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1篇 您的检索式：作者名="Xian Weirvei"

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		题名	作者	年代	出处	被引量
	1	Intellectual disability-related chromatin regulator Brpfl affects electrophysiological feature of hippocampal neurons and related pathways显示文摘Intellectual disability(ID)is a prevalent neurodevelopmental disorder,affecting 1%-2%of children.Recent researches revealed that haploinsufficiency of Brpf1 could result in ID.Hippocampus plays important roles in learning and memory which are impaired in people with ID.To study the roles of Brpf1 in hippocampus,we investigated the morphology,electrophysiology and molecular mechanism in both cultured mouse hippocampal neurons by infecting with AAV-shBrpf1 virus and in mouse model by injecting into hippocampal CA1 area with AAV-shBrpf1 virus.The results showed that knockdown of Brpf1(at about 50%)reduced the mEPSC frequency and amplitude of cultured hippocampal neurons,though it had no effects on the morphology of these neurons;reduced expression of Brpf1 also downregulated the mRNA level of Syt4,Grik3 and Neurod6,which involved in neuronal excitability;knockdown of Brpf1 in mouse hippocampal CA1 region led to increased expression of Cxcl10,which was related with the death and apoptosis of hippocampal neurons.Conclusively,our study found that reduced expression of Brpf1 affected the mEPSC frequency and ampltude of hippocampal neurons as well as dysregulate molecular pathways,which shed new light on Brpfl's role in ID.	Xian Weirvei Yuan Xiangshan Cao Jingli Zhou Gruomin You Linya	2021	解剖学杂志2021，44，S01：	0

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