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| 1 | Geochronology and Petrochemistry of Volcanic Rocks in the Xaignabouli Area, NW Laos显示文摘An integrated study of zircon U-Pb geochronology and petrochemistry, together with zircon Lu-Hf isotopes, has been carried out on the basaltic-andesitic tuff and volcanic breccia from the Nam Hang Formation and andesitic tuff from the Muang-Nan Formation in the Xaignabouli area, which had been mapped as the Permian–Early Triassic on the 1 : 1 000 000 geological map or Late Carboniferous on the 1 : 200 000 geological maps. Zircon U-Pb dating of three samples yielded weighted mean ages of 235±2.6, 232±1.4 and 278±2.8 Ma, respectively, suggesting a Late Triassic origin for the Nam Hang Formation and an Early Permian origin for the Muang-Nan Formation. Geochemically, they are characterized by depletions in HFSEs(e.g., Nb, Ta, Ti) and high LILE/HFSE ratios, and they have positive zircon ε_(Hf)(t) values of 8.7–15.9, which exhibits the continental arc volcanic affinity and partial melting of subducting oceanic slab in the magma source. Combined with spatial occurrence of the volcanic rock and existing geochronological and geochemical data, we suggest that the Xaignabouli-Luang Prabang volcanic belt can be linked to the Loei-Phetchabun belt. The Permian–Triassic volcanic rocks in this belt might be a product of the Nan back-arc basin eastward subduction. | Meifeng Shi Zhenbo Wu Shusheng Liu Zhimin Peng Linnan Guo Fei Nie Siwei Xu | 2019 | Journal of Earth Science2019，30，1： | 6 |
| 2 | Geology, Geochronology, and Hf Isotopic Composition of the Pha Lek Fe Deposit, Northern Laos: Implications for Early Permian Subduction-Related Skarn Fe Mineralization in the Truong Son Belt显示文摘The Truong Son metallogenic belt in central Laos and Vietnam is an important Fe-Cu-Sn-Au polymetallic ore district. The Pha Lek Fe deposit is closely related to Late Carboniferous– Early Permian I-type granitic magmatism, and contains >50 Mt @ 45% to 50% of Fe ore. Ore minerals occur mainly as magnetite and hematite in the skarn alteration zone between a granitic pluton and metamorphosed Middle–Upper Devonian carbonates. The granitic pluton comprises granodiorite and granite, with zircon U-Pb dating indicating synchronous emplacement at 288.2±1.3 and 284.9±1.2 Ma, respectively. Zircons from these granitoids have ε_(Hf)(t) values of 2.9–11.2 and relatively young TDM2 ages(<1.0 Ga), indicating an origin by partial melting of depleted mafic crust or magma mixing. Previous studies have shown that these granitoids have high Y, Yb, and K_2O contents, and low Sr and Na_2O contents, which are interpreted as the melting of mafic continental crust. Pyrite of the main mineralization stage yields an ^(187)Re/^(188)Os-^(187)Os/^(188)Os isochron age of 287±17 Ma, indicating that mineralization is associated with Pha Lek granitic magmatism. A Late Carboniferous–Early Permian subduction-related skarn-type Fe mineralization model is proposed for the Pha Lek deposit. More evidence is needed to verify a hypothesis of volcanic overprinting during Late Triassic post-collisional extension. | Lin Hou Shusheng Liu Linnan Guo Fuhao Xiong Chao Li Meifeng Shi Qiming Zhang Siwei Xu Songyang Wu | 2019 | Journal of Earth Science2019，30，1： | 2 |
| 3 | Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level显示文摘Mesenchymal stem cells(MSCs)have been cited as contributors to heart repair through cardiogenic differentiation and multiple cellular interactions,including the paracrine effect,cell fusion,and mechanical and electrical couplings.Due to heart–muscle complexity,progress in the development of knowledge concerning the role of MSCs in cardiac repair is heavily based on MSC–cardiomyocyte coculture.In conventional coculture systems,however,the in vivo cardiac muscle structure,in which rod-shaped cells are connected end-to-end,is not sustained;instead,irregularly shaped cells spread randomly,resulting in randomly distributed cell junctions.Consequently,contact-mediated cell–cell interactions(e.g.,the electrical triggering signal and the mechanical contraction wave that propagate through MSC–cardiomyocyte junctions)occur randomly.Thus,the data generated on the beneficial effects of MSCs may be irrelevant to in vivo biological processes.In this study,we explored whether cardiomyocyte alignment,the most important phenotype,is relevant to stem cell cardiogenic differentiation.Here,we report(i)the construction of a laser-patterned,biochip-based,stem cell–cardiomyocyte coculture model with controlled cell alignment;and(ii)single-cell-level data on stem cell cardiogenic differentiation under in vivo-like cardiomyocyte alignment conditions. | Zhen Ma Qiuying Liu Huaxiao Yang Raymond B Runyan Carol A Eisenberg Meifeng Xu Thomas K Borg Roger Markwald Yifei Wang Bruce Z Gao | 2013 | Light(Science & Applications)2013，2，1： | 2 |
| 4 | Calcium preconditioning inhibits mitochondrial permeability transition and apoptosis 显示文摘 | Xu Meifeng Wang Yigang Kyoji Hirai | 2001 | Am J Physiol Heart Circ Physiol2001，280，2： | 1 |
| 5 | 显示文摘 | Liu Daoping Xu Yi Song Meifeng | 2003 | Energyand the Environment - Proceedings of the International Conference on Energy and the Environment2003，，1： | 1 |
| 6 | Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium显示文摘 | Dongsheng Zhang Guo-Chang Fan Xiaoyang Zhou Tiemin Zhao Zeeshan Pasha Meifeng Xu Yi Zhu Muhammad Ashraf Yigang Wang | 2007 | Journal of Molecular and Cellular Cardiology2007，，2： | 1 |
| 7 | Differentiation of bone marrow stromal cells into the cardiac phenotype requires intercellular communication with myocytes显示文摘 | Maqsood Wani Yan-Shan Dai | 2004 | Circulation2004，110，： | 1 |
| 8 | Bone marrow stem cells prevent left ventricular remodeing of ischenic heart trough paracrine signaling显示文摘 | Meifeng XU | 2006 | Criculation Research2006，98，： | 1 |
| 9 | HIF-1α induced-VEGF overexpression in bone marrow stem cells protects cardiomyocytes against ischemia显示文摘 | Ying Dai Meifeng Xu Yigang Wang Zeeshan Pasha Tingyu Li Muhammad Ashraf | 2007 | Journal of Molecular and Cellular Cardiology2007，，6： | 1 |
| 10 | HIF-1α induced-VEGF overexpression in bone marrow stem cells protects cardiomyocytes against ischemia显示文摘 | DAI Ying XU Meifeng WANG Yiyang | 2007 | J Mol Cell Cardiol2007，42，6： | 1 |
| 11 | Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium显示文摘 | Dongsheng Zhang Guo-Chang Fan Xiaoyang Zhou Tiemin Zhao Zeeshan Pasha Meifeng Xu Yi Zhu Muhammad Ashraf Yigang Wang | 2007 | Journal of Molecular and Cellular Cardiology2007，，2： | 1 |
| 12 | Downregulation of Protein Kinase C Inhibits Activation of Mitochondrial KATP Channels by Diazoxide显示文摘 | Yigang Wang En Takashi Meifeng Xu | 2001 | Circulation2001，104，： | 1 |
| 13 | Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling 显示文摘 | Ryota Uemura Meifeng Xu Nauman Ahmad | 2006 | Circul Res2006，98，： | 1 |
| 14 | Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium显示文摘 | Dongsheng Zhang Guo-Chang Fan Xiaoyang Zhou Tiemin Zhao Zeeshan Pasha Meifeng Xu Yi Zhu Muhammad Ashraf Yigang Wang | 2007 | Journal of Molecular and Cellular Cardiology2007，，2： | 1 |
| 15 | Control of large linear magnetoelectricity in Co_(3)NiNb_(2)O_(9)显示文摘Magnetoelectric(ME)materials have caught worldwide attentions owing to their potential technological applications in ME switching devices or high-density data storage.However,realizing a sufficiently strong ME effect in one single material is always the key issue.Herein,we systematically investigate the Co_(3)NiNb_(2)O_(9),including the characterization of its crystalline structure,magnetism,specific heat,and pyroelectric properties.It is revealed that Co_(3)NiNb_(2)O_(9) exhibits a remarkable ME response below the magnetic phase transition temperature of TN-32 K.On one hand,the magnetic field-induced electric polarization is observed below TN while it is non-ferroelectric at no magnetic field.The evaluated ME coefficient is as large as 21.2 ps/m.On the other hand,the magnetization is significantly modulated by the applied electric field,with the inverse ME coefficient being 14.1 ps/m.The observed ME responses suggest a stable ME mutual control by the magnetic or electric field in Co_(3)NiNb_(2)O_(9). | Xiang Li Yu Wang Meifeng Liu Yunlong Xie Jiahua Min Xiyu Chen Jingwen Gong Leiyu Li Min Zeng Yiming Xu Yiru Wang Biwen Li Xiuzhang Wang Jun-Ming Liu | 2021 | Journal of Materiomics2021，7，4： | 0 |
| 16 | Enhancing tylosin production by combinatorial overexpression of efflux,SAM biosynthesis,and regulatory genes in hyperproducing Streptomyces xinghaiensis strain显示文摘Tylosin is a 16-membered macrolide antibiotic widely used in veterinary medicine to control infections caused by Gram-positive pathogens and mycoplasmas.To improve the fermentation titer of tylosin in the hyperproducing Streptomyces xinghaiensis strain TL01,we sequenced its whole genome and identified the biosynthetic gene cluster therein.Overexpression of the tylosin efflux gene tlrC,the cluster-situated S-adenosyl methionine(SAM)synthetase gene metK_(cs),the SAM biosynthetic genes adoK_(cs)-metFcs,or the pathway-specific activator gene tylR enhanced tylosin production by 18%,12%,11%,and 11%in the respective engineered strains TLPH08-2,TLPH09,TLPH10,and TLPH12.Co-overexpression of metK_(cs)and adoK_(cs)-metFcs as two transcripts increased tylosin production by 22%in the resultant strain TLPH11 compared to that in TL01.Furthermore,combinational overexpression of tlrC,metK_(cs),adoK_(cs)-metFcs,and tylR as four transcripts increased tylosin production by 23%(10.93g/L)in the resultant strain TLPH17 compared to that in TL01.However,a negligible additive effect was displayed upon combinational overexpression in TLPH17 as suggested by the limited increment of fermentation titer compared to that in TLPH08-2.Transcription analyses indicated that the expression of tlrC and three SAM biosynthetic genes in TLPH17 was considerably lower than that of TLPH08-2 and TLPH11.Based on this observation,the five genes were rearranged into one or two operons to coordinate their overexpression,yielding two engineered strains TLPH23 and TLPH24,and leading to further enhancement of tylosin production over TLPH17.In particular,the production of TLPH23 reached 11.35 g/L.These findings indicated that the combinatorial strategy is a promising approach for enhancing tylosin production in high-yielding industrial strains. | Penghui Dai Yuyao Qin Luyuan Li Haidi Li Lihuo Lv Danying Xu Yuqing Song Tingting Huang Shuangjun Lin Zixin Deng Meifeng Tao | 2023 | Synthetic and Systems Biotechnology2023，8，3： | 0 |
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