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| 1 | On a novel multi - swarm fruit fly optimization algorithm and its application显示文摘 | Xiaofang Yuan Xiangshan Dai Jingyi Zhao Qian He | 2014 | Applied Mathematics and Computation2014，，： | 1 |
| 2 | On a Novel Multi-swarm Fruit Fly Optimization Algorithm and Its Application 显示文摘 | Yuan Xiaofang Dai Xiangshan Zhao Jingyi | 2014 | Applied Mathematics and Computa-tion2014，233，3： | 1 |
| 3 | Intellectual disability-related chromatin regulator Brpfl affects electrophysiological feature of hippocampal neurons and related pathways显示文摘Intellectual disability(ID)is a prevalent neurodevelopmental disorder,affecting 1%-2%of children.Recent researches revealed that haploinsufficiency of Brpf1 could result in ID.Hippocampus plays important roles in learning and memory which are impaired in people with ID.To study the roles of Brpf1 in hippocampus,we investigated the morphology,electrophysiology and molecular mechanism in both cultured mouse hippocampal neurons by infecting with AAV-shBrpf1 virus and in mouse model by injecting into hippocampal CA1 area with AAV-shBrpf1 virus.The results showed that knockdown of Brpf1(at about 50%)reduced the mEPSC frequency and amplitude of cultured hippocampal neurons,though it had no effects on the morphology of these neurons;reduced expression of Brpf1 also downregulated the mRNA level of Syt4,Grik3 and Neurod6,which involved in neuronal excitability;knockdown of Brpf1 in mouse hippocampal CA1 region led to increased expression of Cxcl10,which was related with the death and apoptosis of hippocampal neurons.Conclusively,our study found that reduced expression of Brpf1 affected the mEPSC frequency and ampltude of hippocampal neurons as well as dysregulate molecular pathways,which shed new light on Brpfl's role in ID. | Xian Weirvei Yuan Xiangshan Cao Jingli Zhou Gruomin You Linya | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 4 | Isolation and cloning of a new gene encoding maize initiation factor显示文摘It was demonstrated that parental gene expression of maize in hybrid genetic background was different from that in their inbred lines. RTPCR revealed a cDNA overexpressed in hybrid maize. The cDNA was reamplified and used to screen a corresponding cDNA library. A full length of a cDNA insert ZH01 was isolated and shown to have an open reading frame encoding 414a.a. Sequence comparison shows that ZH01 has extremely high similarity with the previously reported plant initiator factor elF4A and distinct difference from another maize elF4A gene MIF4A. Overexpression of ZH01 in hybrid may involve vigorous growth of hybrid maize seedlings. | Hu Jianguang Zhao Xiangshan Yuan Ziqiang Qian Xiaoying Yang Jinshui | 1998 | Chinese Science Bulletin1998，43，4： | 0 |
| 5 | Analysis of cellular diversity and transcriptional regulatory network in human basal ganglia by single cell and bulk RNA sequencing显示文摘The basal ganglia is a critical subcortical nuclei in several parallel and closed circuits,which mainly modulate thalamus-cortex activity.Dysfunction in any one of these loops connecting cortex can lead to movement and/or mood disorders.To understand cellular complexity,differential gene expression and transcriptional regulatory network of human basal ganglia under normal condition,we performed single cell RNA sequencing of 2424 cells sampled from the basal ganglia of human postmortem brains including caudate,putamen,substantia nigra and globus pallidus. | Li Fengjiao Mohammadi H.B.Asad Yuan Xiangshan Xian Weiwei Liu Qiong Li Wensheng Zhou Guomin Wang Edwin You Linya | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 6 | Understandingnormal and diseased human basal ganglia using combinatory indexing single nuclei RNA sequencing显示文摘With the advent of single cell technology and its rapid applications in the biomedical field,it becomes possible to identify,categorize and characterize each single cell in the brain.Shanghai Brain Bank is accumulating donorbrains very fast(estimately 80 brains till now)from people with normal aging or various neurodegenerative diseases.The basal ganglia is critical for movement control,behavior,cognition,emotion and reward.Many neurodegenerative diseases are related to the abnormality or aging of human basal ganglia.Single nuclei transcriptomic profiles of both normal and diseased human basal ganglia are still sparse.In our study,we systematically examined different nuclei(caudate,putamen,globus pallidus,and substantia nigra)in human basal ganglia from 6 control and 5 diseased donors(2 psychiatric diseases,2 PD and 1 AD)using combinatory indexing single nuclei RNA sequencing.Gene expression was measured on a total of 22309 control and 42590 diseased single cells. | Li Fengjiao Li Peilong Yuan Xiangshan Xian Weiwei Liu Qiong Li Wensheng Zhu Ying You Linya | 2021 | 解剖学杂志2021，44，S01： | 0 |
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