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| 1 | A randomized controlled clinical trial: Interruption of intrauterine transmission of hepatitis B virus infection with HBIG显示文摘瞄准:与积极 HBeAg 和 HBsAg 在怀孕女人与 HBIG 评估 HBV 的子宫内的感染的打断的功效。方法:未来的使随机化的控制试用被采用。有积极 HBeAg 和 HBsAg 的六十个盒子与包括的标准是重合的,并且 8 个盒子被排除。52 个盒子被分析(在试用的 28 个盒子组织, 24 在控制组织) 。在审判组的所有情况静脉内地收到了 200 IU HBIG 在 3 次从的每 4 wk 28 (th ) wk。控制的盒子以一样的方法组织收到的安慰剂。所有怀孕女人在试用的开始和试用(交货) 的结束为 HBeAg 和 HBV-DNA 被检测。所有新生儿的脐带血为同时检测 HBeAg 和 HBV-DNA 被收集。结果:为在试用组的新生儿的 HBeAg 的调查,新生儿的 28 个盒子中的 6 个有积极 HBeAg,是的 HBeAg 积极的率 21.4% , 95% CI being 的全部的率 8%-41% 。在控制组,新生儿的 24 个盒子中的 19 个有积极 HBeAg, HBeAg 积极的率是 79.2% , 95%CI 的率 5%-93% 。由统计分析, chi (2 )= 17.26, P <
0.01, RR = 0.27, 95% CI (6.3 乘 10 (8.6 乘的 -6), 10 (-5)) 。为在审判组的新生儿的 HBV-DNA 的调查,新生儿的 28 诉讼中的 7 个有积极 HBV-DNA,是的 HBV-DNA 积极的率 25% , 95% CI being 的全部的率 11%-45% 。在控制组,新生儿的 24 个盒子中的 20 个有积极 HBV-DNA, HBV-DNA 积极的率是 83.3% , 95% CI being 的全部的率 63%-95% 。由统计分析, chi (2 )= 17.62, P <
0.01, RR = 0.30, 95% CI (1.5 乘 10 (1.7 乘的 -5), 10 (-4) 。结果显示处于 HBeAg 积极的率和在二个组之间的新生儿的 HBV-DNA 积极的率有有效差量。在试用组, 28 个新生儿中的 7 个有 HBV-DNA 积极,但是新生儿的 HBV-DNA 负担比他们的母亲的低。在控制组, 24 个新生儿中的 20 个仍然有 HBV-DNA 积极,并且新生儿的 HBV-DNA 负担他们的母亲接近了那些。统计分析显示没有 HBIG 干预和他们的子代,在在出生后的女人之间的 HBV-DNA 负担没有有效差量(T = 81.5, P >
0.1 ) 。结论:与 HBIG 阻止 HBV 的子宫内的感染有效、安全 28 (th ) 在有积极 HBeAg 和 HBsAg 的怀孕女人的 wk。在临床的申请,有否定 HBeAg 和积极 HBV-DNA 的那些怀孕女人也需要被 HBIG 打断。 | Qin XH Lin Xi-ao Xiao-Bo Lu Yue-Xin Zhang Xia Cai | 2006 | World Journal of Gastroenterology2006，12，21： | 25 |
| 2 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 3 | Rectification and Rapid Activation at Low Ca^2+ of Ca^2+ -activated,Voltage-dependent BK Currents:Consequences of Rapid Inactivation by a Novel Ⅱ Subunit 显示文摘 | XIA XM DING JP ZENG XH | 2000 | J Neurosci(S0020- 7454)2000，20，： | 1 |
| 4 | Mercury in urban soils with various types of land use in Beijing,China显示文摘 | Chen X Xia XH Wu S | | 0，，： | 1 |
| 5 | A modi fled MELD model for Chinese pre-ACLF and ACLF patients and it reveals poor prognosis in pre-ACLF patients 显示文摘 | Xia Q Dai XH Zhang YM | 2013 | Plos One2013，8，64： | 1 |
| 6 | Ultrasonic synthesis and photocatalytic activity Investigation of TiO2 nano- arrays显示文摘 | Xia XH Luo YS Wang Z | 2007 | Materials Letters2007，61，： | 1 |
| 7 | Real-time detection of gene expression in cancer cells using molecular beacon imaging:new strategies for cancer research显示文摘 | Peng XH Cao ZH Xia JT | 2005 | Cancer Res2005，65，： | 1 |
| 8 | MiR-98 is involved in rat embryo implantation by targeting Bel-xl 显示文摘 | Xia HF Jin XH Cao ZF | 2014 | FEBS Lett2014，588，4： | 1 |
| 9 | Porous anodic alumina with continuously manipulated pore/cell size显示文摘 | Chen W Wu JS Xia XH | | 0，，05： | 1 |
| 10 | Smad2,Smad3 and Smad4 cooperate with Sp1 to induce p15^Ink4B transcription in response to TGF-β显示文摘 | Feng XH Xia L Derynck R | 2000 | EMBO J2000，19，19： | 1 |
| 11 | Temperature effect on the nonvolatile compounds of Maillard reaction products derived fi'om xylose-soybean peptide system: further insights into thermal degradation and cross - linking 显示文摘 | Lan XH Liu P Xia SQ | 2010 | Food Chem2010，120，4： | 1 |
| 12 | Angiotensin II enhances carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbits显示文摘 | Li YL Xia XH Zheng H | 2006 | Cardiovasc Res2006，71，1： | 1 |
| 13 | Medical Document Clustering Using Ontolo gy-Based Term Similarity Measures显示文摘 | Zhang XD Jing LP Hu XH NG MK Xia JL Zhou XH | 2008 | International Journal of Data Warehousing&Mining2008，4，1： | 1 |
| 14 | Cellular modeling and simulation of brugada syndrome 显示文摘 | L XIA Y ZHANG XH LU | 2005 | IEEE Computers in Cardiology2005，32，： | 1 |
| 15 | Multiple regulatory sites in large conductance calcium-activated potassium channels 显示文摘 | Xia XM Zeng XH Lingle CJ | 2002 | Nature2002，418，： | 1 |
| 16 | MicroRNA expression and regula, tion in the uterus during embryo implantation in rat 显示文摘 | Xia HF Jin XH Cao ZF | 2014 | FEBS J2014，281，7： | 1 |
| 17 | Distribution of PAEs in the middle and lower reaches of the Yellow River 显示文摘 | Sha YJ Xia XH Yang ZF | 2007 | Environ Monit Assess2007，124，13： | 1 |
| 18 | Rectification and rapid activation at low Ca^2+ of Ca^2+ -activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit显示文摘 | Xia XM Ding JP Zeng XH | 2000 | J Neurosci2000，20，13： | 1 |
| 19 | BK Channels with b3a subunits generate Use-Dependent slow after hyperpolarizing Currents by an inactivation-coupled mechanism 显示文摘 | Zeng XH Benzinger GR Xia XM | 2007 | Neuroscience2007，27，17： | 1 |
| 20 | Temporal and spatial regulation of let-7a in the uterus during embryo implantation in the rat 显示文摘 | Xia HF Jin XH Song PP | 2010 | J Reprod Dev2010，56，1： | 1 |
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