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| 1 | Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration显示文摘 | Yu, Y. Yao, A. H. Chen, N. Pu, L. Y. Fan, Y. Lv, L. Sun, B. C. Li, G. Q. Wang, X. H. | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 45 |
| 2 | Identification of differentially expressed genes in omental adipose tissues of obese patients by suppression subtractive hybridization显示文摘 | Qiu, J. Ni, Y. H. Gong, H. X. Fei, L. Pan, X. Q. Guo, M. Chen, R. H. Guo, X. R. | 2007 | 南京医科大学学报(自然科学版)2007，27，4： | 34 |
| 3 | Intracellular tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus. Role of JAK/STAT signaling显示文摘 | Zeng, Y. Zhang, X. H. Huang, Z. Cheng, L. Yao, S. H. Qin, D. Chen, X. Y. Tang, Q. Lv, Z. G. Zhang, L. Lu, C. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 31 |
| 4 | Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro显示文摘Gastrin and cyclooxygenase-2(COX-2) playimportant roles in the carcinogenesis and progression ofgastric cancer.However,it remains unknown whether the combination of cholecystokinin-2(CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer.Here,we demonstrated that the combination of AG-041R(a CCK-2 receptor antagonist) plus NS-398(a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition,apoptosis induction,down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells.These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.(C)2008 Elsevier Ireland Ltd.All rights reserved. | Sun, W. H. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 30 |
| 5 | Common Genetic Variants in Pre-MicroRNAs Were Associated With Increased Risk of Breast Cancer in Chinese Women显示文摘 | Hu, Z. B. Liang, J. Wang, Z. W. Tian, T. Zhou, X. Y. Chen, J. P. Miao, R. F. Wang, Y. Wang, X. R. Shen, H. B. | 2009 | 南京医科大学学报(自然科学版)2009，29，4： | 29 |
| 6 | EFFECT OF CHEMICAL COMPOSITION ON RETAINED AUSTENITE IN TRIP STEEL显示文摘The systematic chemical compositions including common C, Si, Mn, Al, and micro- alloying elements of Ti and Nb were designed for high volume fraction of retained austenite as much as possible. The thermo-cycle experiments were conducted by using Gleeble 2000 thermo-dynamic test machine for finding the appropriate composition. The experimental results showed that chemical composition had a significant effect on retained austenite, and the appropriate compositions were determined for commercial production of TRIP steels. | Y. Chen and X. ChenWuhan University of Science and Technology, Wuhan 430081, ChinaQ.F. Wang, G.L. Yuan and. C. Y. LiTechnical Center of Wuhan Iron and Steel Co., Wuhan 430080, ChinaX. Y. Li and Y.X. WangCentral Iron and Steel Research Institute, Beijing 1 | 2002 | Acta Metallurgica Sinica(English Letters)2002，15，4： | 19 |
| 7 | Interactions of IL-12A and IL-12B Polymorphisms on the Risk of Cervical Cancer in Chinese Women显示文摘 | Chen, X. J. Han, S. P. Wang, S. N. Zhou, X. Y. Zhang, M. F. Dong, J. Shi, X. Y. Qian, N. F. Wang, X. R. Wei, Q. Y. Shen, H. B. Hu, Z.B. | 2009 | 南京医科大学学报(自然科学版)2009，29，3： | 16 |
| 8 | IGF-1R as an anti-cancer target—trials and tribulations显示文摘Type I insulin-like growth factor receptor (IGF-1R) has long been recognized for its role in tumorigenesis and growth, but only recently have the tools for targeting the IGF pathway become available. More than 10 IGF/IGF-1R inhibitors have entered clinical trials, and these belong to three main classes: (1) monoclonal antibodies against IGF-1R, (2) monoclonal antibodies against IGF-1R ligands (IGF-1 and IGF- 2), and (3) IGF-1R tyrosine kinase inhibitors. These IGF-1R-targeting agents share common effects on IGF-1R signaling but differ in mechanisms of action, spectrum of target inhibition, and pharmacological features. Clinical activity of IGF-1R inhibitors has been demonstrated with sustained responses in a small number of patients with select tumor types, such as Ewing sarcoma and thymoma. However, many large clinical trials involving patients with adult tumors, including non-small cell lung cancer, breast cancer, and pancreatic cancer, failed to show clinical benefit in the overall patient population. Possible reasons for failure include the complexity of the IGF-1R/insulin receptor system and parallel growth and survival pathways, as well as a lack of patient selection markers. While IGF-1R remains a valid target for selected tumor types, identification of predictive markers and rational combinations will be critical to success in future development. | Helen X. Chen Elad Sharon | 2013 | Chinese Journal of Cancer2013，32，5： | 16 |
| 9 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 10 | Identification of JWA as a novel functional gene responsive to environmental oxidative stress induced by benzo a pyrene and hydrogen peroxide显示文摘 | Chen, R. Qiu, W. Liu, Z. L. Cao, X. J. Zhu, T. Li, A. P. Wei, Q. Y. Zhou, J. W. | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 9 |
| 11 | Late Cretaceous biota and the Cretaceous-Paleogene(K--Pg)Boundary in Jiayin of Heilongjiang,China显示文摘An international cooperative study of the Late Cretaceous biota and non-marine strata including the Cretaceous-Paleogene(K--Pg) boundary in Jiayin near the Heilongjiang River,China during 2002-2010,is summarized in this paper. The strata includes the Upper Cretaceous Yong'ancun-,Taipinglinchang-,Yuliang-zi-,and Furao formations,and the Paleocence Wuyun Formation consisting of Baoshantou Member and a Coalbearing Member. Seven palynological assemblages from Santonian to Paleocene are recognized,which is used for definition of the K--Pg boundary. Through the palynological analysis of three drilled boreholes (XHY-2005,2006,2008) in Xiaoheyan of western Jiayin,the K--Pg boundary is defined within 20. 00-20. 05 m in the borehole XHY-2006 (as a standard boundary) which is just between the top of Furao Formation (late Maasterichtian) and the base of Baishantou Member (early Danian) . These new research results are supported by paleo- magnetic,geochemical and other analyses,also. On the other hand,the presence of eight taxa of Maasterichtian dinosaurs (mostly hadrosaurids) have been recognized by the authors; and two mega-plant assemblages from the Yong'ancun Fm (Santonian) to Taipinglinchang Fm (Campanian) are confirmed. These research a-chievements indicate that the Upper Cretaceous-Paleocene in Jiayin can be well correlated to the strata in the neighboring Zeya-Bureja basin,Russia. The K--Pg boundary definited in Jiayin is the first well documented non-marine K--Pg boundary in China. Also the related paleoclimate,paleoenvironment and the mass extinctions in this area during the Cretaceous-Paleocene transition are also discussed. | Sun G. Akhmetiev M. Markevich V. Ashraf A. R. Bugdaeva E. Godefroit P. Bolotsky Yu. Dong Z. M. Golovneva L. Yang H. X. Sun C. L. Sun Y. W. Quan C. Kodrul T. Kezina T. Johnson K. Nishida H Dilcher D. L. Harding I. Chen Y. J. | 2011 | Global Geology2011，14，3： | 9 |
| 12 | 草地场景真实感模拟技术综述显示文摘草体作为自然场景的一种重要组成元素,其数量众多、覆盖范围广,因此很难实现实时绘制,大规模草地场景真实感模拟已成为计算机图形学中研究的热点和难点之一.文中对20多年来草地场景真实感模拟技术的发展情况进行综述,分别从绘制技术、LOD表达、动态模拟以及业界现状等几个方面做了比较深入的介绍,分析并比较了一些典型方法的基本原理和优缺点;最后对该领域未来的发展趋势进行了展望. | 邱航 陈雷霆 Jim X. Chen 凌飞 | 2010 | 计算机辅助设计与图形学学报2010，22，9： | 8 |
| 13 | 视频传输差错掩盖技术研究现状与发展趋势显示文摘讨论了视频差错掩盖研究的发展过程和现状.介绍了常见的空域和时域差错掩盖算法,特别是基于边缘检测的空域自适应差错掩盖算法、基于运动向量外插的时域差错掩盖算法、多步多权值块变形差错掩盖算法以及基于失真度估计的SVC质量分级自适应差错掩盖算法.分析了这些算法在不同有损传输环境下的差错掩盖性能和适用环境.预测了差错掩盖技术可能的发展趋势. | 彭强 张蕾 Chen Jim X. | 2009 | 西南交通大学学报2009，44，4： | 8 |
| 14 | Effects of temperature and thermally-induced microstructure change on hydraulic conductivity of Boom Clay显示文摘Boom Clay is one of the potential host rocks for deep geological disposal of high-level radioactive nuclear waste in Belgium. In order to investigate the mechanism of hydraulic conductivity variation under complex thermo-mechanical coupling conditions and to better understand the thermo-hydromechanical(THM) coupling behaviour of Boom Clay, a series of permeability tests using temperaturecontrolled triaxial cell has been carried out on the Boom Clay samples taken from Belgian underground research laboratory(URL) HADES. Due to its sedimentary nature, Boom Clay presents acrossanisotropy with respect to its sub-horizontal bedding plane. Direct measurements of the vertical(Kv)and horizontal(Kh)hydraulic conductivities show that the hydraulic conductivity at 80℃ is about 2.4 times larger than that at room temperature(23℃), and the hydraulic conductivity variation with temperature is basically reversible during heatingecooling cycle. The anisotropic property of Boom Clay is studied by scanning electron microscope(SEM) tests, which highlight the transversely isotropic characteristics of intact Boom Clay. It is shown that the sub-horizontal bedding feature accounts for the horizontal permeability higher than the vertical one. The measured increment in hydraulic conductivity with temperature is lower than the calculated one when merely considering the changes in water kinematic viscosity and density with temperature. The nuclear magnetic resonance(NMR) tests have also been carried out to investigate the impact of microstructure variation on the THM properties of clay. The results show that heating under unconstrained boundary condition will produce larger size of pores and weaken the microstructure. The discrepancy between the hydraulic conductivity experimentally measured and predicted(considering water viscosity and density changes with temperature) can be attributed to the microstructural weakening effect on the thermal volume change behaviour of Boom Clay. Based on the experimental results, a hydraulic conductivity evolution model is proposed and then implemented in ABAQUS. Three-dimensional(3D) numerical simulation of the admissible thermal loading for argillaceous storage(ATLAS) Ⅲ in situ heating test has been conducted subsequently, and the numerical results are in good agreement with field measurements. | W.Z. Chen Y.S. Ma H.D. Yu F.F. Li X.L. Li X. Sillen | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，3： | 7 |
| 15 | Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population显示文摘 | Jin, G. F. Wang, L. N. Chen, W. S. Hu, Z. B. Zhou, Y. Tan, Y. F. Wang, J. M. Hua, Z. L. Ding, W. L. Shen, J. Zhang, Z. F. Wang, X. R. Xul, Y. C. Shen, H. B. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 7 |
| 16 | Variant genotypes and haplotypes of the epidermal growth factor gene promoter are associated with a decreased risk of gastric cancer in a high-risk Chinese population显示文摘 | Jin, G. F. Miao, R. F. Deng, Y. M. Hu, Z. B. Zhou, Y. Tan, Y. F. Wang, J. M. Hua, Z. L. Ding, W. L. Wang, L. Chen, W. S. Shen, J. Wang, X. R. Xu, Y. C. Shen, H. B. | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 7 |
| 17 | Effect of a High Magnetic Field on the Shape of the γ' Precipitates in Cast Nickel-based Superalloy K52显示文摘The shape change of the γ' precipitates of cast Ni-based superalloy K52 after aging treatment under a high magnetic field was investigated. The results show that duplex γ' precipitates are present in the γ' matrix after aging treatment with or without the magnetic field. One is the coarse particles with average size of 500 nm; the other is fine spherical γ' precipitates with average of 100 nm in diameter. The application of a 10T magnetic field only results in the shape of the coarse γ' particles changing from spherical to cuboidal when the alloys subjected to the same heat treatments. This shape change was mainly discussed based on the strain energy increase caused by the difference in magnetostriction between the γ' matrix and γ' precipitates. The fine γ' particles still keep spherical. Further TEM observations shows that a number of γ' particles in nano-scale precipitate in the coarse γ' particles in the specimens treated without the magnetic field. In addition, it was found that the magnetic field caused the decrease of the hardness in the alloy, and the hardness was associated with the field direction. | X. Ren G.Q. Chen W.L. Zhou C.W. Wu C. Yuan J.S. Zhang | 2009 | Journal of Materials Science & Technology2009，25，3： | 6 |
| 18 | CREVICE CORROSION BEHAVIOR OF X70 STEEL IN HCO_3^- SOLUTION UNDER CATHODIC POLARIZATION显示文摘X70 钢的缝隙腐蚀行为与楔形的缝隙汇编 under-1000 mV ( SCE )被调查在有各种各样的HCO3- concentrations.The 潜力的解决方案的 cathodic 极化,当前,在缝隙以内的 pH 和氧内容被测量与或没有显示的在外面联合的 specimen.The 结果在缝隙的 X70 钢的极化潜力在 cathodic polarization.There 下面随时间的增加落下,这是HCO3- concen | C.W. Du X.G. Li X. Chen P. Liang H. Guo | 2008 | Acta Metallurgica Sinica(English Letters)2008，21，4： | 6 |
| 19 | SURFACE ANALYSIS OF ALUMINUM ALLOYS INFLUENCED BY SULFATE- REDUCING BACTERIA显示文摘The morphology and chemical compositions of surface and corrosion phases for two aluminum alloys(7075 and 2024 ) in the aqueous mediums containing sulfate reducing bacteria(SRB) were studied by the methods of scanning electron microscopy (SEM) and energy dispersive x ray analysis (EDXA). The results showed that serious pitting corrosion took place when aluminum alloys were exposed in the mediums containing SRB, whereas no pitting corrosion were found on the surfaces of aluminum alloys only exposed in blank mediums non containing SRB. It was demonstrated with EDXA that corrosion of aluminum alloys exposed in the solutions containing SRB, whereas the corrosion in the solution non containing microorganisms was attributed to the presence of chloride ions(Cl ). | X. L. Wu, J.H. Liu and X.Y. Chen Department of Materials Science and Engineering, Beijing University of Aeronautics and Astronautics, Beijing 100083, China | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，5： | 6 |
| 20 | Experimental Investigation of Forced Convective Boiling Flow Instabilities in Horizontal Helically Coiled Tubes显示文摘ExperimentalInvestigationofForcedConvectiveBoilingFlowInstabilitiesinHorizontalHelicallyCoiledTubesL.J.Guo;Z.P.Feng;X.J.Chen(... | L. J. Guo Z. P. Feng X. J. Chen N. H. Thomas | 1996 | Journal of Thermal Science1996，5，3： | 5 |
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