | Mingrui Wu Jieping Ye | 2009 | IEEE Trans on Pattern Analysis and Machine Intelligence2009，31，11： | 1 |
| 9 | A small sphere and large margin approach for novelty detection using training data with outliers显示文摘 | Wu Mingrui Ye Jieping | 2009 | IEEE Trans on Pattern Analysis and Machine Intelligence2009，31，11： | 1 |
| 10 | Gold-vapor-assisted chemical vapor deposition of aligned monolayer WSe2 with large domain size and fast growth rate显示文摘Orientation-controlled growth of two-dimensional(2D)transition metal dichalcogenides(TMDCs)may enable many new electronic and optical applications.However,previous studies reporting aligned growth of WSe2 usually yielded very small domain sizes.Herein,we introduced gold vapor into the chemical vapor deposition(CVD)process as a catalyst to assist the growth of WSe2 and successfully achieved highly aligned monolayer WSe2 triangular flakes grown on c-plane sapphire with large domain sizes(130μm)and fast growth rate(4.3μm·s^−1).When the aligned WSe2 domains merged together,a continuous monolayer WSe2 was formed with good uniformity.After transferring to Si/SiO2 substrates,field effect transistors were fabricated on the continuous monolayer WSe2,and an average mobility of 12 cm^2·V^−1·s−1 was achieved,demonstrating the good quality of the material.This report paves the way to study the effect of catalytic metal vapor in the CVD process of TMDCs and contributes a novel approach to realize the growth of aligned TMDC flakes. | Mingrui Chen Anyi Zhang Yihang Liu Dingzhou Cui Zhen Li Yu-Han Chung Sai Praneetha Mutyala Matthew Mecklenburg Xiao Nie Chi Xu Fanqi Wu Qingzhou Liu Chongwu Zhou Mork | 2020 | Nano Research2020，13，10： | 1 |
| 11 | A Small Sphere and Large Margin Approach for Novelty Detection Using Training Data with Outliers显示文摘 | Wu Mingrui Ye Jieping | 2009 | IEEE Transactions on Pattern Analysis and Machine Intelligence2009，31，11： | 1 |
| 12 | A small sphere and large margin approach for novelty detection using training data with outliers显示文摘 | Wu Mingrui Ye Jieping | 2009 | IEEE Transactions on Pattern Analysis and Machine Intelligence2009，31，11： | 1 |
| 13 | A Small Sphere and Large Margin Approach for Novelty Detection Using Training Data with Outliers显示文摘 | Wu Mingrui Ye Jieping | | 0，，11： | 1 |
| 14 | Acetylation of ezrin regulates membrane–cytoskeleton interaction underlying CCL18-elicited cell migration显示文摘Ezrin,a membrane–cytoskeleton linker protein,plays an essential role in cell polarity establishment,cell migration,and division.Recent studies show that ezrin phosphorylation regulates breast cancer metastasis by promoting cancer cell survivor and promotes intrahepatic metastasis via cell migration.However,it was less characterized whether there are additional post-translational modifications and/or post-translational crosstalks on ezrin underlying context-dependent breast cancer cell migration and invasion.Here we show that ezrin is acetylated by p300/CBP-associated factor(PCAF)in breast cancer cells in response to CCL18 stimulation.Ezrin physically interacts with PCAF and is a cognate substrate of PCAF.The acetylation site of ezrin was mapped by mass spectrometric analyses,and dynamic acetylation of ezrin is essential for CCL18-induced breast cancer cell migration and invasion.Mechanistically,the acetylation reduced the lipid-binding activity of ezrin to ensure a robust and dynamic cycling between the plasma membrane and cytosol in response to CCL18 stimulation.Biochemical analyses show that ezrin acetylation prevents the phosphorylation of Thr567.Using atomic force microscopic measurements,our study revealed that acetylation of ezrin induced its unfolding into a dominant structure,which prevents ezrin phosphorylation at Thr567.Thus,these results present a previously undefined mechanism by which CCL18-elicited crosstalks between the acetylation and phosphorylation on ezrin control breast cancer cell migration and invasion.This suggests that targeting PCAF signaling could be a potential therapeutic strategy for combating hyperactive ezrin-driven cancer progression. | Xiaoyu Song Wanjuan Wang Haowei Wang Xiao Yuan Fengrui Yang Lingli Zhao McKay Mullen Shihao Du Najdat Zohbi Saravanakumar Muthusamy Yalei Cao Jiying Jiang Peng Xia Ping He Mingrui Ding Nerimah Emmett Mingming Ma Quan Wu Hadiyah-Nicole Green Xia Ding Dongmei Wang Fengsong Wang Xing Liu | 2020 | Journal of Molecular Cell Biology2020，12，6： | 1 |
| 15 | A Small Sphere and Large Margin Approach for Novelty Detection Using Training Data with Outliers显示文摘 | Wu Mingrui Ye Jieping | 2009 | Pattern Analysis and Machine Intelligence2009，31，11： | 1 |
| 16 | A small sphere and large margin approach for novelty detection using training data with outliers显示文摘 | Wu Mingrui and Ye Jieping | 2009 | IEEE Transactions on Pattern Analysis and Machine Intelligence2009，31，11： | 1 |
| 17 | Gradient descent optimization of smoothed information retrieval metrics 显示文摘 | Chapelle O Wu Mingrui | 2010 | Information Retrieval Journal2010，13，6： | 1 |
| 18 | A Direct Method for Building Sparse Kernel Learning Algorithms显示文摘 | Wu Mingrui Scholkopf B Bakir G | 2006 | Machine Learning Research2006，7，： | 1 |
| 19 | Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing显示文摘The differences in size and function between primate and rodent brains,and the association of disturbed excitatory/inhibitory balance with many neurodevelopmental disorders highlight the importance to study primate ganglionic eminences(GEs)development.Here we used single-cell RNA and ATAC sequencing to characterize the emergence of cell diversity in monkey and human GEs where most striatal and cortical interneurons are generated.We identified regional and temporal diversity among progenitor cells which give rise to a variety of interneurons.These cells are specified within the primate GEs by well conserved gene regulatory networks,similar to those identified in mice.However,we detected,in human,several novel regulatory pathways or factors involved in the specification and migration of interneurons.Importantly,comparison of progenitors between our human and published mouse GE datasets led to the discovery and confirmation of outer radial glial cells in GEs in human cortex.Our findings reveal both evolutionarily conservative and nonconservative regulatory networks in primate GEs,which may contribute to their larger brain sizes and more complex neural networks compared with mouse. | Ziqi Zhao Dan Zhang Fuqiang Yang Mingrui Xu Shaoli Zhao Taotao Pan Chuanyu Liu Yongjie Liu Qingfeng Wu Qiang Tu Ping Zhou Rong Li Jia Kang Lan Zhu Fei Gao Yaqing Wang Zhiheng Xu | 2022 | Cell Research2022，32，5： | 1 |
| 20 | Biopolymer-Based Aerogels for Electromagnetic Wave Shielding and Absorbing显示文摘The rapid development of communication technology and electronic industry has brought unprecedented serious electromagnetic interference(EMI)and electromagnetic wave(EMW)pollution.Although EMI shields and EMW absorbers based on metal or magnetic materials were used to solve these problems,they have long been criticized for their high price,high density and easy corrosion.In order to achieve low density and efficient dissipation of electromagnetic energy,aerogels stand out among manifold materials.However,constructing aerogels with good EMI shielding or EMW absorption performance and acceptable mechanical properties is not an easy task.Burgeoning biopolymers,such as cellulose,lignin,chitin/chitosan and alginate,breathe new life into aerogels for high-efficiency EMW shielding and absorbing.Here,we reviewed the contributions of biopolymers in the fields of aerogels for EMW shielding and absorbing.At the same time,some challenges and outlook were also pointed out,aiming to promote the advance of aerogel-based EMI shields and EMW absorbers as well as the rational utilization of biopolymers. | Mingrui Han Runa Zhang Qilei Wu Na Wu Jiurong Liu | 2023 | Chinese Journal of Chemistry2023，41，3： | 0 |
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