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| 1 | CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization显示文摘Despite the diverse etiologies of drug-induced liver injury(DILI),innate immunity activation is a common feature involved in DILI progression.However,the involvement of innate immunity regulation in inflammation resolution and liver regeneration in DILI remains obscure.Herein,we identified the chemokine CCL5 as a central mediator of innate immunity regulation in the pathogenesis of DILI.First,we showed that serum and hepatic CCL5 levels are elevated in both DILI patients and an APAP-induced liver injury(AILI)mouse model.Interestingly,both nonparenchymal cells and stressed hepatocytes are cell sources of CCL5 induction in response to liver injury.Functional experiments showed that CCL5 deficiency has no effect on the early phase of AILI but promotes liver repair in the late phase mainly by promoting inflammation resolution and liver regeneration,which are associated with an increased number of hepatic M2 macrophages.Mechanistically,CCL5 can directly activate M1 polarization and impede M2 polarization through the CCR1-and CCR5-mediated activation of the MAPK and NF-κB pathways.We then showed that CCL5 inhibition mediated by either a CCL5-neutralizing antibody or the antagonist Met-CCL5 can greatly alleviate liver injury and improve survival in an AILI mouse model.Our data demonstrate CCL5 induction during DILI,identify CCL5 as a novel innate immunity regulator in macrophage polarization,and suggest that CCL5 blockage is a promising therapeutic strategy for the treatment of DILI. | Meng Li Xuehua Sun Jie Zhao Lei Xia Jichang Li Min Xu Bingrui Wang Han Guo Chang Yu Yueqiu Gao Hailong Wu Xiaoni Kong Qiang Xia | 2020 | Cellular & Molecular Immunology2020，17，7： | 13 |
| 2 | A new method of optimum design for valve type hydraulic impacters--the ratio of backhaul velocity C显示文摘 | XU Jichang SHU Dawen | 2003 | Journal of Kunming University of Science and Institute of Technology2003，，3： | 1 |
| 3 | Research on an Intraplate Movement Model by Inversion of GPS Data in North China显示文摘 | Wu Jichang Xu Caijun Chao Dingbo | 2001 | Journal of Geodynamics2001，31，： | 1 |
| 4 | A multicentre randomised trial comparing weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>S-1 with weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>5-fluorouracil for patients with advanced gastric cancer显示文摘 | Dingzhi Huang Yi Ba Jianping Xiong Nong Xu Zhao Yan Zhixiang Zhuang Zhuang Yu Huiping Wan Yang Zhang Ting Deng Rongsheng Zheng Zengqing Guo Chunhong Hu Meiling Wang Zhonghe Yu Yang Yao Jichang Meng | 2013 | European Journal of Cancer2013，，： | 1 |
| 5 | Weak ties: Subtle role of information diffusion in online social networks显示文摘 | Zhao Jichang Wu Junjie Xu Ke | 2010 | Physical Review E2010，82，01： | 1 |
| 6 | Weak ties: subtle role of information diffusion in online social networks显示文摘 | Zhao Jichang Wu Junjie Xu Ke | 2010 | Physical Review E2010，82，1： | 1 |
| 7 | Clinical application of radioimmunoguided surgery in colorectal cancer using125i-labeled carcinoembryonic antigen-specific monoclonal antibody submucosally显示文摘 | Jin Gu M.D. Jun Zhao M.D. Zhenfu Li Ph.D. Zhi Yang Ph.D. Jichang Zhang M.D. Zhian Gao M.D. Yi Wang M.D. Guangwei Xu M.D | 2003 | Diseases of the Colon & Rectum2003，，12： | 1 |
| 8 | The sagittal curving osteotomy: A modified technique for advancement genioplasty 显示文摘 | Jichang Wang Lai Gui Qiaoyan Xu | 2007 | Plast Reconstr&Aesth Surg2007，60，： | 1 |
| 9 | A general law of human mobility显示文摘The intrinsic factors that drive human mobility have remained unclear for decades. Our observations from both intra-urban and inter-urban trips demonstrate a general law of human mobility. Specifically, the probability that a trip will occur is inversely proportional to the size of population located inside a circle with radius equal to the travel distance centered at the trip origin. A simple parameterless rank-based model is presented; this model can predict human flows with a convincing fidelity. Moreover, existing models can be implemented as special cases of our model, suggesting that our model is stable at more spatial scales. Our model also creates a fundamental bridge between individual mobility and social relationships. | LIANG Xiao ZHAO JiChang XU Ke | 2015 | Science China(Information Sciences)2015，58，10： | 1 |
| 10 | Link Prediction in Com- plex Networks : A Clustering Perspective 显示文摘 | Xu Feng Zhao Jichang Xu Ke | 2012 | Physics of Condensed Matter2012，85，1： | 1 |
| 11 | Magnetic nano-beads based separation combined with propidium monoazide treatment and multiplex PCR assay for simultaneous detection of viable Salmonella Typhimurium, Escherichia coli O157:H7 and Listeria monocytogenes in food products显示文摘 | Youjun Yang Feng Xu Hengyi Xu Zoraida P. Aguilar Ruijiang Niu Yong Yuan Jichang Sun Xingyong You Weihua Lai Yonghua Xiong Cuixiang Wan Hua Wei | 2013 | Food Microbiology2013，，2： | 1 |
| 12 | An Empirical Research on Metropolitanization and Housing Price Differentiation Based on the Data of 31 Provincial Capitals and Municipalities with Independent Planning Status in China显示文摘Under the background of population aggregation in megacities,some adjustments are made to the urbanization strategy,whose focus is shifted to the development of megacities and megacity clusters.Meanwhile,the housing price differentiation among cities tends to become increasingly serious.This paper,from the perspective of population mobility,takes provincial capitals and municipalities with independent planning status(PCs&MIPSs)as research samples to evaluate the level of housing price differentiation within provincial-level administrative divisions of China,and analyze from the perspective of demand side how the metropolitanization effects regarding the population formed due to population aggregation in megacities affect the housing prices of megacities and the housing price difference between megacities and other cities.The research found that:1)The increasing net inflow of population boosts the housing prices and accelerate the housing price differentiation;2)The impact of the increasing net inflow of population on housing price increases and housing price differentiation has regional heterogeneity and city size heterogeneity;3)The income gap strengthens the effect of population inflow upon the housing price differentiation. | Shengguo LI Xiaodong DING Shijie XU Jichang DONG Zhi DONG | 2022 | Journal of Systems Science and Information2022，10，5： | 0 |
| 13 | Theoretical insights on the hydration of quinones as catholytes in aqueous redox flow batteries显示文摘Quinones have been widely studied as a potential catholyte in water-based redox flow batteries(RFBs)due to their ability to carry both electrons and protons in aqueous solutions.The wide variety of quinones and derivatives offers exciting opportunities to optimize the device performance while poses theoretical challenges to quantify their electrochemical behavior as required for molecular design.Computational screening of target quinones with high performance is far from satisfactory.While solvation of quinones affects their potential application in RFBs in terms of both electrochemical windows,stability,and charge transport,experimental data for the solvation structure and solvation free energies are rarely available if not incomplete.Besides,conventional thermodynamic models are mostly unreliable to estimate the properties of direct interest for electrochemical applications.Here,we analyze the hydration free energies of more than 1,400 quinones by combining the first-principles calculations and the classical density functional theory.In order to attain chemical insights and possible trends,special attention is placed on the effects of'backbones'and functional groups on the solvation behavior.The theoretical results provide a thermodynamic basis for the design,synthesis,and screening of high-performance catholytes for electrical energy storage. | Jipeng Li Huan Xu Jingqi Wang Yujun Wang Diannan Lu Jichang Liu Jianzhong Wu | 2021 | Chinese Journal of Chemical Engineering2021，34，9： | 0 |
| 14 | Emerging roles of DJ-1 in liver diseases through regulation of oxidative stress and immune response显示文摘Reactive oxygen species(ROS)and immune response play critical roles in the progression of liver diseases.DJ-1,also known as Parkinson disease 7(Park7),is extensively expressed in cells and tissues,where it governs numerous biological functions including chaperone activity,protease function,transcriptional and mitochondrial regulation,and ROS modulation.Moreover,we have established that DJ-1 plays a critical role in initiating an inflammatory response by modulating ROS generation.Therefore,DJ-1 may play an important role in the progression of liver diseases by modulating ROS and the immune response.Recently,we have shown that DJ-1 deficiency negatively regulates proliferation of hepatic progenitor cells(HPCs)by impairing the formation of HPC-associated fibrosis and inflammatory niches.Deficiency of DJ-1 ameliorates liver fibrosis by inhibiting hepatic ROS production and inflammation;moreover,in a classic diethylnitrosamine(DEN)-mediated hepatocellular carcinoma(HCC)mouse model,deletion of DJ-1 ameliorates tumorigenesis and HCC cell proliferation by regulating hepatic inflammation and reducing the activity of the interleukin 6/signal transducer and activator of transcription 3(IL-6/STAT3)signaling pathway.Taken together,these data suggest a critical function for,and therapeutic value of,DJ-1 in treatment of liver diseases.The aim of this review is to summarize these functions and the underlying molecular mechanisms of DJ-1 in liver diseases,and to highlight the potential therapeutic value and future research direction of DJ-1 in liver diseases. | Min Xu Lili Chen Jichang Li Hailong Wu Qiang Xia Xiaoni Kong | 2018 | Liver Research2018，2，2： | 0 |
| 15 | Polar Sea Ice Identification and Classification Based on HY-2A/SCAT Data显示文摘In this paper,a Bayesian sea ice detection algorithm is first used based on the HY-2A/SCAT data,and a backpropagation(BP)neural network is used to classify the Arctic sea ice type.During the implementation of the Bayesian sea ice detection algorithm,linear sea ice model parameters and the backscatter variance suitable for HY-2A/SCAT were proposed.The sea ice extent obtained by the Bayesian sea ice detection algorithm was projected on a 12.5 km grid sea ice map and validated by the Advanced Microwave Scanning Radiometer 2(AMSR2)15%sea ice concentration data.The sea ice extent obtained by the Bayesian sea ice detection al-gorithm was found to be in good agreement with that of the AMSR2 during the ice growth season.Meanwhile,the Bayesian sea ice detection algorithm gave a wider ice edge than the AMSR2 during the ice melting season.For the sea ice type classification,the BP neural network was used to classify the Arctic sea ice type(multi-year and first-year ice)from January to May and October to De-cember in 2014.Comparison results between the HY-2A/SCAT sea ice type and Equal-Area Scalable Earth Grid(EASE-Grid)sea ice age data showed that the HY-2A/SCAT multi-year ice extent variation had the same trend as the EASE-Grid data.Classification errors,defined as the ratio of the mismatched sea ice type points between HY-2A/SCAT and EASE-Grid to the total sea ice points,were less than 12%,and the average classification error was 8.6%for the study period,which indicated that the BP neural network classification was a feasible algorithm for HY-2A/SCAT sea ice type classification. | XU Rui ZHAO Chaofang ZHAI Xiaochun ZHAO Ke SHEN Jichang CHEN Ge | 2022 | Journal of Ocean University of China2022，21，2： | 0 |
| 16 | TREATMENT OF FULMINANT LIVER FAILURE WISTAR RATS WITH IMPLANTED ARTIFICIAL CELLS MICROENCAPSULATED LIVING HEPATOCYTES显示文摘TREATMENTOFFULMINANTLIVERFAILUREWISTARRATSWITHIMPLANTEDARTIFICIALCELLSMICROENCAPSULATEDLIVINGHEPATOCYTESSongJichang,LiTao,XuJ... | Song Jichang, Li Tao, Xu Jianheng,Cui Runhai,Gao Ru, Yang Jun, Li Bing(Tianjin Hepato-Binary Disease Research institute,Tianjin, 300170,China) | 1996 | Chinese Journal of Biomedical Engineering(English Edition)1996，5，4： | 0 |
| 17 | Experimental Study of UDS Solvents for Purifying Highly Sour Natural Gas at Industrial Side-stream Plant显示文摘The desulfurization performance of the UDS solvents was investigated at an industrial side-stream plant and was compared with that of MDEA solvent.A mass transfer performance model was employed for explaining the COS absorption into different solvents.Meanwhile,the regeneration performance of the UDS solvents was evaluated in side-stream tests.Results indicate that under the conditions covering an absorption temperature of 40℃,a pressure of 8.0 MPa,and a gas to liquid volume ratio(V/L)of around 230,the H2S content in purified gas can be reduced to 4.2 mg/m3 and 0 by using solvents UDS-II and UDS-III,respectively.Moreover,the total sulfur content in both purified gases is less than 80 mg/m3.As a result,the UDS-III solvent shows by 30 percentage points higher in COS removal efficiency than MDEA.In addition,the total volume mass transfer coefficient of UDS solvent is found to be twice higher than that of MDEA.Furthermore,the UDS solvents exhibit satisfactory thermal stability and regeneration performance. | Ke Yuan Shen Benxian Sun Hui Liu Jichang Liu Lu Xu Shenyan | 2016 | China Petroleum Processing & Petrochemical Technology2016，18，1： | 0 |
| 18 | Tn5-FISH,a novel cytogenetic method to image chromatin interactions with sub-kilobase resolution显示文摘There is an increasing interest in understanding how three-dimensional(3D)organization of the genome is regulated.Different strategies have been employed to identify genome-wide chromatin interactions.However,due to current limitations in resolving genomic contacts,visualization and validation of these genomic loci with sub-kilobase resolution remain unsolved to date.Here,we describe Tn5 transposase-based Fluorescencein situhybridization(Tn5-FISH),a PCR-based,cost-effective imaging method,which can co-localize the genomic loci with sub-kilobase resolution,dissect genome architecture,and verify chromatin interactions detected by chromatin configuration capture(3C)-derived methods.To validate this method,short-range interactions in keratin-encoding gene(KRT)locus in topologically associated domain(TAD)were imaged by triple-color Tn5-FISH,indicating that Tn5-FISH is very useful to verify short-range chromatin interactions inside the contact domain and TAD.Therefore,Tn5-FISH can be a powerful molecular tool for the clinical detection of cytogenetic changes in numerous genetic diseases such as cancers. | Jing Niu Xu Zhang Li Guipeng Pixi Yan Qing Yan Qionghai Dai Dayong Jin Xiaohua Shen Jichang Wang Michael QZhang Juntao Gao | 2020 | Journal of Genetics and Genomics2020，47，12： | 0 |
| 19 | Study on ELISA for detection of sulfamethazine residues显示文摘In this study,various factors of ELISA for detection of sulfamethazine residues were explored,the coating antigen was diluted to 1:400,the best coating condition was at 4℃overnight,the working concentration of HRP-IgG enzyme conjugate was 1:7 000.The pre-incubation time and incubation time was 30 min and 120 min,respectively,the substrate solution working time was 20 min.Two moL·L^(-1) H_2SO_4 was used to stop the reaction and checked.A standard curve of direct competitive ELISA had been established to detect the sulfamethazine residues in milk.The detection limit of this method was 1.97 ng·mL^(-1).The mean concentration of sulfamethazine required to inhibit 30% antibody was 7.1 ng·mL^(-1).The linear range of the detection was 5-200 ng·mL^(-1). The recovery ratio was between 73.20% and 91.16%.The CV% of within array and between arrays was less than 10%. | LI Jichang HE Liang XU Shiwen HUO Guicheng DING Liangjun LIU Ning | 2007 | Journal of Northeast Agricultural University(English Edition)2007，14，3： | 0 |
| 20 | One-pot synthesis of CoO-ZnO/rGO supported on Ni foam for high-performance hybrid supercapacitor with greatly enhanced cycling stability显示文摘The high specific capacitance along with good cycling stability are crucial for practical applications of supercapacitors,which always demands high-performance and stable electrode materials.In this work,we report a series of ternary composites of CoO-ZnO with different fractions of reduced graphene oxide(rGO)synthesized by in-situ growth on nickel foam,named as CZG-1,2 and 3,respectively.This sort of binder-free electrodes presents excellent electrochemical properties as well as large capacitance due to their low electrical resistance and high oxygen vacancies.Particularly,the sample of CZG-2(CoO-ZnO/rGO 20 mg)in a nanoreticular structure shows the best electrochemical performance with a maximum specific capacitance of 1951.8 F/g(216.9 mAh/g)at a current intensity of 1 A/g.The CZG-2-based hybrid supercapacitor delivers a high energy density up to 45.9 Wh/kg at a high power density of 800 W/kg,and kept the capacitance retention of 90.1%over 5000 charge-discharge cycles. | Mingsheng Xu Mingze Sun Sajidur Rehman Kangkang Ge Xiaolong Hu Haizhen Ding Jichang Liu Hong Bi | 2021 | Chinese Chemical Letters2021，32，6： | 0 |
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