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| 1 | Histone methyltransferase G9a contributes to H3K27 methylation in vivo显示文摘 | Hui Wu Xiuzhen Chen Jun Xiong Yingfeng Li Hong Li Xiaojun Ding Sheng Liu She Chen Shaorong Gao Bing Zhu | 2011 | Cell Research2011，21，2： | 8 |
| 2 | Wogonoside inhibits tumor growth and metastasis in endometrial cancer via ER stress-Hippo signaling axis显示文摘Wogonoside,a bioactive flavonoid component derived from Scutellaria baicalensis Georgi,has been reported to inhibit tumor growth in mice bearing various types of cancer cells such as breast cancer,lung cancer,and leukemia cells.However,whether wogonoside could inhibit tumor growth of endometrial cancer has not been elucidated.In this study,we explored the function of wogonoside on tumor growth and the underlying mechanism on endometrial cancer.Firstly,we investigated the effect of wogonoside on endometrial cancer cells and found that wogonoside could significantly decrease cell proliferation and metastasis.Mechanistically,wogonoside could aggravate the extent of ER stress and upregulate the phosphorylation level of Mammalian Ste20-like kinase 1,leading to the activation of the Hippo signaling pathway.Taken together,in vitro and in vivo data demonstrated that wogonoside could be a potent inducer of ER stress and could be further developed into a promising therapy for endometrial cancer. | Shaorong Chen Zhuna Wu Yumin Ke Pingping Shu Caihong Chen Ruying Lin Qirong Shi | 2019 | Acta Biochimica et Biophysica Sinica2019，51，11： | 8 |
| 3 | Viable mice produced from three-factor induced pluripotent stem (iPS) cells through tetraploid complementation显示文摘 | Lan Kang Tong Wu Yu Zao Ye Yuan Jing He Yu Zhang Tong Luo Zhaohui Kou Shaorong Gao | 2011 | Cell Research2011，21，3： | 5 |
| 4 | Nuclear m^(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos显示文摘N^(6)-methyladenosine(m^(6)A)on chromosome-associated regulatory RNAs(carRNAs),including repeat RNAs,plays important roles in tuning the chromatin state and transcription,but the intrinsic mechanism remains unclear.Here,we report that YTHDC1 plays indispensable roles in the self-renewal and differentiation potency of mouse embryonic stem cells(ESCs),which highly depends on the m^(6)A-binding ability.Ythdcl is required for sufficient rRNA synthesis and repression of the 2-cell(2C)transcriptional program in ESCs,which recapitulates the transcriptome regulation by the LINE1 scaffold.Detailed analyses revealed that YTHDC1 recognizes m^(6)A on LINE1 RNAs in the nucleus and regulates the formation of the LINE1-NCL partnership and the chromatin recruitment of KAP1.Moreover,the establishment of H3K9me3 on 2C-related retrotrans-posons is interrupted in Ythdcl-depleted ESCs and inner cell mass(ICM)cells,which consequently increases the transcriptional activities.Our study reveals a role of m^(6)A in regulating the RNA scaffold,providing a new model for the RNA-chromatin cross-talk. | Chuan Chen Wenqiang Liu Jiayin Guo Yuanyuan Liu Xuelian Liu Jun Liu Xiaoyang Dou Rongrong Le Yixin Huang Chong Li Lingyue Yang Xiaochen Kou Yanhong Zhao You Wu Jiayu Chen Hong Wang Bin Shen Yawei Gao Shaorong Gao | 2021 | Protein & Cell2021，12，6： | 4 |
| 5 | CRISPR/Cas9-mediated genome engineering of the ferret显示文摘 | Zhaohui Kou Qian Wu Xiaochen Kou Chonghai Yin Hong Wang Zhentao Zuo Yan Zhuo Antony Chen Shaorong Gao Xiaoqun Wang | 2015 | Cell Research2015，25，12： | 3 |
| 6 | Accurate annotation of accessible chromatin in mouse and human primordial germ cells显示文摘广泛、精确的染色质改变在初发的细菌房间(PGC ) 期间是必要的为越过代的基因信息的永存的开发。这里,我们报导 DNase 我过分敏感的地点(DHS ) 标记的远侧的 cis 规章的元素(CRE ) 在鼠标和人的 PGC 开发期间显示出时间地限制的活动。把 DHS 地图用作代理,我们精确地在老鼠 PGC 定位 pluripotency 抄写因素的染色体宽的有约束力的地点。出人意料地,我们发现老鼠女性 meiotic 再结合热点能被 DHS 捕获,并且第一次,我们在老鼠女性 PGC 识别了 12,211 个再结合热点。与 meiotic 女性 PGC 的相对照,有丝分裂拘捕的男 PGC 的染色质 ? 通过在远侧的规章的区域的原子抄写因素 Y (NFY ) 绑定是容许的。而且,我们在 PGC CRE 上检验了进化压力,并且比较 genomic 分析表明那只老鼠和人的 PGC CRE evolutionarily 在哺乳动物外面越过脊椎动物树被保存并且出现强壮的保存。因此,我们的结果在鼠标和人的 PGC 开发期间揭示唯一的、时间地可存取的染色质配置。 | Jingyi Li Shijun Shen Jiayu Chen Wenqiang Liu Xiaocui Li Qianshu Zhu Beiying Wang Xiaolong Chen Li Wu Mingzhu Wang Liang Gu Hong Wang Jiqing Yin Cizhong Jiang Shaorong Gao | 2018 | Cell Research2018，28，11： | 2 |
| 7 | Novel polymer acceptors achieving 10.18% efficiency for all-polymer solar cells显示文摘Polymer acceptors based on extended fused ring p skeleton has been proven to be promising candidates for all-polymer solar cells(all-PSCs), due to their remarkable improved light absorption than the traditional imide-based polymer acceptors. To expand structural diversity of the polymer acceptors, herein,two polymer acceptors PSF-IDIC and PSi-IDIC with extended fused ring p skeleton are developed by copolymerization of 2,20-((2 Z,20 Z)-((4,4,9,9-tetrahexadecyl-4,9-dihydro-s-indaceno [1,2-b:5,6-b']dithio phene-2,7-diyl)bis(methanylylidene))bis(3-oxo-2,3-dihydro-1 H-indene-2,1-diylidene))dimalononitrile(IDIC-C16) block with sulfur(S) and fluorine(F) functionalized benzodithiophene(BDT) unit and silicon(Si) atom functionalized BDT unit, respectively. Both polymer acceptors exhibit strong light absorption.The PSF-IDIC exhibits similar energy levels and slightly higher absorption coefficient relative to the PSi-IDIC. After blended with the donor polymer PM6, the functional atoms on the polymer acceptors show quite different effect on the device performance. Both of the acceptors deliver a notably high open circuit voltage(V_(OC)) of the devices, but PSi-IDIC achieves higher V OCthan PSF-IDIC. All-PSC based on PM6:PSi-IDIC attains a power conversion efficiency(PCE) of 8.29%, while PM6:PSF-IDIC-based device achieves a much higher PCE of 10.18%, which is one of the highest values for the all-PSCs reported so far. The superior device performance of PM6:PSF-IDIC is attributed to its higher exciton dissociation and charge transport, decreased charge recombination, and optimized morphology than PM6:PSi-IDIC counterpart. These results suggest that optimizing the functional atoms of the side chain provide an effective strategy to develop high performance polymer acceptors for all-PSCs. | Shaorong Huang Feiyan Wu Zuoji Liu Yongjie Cui Lie Chena Yiwang Chen | 2021 | Journal of Energy Chemistry2021，30，2： | 2 |
| 8 | Effect of angelica sinensis on cardiovascular system显示文摘 | WU Shaorong LI Zicheng QIU Hanzhang | 2001 | Research of Traditional Chinese Medicine2001，17，3： | 1 |
| 9 | Energy analysis of evaporating thin falling film instability in vertical tube 显示文摘 | Du Xiaoze Wang Buxuan Wu Shaorong | 2001 | International Journal of Heat and Mass Transfer2001，79，4： | 1 |
| 10 | Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation/Hydroxymethylation in Reprogramming显示文摘 | Yawei Gao Jiayu Chen Ke Li Tong Wu Bo Huang Wenqiang Liu Xiaochen Kou Yu Zhang Hua Huang Yonghua Jiang Chao Yao Xiaolei Liu Zhiwei Lu Zijian Xu Lan Kang Jun Chen Hailin Wang Tao Cai Shaorong Gao | 2013 | Cell Stem Cell2013，，： | 1 |
| 11 | Thermal and mechanical properties of PPO filled epoxy resins compatibilized by triallylisocyanurate显示文摘 | Wu Shaorong Dong Ningbo Lin Zongkuan | 2000 | Polymer International2000，49，： | 1 |
| 12 | 显示文摘 | Wu Shaorong ZhangZuoyi | 2003 | Desalination2003，155，： | 1 |
| 13 | Zinc-finger protein 382 antagonises CDC25A and ZEB1 signaling pathway in breast cancer显示文摘Our previous studies found that Zinc-finger protein 382(ZNF382)played as a tumor suppressor gene in esophageal and gastric cancers,and a positive correlation between the high expression of ZNF382 and better outcome in breast cancer patients.However,the biological roles and mechanisms of ZNF382 in breast cancer remains unclear.We detected ZNF382 expression by reverse-transcription PCR(RT-PCR)and real-time quantitative PCR(qRT-PCR)in breast cancer cells and tissues,and explored the impacts and mechanisms of ectopic ZNF382 expression in breast cancer cells in vitro and in vivo,respectively.Our results revealed that ZNF382 was significantly down-regulated in breast cancer tissues compared with adjacent non-cancer tissues.Restoration of ZNF382 expression in silenced breast cancer cells not only inhibited tumor cell colony formation,viability,migration and invasion,and epithelial-mesenchymal-transition(EMT),but also induced apoptosis and G0/G1 arrest.In conclusion,ZNF382 could induce G0/G1 cell cycle arrest through inhibiting CDC25A signaling,and,inhibit cell migration,invasion and EMT by antagonizing ZEB1 signaling in breast cancer cells. | Shuman Li Xiaoqian He Yan Wang Weihong Chen Ran Sun Shaorong Tian Sanxiu He Chunyun Pu Chen Li Dishu Zhou Yu Jiang Qian Tao Lili Li Lin Ye Yue Wu Weiyan Peng Tingxiu Xiang | 2023 | Genes & Diseases2023，10，2： | 1 |
| 14 | Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation显示文摘Chromatin remodeling is essential for epigenome reprogramming after frilization.However,the underlying mechanisms of chromatin remodeling remain to be explored.Here,we investigated the dynamic changes in nucleosome occupancy and positioning in pronucleus-stage zygotes using ultra low-input MNase seq.We observed distinct features of inheritance and reconstruction of nucleosome positioning in both paternal and maternal genomes.Genome wide de novo nucleosome occupancy in the paternal genome was observed as early as 1 h after the injection of sperm into ooplasm.The nucleosome positioning pattern was continually rebuilt to form nucleosome-depleted regions(NDRs)at promoters and transcription factor(TF)binding sites with differential dynamics in paternal and maternal genomes.NDRs formed more quickly on the promoters of genes involved in zygotic genome activation(ZGA),and this formation is closely linked to histone acetylation,but not transcription elongation or DNA replication.Importantly,we found that NDR establishment on the binding motifs of specific TFs might be associated with their potential pioneer functions in ZGA.Further investigations suggested that the predicted factors MLX and RFX1 played important roles in regulating minor and major ZGA,respectively.Our data not only elucidate the nucleosome positioning dynamics in both male and female pronuclei fllowing frtiliatin,but also provide an eficient method for identifying key transcription regulators during development. | Chenfei Wang Chuan Chen Xiaoyu Liu Chong Li Qiu Wu Xiaolan Chen Lingyue Yang Xiaochen Kou Yanhong Zhao Hong Wang Yawei Gao Yong Zhang Shaorong Gao | 2022 | Cell Research2022，32，9： | 1 |
| 15 | Thermal hydraulic performance of a seawater desalination system coupled with a nuclear heating reactor 显示文摘 | WU Shaorong DU Xiaoze CHENG Ling | 2001 | Desalination2001，140，3： | 1 |
| 16 | Coupling of nuclear heating reactor with desalination process 显示文摘 | WU Shaorong ZHENG Wenxiang | 2002 | Desalination2002，142，2： | 1 |
| 17 | Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation/Hydroxymethylation in Reprogramming显示文摘 | Yawei Gao Jiayu Chen Ke Li Tong Wu Bo Huang Wenqiang Liu Xiaochen Kou Yu Zhang Hua Huang Yonghua Jiang Chao Yao Xiaolei Liu Zhiwei Lu Zijian Xu Lan Kang Jun Chen Hailin Wang Tao Cai Shaorong Gao | 2013 | Cell Stem Cell2013，，： | 1 |
| 18 | Sirt6通过表观遗传调控Wnt信号通路控制造血干细胞的稳态显示文摘Wnt信号通路对造血干细胞稳态的维持是至关重要的,但Wnt信号在造血干细胞中的表观遗传调控规律仍然是未知的。 | 汪虎 Daojun Diao Zhencan Shi Xudong Zhu Yawei Gao Shaorong Gao Xiaoyu Liu You Wu K.Lenhard Rudolph Guanghui Liu Tangliang Li 鞠振宇 | 2017 | 科学新闻2017，19，4： | 0 |
| 19 | Design and experiment of bio-inspired GER fluid damper显示文摘Dear editor,With the rapid development of industrial robots,the influence of vibration has been considerably increasing.The consequent demand for vibration suppression in robot systems has become increasingly urgent.The effective vibration suppression can remarkably improve the performance of robots such as operation stability,detective and tracking accuracy,and the security of interaction with the human body. | Huayan PU Yining HUANG Yi SUN Min WANG Shujin YUAN Zhen KONG Peipei YANG Liufeng CHU Jinbo WU Yan PENG Shaorong XIE Jun LUO | 2020 | Science China(Information Sciences)2020，63，7： | 0 |
| 20 | Erratum to:Influences of chemical reactions on polysulfide reduction reaction process on promotor surface in Li-S batteries显示文摘Erratum to Nano Research,2024,17(4):2712-2718 http://gffzzd3cc09b8251d45dfskoxqk5of95kb6bpu.ffgz.tsg.suse.edu.cn/10.1007/s12274-023-6129-5 The affiliation of the author,Wenhui Duan,is“2 Department of Physics,Tsinghua University,Beijing 100084,China”,instead of“1 Tsinghua-Foxconn Nanotechnology Research Center,Tsinghua University,Beijing 100084,China;2 Department of Physics,Tsinghua University,Beijing 100084,China”.And the affiliation of the author,Wenhui Duan,in the online version and the ESM file of this paper has been corrected. | Yufeng Luo Zhenhan Fang Zixin Hong Shaorong Duan Haitao Liu Hengcai Wu Qunqing Li Yuegang Zhang Shoushan Fan Wenhui Duan Jiaping Wang | 2024 | Nano Research2024，17，5： | 0 |
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