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| 1 | CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization显示文摘Despite the diverse etiologies of drug-induced liver injury(DILI),innate immunity activation is a common feature involved in DILI progression.However,the involvement of innate immunity regulation in inflammation resolution and liver regeneration in DILI remains obscure.Herein,we identified the chemokine CCL5 as a central mediator of innate immunity regulation in the pathogenesis of DILI.First,we showed that serum and hepatic CCL5 levels are elevated in both DILI patients and an APAP-induced liver injury(AILI)mouse model.Interestingly,both nonparenchymal cells and stressed hepatocytes are cell sources of CCL5 induction in response to liver injury.Functional experiments showed that CCL5 deficiency has no effect on the early phase of AILI but promotes liver repair in the late phase mainly by promoting inflammation resolution and liver regeneration,which are associated with an increased number of hepatic M2 macrophages.Mechanistically,CCL5 can directly activate M1 polarization and impede M2 polarization through the CCR1-and CCR5-mediated activation of the MAPK and NF-κB pathways.We then showed that CCL5 inhibition mediated by either a CCL5-neutralizing antibody or the antagonist Met-CCL5 can greatly alleviate liver injury and improve survival in an AILI mouse model.Our data demonstrate CCL5 induction during DILI,identify CCL5 as a novel innate immunity regulator in macrophage polarization,and suggest that CCL5 blockage is a promising therapeutic strategy for the treatment of DILI. | Meng Li Xuehua Sun Jie Zhao Lei Xia Jichang Li Min Xu Bingrui Wang Han Guo Chang Yu Yueqiu Gao Hailong Wu Xiaoni Kong Qiang Xia | 2020 | Cellular & Molecular Immunology2020，17，7： | 13 |
| 2 | Comparison on Adsorptive Separation of n-Paraffins Based on Binderless and Binder-containing Zeolite 5A Pellets显示文摘Binderless zeolite is considered to be a potential alternative for binder-containing zeolite in the industrial applications of adsorptive separation process. Synthesized binderless zeolite and commercial binder-containing product were used in adsorptive separation of n-paraffins from a model oil, with their performance compared. It is indicated that the binderless zeolite exhibits by 25%-35% higher in saturated adsorption capacity and by 115%-130% more adsorption amount at the breakthrough point with much shorter length of mass-transfer zone. Adsorptive separation of n-paraffins from naphtha was carried out in a fixed-bed adsorber containing the synthesized binderless zeolite 5 A under the operating conditions covering a feed space velocity of 90 h-1 and an adsorption temperature of 573 K. As compared to original naphtha, the raffinate shows by 34 units more in research octane number and by around 10% more of potential aromatic content, while the desorption oil exhibits by 13.3% more ethylene yield and by 11.7% higher in total olefins yield. | Kong Ruiqi Jiang Hao Wang Dan Tan Jialun Ren Danni Sun Hui Shen Benxian Liu Jichang Tang Sheng Zhao Deyin Chang Xiaohu | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，4： | 2 |
| 3 | A multicentre randomised trial comparing weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>S-1 with weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>5-fluorouracil for patients with advanced gastric cancer显示文摘 | Dingzhi Huang Yi Ba Jianping Xiong Nong Xu Zhao Yan Zhixiang Zhuang Zhuang Yu Huiping Wan Yang Zhang Ting Deng Rongsheng Zheng Zengqing Guo Chunhong Hu Meiling Wang Zhonghe Yu Yang Yao Jichang Meng | 2013 | European Journal of Cancer2013，，： | 1 |
| 4 | Weak ties: Subtle role of information diffusion in online social networks显示文摘 | Zhao Jichang Wu Junjie Xu Ke | 2010 | Physical Review E2010，82，01： | 1 |
| 5 | Evenness is important in assessing progress towards sustainable development goals显示文摘Sustainable development goals(SDGs)emphasize a holistic achievement instead of cherry-picking a few.However,no assessment has quantitatively considered the evenness among all 17 goals.Here,we propose a systematic method,which first integrates both the evenness and the overall status of all goals,to distinguish the ideal development pathways from the uneven ones and then revisit the development trajectory in China from 2000 to 2015.Our results suggest that,despite the remarkable progress,a bottleneck has occurred in China since 2013 due to the stagnant developments in some SDGs.However,many far-reaching policies in China have been targeting these deficiencies since then,providing a perspective on how a country approaches sustainable development by promoting evenness among all SDGs.Our results also indicate that regions with the slowest progress are the developed provinces,owing to the persistent uneven status of all goals.Our study demonstrates the importance of adopting evenness in assessing and guiding sustainable development. | Yali Liu Jianqing Du Yanfen Wang Xiaoyong Cui Jichang Dong Yanbin Hao Kai Xue Hongbo Duan Anquan Xia Yi Hu Zhi Dong Bingfang Wu Xinquan Zhao Bojie Fu | 2021 | National Science Review2021，8，8： | 1 |
| 6 | Weak ties: subtle role of information diffusion in online social networks显示文摘 | Zhao Jichang Wu Junjie Xu Ke | 2010 | Physical Review E2010，82，1： | 1 |
| 7 | Clinical application of radioimmunoguided surgery in colorectal cancer using125i-labeled carcinoembryonic antigen-specific monoclonal antibody submucosally显示文摘 | Jin Gu M.D. Jun Zhao M.D. Zhenfu Li Ph.D. Zhi Yang Ph.D. Jichang Zhang M.D. Zhian Gao M.D. Yi Wang M.D. Guangwei Xu M.D | 2003 | Diseases of the Colon & Rectum2003，，12： | 1 |
| 8 | Molecular Cloning and Bioinformatics Analysis of T3SS Effector HopPmaJ from Vibrio alginolyticus显示文摘In this paper,the hopPmaJ gene,which encodes type III effector HopPmaJ of Vibrio alginolyticus,was cloned,sequenced and bioinformatically predicted.The results showed that hopPmaJ(GenB ank accession number:KX245315)is 345 bp in length and encodes 114 amino acids,with a theoretical molecular mass of 12.774 kD,and a pI of 4.45.The protein has multiple functional domains and binding sites,but no signal peptide.The tertiary structure of the protein is a homodimer.Based on multiple parameters,the possible dominant B cell antigenic epitopes of HopPmaJ were predicted to be at positions 13-16,29-30,40-42,45-49 and 84-91. | Jingmin ZHAO Mingsheng QIU Huanying PANG Dawei SONG Yunsheng CHANG Yang HUANG Jichang JIAN | 2017 | Agricultural Biotechnology2017，6，4： | 1 |
| 9 | The Effects of Different Ratios of Feldspathic Sandstone and Sand Compound Soil on Water-stable Aggregates in 4 Years Crop Planting显示文摘To study the formation process of feldspathic sandstone and sand compound soil in the Mu Us Desert,1∶ 1,1∶ 2 and 1∶ 5 ratios of feldspathic sandstone and sand were mixed to obtain compound soil to plant crops,and analyze the rules of changes in water-stable aggregates of the compound soil among the 4 years crops growing process. The results showed,before crop planting,the order of mass percent of> 0. 25 mm and 0. 25-2. 00 mm water-stable aggregates in three kinds of compound soil was 1∶ 1 > 1∶ 2 > 1∶ 5,showing that the overall content was low; the mass percent of > 0. 25 mm water-stable aggregates remained at 18. 38%-28. 22%; the mass percent of 0. 25-0. 50 mm,0. 50-2. 00 mm,2. 00-5. 00 mm,and > 5. 00 mm water-stable aggregates was close with each other in each kind of compound soil. After4 years of planting,the mass percent of > 0. 25 mm water-stable aggregates in 1∶ 2 compound soil increased significantly and exceeded other2 kinds of compound soil,reached 32. 34%; the main components of > 0. 25 mm water stable aggregates in 1∶ 1,1∶ 2,and 1∶ 5 compound soil were 0. 25-0. 50 mm( 53. 54%),0. 25-0. 50 mm( 59. 43%),0. 05-2. 00 mm( 52. 16%),aggregates; 0. 25-2. 00 mm aggregates increased significantly in all three kinds of compound soil,with the highest increase in 1∶ 2 compound soil; the organic matters of 1∶ 2 compound soil were significantly correlated with 0. 25-0. 50 mm and 0. 25-2. 00 mm water-stable aggregates. The results showed that the ratio of 0. 25-2. 00 mm aggregates in the three kinds of compound soil was increased after 4 years of crop planting and 1∶ 2 compound soil was most favorable for the formation of aggregates. | Tong ZHAO Jichang HAN Yang ZHANG Huanyuan WANG Xian JI | 2017 | Asian Agricultural Research2017，9，3： | 1 |
| 10 | A general law of human mobility显示文摘The intrinsic factors that drive human mobility have remained unclear for decades. Our observations from both intra-urban and inter-urban trips demonstrate a general law of human mobility. Specifically, the probability that a trip will occur is inversely proportional to the size of population located inside a circle with radius equal to the travel distance centered at the trip origin. A simple parameterless rank-based model is presented; this model can predict human flows with a convincing fidelity. Moreover, existing models can be implemented as special cases of our model, suggesting that our model is stable at more spatial scales. Our model also creates a fundamental bridge between individual mobility and social relationships. | LIANG Xiao ZHAO JiChang XU Ke | 2015 | Science China(Information Sciences)2015，58，10： | 1 |
| 11 | Link Prediction in Com- plex Networks : A Clustering Perspective 显示文摘 | Xu Feng Zhao Jichang Xu Ke | 2012 | Physics of Condensed Matter2012，85，1： | 1 |
| 12 | Polar Sea Ice Identification and Classification Based on HY-2A/SCAT Data显示文摘In this paper,a Bayesian sea ice detection algorithm is first used based on the HY-2A/SCAT data,and a backpropagation(BP)neural network is used to classify the Arctic sea ice type.During the implementation of the Bayesian sea ice detection algorithm,linear sea ice model parameters and the backscatter variance suitable for HY-2A/SCAT were proposed.The sea ice extent obtained by the Bayesian sea ice detection algorithm was projected on a 12.5 km grid sea ice map and validated by the Advanced Microwave Scanning Radiometer 2(AMSR2)15%sea ice concentration data.The sea ice extent obtained by the Bayesian sea ice detection al-gorithm was found to be in good agreement with that of the AMSR2 during the ice growth season.Meanwhile,the Bayesian sea ice detection algorithm gave a wider ice edge than the AMSR2 during the ice melting season.For the sea ice type classification,the BP neural network was used to classify the Arctic sea ice type(multi-year and first-year ice)from January to May and October to De-cember in 2014.Comparison results between the HY-2A/SCAT sea ice type and Equal-Area Scalable Earth Grid(EASE-Grid)sea ice age data showed that the HY-2A/SCAT multi-year ice extent variation had the same trend as the EASE-Grid data.Classification errors,defined as the ratio of the mismatched sea ice type points between HY-2A/SCAT and EASE-Grid to the total sea ice points,were less than 12%,and the average classification error was 8.6%for the study period,which indicated that the BP neural network classification was a feasible algorithm for HY-2A/SCAT sea ice type classification. | XU Rui ZHAO Chaofang ZHAI Xiaochun ZHAO Ke SHEN Jichang CHEN Ge | 2022 | Journal of Ocean University of China2022，21，2： | 0 |
| 13 | Comparative Study on Microstructure and Mechanical Properties of Coarse-grained WC-based Cemented Carbides Sintered with Ultrafine WC or (W+C) as Additives显示文摘The effects of ultrafine WC(WC_(UF),0.5μm) or W(1μm) and C(0.3μm)(W+C)_(UF) additives on the densification,microstructure and mechanical properties of coarse-grained cemented carbides were compared systematically.Overall,the cemented carbides with WC_(UF)/(W+C)_(UF) additives are almost fully densification to be higher than 99%,and the average grain size is kept above 2.8μm.The WC_(UF) additive assists grains to(truncated)trigonal prism shape by two dimensional(2D) growth,whereas the(W+C)_(UF) additive assists grains to rounded shape by three dimensional(3D) growth,lowers WC contiguity and increases face-centered-cubic Co.The hardness and bending strength of(75WC_(C)-15WC_(UF))-10Co are 86.6 HRA and 2 272 MPa,respectively,both higher than those of(75WC_(C)-15(W+C)_(UF))-10Co,which could be ascribed to the enhanced densification and unblemished grains.However,the fracture toughness of the(75WC_(C)-15(W+C)_(UF))-10Co is 23.5 MPa·m^(1/2),higher than that of the(75WC_(C)-15WC_(UF))-10Co due to the uniform WC-Co structure and flexible binder phase. | 于淞百 闵凡路 LI De NOUDEM Guillaume Jacques ZHANG Hailong MA Jichang ZHAO Kui YAO Zhanhu 张建峰 | 2024 | Journal of Wuhan University of Technology(Materials Science)2024，39，2： | 0 |
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