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| 1 | Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior显示文摘为过去的几十年,在中国的传染疾病侧面在社会、经济的方面,环境,食物的质量,水,住房,和公共健康基础结构与快速的开发一直在变。尤其是, 5 应具报的传染疾病几乎被根除了,并且 18 另外的应具报的传染疾病的发生显著地被减少了。出人意料地,包括 HIV,普鲁斯病,梅毒,和登革热发烧,超过 10 应具报的传染疾病的发生一直在增加。不过,经常的传染疾病爆发 / 事件每年几乎被报导了,并且进口了传染疾病自从 2015,增加了。已知的病原体的新病原体和超过 100 新遗传型或 serotypes 被识别了。一些传染疾病似乎被各种各样的因素加重,包括快速的都市化,大量候鸟工人,在气候的变化,生态学,和政策,例如把农田还给森林。这评论在设法出现和 re-emerging 从中国总结当前的经验和课传染疾病,特别生态学的效果,气候,和行为,它应该在帮助另外的国家控制并且阻止传染疾病有优点。 | Qiyong Liu Wenbo Xu Shan Lu Jiafu Jiang Jieping Zhou Zhujun Shao Xiaobo Liu Lei Xu Yanwen Xiong Han Zheng Sun Jin Hai Jiang Wuchun Cao Jianguo Xu | 2018 | Frontiers of Medicine2018，12，1： | 23 |
| 2 | BE-PLUS: a new base editing tool with broadened editing window and enhanced fidelity显示文摘基础编辑() ,包含 cytidine 脱氨基酶和催化地有缺点的 Cas9,广泛地被用来执行基础编辑。然而,狭窄的编辑窗口是限制它的实用程序。这里,我们开发了依照到由熔化 10 的 U (T) 范围(加) 的更大的 C 为招募 GCN4 肽拷贝到 nCas9 (D10A ) 的编程作为基础编辑命名的一种新编辑技术 scFv-APOBEC-UGI-GB1 到目标地点。新系统完成与一扇拓宽的窗户的基础编辑,导致一个增加的指向染色体的范围。有趣地,新系统很产出更少讨厌的 indels 和 non-C-to-T 变换。我们也通过站 codons (iSTOP ) 的正式就职越过整个染色体在基因混乱表明了它的潜在的使用。一起拿,加系统与编辑窗口和提高的忠实增加提供一个新编辑工具。 | Wen Jiang Songjie Feng Shisheng Huang Wenxia Yu Guanglei Li Guang Yang Yajing Liu Yu Zhang Lei Zhang Yu Hou Jia Chen Jieping Chen Xingxu Huang | 2018 | Cell Research2018，28，8： | 20 |
| 3 | Genetic dissection of maize seedling root system architecture traits using an ultra-high density bin-map and a recombinant inbred line population显示文摘Maize(Zea mays) root system architecture(RSA)mediates the key functions of plant anchorage and acquisition of nutrients and water. In this study,a set of 204 recombinant inbred lines(RILs) was derived from the widely adapted Chinese hybrid ZD958(Zheng58 Chang7-2),genotyped by sequencing(GBS) and evaluated as seedlings for 24 RSA related traits divided into primary,seminal and total root classes. Signi ficant differences between the means of the parental phenotypes were detected for 18 traits,and extensive transgressive segregation in the RIL population was observed for all traits. Moderate to strong relationships among the traits were discovered. A total of 62 quantitative trait loci(QTL) were identi fied that individually explained from1.6% to 11.6%(total root dry weight/total seedling shoot dry weight) of the phenotypic variation. Eighteen,24 and 20 QTL were identi fied for primary,seminal and total root classes of traits,respectively. We found hotspots of 5,3,4 and 12 QTL in maize chromosome bins 2.06,3.02-03,9.02-04,and 9.05-06,respectively,implicating the presence of root gene clusters or pleiotropic effects. These results characterized the phenotypic variation and genetic architecture of seedling RSA in a population derived from a successful maize hybrid. | Weibin Song Baobao Wang Andrew L Hauck Xiaomei Dong Jieping Li Jinsheng Lai | 2016 | Journal of Integrative Plant Biology2016，58，3： | 13 |
| 4 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 5 | Effects of preventive acupuncture or moxibustion at the Guanyuan acupoint on expression of interleukin-2 and its receptors in hypothalamus, serum, and uterus of menopausal rats显示文摘BACKGROUND: Previous studies have indicated preventive acupuncture and moxibustion at the Guanyuan point have positive effects on the immune system of menopausal rats. OBJECTIVE: To observe the effects of preventive acupuncture or moxibustion at the Guanyuan point on interleukin-2 (IL-2) and its receptor (IL-2R mRNA) levels in hypothalamus, serum, and uterus of menopausal rats. DESIGN: Randomized control animal experiment. SETTING: School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine. MATERIALS: This study was performed at the Laboratory of Beijing University of Chinese Medicine from November 2004 to July 2005. The vaginal smear method was used to determine the estrus cycle of 9.5-month-old Sprague Dawley (SD) female rats. Three continuous estrus cycles were measured, and 160 rats with estrus cycle disorder, weighing (300 ± 20) g, were included in this study. The rats were randomly divided into four groups: preventive acupuncture group (n =48), preventive moxibustion group (n =48), model groups (n =48), and 10-month-old group (n =16). Sixteen 3.5-month-old healthy SD female rats, weighing (240 ± 20) g, were also assigned to the young group. All rats were clean grade and were purchased from the Laboratory Animal Center, Beijing University of Chinese Medicine. The experiment was in accordance with animal ethics standards. METHODS: Acupuncture was applied to the preventive acupuncture group at 10 months of age. The needle was inserted upward and perpendicularly two fen to a point that was two fen below the Guanyuan point. The rats freely moved around during needle retention (20 minutes). Acupuncture was administered twice a week and continued for eight weeks. A moxa cone (small) moxibustion was applied to the preventive moxibustion group at 10 months of age. The rats were caught gently and kept at the same position as the preventive acupuncture group. The moxa cone was ignited and held to the Guanyuan point directly. Only one moxa cone was used each time. After moxibustion, the local skin turned slightly red. Moxibustion was used twice a week and continued for eight weeks. Nothing except gently catching and lying was administered to the model group and the young group. MAIN OUTCOME MEASURES: Radioimmunoassay, in situ hybridization, and similar methods were employed to detect IL-2 in serum and the uterus, as well as IL-2R mRNA expression in the hypothalamus and uterus arcuate nuclei, of the preventive acupuncture group, preventive moxibustion group, model groups (at 12, 14, and 16 months), 10 month old group (at 10 months), and the young group (at 4 months). RESULTS: All 176 rats were included in the final analysis. ① IL-2R mRNA: IL-2R mRNA expression decreased significantly in the uterus of 12-, 14-, and 16-month-old model groups and in the hypothalamus of 14- and 16-month-old model groups (P < 0.05-0.01). Compared to the same month-aged model groups, the expression of IL-2R mRNA increased significantly in the hypothalamus and uterus of 16-month-old preventive acupuncture or moxibustion groups (P < 0.05-0.01).② IL-2: IL-2 in serum of 12- and 14-month-old model groups and in the uterus of 12-, 14-, and 16-month-old model groups decreased significantly compared to the young group (P < 0.05-0.01). IL-2 serum levels increased significantly in the 16-month-old group with preventive moxibustion; in addition, IL-2 expression levels increased significantly in the uterus of the 12-month-old group with preventive moxibustion, as well as the 12- and 16-month-old groups with preventive acupuncture (P < 0.05-0.01). CONCLUSION: As a rat ages and becomes menopausal, IL-2R mRNA expression in the hypothalamus anduterus, as well as IL-2 levels in the serum and uterus, decrease. However, preventive acupuncture and preventive moxibustion can repress the decrease to some extent. This effect is even greater in the late stages of menopause (16-month-old rats). | Xiaohong Li Yuwei He Jieping Xie Lufen Zhang Dengfang Zhou Jinghui Zhai Rui Zhan Jun Zhou Limin Qu Yangchun Tian | 2008 | Neural Regeneration Research2008，3，1： | 5 |
| 6 | An efficient flood dynamic visualization approach based on 3D printing and augmented reality显示文摘Flood visualization is an effective and intuitive tool for representing flood information from abstract spatiotemporal data.With the growing demand for flood disaster visualizations and mitigation,augmented flood visualizations that support decision makers’perspectives are needed,which can be enhanced by emerging augmented reality(AR)and 3D printing technologies.This paper proposes an innovative flood AR visualization method based on a 3D-printed terrain model and investigates essential techniques,such as the suitable size calculation of the terrain models,the adaptive processing of flood data,and hybridizing virtual flood and terrain models.A prototype experimental system(PES)based on the proposed method and a comparison experimental system(CES)based on a virtual terrain are developed to conduct comparative experiments,which combine the system performance and questionnaire method to evaluate the efficiency and usability of the proposed method.The statistical results indicate that the method is useful for assisting participants in understanding the flood hazard and providing a more intuitive and realistic visual experience compared with that of the traditional AR flood visualization method.The frame rate is stable at 60 frames per second(FPS),which means that the proposed method is more efficient than the traditional AR flood visualization method. | Guoyong Zhang Jianhua Gong Yi Li Jun Sun Bingli Xu Dong Zhang Jieping Zhou Ling Guo Shen Shen Bingxiao Yin | 2020 | International Journal of Digital Earth2020，13，11： | 4 |
| 7 | Vertical distribution of Artemisia halodendron root system in relation to soil properties in Horqin Sandy Land, NE China显示文摘organic carbon;;nitrogen;;allocation;;Horqin Sandy Land;;soil | YongQing Luo XueYong Zhao JiePing Ding Tao Wang | 2016 | Research in Cold and Arid Regions2016，8，5： | 4 |
| 8 | PTEN基因甲基化及其表达异常与胃癌的关系(英文)显示文摘Objective:To probe into the relationships between PTEN gene expression,the promoter methylation and gastric cancer and its clinical pathological specific features.Methods:We analyzed the PTEN gene promoter methylation and mRNA expression status in gastric cancer tissues and its adjacent normal tissues by methylation specific PCR(MSP) and reverse transcription-polymerase chain reaction(RT-PCR) techniques.Results:PTEN promoters in 48.2%(27/56) gastric cancer tissues and 3.6(2/56) adjacent normal tissues were methylated and the PTEN promoter methylation rate in carcinoma tissues was obviously higher(P < 0.05).Of the 2 cases where the adjacent gastric tissues were methylated,the gastric cancer tissues were both methylated.Of the 29 gastric cancers with lymph node metastasis,19 had their PTEN gene promoters methylated and the PTEN gene promoter methylation in cases with lymph node metastasis was obviously higher than that without lymph node metastasis(P < 0.05).RT-PCR result showed that no expression of PTEN mRNA existed in any of the methylated gastric cancer tissues.Conclusion:The expression loss of PTEN gene mRNA in gastric cancers is related to their promoter methylation and might be one of the reasons for the generation,development and metastasis of gastric cancers. | Song Liu Jieping Yu Ping Fu Honggang Yu | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，10： | 3 |
| 9 | Winter wheat mapping using a random forest classifier combined with multi-temporal and multi-sensor data显示文摘Wheat is a major staple food crop in China.Accurate and cost-effective wheat mapping is exceedingly critical for food production management,food security warnings,and food trade policy-making in China.To reduce confusion between wheat and non-wheat crops for accurate growth stage wheat mapping,we present a novel approach that combines a random forest(RF)classifier with multi-sensor and multi-temporal image data.This study aims to(1)determine whether an RF combined with multi-sensor and multi-temporal imagery can achieve accurate winter wheat mapping,(2)to find out whether the proposed approach can provide improved performance over the traditional classifiers,and(3)examine the feasibility of deriving reliable estimates of winter wheat-growing areas from medium-resolution remotely sensed data.Winter wheat mapping experiments were conducted in Boxing County.The experimental results suggest that the proposed method can achieve good performance,with an overall accuracy of 92.9%and a kappa coefficient(κ)of 0.858.The winter wheat acreage was estimated at 33,895.71 ha with a relative error of only 9.3%.The effectiveness and feasibility of the proposed approach has been evaluated through comparison with other image classification methods.We conclude that the proposed approach can provide accurate delineation of winter wheat areas. | Jiantao Liu Quanlong Feng Jianhua Gong Jieping Zhou Jianming Liang Yi Li | 2018 | International Journal of Digital Earth2018，11，8： | 3 |
| 10 | Factors affecting directional migration of bone marrow mesenchymal stem cells to the injured spinal cord显示文摘Microtubule-associated protein 1B plays an important role in axon guidance and neuronal migration. In the present study, we sought to discover the mechanisms underlying microtubule-associated protein 1B mediation of axon guidance and neuronal migration. We exposed bone marrow mesenchymal stem cells to okadaic acid or N-acetyl-D-erythro-sphingosine(an inhibitor and stimulator, respectively, of protein phosphatase 2A) for 24 hours. The expression of the phosphorylated form of type I microtubule-associated protein 1B in the cells was greater after exposure to okadaic acid and lower after N-acetyl-D-erythro-sphingosine. We then injected the bone marrow mesenchymal stem cells through the ear vein into rabbit models of spinal cord contusion. The migration of bone marrow mesenchymal stem cells towards the injured spinal cord was poorer in cells exposed to okadaic acid- and N-acetyl-D-erythro-sphingosine than in non-treated bone marrow mesenchymal stem cells. Finally, we blocked phosphatidylinositol 3-kinase(PI3K) and extracellular signal-regulated kinase 1/2(ERK1/2) pathways in rabbit bone marrow mesenchymal stem cells using the inhibitors LY294002 and U0126, respectively. LY294002 resulted in an elevated expression of phosphorylated type I microtubule-associated protein 1B, whereas U0126 caused a reduction in expression. The present data indicate that PI3 K and ERK1/2 in bone marrow mesenchymal stem cells modulate the phosphorylation of microtubule-associated protein 1B via a cross-signaling network, and affect the migratory efficiency of bone marrow mesenchymal stem cells towards injured spinal cord. | Peng Xia Su Pan Jieping Cheng Maoguang Yang Zhiping Qi Tingting Hou Xiaoyu Yang | 2014 | Neural Regeneration Research2014，9，18： | 3 |
| 11 | Extra-copy nifA enhances the nodulation efficiency of Sinorhizobium fredii显示文摘Previous investigations have shown that nifA gene is involved in nodulation and symbiotic nitrogen fixation regulation of Rhizobium. We study the role of nifA on nodulation of leguminous plants. We found that Sinorhizo-bium fredii harboring multi-copy plasmid carrying the con-stitutively expressed Klebsiella pneumoniae nifA exhibited an increase of nodulation activity and nodulation competitiveness on soybean plants. The Nod-factor secreted by the rhizobia cells containing the multi-copied nifA was assayed, and preliminary results showed that S. fredii containing the multi-copy plasmid carrying nifA produced higher strength of Nod-factor than the rhizobia containing the same plasmid carrying the vector did. | Zhao Jieping Dai Xiaomi Xu Ling Zhu Jiabi Shen Shanjiong Yu Guanqiao | 2002 | Chinese Science Bulletin2002，47，7： | 2 |
| 12 | Music snippet extraction via melody-based repeated pattern discovery显示文摘In this paper,we present a complete set of procedures to automatically extract a music snippet,defined as the most representative or the highlighted excerpt of a music clip. We first generate a modified and compact similarity matrix based on selected features and distance metrics,and then several improved techniques for music repeated pattern discovery are utilized because a music snippet is usually a part of the repeated melody,main theme or chorus. During the process,redundant and wrongly detected patterns are discarded,boundaries are corrected using beat information,and final clusters are also further sorted according to the occurrence frequency and energy information. Subsequently,following our methods,we designed a music snippet extraction system which allows users to detect snippets. Experiments performed on the system show the superiority of our proposed approach. | XU JiePing ZHAO Yang CHEN Zhe LIU ZiLi | 2009 | Science in China(Series F)2009，52，5： | 2 |
| 13 | The influence of Chinese sentence stress on pitch and duration显示文摘The key to improve the naturalness of the synthetic speech is to build a perfect prosodic model. Thus the preliminary study of the influence of sentence stress on prosodic features in Standard Chinese is presented, in which the relationship between duration and pitch under different sentence stress levels is revealed. The results show that: (a) The pitch is the most important factor which carries the sentence stress, with the increase of the sentence stress level, the distribution of pitch moves towards high frequency area. (b) In the case of 'Stress' and 'Light', two peaks are found in the distribution of duration, which means that the duration of some words are affected by sentence stress, but of others are not. (c) The relationship between pitch and duration in 'Normal’, 'Stress' and 'Light' are un-correlated, positive correlation and negative correlation respectively. The research lays a foundation for building a perfect prosodic model for standard Chinese speech synthesis system. The results of research are also used to classify sentence stress using a neural network, and 63% identification ratio has been obtained in an open set test. An automatic method for the sentence stress labeling is also suggested. | XU Jieping CHU Min HE Lin LU Shinan GUAN Dinghua (Institute of Acoustics, Academia Sinica Beijing 100080) | 2000 | Chinese Journal of Acoustics2000，19，3： | 2 |
| 14 | Protecting-Group-Free Total Synthesis and Biological Investigation of Cabucine Oxindole A显示文摘Owing to their challenging structures and promising biological profiles,spirooxindole alkaloids have long attracted much attention from the synthetic community.Herein,we wish to describe a concise,protecting-group-free total synthesis of cabucine oxindole A,a putative natural spirooxindole alkaloid and a possible biosynthetic congener of cabucine and palmirine.Key transformations of our approach include a one-step,organocatalytic and enantioselective construction of the spiro[pyrrolidine-3,3'-oxindole]moiety and a Korte rearrangement to furnish the final dihydropyran motif.Biological investigation of 1 and its synthetic intermediates revealed lactone 2 as a mild MOLT-4 and MCF7 cell line inhibitor. | Shengling Xie Chengqing Ning Qingzhen Yu Jieping Hou Jing Xu | 2021 | Chinese Journal of Chemistry2021，39，1： | 2 |
| 15 | Lightweight Body-In-White Design Driven by Optimization Technology显示文摘Structural optimization technologies are increasingly applied to lightweight automotive structural design.In a body-inwhite(BIW)development project,optimization technologies are applied in three steps that are seamlessly integrated into engineering practice.By following a design-driven approach,an innovative design that was 50.65 kg lighter than the base design was achieved.First,topology optimization was used to investigate the optimal material distribution in a given design space,and helped in extracting the main load path,while considering crashworthiness,NVH,and static stiffness performance requirements.In the second step,the effective design of a beam cross-section and feasible joints was carried out based on optimization technology and expert knowledge.In this step,the deep involvement of manufacturing process experts on stamping and joint connection feasibility analysis increased the chance of success remarkably.The sensitivity analysis,topography optimization,and gauge optimization of the created draft 3D BIW frame comprised the last step before finalizing the initial design.The new design was validated by full load case simulations,including full vehicle crashworthiness analysis,mode frequency,and body mount point dynamic stiffness analysis,and BIW stiffness and component attachment stiffness analysis.The validation results indicate that the new BIW design achieves the performance goal,while being 13.3%lighter than the base design. | Heguo Ou Xiaodong Tang Jieping Xiao Yuanbo Wang Zhongmin Ma | 2018 | Automotive Innovation2018，1，3： | 2 |
| 16 | Efficient Sparse Generalized Multiple Kernel Learning显示文摘 | Yang Haiqin Xu Zenglin Ye Jieping | 2011 | IEEE Transactions on Neural Networks2011，22，3： | 1 |
| 17 | Multi-class Diserimiant Kernel Learning via Convex Programming显示文摘 | Ye Jieping Ji Shuiwang Chen Jianhui | 2008 | Journal of Machine Learning Research2008，9，： | 1 |
| 18 | Cyclooxygenase-2 inhibitor nimesulide suppresses telomerase activity by blocking Akt/PKB activation in gastric cancer cell line显示文摘 | Baoping Y Guoyong H Jieping Y | 2004 | Dig Dis Sci2004，49，6： | 1 |
| 19 | Two-Dimensional Linear Discriminate Analysis 显示文摘 | Ye Jieping Janardan R Li Qi | 2005 | Neural Information Processing Systems2005，17，2： | 1 |
| 20 | Interaction Between Fumed-Silica and Epoxidized Natural Rubber显示文摘 | Yongyue Luo Yueqiong Wang Jieping Zhong | 2011 | Journal of Inorganic and Organometallic Polymers and Materials2011，21，4： | 1 |
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