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| 1 | Effect of contrast-enhanced ultrasound on differential diagnosis of intrahepatic cholangiocarcinoma and arterial phase enhanced hepatic inflammatory lesions显示文摘Objective: To investigate differential diagnosis between intrahepatic cholangiocarcinoma(ICC) and arterial phase enhanced hepatic inflammatory lesions in patients without liver cirrhosis using contrast-enhanced ultrasound(CEUS).Methods: ICC and hepatic inflammatory lesions cases with CEUS and pathological diagnosis between Sep 2013 and Oct 2016 were investigated retrospectively. Imaging features of conventional ultrasound and CEUS were analyzed. The parameters of time intensity curve(TIC), including the arrival time, peak intensity(PI) in the lesions, the starting time for washout, and the intensity difference at 3 min(ΔI_3) after contrast agent infection between the lesion and the liver parenchyma, were compared between ICC and hepatic inflammatory lesions.Results: Twenty-five ICC and fifteen inflammatory patients were included in this study. Seventeen ICC(68.0%)and two inflammatory cases(13.3%) showed bile duct dilatation on conventional ultrasound. Using CEUS, three ICC cases(12.0%) were misdiagnosed as inflammatory lesions and three inflammatory lesions(20.0%) as ICC; two ICC(8.0%) and one inflammatory case(6.7%) could not be made definite diagnosis. Washout started at 34.5±3.5 s and 61.5±12.9 s for ICC and inflammatory lesions respectively(P<0.001). The intensity difference between lesion and liver parenchyma at 3 min after contrast agent injection was 10.8±3.1 dB in ICC and 4.2±2.3 dB in inflammatory group(P<0.001). The sensitivity and specificity differentiating ICC and inflammatory lesions were76% and 87% if the cut-off value of the intensity difference was 7.7 d B.Conclusions: Combined with TIC analysis, and particularly with the characteristic of the early-starting and obvious washout in ICC, CEUS can be useful in differential diagnosis between hepatic inflammatory lesions and ICC. | Shanshan Yin Qiuli Cui Kun Yan Wei Yang Wei Wu Liping Bao Minhua Chen | 2017 | Chinese Journal of Cancer Research2017，29，3： | 13 |
| 2 | Large-scale Ni-MOF derived Ni_(3)S_(2) nanocrystals embedded in N-doped porous carbon nanoparticles for high-rate Na+ storage显示文摘Metal organic framework(MOF) has been confirmed as the promising precursor to develop the conve rsion-typed anode mate rials of sodium-ion batteries(SIBs) because of the tunable structure design and simple functional modification.Here,we prepare the ultrasmall Ni_(3)S_(2) nanocrystals embedded into N-doped porous carbon nanoparticles using the scalable Ni-MOF as precursor(denoted as Ni_(3)S_(2)@NPC).The ultrasmall size of Ni_(3)S_(2) can work for accelerated electro n/ion transfer to facilitate the electrochemical reaction kinetics.Moreover,the robust conductivity network originated from N-doped porous carbon nanoparticles can not only improve the electron conductivity,but also enhance the electrode integrity and stability of the electrode/electrolyte interface.In addition,the N heteroatoms provide extra Na storage sites.Accordingly,the electrode delivers the obviously competitive capacities and high-power output with respect to the currently reported Ni_(3)S_(2)/C composites.This study provides a scalable and universal strategy to develop the advanced transition metal sulfides for practically feasible SIBs. | Miao Yang Qiuli Ning Chaoying Fan Xinglong Wu | 2021 | Chinese Chemical Letters2021，32，2： | 3 |
| 3 | Insights into the origin of purely sediment-derived Himalayan leucogranites:Si-O isotopic constraints显示文摘Granite is the dominant rock type in Earth’s continental crust.The origin of granite can be directly or indirectly related to the fractional crystallization of mantle-derived basaltic melt or the reworking of pre-existing continental or oceanic crust, which contribute to the growth of continental crust. Among the various types of granites, the peraluminous leucogranites in the Himalayan orogen, which are high in SiO_2(>73%) and low in mafic minerals (<5%), | Xiaochi Liu Xianhua Li Yu Liu Lei Yang Qiuli Li Fuyuan Wu Huimin Yu Fang Huang | 2018 | Science Bulletin2018，63，19： | 3 |
| 4 | Inhibition of ROS elevation and damage to mitochondrial function prevents lead-induced neurotoxic effects on structures and functions of AFD neurons in Caenorhabditis elegans显示文摘Here we investigated the possible roles of oxidative stress in the formation of decreased thermotaxis to cultivation temperature in lead(Pb)-exposed nematodes Caenorhabditis elagans.Exposure to Pb at the examined concentrations decreased thermotaxis behaviors,and induced severe deficits in the structural properties of AFD sensory neurons.Meanwhile,Pb exposure caused the induction of severe oxidative damage,reactive oxygen species(ROS) production,and mitochondrial dysfunction in young adults.Moreover,pre-treatment with the antioxidants dimethyl sulfoxide(DMSO),ascorbate and N-acetyl-L-cysteine(NAC),used to inhibit both the ROS elevation and the mitochondrial dysfunction caused by Pb exposure,at the L2-larval stage prevented the induction of oxidative damage and the formation of severe deficits in thermotaxis and structural properties of AFD sensory neurons in Pb-exposed young adults.Therefore,the formation of oxidative stress caused by Pb exposure may be due to both the induction of ROS elevation and damage to mitochondrial function,and oxidative stress may play a key role in inducing the neurotoxic effects on the structures and function of AFD sensory neurons in Pb-exposed nematodes. | Qiuli Wu Peidang Liu Yinxia Li Min Du Xiaojuan Xing Dayong Wang | 2012 | Journal of Environmental Sciences2012，24，4： | 3 |
| 5 | Optimization of riboflavin production by recombinant Bacillus subtilis RH44 using statistical design显示文摘 | WU Qiuli CHEN Tao CHEN Xun | 2007 | Applied Microbiology and Biotechnology2007，76，4： | 1 |
| 6 | Association of oxidative stress with the formation of reproductive toxicity from mercury exposure on hermaphrodite nematode Caenorhabditis elegans 显示文摘 | WU Qiuli HE Kewen LIU Peidang | 2011 | Environmental Toxicology and Pharmacology2011，32，2： | 1 |
| 7 | Optimization of n-boflavin production by recombinant Bacillus subtilis RH44 using statistical design显示文摘 | WU Qiuli CHEN Tao CHEN Xun | 2007 | Appl Microbiol Bioteclmol2007，76，4： | 1 |
| 8 | Optimising photoelectroncatalytic oxidation of fulvic acid using response surface methodology显示文摘 | FU Jianfeng ZHAO Yaqian WU Qiuli | 2006 | J Hazard Mater2006，144，12： | 1 |
| 9 | Optimization of riboflavin production by recombinant Bacillus subtilis RH44 using statistical design显示文摘 | WU Qiuli CHEN Tao CHEN Xun | 2007 | Applied Microbiology and Biotechnology2007，76，4： | 1 |
| 10 | Accessary Minerals SIMS U-Th-Pb Dating for Kimberlite and Lamproite显示文摘Kimberlite and lamproite,the major source of diamonds,are volatile-rich potassic ultramafic rocks that originate from the deep lithospheric mantle.These rocks are important for deciphering the composition | LI Qiuli LI Xianhua WU Fuyuan LIU Yu TANG Guoqiang | 2016 | Acta Geologica Sinica(English Edition)2016，90，S1： | 1 |
| 11 | Optimising photo-electrocatalytic oxidation of fulvic acid using response sur-face methodology显示文摘 | Fu Jianfeng Zhao Yaqian Wu Qiuli | 2006 | Journal of Hazardous Materials2006，144，12： | 1 |
| 12 | Multiple thermal events recorded in the Acasta Gneiss Complex:Evidence from in-situ dating of zircon, titanite, and apatite显示文摘In-situ dating of the zircons, titanites, and apatites in the rock fragments of approximately 1 cm2in size from the Acasta Gneiss Complex was performed using secondary ion mass spectrometry or laser ablation inductively coupled plasma mass spectrometry to provide constraints on the thermal history of the Acasta Gneiss Complex. The zircons in these rock fragments typically exhibit multiple age populations, reflecting the presence of inherited zircons or the post-crystallization process of zircon overgrowth. Combined with previous studies, our zircon dating results reveal multiple magmatic events that occurred in the Acasta Gneiss Complex, specifically at >3.96, ~3.72, and ~3.57 Ga, respectively. A titanite Pb-Pb isochron age of2911±22 Ma(95% confidence level, MSWD=1.5) for sample AY199 is identified, consistent with the timing of the latest Archean magmatism in the Acasta Gneiss Complex. The titanite U-Pb ages for samples AC478 and AY066 are 1932±270 Ma(95% confidence level, MSWD=2.3) and 1813±45 Ma(95% confidence level, MSWD=2.3), respectively. The apatites in sample P090803-C exhibit a Pb-Pb isochron age of 1833±26 Ma(95% confidence level, MSWD=1.4). The apatite U-Pb ages for samples AC478, AY199, and AY066 are 1850±20 Ma(95% confidence level, MSWD=1.3), 1827±100 Ma(95% confidence level, MSWD=6.3), and 1807±58 Ma(95% confidence level, MSWD=3.9), respectively. Titanites in samples AC478 and AY066, as well as the apatites in all four investigated samples, show a uniform age(Pb-Pb or U-Pb age) of ~1.9–1.8 Ga,indicating U-Pb system reset in these minerals due to the Wopmay orogeny and documenting that the peak temperature condition associated with the Wopmay orogeny exceeded the apatite U-Pb closure temperature and approached or exceeded that of titanite. | Qingfeng MEI Jinhui YANG Jinfeng SUN Qiuli LI Shitou WU Xiaoxiao LING Peng PENG Hao WANG | 2024 | Science China Earth Sciences2024，67，3： | 0 |
| 13 | Research Progress on Rapid Breeding Technology of Anoectochilus roxburghii Seedlings显示文摘As a traditional precious Chinese herbal medicine,Anoectochilus roxburghii has the cooling and detoxifying effects,and can nourish yin to reduce pathogenic fire,and has anti-inflammatory and analgesic effects. In this paper,we summarized the research progress in detail about the biological characteristics,resource distribution,composition,medicinal value and rapid seedling breeding technology concerning the rare Chinese herbal medicine A. roxburghii,in order to provide a reference for the in-depth study and rational development and utilization of A.roxburghii. | Qinger JIANG Xiaojing TAN Qiuli WU Mei WU Xiaoxia SHEN Zhonghua WANG | 2018 | Medicinal Plant2018，9，1： | 0 |
| 14 | NPR-9 regulates the innate immune response in Caenorhabditis elegans by antagonizing the activity of AIB interneurons显示文摘npr-9 encodes a homologue of the gastrin-releasing peptide receptor (GRPR) and is expressed in AIB interneurons. In this study, we investigated the role of NPR-9 in the neuronal control of innate immunity using the model system Caenorhabditis elegans. After exposure to Pseudomonas aeruginosa PA14, npr-9(tm1652) mutants showed resistance to infection, decreased PA14 colonization and increased expression of immunity-related genes. Nematodes overexpressing NPR-9 exhibited increased susceptibility to infection, increased PA14 colonization and reduced expression of immunity-related genes. In nematodes, ChR2-mediated AIB interneuron activation strengthened the innate immune response and decreased PA14 colonization. Overexpression of NPR-9 suppressed the innate immune response and increased PA14 colonization in nematodes with the activation of AIB interneurons mediated by ChR2 or by expressing pkc-1(gf) in AIB interneurons. We, therefore, hypothesize that NPR-9 regulates the innate immune response by antagonizing the activity of AIB interneurons. Furthermore, expression of GRPR, the human homologue of NPR-9, could largely mimic NPR-9 function by regulating innate immunity in nematodes. Our results provide insight into the pivotal role of interneurons in controlling innate immunity and the complex biological functions of GRPRs. | Yonglin Yu Lingtong Zhi Qiuli Wu Lina Jing Dayong Wang | 2018 | Cellular & Molecular Immunology2018，15，1： | 0 |
| 15 | X-irradiation for inhibiting glial scar formation in injured spinal cord显示文摘X-irradiation has a beneficial effect in treating spinal cord injury. We supposed that X-irradiation could improve the microenvironment at the site of a spinal cord injury and inhibit glial scar formation. Thus, this study was designed to observe the effects of 8 Gy X-irradiation on the injury site at 6 hours and 2, 4, 7, and 14 days post injury, in terms of improvement in the microenvironment and hind limb motor function. Immunohistochemistry showed that the expression of macrophage marker ED-1 and the area with glial scar formation were reduced. In addition, the Basso, Beattie and Bresnahan score was higher at 7 days post injury relative to the other time points post injury. Results indicated that X-irradiation at a dose of 8 Gy can inhibit glial scar formation and alleviate the inflammatory reaction, thereby repairing spinal cord injury. X-irradiation at 7 days post spinal cord injury may be the best time window. | Guangzhi Ning Renhui Chen Yulin Li Qiang Wu Qiuli Wu Yan Li Shiqing Feng | 2013 | Neural Regeneration Research2013，8，17： | 0 |
| 16 | Hyperbaric oxygen treatment for experimental intraocular hypertension in rats: An electroretinogram detection显示文摘BACKGROUND: Hyperbaric oxygen (HBO) is used for treating glaucoma, and affirmative curative effect has been obtained. HBO can sensitively reflect the obviously heightened b wave of electroretinogram (ERG) of injured tissue. OBJECTIVE: To observe the effect of HBO treatment on retinal function of rats with acute experimental intraocular hypertension with ERG. DESIGN: Randomized controlled experiment. SETTING: Department of Ophthalmology, Third Xiangya Hospital, Central South University; Department of Hyperbaric Oxygen, Xiangya Hospital, Central South University; Department of Anatomy, Xiangya Hospital, Central South University. MATERIALS: Eighteen adult healthy Wistar rats, of either gender, weighing from 150 to 250 g, were provided by the Animal Room of Central South University. Type YLCO. 5/ⅠA baby hyperbaric oxygen chamber, type LMS-2A two-channel physiological recorder, type BG-1 retina exposure system, Jiangwan type Ⅰstereotaxis instrument. METHODS: This experiment was carried out in the Central South University between March and September 2006. Eighteen healthy Wistar rats were made into models of acute experimental intraocular hypertension. Then, they were divided into two groups: model group and HBO treatment group, with 9 in each group. Following 7 days of HBO treatment, the rats in HBO treatment group were placed in Type YLCO. 5/ⅠA baby hyperbaric oxygen chamber, which was pressurized with pure oxygen( volume fraction 0.825±0.025).The treatment pressure was 0.2 MPa. The rats in HBO treatment group daily inhaled HBO for 80 minutes within 7 days; Rats in the model group were untouched. The performance of eyes was observed under the status of intraocular hypertension. ERG was recorded before, during and 7 days after modeling, meanwhile, the recovery rate of b wave from ERG was calculated. Recovery rate of b wave from ERG=(amplitude of b wave 7 days after modeling/ amplitude of b wave before modeling)×100%. MAIN OUTCOME MEASURES: ① Performance of eyes under the status of intraocular hypertension. ② Recovery rate of b wave of ERG. RESULTS: All the 18 rats were involved in the final analysis. ① Performance of eyes under the status of intraocular hypertension.: When intraocular pressure increased until b wave of ERG disappeared, two eyes of rats with corneal opacity, dilated pupils, pale iris and stiffened eyeballs were found. ② Recovery rate of b wave of ERG in the HBO treatment group was significantly higher than that in the model group [(60.04± 19.33)% vs. (41.85±13.20)%,t =3.298,P < 0.01]. CONCLUSION: HBO treatment can obviously promote the recovery of retinal function following acute intraocular hypertension. | Junhui Yi Zhengrong Peng Qiuli Liu Zhongqi Wu | 2007 | Neural Regeneration Research2007，2，1： | 0 |
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