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| 1 | Chinese consensus guidelines for diagnosis and management of gastrointestinal stromal tumor显示文摘In order to further promote the standardization of diagnosis and treatment of gastrointestinal stromal tumor(GIST) in China, the members of Chinese Society of Clinical Oncology(CSCO) Expert Committee on GIST thoroughly discussed the key contents of the consensus guidelines, and voted on the controversial issue. In final, the Chinese consensus guidelines for the diagnosis and management of GIST(2017 edition) was formed on the basis of 2013 edition consensus guidelines, which is hereby announced. The consensus included the pathological diagnosis,recurrence risk classification evaluation, targeted agent therapy, surgery and principles of surveillance of GIST. | jian li yingjiang ye jian wang bo zhang shukui qin yingqiang shi yulong he xiaobo liang xiufeng liu ye zhou xin wu xinhua zhang ming wang zhidong gao tianlong lin hui cao lin shen | 2017 | Chinese Journal of Cancer Research2017，29，4： | 104 |
| 2 | Crustal velocity structure in the Emeishan large igneous province and evidence of the Permian mantle plume activity显示文摘The Emeishan large igneous province(ELIP) in SW China is interpreted to be associated with an ancient mantle plume. Most of the constraints on the role of mantle plume in the generation of the Emeishan flood basalts were provided by geological and geochemical methods, but the geophysical investigation is very limited. In order to better understand the deep structure and features of ELIP, we have studied the crustal velocity structure using the data acquired from the Lijiang-Panzhihua-Qingzhen wide-angle seismic profile. This profile crosses the three sub-zones of the ELIP(the inner, intermediate, and outer zones), divided based on the differential erosion and uplift of the Maokou limestone. The results provided by the active source seismic experiment demonstrate:(1) The average depth of the crystalline basement along the profile is about 2 km.(2) The middle crust in the Inner Zone is characterized by high-velocity anomalies, with the average velocity of 6.2-6.6 km/s, which is about 0.1– 0.2 km/s higher than the normal one. The velocity of the lower crust in the inner zone is 6.9-7.2 km/s, higher than those observed in the intermediate and outer zones(6.7-7.0 km/s). Relatively low velocity anomalies appear in the upper, middle and lower crusts near the junction of the inner zone and intermediate zone, probably due to the effect of the Xiaojiang fault(XJF).(3) The average velocity of the crust is comparatively low on both sides of XJF, especially on the east side, and the average velocity of the consolidated continental crust is also low there. This may suggest that the XJF extends at least down to 40 km deep, even beyond through the crust.(4) The depth to the Moho discontinuity decrease gradually from 47-53 km in the inner zone, via 42-50 km in the intermediate zone to 38-42 km in the outer zone. In the inner zone, the Moho uplifts locally and the(consolidated) crust is characterized by high-velocity anomalies, which are likely related to intensive magma intrusion and underplating associated with melting of plume head. Overall the crustal velocity structure in the study area recorded the imprint left by the Permian Emeishan mantle plume. | XU Tao ZHANG ZhongJie LIU BaoFeng CHEN Yun ZHANG MingHui TIAN XiaoBo XU YiGang TENG JiWen | 2015 | Science China Earth Sciences2015，58，7： | 36 |
| 3 | SQUAMOSA Promoter-Binding Protein-Like Transcription Factors:Star Players for Plant Growth and Development显示文摘SQUAMOSA Promoter-Binding Protein-Like (SPL) genes encode plantspecific transcription factors that play important roles in plant phase transition,flower and fruit development,plant architecture,gibberellins signaling,sporogenesis,and response to copper and fungal toxins.In Arabidopsis,many SPL genes are post-transcriptionally regulated by the microRNA (miRNA) miR156,among which AtSPL9 in turn positively regulates the expression of the second miRNA miR172.This miR156AtSPL9-miR172 regulatory pathway plays critical roles during juvenile to adult leaf development and the miR156-SPLs feedback interaction persists all through the plant development,which may be conserved in other plants.In the present paper,we provide a concise review on the most recent progress in the regulatory mechanisms associated with plant SPL transcription factors,especially in relation to miRNAs.The potential application of these discoveries in agriculture is briefly discussed. | Xiaobo Chen Zenglin Zhang Danmei Liu Kai Zhang Aili Li Long Mao | 2010 | Journal of Integrative Plant Biology2010，52，11： | 31 |
| 4 | Urine-derived stem cells:A novel and versatile progenitor source for cell-based therapy and regenerative medicine显示文摘Engineered functional organs or tissues,created with autologous somatic cells and seeded on biodegradable or hydrogel scaffolds,have been developed for use in individualswith tissue damage suffered fromcongenital disorders,infection,irradiation,or cancer.However,in those patients,abnormal cells obtained by biopsy fromthe compromised tissue could potentially contaminate the engineered tissues.Thus,an alternative cell source for construction of the neo-organ or functional recovery of the injured or diseased tissues would be useful.Recently,we have found stem cells existing in the urine.These cells are highly expandable,and have self-renewal capacity,paracrine properties,and multi-differentiation potential.As a novel cell source,urine-derived stem cells(USCs)provide advantages for cell therapy and tissue engineering applications in regeneration of various tissues,particularly in the genitourinary tract,because they originate from the urinary tract system.Importantly,USCs can be obtained via a non-invasive,simple,and low-cost approach and induced with high efficiency to differentiate into three dermal cell lineages. | Deying Zhang Guanghui Wei Peng Li Xiaobo Zhou Yuanyuan Zhang | 2014 | Genes & Diseases2014，1，1： | 34 |
| 5 | Recent progress of nanomaterials for microwave absorption显示文摘Microwave absorbing materials have received considerable interest over the years for their applications in stealth,communications,and information processing technologies.These materials often require functionalization at the nanoscale so to achieve desirable dielectric and magnetic properties which induce interaction with incident electromagnetic radiation.This article presents a comprehensive review on the recent research progress of nanomaterials for microwave absorption,including the basic mechanism of microwave absorption(e.g.,dielectric loss,magnetic loss,dielectric/magnetic loss coupling),measurement principle(e.g.,fundamentals of analysis,performance evaluation,common interaction pathways:Debye relaxation,Eddy current loss,natural resonance,size and shape factors),and the advances and performance review in microwave absorption(e.g.,absorption bandwidth,reflection loss values,absorption peak position)using various nanomaterials,such as carbon nanotubes,carbon fibers,graphenes,oxides,sulfides,phosphides,carbides,polymers and metal organic frameworks.Overall,this article not only provides an introduction on the fundamentals of microwave absorption research,but also presents a timely update on the research progress of the microwave absorption performance of various nanomaterials. | Michael Green Xiaobo Chen | 2019 | Journal of Materiomics2019，5，4： | 33 |
| 6 | Design concept for electrocatalysts显示文摘Metal-based electrocatalysts with different sizes(single atoms,nanoclusters,and nanoparticles)show different catalytic behaviors for various electrocatalytic reactions.Regulating the coordination environment of active sites with precision to rationally design an efficient electrocatalyst is of great significance for boosting electrocatalytic reactions.This review summarizes the recent process of heterogeneous supported single atoms,nanoclusters,and nanoparticles catalysts in electrocatalytic reactions,respectively,and figures out the construct strategies and design concepts based on their strengths and weaknesses.Specifically,four key factors for enhancing electrocatalytic performance,including electronic structure,coordination environment,support property,and interfacial interactions are proposed to provide an overall comprehension to readers in this field.Finally,some insights into the current challenges and future opportunities of the heterogeneous supported electrocatalysts are provided. | Yao Wang Xiaobo Zheng Dingsheng Wang | 2022 | Nano Research2022，15，3： | 27 |
| 7 | Apoptosis-inducing activity of the antimicrobial peptide cecropin of Musca domestica in human hepatocellular carcinoma cell line BEL-7402 and the possible mechanism显示文摘我们在人的 hepatocellular 癌房间线 BEL-7402 和它的内在的机制学习了蝇属 domestica 的抗菌剂肽 cecropin 的导致 apoptosis 性质。人的 hepatocellular 癌 BEL-7402 房间和人的正常的肝房间的增长抑制被 MTT 试金决定,并且房间生存能力被 trypan 蓝色染料排除试金决定。与 cecropin 对待的 apoptotic 肿瘤房间被传播电子显微镜学和 terminal-deoxynucleotidyl transferase 检验标记的调停的刻痕结束。apoptosis 率被流动 cytometry (FCM ) 与 PI/Annexin-V 测量两倍染色。西方的污点分析和 RT-PCR 被用来决定涉及 apoptosis 的蛋白质的表示层次,例如船边交货, Fas-L, caspase-8,和 caspase-3。试验性的结果证明蝇属 domestica cecropin 在剂量依赖者和时间依赖者礼貌禁止了人的 hepatocellular 癌 BEL-7402 房间的增长,没有影响正常的肝房间的增长。FCM 证明房间 apoptosis 率是 5. | Xiaobao Jin | 2010 | Acta Biochimica et Biophysica Sinica2010，42，4： | 23 |
| 8 | Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior显示文摘为过去的几十年,在中国的传染疾病侧面在社会、经济的方面,环境,食物的质量,水,住房,和公共健康基础结构与快速的开发一直在变。尤其是, 5 应具报的传染疾病几乎被根除了,并且 18 另外的应具报的传染疾病的发生显著地被减少了。出人意料地,包括 HIV,普鲁斯病,梅毒,和登革热发烧,超过 10 应具报的传染疾病的发生一直在增加。不过,经常的传染疾病爆发 / 事件每年几乎被报导了,并且进口了传染疾病自从 2015,增加了。已知的病原体的新病原体和超过 100 新遗传型或 serotypes 被识别了。一些传染疾病似乎被各种各样的因素加重,包括快速的都市化,大量候鸟工人,在气候的变化,生态学,和政策,例如把农田还给森林。这评论在设法出现和 re-emerging 从中国总结当前的经验和课传染疾病,特别生态学的效果,气候,和行为,它应该在帮助另外的国家控制并且阻止传染疾病有优点。 | Qiyong Liu Wenbo Xu Shan Lu Jiafu Jiang Jieping Zhou Zhujun Shao Xiaobo Liu Lei Xu Yanwen Xiong Han Zheng Sun Jin Hai Jiang Wuchun Cao Jianguo Xu | 2018 | Frontiers of Medicine2018，12，1： | 23 |
| 9 | Genome analysis of Taraxacum kok-saghyz Rodin provides new insights into rubber biosynthesis显示文摘The Russian dandelion Taraxacum kok-saghyz Rodin(TKS), a member of the Composite family and a potential alternative source of natural rubber(NR) and inulin, is an ideal model system for studying rubber biosynthesis. Here we present the draft genome of TKS, the first assembled NR-producing weed plant. The draft TKS genome assembly has a length of 1.29 Gb, containing 46 731 predicted protein-coding genes and68.56% repeats, in which the LTR-RT elements predominantly contribute to the genome enlargement. We analyzed the heterozygous regions/genes, suggesting its possible involvement in inbreeding depression.Through comparative studies between rubber-producing and non-rubber-producing plants, we found that enzymes of the mevalonate(MVA) pathway and rubber elongation might be critical for rubber biosynthesis, and several key isoforms have been isolated and shown to be predominantly expressed in the latex, indicating their crucial functions in rubber biosynthesis. Moreover, for two important families in rubber elongation, the CPT/CPTL and REF/SRPP families, diverse evolutionary tracks have been revealed. These results provide valuable resources and new insights into the mechanism of NR biosynthesis,and facilitate the development of alternative NR-producing crops. | Tao Lin Xia Xu Jue Ruan Shizhong Liu Shigang Wu Xiujuan Shao Xiaobo Wang Lin Gan Bi Qin Yushuang Yang Zhukuan Cheng Suhua Yang Zhonghua Zhang Guosheng Xiong Sanwen Huang Hong Yu Jiayang Li | 2018 | National Science Review2018，5，1： | 22 |
| 10 | 关于6A02铝合金板热成型-整体淬火工艺的实验研究显示文摘作为重要的轻质结构材料,铝合金已广泛用于汽车和航空工业。主要用来制造具有高强度,精确尺寸的零件。本文中开发了一种特殊装置,用来研究冷轧6A02铝合金板热成型-整体淬火工艺。用测维氏硬度和拉伸试验来反映强化效果。用扫描电镜(SEM)透射电镜(TEM)、和电子背散射衍射进行显微检测来阐明强化机理。结果表明,随着固溶时间(<50 min)延长维氏硬度增大,强化效应越大。成型零件的维氏硬度能从冷轧态的73 HV或热成型-整体淬火工艺(在520℃固溶50 min,以50°C/s冷却,以160°C/10 h时效)加热后的40 HV增加到106.5 HV。相应的拉伸强度和屈服强度分别是315.6 MPa和253.6 MPa。强化相是未成形的弥散的GP区,约5 nm大小。轧制态的可热处理的铝合金板通常直接用热成型-整体淬火工艺不作任何前处理。 | Fan Xiaobo He Zhubin Yuan Shijian Zheng Kailun | 2013 | 热处理技术与装备2013，34，6： | 19 |
| 11 | Hypoxia-regulated microRNAs in human cancer显示文摘 | Guomin SHEN Xiaobo LI Yong-feng JIA Gary A PIAZZA Yaguang XI | 2013 | Acta Pharmacologica Sinica2013，34，3： | 18 |
| 12 | Downstaging and resection of hepatocellular carcinoma in patients with extrahepatic metastases after stereotactic therapy显示文摘Background:A combination of tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies with local regional therapy has elicited yield substantial clinical benefits in patients who have hepatocellular carcinoma(HCC)with extrahepatic metastases.Using this treatment strategy to convert HCC patients with extrahepatic metastases from unresectable to resectable has not yet been reported.Methods:Consecutive hepatocellular carcinoma patients with extrahepatic metastases who received first-line therapy with a combination of TKIs and anti-PD-1 antibodies and at least one local regional therapy were analysed.Results:Nine patients with localized disease who received first-line systemic therapy were enrolled.At baseline,all of them had oligometastatic disease,namely,Barcelona Clinic Liver Cancer stage C(or Chinese Liver Cancer stage IIIB).The most common treatment administered was lenvatinib plus anti-PD-1 antibody and transarterial chemoembolization,and the median time span from systemic therapy to surgery was 3.2(IQR,2.8-6.2)months.Three patients achieved a pathological complete response.Six patients underwent laparoscopic surgery,and the other 3 patients underwent open surgery.After a median follow-up of 10.2(IQR,8.6-20.0)months,7 patients survived without disease recurrence,and 2 experienced tumour recurrence.All patients had any-grade AEs,and 55.6%of the patients experienced grade 3 AEs.Fatigue was the most common AE,followed by elevated aminotransferase levels and hypertension.Conclusions:Stereotactic therapy is a feasible conversion therapy for HCC patients with extrahepatic metastases to become resectable.This is the first study to analyse therapeutic outcomes of patients receiving these therapies for HCC with extrahepatic metastases. | Xiaobo Yang Haifeng Xu Bangyou Zuo Xu Yang Jin Bian Junyu Long Dongxu Wang Junwei Zhang Cong Ning Yanyu Wang Ziyu Xun Yunchao Wang Xin Lu Yilei Mao Xinting Sang Haitao Zhao | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 17 |
| 13 | Tracing the major source area of the mountainous runoff generation of the Heihe River in northwest China using stable isotope technique显示文摘Based on the data of δ18O in precipitation during the period of April 2006 through May 2007 in the upper catchment of the main stream of the Heihe River in the Qilian Mountains, we found that there existed an evident altitude effect on δ18O in precipitation, and the δ18O-altitude gradient was _0.18‰/100 m. When δ18O in river water at the outlet of the mountainous drainage area of the main stream of the Heihe River was combined with the δ18O-altitude relation, it was realized that the mountainous runoff was generated mostly at high altitudes. Using two component models, we revealed that 80.2% of the annual total mountainous runoff amount was generated at the alpine permafrost-snow-ice zone with an altitude of above 3600 m a.s.l. | WANG NingLian ZHANG ShiBiao HE JianQiao PU JianChen WU XiaoBo JIANG Xi | 2009 | Chinese Science Bulletin2009，54，16： | 16 |
| 14 | Characteristics and accumulation mechanism of tight sandstone gas reservoirs in the Upper Paleozoic, northern Ordos Basin, China显示文摘The Ordos Basin is a significant petroliferous basin in the central part of China.The Carboniferous and Permian deposits of transitional and continental facies are the main gas-bearing layers in the north part of the basin.The Carboniferous and Permian natural gas reservoirs in the northern Ordos Basin are mainly tight sandstone reservoirs with low porosity and low permeability,developing lots of 'sweet spots' with comparatively high porosity and permeability.The tight sandstones in the study area are gas-bearing,and the sweet spots are rich in gas.Sweet spots and tight sandstones are connected rather than being separated by an interface seal.Sweet spot sand bodies are vertically and horizontally overlapped,forming a large gas reservoir group.In fact,a reservoir formed by a single sweet spot sand body is an open gas accumulation.In the gentle dipping geological setting and with the source rocks directly beneath the tight reservoirs over a large area,the balance between gas charging into tight reservoirs from source rocks and gas loss from tight reservoirs through caprock is the key of gas accumulation in tight sandstones.Both the non-Darcy flow charging driven by source-reservoir excess pressure difference and the diffusion flow charging driven by source-reservoir gas concentration difference play an important role in gas accumulation.The results of mathematical modeling indicate that the gas accumulation cannot be formed by just one of the above mechanisms.The diffusion of gas from source rocks to reservoirs is a significant mechanism of tight sandstone gas accumulation. | Liu Guangdi Sun Mingliang Zhao Zhongying Wang Xiaobo Wu Shenghe | 2013 | Petroleum Science2013，10，4： | 16 |
| 15 | Hypoxia-inducible factor-lαand semaphorin4D genes involved with tumor-associated macrophage-induced metastatic behavior and clinical significance in colon cancer显示文摘 | Mu Linjun Wang Jinshen Chen Yuezhi Li Leping Guo Xiaobo Zheng Sheng Jing Changqing | 2014 | Chinese Medical Journal2014，，20： | 15 |
| 16 | Reducing the radiation dose with the adaptive statistical iterative reconstruction technique for chest CT in adults: a parameter study显示文摘 | Liu Wenyun Ding Xiaobo Kong Boyu Fan Baoyan Chen Liang | 2014 | Chinese Medical Journal2014，，7： | 15 |
| 17 | Etiology, pathogenesis, antivirals and vaccines of hand,foot, and mouth disease显示文摘Hand, foot, and mouth disease(HFMD), caused by enteroviruses, is a syndrome characterized by fever with vesicular eruptions mainly on the skin of the hands, feet, and oral cavity. HFMD primarily afects infants and young children. Although infection is usually self-limited, severe neurological complications in the central nervous system can present in some cases, which can lead to death. Widespread infection of HFMD across the Asia-Paciic region over the past two decades has made HFMD a major public health challenge, ranking irst among the category C notiiable communicable diseases in China every year since2008. his review summarizes our understanding of HFMD, focusing on the etiology and pathogenesis of the disease, as well as on progress toward antivirals and vaccines. he review also discusses the implications of these studies as they relate to the control and prevention of the disease. | Xiaobo Lei Sheng Cui Zhendong Zhao Jianwei Wang | 2015 | National Science Review2015，2，3： | 15 |
| 18 | Molecular cloning and functional analysis of the FLOWERING LOCUS T(FT) homolog Gh FT1 from Gossypium hirsutum显示文摘FLOWERING LOCUS T(FT) encodes a member of the phosphatidylethanolamine-binding protein(PEBP) family that functions as the mobile floral signal, playing an important role in regulating the floral transition in angiosperms. We isolated an FT-homolog(Gh FT1) from Gossypium hirsutum L. cultivar,Xinluzao 33 Gh FT1 was predominantly expressed in stamens and sepals, and had a relatively higher expression level during the initiation stage of fiber development. Gh FT1 m RNA displayed diurnal oscillations in both long-day and short-day condition,suggesting that the expression of this gene may be under the control of the circadian clock. Subcellular analysis revealed that Gh FT1 protein located in the cytoplasm and nucleus. Ectopic expression of Gh FT1 in transgenic arabidopsis plants resulted in early flowering compared with wild-type plants. In addition,ectopic expression of Gh FT1 in arabidopsis ft-10 mutants partially rescued the extremely late flowering phenotype. Finally, several Researchflowering related genes functioning downstream of At FT were highly upregulated in the 35S::Gh FT1 transgenic arabidopsis plants. In summary, Gh FT1 is an FT-homologous gene in cotton that regulates flower transition similar to its orthologs in other plant species and thus it may be a candidate target for promoting early maturation in cotton breeding. | Danli Guo Chao Li Rui Dong Xiaobo Li Xiangwen Xiao Xianzhong Huang | 2015 | Journal of Integrative Plant Biology2015，57，6： | 14 |
| 19 | Myelin Oligodendrocyte Glycoprotein-IgG Contributes to Oligodendrocytopathy in the Presence of Complement, Distinct from Astrocytopathy Induced by AQP4-IgG显示文摘Immunoglobulin G against myelin oligodendrocyte glycoprotein(MOG-Ig G) is detectable in neuromyelitis optica spectrum disorder(NMOSD) without aquaporin-4 Ig G(AQP4-Ig G), but its pathogenicity remains unclear.In this study, we explored the pathogenic mechanisms of MOG-Ig G in vitro and in vivo and compared them with those of AQP4-Ig G. MOG-Ig G-positive serum induced complement activation and cell death in human embryonic kidney(HEK)-293 T cells transfected with human MOG. In C57 BL/6 mice and Sprague-Dawley rats, MOG-Ig G only caused lesions in the presence of complement. Interestingly, AQP4-Ig G induced astroglial damage, while MOGIg G mainly caused myelin loss. MOG-Ig G also induced astrocyte damage in mouse brains in the presence ofcomplement. Importantly, we also observed ultrastructural changes induced by MOG-Ig G and AQP4-Ig G. These findings suggest that MOG-Ig G directly mediates cell death by activating complement in vitro and producing NMOSDlike lesions in vivo. AQP4-Ig G directly targets astrocytes,while MOG-Ig G mainly damages oligodendrocytes. | Ling Fang Xinmei Kang Zhen Wang Shisi Wang Jingqi Wang Yifan Zhou Chen Chen Xiaobo Sun Yaping Yan Allan G. Kermode Lisheng Peng Wei Qiu | 2019 | Neuroscience Bulletin2019，35，5： | 13 |
| 20 | Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation显示文摘The outcome of early intravenous thrombolysis for ischemic stroke in patients with atrial fibrillation(AF)is worse than that without thrombosis. How to increase the efficacy of intravenous thrombolysis for AF-related ischemic stroke remains largely unknown. In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome(P \ 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were:heart failure(P = 0.045); high systolic pressure(P = 0.039); high blood glucose(P = 0.030); and a high National Institutes of Health Stroke Scale(NIHSS) score(P \ 0.001). Moreover, high systolic pressure at admission(P = 0.007), high blood glucose(P = 0.027), and a high NIHSS score(P \ 0.001) were independent risk factors for mortality at 3 months. Besides thrombolysis, a high NIHSS score(P = 0.006) and warfarin taken within 48 h before stroke onset(P = 0.032) were also independent risk factors for symptomatic hemorrhage within 24 h after treatment. Ischemic stroke patients with AF benefited from intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 h after stroke. | Qiuyun Zhao Xiaobo Li Wanli Dong Min Ye Yongjun Cao Meijuan Zhang Qiantao Cheng Junshan Zhou Guofang Chen Ming Yu Shanshan Hong Xiue Wei Bei Wang Guiyun Cui Peng Zhang Hong Ding Rongzhen Xu Yan Chen Yun Xu | 2016 | Neuroscience Bulletin2016，32，2： | 13 |
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