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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 3 | Thermal and Transmission Properties of UV Nonlinear Optical Material——ZnCd(SCN)_4 Crystal显示文摘Zinc cadmium thiocyanate(ZCTC), ZnCd(SCN) 4, has been discovered as a UV second order nonlinear optical coordination crystal. Its thermal and transmission properties are reported. The thermal decomposition is characterized by using the X ray powder diffraction (XRPD) and infrared (IR) spectroscopy at room temperature. The absorptions of intrinsic ions and ZCTC in a solution state are discussed as well as transmission properties of the ZCTC crystal. An effective method of reducing the surface reflection loss of ZCTC crystal is introduced. | NING H X, XU D, WANG X Q, CHENG X F, YANG Z H (Institute of Cryst. Mater. and State Key Lab. of Cryst. Mater., Shandong University, Jinan 250100, CHN) | 2002 | Semiconductor Photonics and Technology2002，8，1： | 4 |
| 4 | EZH2、p-ERK1/2、p-STAT和MYC联合表达在EZH2阳性霍奇金淋巴瘤及其相关大B细胞淋巴瘤鉴别诊断中的应用显示文摘EZH2是一种重要的甲基转移酶,在不同肿瘤的发生中起重要作用。作者前期实验发现,EZH2在一系列侵袭性B细胞淋巴瘤(ABCLs)、T细胞淋巴瘤和组织细胞肿瘤中表达,同时伴有细胞内信号分子p-ERK、MYC和p-STAT3的不同程度表达,而这些信号分子均是EZH2表达的潜在调节因子。作者选择26例结节性淋巴细胞为主型霍奇金淋巴瘤(NLPHL)、31例经典型霍奇金淋巴瘤(cHL)、19例富于T细胞/组织细胞的大B细胞淋巴瘤(THRLBCL)及9例形态学介于弥漫大B细胞淋巴瘤和经典型霍奇金淋巴瘤(BCLu-DLBCL/cHL)之间的未分类B细胞淋巴瘤,采用EZH2、p-ERK、MYC和p-STAT3进行了共表达研究。结果发现,NLPHL中肿瘤性LP细胞和cHL中R-S细胞,以及THRLBCL和BCLu-DLBCL/cHL中的肿瘤细胞均强阳性表达EZH2。 | 王婷 余英豪 Tian X Xu J Dorfman D M | 2019 | 临床与实验病理学杂志2019，35，5： | 3 |
| 5 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 6 | Delermlnatlon of Mechanlcal Properties of A1-Mg Alloys Dissimilar Friction Stir Wel- ded Interface by Indentation Methods 显示文摘 | Venkateswaran P Xu Z H Li X D | 2009 | Journal of Materials Science2009，44，15： | 1 |
| 7 | The transmembrane protein semaphorin 6A repels embryonic sympathetic axons显示文摘 | Xu X M Fisher D A Zhou L | 2000 | J Neurosci2000，20，： | 1 |
| 8 | Selective detection of HCHO gas using mixed oxides of ZnO/ZnSnO3 显示文摘 | XU J Q JIA X H LOU X D | 2007 | Sensors and Actuators B2007，120，： | 1 |
| 9 | Numerical simulation of oblique water entry of an asymmetrical wedge显示文摘 | Xu G D Duan W Y Wu G X | 2008 | Ocean Engineering2008，35，16： | 1 |
| 10 | Electrochemical and XPS studies on the aqueous corrosion resistance of niobium-implanted zircaloy-4显示文摘 | Chen X W Bai X D Xu J | 2002 | Journal of Materials Science Letters2002，21，22： | 1 |
| 11 | Analysis and structure prediction of chlorinated polycyclic aromatic hydrocarbons released from combustion of polyvinyl chloride显示文摘 | Wang D Xu X Chu S | 2003 | Chemosphere2003，53，5： | 1 |
| 12 | Fabrication of Raspberry SiO2/Polystyrene Particles and Superhydrophobic ParticulateFilm with High Adhesive Force显示文摘 | Xu D Z Wang M Z Ge X W | 2012 | J Mater Chem2012，22，： | 1 |
| 13 | Preparation,morphology and properties of waterborne-polyurethane/silica显示文摘 | WU D M XU H P QIU F X | 2011 | Polymer-Plastics Technology and Engineering2011，50，5： | 1 |
| 14 | Anti-hyperglycemic activity of chromium(III) malate complex in alloxan-induced diabetic rats显示文摘 | Wu X Y Li F Xu W D | 2011 | Biological Trace Element Research2011，143，2： | 1 |
| 15 | Anal Chim Acta显示文摘 | Cao D S Hu Q N Xu Q S Yang Y N Zhao J C Lu H M Zhang L X Liang Y Z | 2011 | 692(1-2):502011，692，12： | 1 |
| 16 | Effect of Aging at 700 'C on Precipitation and Toughness of AISI 321 and AISI 317 Austenitic Stainless Steel Welds 显示文摘 | Guan K S Xu X D Xu H | 2005 | Nuclear Engineering and Design2005，235，23： | 1 |
| 17 | Dynamics of magnetization, reversal, and uhrafast demagnetization of TbFeCo amor- phous films显示文摘 | LIU X D XU Z GAO R X | 2008 | Appl Phys Let2008，92，23： | 1 |
| 18 | Multiple positi;e solutions for the boundary val- Ue problem of a nonlinear fractional differential equation显示文摘 | Xu X Jiang D Yuan C | 2009 | Nonlinear Analysis2009，，71： | 1 |
| 19 | Patterns of gene expression associated with BMP-2-induced osteoblast andadipocyte differentiation of mesenchymal progenitorcell 3T3-F442A显示文摘 | JI X CHEN D XU C | 2000 | J Bone Mineral Metab2000，18，： | 1 |
| 20 | On the distributions of wave periods,wavelengths,and amplitudes in a random wave field显示文摘 | XU D L LI X ZHANG L Z | | 0，，： | 1 |
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