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| 1 | Whole-Genome Resequencing of a Worldwide Collection of Rapeseed Accessions Reveals the Genetic Basis of Ecotype Divergence显示文摘Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underlying the divergence of these ecotypes are largely unknown. Here,we report the global pattern of genetic polymorphisms in rapeseed determined by resequencing a worldwide collection of 991 germplasm accessions.A total of 5.56 and 5.53 million singlenucleotide polymorphisms (SNPs)as Well as 1.86 and 1.92 million InDels were identified by mapping reads to the reference genomes of 'Darmor-bzh'and 'Tapidor,'respectively.We generated a map of allelic drift paths that shows splits and mixtures of the main populations,and revealed an asymmetric evolution of the two subgenomes of B.napus by calculating the genetic diversity and linkage disequilibrium parameters.Selective-sweep analysis revealed genetic changes in genes orthologous to those regulating various aspects of plant development and response to stresses.A genome-wide association study identified SNPs in the promoter regions of FLOWERING LOCUS T and FLOWERING LOCUS C orthologs that corresponded to the different rapeseed ecotype groups. Our study provides important insights into the genomic footprints of rapeseed evolution and flowering-time divergence among three ecotype groups,and will facilitate screening of molecular markers for accelerating rapeseed breeding. | Dezhi Wu Zhe Liang Tao Yan Ying Xu Lijie Xuan Juan Tang Gang Zhou Ulrike Lohwasser Shuijin Hua Haoyi Wang Xiaoyang Chen Qian Wang Le Zhu Antony Maodzeka Nazim Hussain Zhilan Li Xuming Li Imran Haider Shamsi Ghulam Jilani Linde Wu Hongkun Zheng Guoping Zhang Boulos Chalhoub Lisha Shen Hao Yu Lixi Jiang | 2019 | Molecular Plant2019，12，1： | 10 |
| 2 | Progress and Challenges for Live-cell Imaging of Genomic Loci Using CRISPR-based Platforms显示文摘Chromatin conformation,localization,and dynamics are crucial regulators of cellular behaviors. Although fluorescence in situ hybridization-based techniques have been widely utilized for investigating chromatin architectures in healthy and diseased states,the requirement for cell fix-ation precludes the comprehensive dynamic analysis necessary to fully understand chromatin activ-ities. This has spurred the development and application of a variety of imaging methodologies for visualizing single chromosomal loci in the native cellular context. In this review,we describe currently-available approaches for imaging single genomic loci in cells,with special focus on clus-tered regularly interspaced short palindromic repeats (CRISPR)-based imaging approaches. In addition,we discuss some of the challenges that limit the application of CRISPR-based genomic imaging approaches,and potential solutions to address these challenges. We anticipate that,with continued refinement of CRISPR-based imaging techniques,significant understanding can be gained to help decipher chromatin activities and their relevance to cellular physiology and pathogenesis. | Xiaotian Wu Shiqi Mao Yachen Ying Christopher J.Krueger Antony K. Chen | 2019 | Genomics, Proteomics & Bioinformatics2019，17，2： | 5 |
| 3 | Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives显示文摘Cancer is a major health concern and leading burden on economy worldwide. An increasing effort is devoted to isolation and development of plant-derived dietary components as effective chemo-preventive products. Phytochemical compounds from natural resources such as fruits and vegetables are responsible for decreasing the risk of certain cancers among the consuming populations. Apigenin, a flavonoid phytochemical found in many kinds of fruits and vegetables, has been shown to exert significant biological effects, such as anti-oxidant, anti-inflammatory and most particularly anti-neoplastic properties. This review is intended to summarize the most recent advances in the anti-proliferative and chemo-preventive effects of apigenin in different cancer models. Analysis of the data from the studied cancer models has revealed that apigenin exerts its anti-proliferative effects through multiple and complex pathways. This guided us to discover some controversial results about the exact role of certain molecular pathways such as autophagy in the anticancer effects of apigenin. Further, there were cumulative positive evidences supporting the involvement of certain pathways such as apoptosis, ROS and DNA damage and repair. Apigenin possesses a high potential to be used as a chemosensitizing agent through the up-regulation of DR5 pathway. According to these preclinical findings we recommend that further robust unbiased studies should consider the possible interactions between different molecular pathways. | Jumah Masoud Mohammad SALMANI ZHANG Xiao-Ping Joe Antony JACOB CHEN Bao-An | 2017 | Chinese Journal of Natural Medicines2017，15，5： | 4 |
| 4 | CRISPR/Cas9-mediated genome engineering of the ferret显示文摘 | Zhaohui Kou Qian Wu Xiaochen Kou Chonghai Yin Hong Wang Zhentao Zuo Yan Zhuo Antony Chen Shaorong Gao Xiaoqun Wang | 2015 | Cell Research2015，25，12： | 3 |
| 5 | Inter-Organizational Communication as a Relational Competency:Antecedents and Performance Outcomes in Collaborative Buyer supplier Relationships 显示文摘 | Lado A A Chen I J Paulraj Antony | 2008 | Journal of Operations Management2008，26，1： | 1 |
| 6 | Inter-organizational communication as a relational competency: Antecedents and performance outcomes in collaborative buyer–supplier relationships显示文摘 | Antony Paulraj Augustine A. Lado Injazz J. Chen | 2007 | Journal of Operations Management2007，，1： | 1 |
| 7 | A four-wing chaotic attractor generated from a new 3-D quadratic autonomous system显示文摘 | QI Guoyuan CHEN Guanrong Wyk Michael Antonie van | 2008 | Chaos Solitons and Fractals2008，38，3： | 1 |
| 8 | Seasonal characteristics and regional transport of PM 2.5 in Hong Kong显示文摘 | Peter K.K. Louie John G. Watson Judith C. Chow Antony Chen Della W.M. Sin Alexis K.H. Lau | 2005 | Atmospheric Environment2005，，9： | 1 |
| 9 | Use of vir- tual surgery and stereolithograpby-guided osteotomy for mandibular reconstruction with the free fibula 显示文摘 | Antony A K Chen W F Kolokythas A | 2011 | Plast Reconstr Surg2011，128，： | 1 |
| 10 | Towards a theory of supply chain management: the constructs and measurements显示文摘 | Injazz J Chen Antony Paulraj | 2004 | Journal of Operations Management2004，，2： | 1 |
| 11 | Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging显示文摘 | Daniel L. J. Thorek Antony K. Chen Julie Czupryna Andrew Tsourkas | 2006 | Annals of Biomedical Engineering2006，，1： | 1 |
| 12 | Strategic purchasing, supply management, and firm performance显示文摘 | Injazz J. Chen Antony Paulraj Augustine A. Lado | 2004 | Journal of Operations Management2004，，5： | 1 |
| 13 | Identification of known and novel genes whose expression is regulated by endogenous retinoic acid during early embryonic development of the mouse显示文摘 | Chen M H Antoni L Bavik C O | 2002 | Mech Dev2002，114，12： | 1 |
| 14 | Levels of strategic purchasing: Impact on supply integration and performance 显示文摘 | Antony Paulraj Injazz J Chen James Flynn | 2006 | Journal of Purchasing and Supply Management2006，12，3： | 1 |
| 15 | Strategic Purchasing,Supply Management,and Firm Performance显示文摘 | Injazz J Chen Antony Paulraj Augustine A Lado | 2004 | Journal of Operations Management2004，22，： | 1 |
| 16 | Seasonal characteristics and regional transport of PM 2.5 in Hong Kong显示文摘 | Peter K.K. Louie John G. Watson Judith C. Chow Antony Chen Della W.M. Sin Alexis K.H. Lau | 2005 | Atmospheric Environment2005，，： | 1 |
| 17 | Use of virtual surgery and stereolithography-guided osteotomy for mandibular reconstruction with the free fibula显示文摘 | Antony AK Chen WF Kolokythas A | 2011 | Plast Reconstr Surg2011，128，5： | 1 |
| 18 | Inhibition of retroviral Gag assembly by non-silencing miRNAs promotes autophagic viral degradation显示文摘 | Na Qu Zhao Ma Mengrao Zhang Muaz N. Rushdi Christopher J. Krueger Antony K. Chen | 2018 | Protein & Cell2018，9，7： | 1 |
| 19 | A four-wing chaotic attractor generated from a new 3-D quadratic autonomous system 显示文摘 | Qi Guoyuan Chen Guanrong Michael Antonie van Wyk | 2008 | Chaos Solitons and Fractals2008，38，： | 1 |
| 20 | Contribu- tion of Msh2 and Msh6 subunits to the asymmetric ATPase and DNA mismatch binding activities of Saccharomyces cerevisiaes Msh2-Msh6 mismatch repair protein 显示文摘 | ANTONY E KHUBCHANDANI S CHEN S | 2006 | DNA Repair2006，5，： | 1 |
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