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| 1 | Serological Investigation of Laboratory-Confirmed and Suspected Ebola Virus Disease Patients During the Late Phase of the Ebola Outbreak in Sierra Leone显示文摘This study aimed to investigate the serological characteristics of Ebola virus(EBOV) infection during the late phase of the Ebola outbreak in Sierra Leone. In total, 877 blood samples from 694 suspected Ebola virus disease(EVD) cases assessed from March to December 2015, were analyzed via real-time reverse transcription polymerase chain reaction(RT-PCR) for viral RNA and enzyme-linked immunosorbent assay(ELISA) and Luminex to detect antibodies against EBOV. Viral load and EBOV-specific IgM/IgG titers displayed a declining trend during March to December 2015. Viral RNA load decreased rapidly at earlier stages after disease onset, while EBOV-specific IgM and IgG still persisted in 58.1%(18/31) and 93.5%(29/31) of the confirmed EVD patients and in 3.8%(25/663) and 17.8%(118/663) of the RNA-negative suspected patients in the later phase, respectively. Dynamic analysis of longitudinally collected samples from eight EVD patients revealed typically reversed trends of declining viral load and increasing IgM and/or IgG titers in response to the EBOV infection.The present results indicate that certain populations of Sierra Leone developed immunity to an EBOV infection in the late phase of the outbreak, providing novel insights into the risk assessment of EBOV infections among human populations. | Yang Liu YuLan Sun Wei Wu AQian Li XianDa Yang Shuo Zhang Chuan Li QiuDong Su ShaoJian Cai DaPeng Sun HaiYang Hu Zhe Zhang XiuXu Yang Idrissa Kamara Sheku Koroma Gerald Bangura Alie Tia Abdul Kamara Matt Lebby Brima Kargbo Jiandong Li Shiwen Wang XiaoPing Dong YueLong Shu WenBo Xu George F. Gao GuiZhen Wu DeXin Li William J. Liu MiFang Liang | 2018 | Virologica Sinica2018，33，4： | 2 |
| 2 | Direction-of-arrival estimation based on the joint diagonalization structure of multiple fourth-order cumulant matrices显示文摘 | ZENG Wenjun LI Xilin ZHANG Xianda | 2009 | IEEE Signal Processing Letters2009，16，3： | 1 |
| 3 | Nonorthogonal joint diagonalization free of degenerate solution显示文摘 | LI Xilin ZHANG Xianda | 2007 | IEEE Transactions on Signal Processing2007，55，5： | 1 |
| 4 | A family of generalized constant modulus algorithms for blind equalization显示文摘 | Li Xilin Zhang Xianda | 2006 | IEEE Trans on Communications2006，54，11： | 1 |
| 5 | Numerical mtatel for the zonal disinte~ation of the rock massaround deep underground workings 显示文摘 | LI Shucai FEN( Xianda LI Shuchen | 2013 | Theoretical and Applied Fracture Mechanics2013，67，5： | 1 |
| 6 | Nonorthogonal joint diagonalization free of degenerate solution显示文摘 | LI XILIN ZHANG XIANDA | 2007 | IEEE Transactions on Signal Processing2007，55，5： | 1 |
| 7 | Hybrid iterative decoding for low- density parity-check codes based on finite Geometries 显示文摘 | Li Jian Zhang Xianda | 2008 | IEEE CommunLett2008，12，1： | 1 |
| 8 | Blind adaptive multiuser detection based on affine projection algorithm 显示文摘 | Li J Zhang Xianda | 2005 | IEEE Signal Processing Letters2005，12，10： | 1 |
| 9 | A family of generalized constant modulus algorithms for blind equalization显示文摘 | LI Xilin ZHANG Xianda | 2006 | IEEE Transactions On Cummunications2006，54，11： | 1 |
| 10 | Direction-of-arrival estimation based on the joint diagonalization structure ofmultiple fourth-order cumulant matrices显示文摘 | Zeng Wenjun Li Xilin Zhang Xianda | 2009 | IEEE Signal Processing Letters2009，16，3： | 1 |
| 11 | Direction-of-arrival estimation based on the joint diagonalization structure of multiple fourth-order cumulant matrices 显示文摘 | ZENG WENJUN LI XILIN ZHANG XIANDA | 2009 | IEEE Transactions on Signal Processing Letters2009，16，3： | 1 |
| 12 | Direction of arrival estimation based on the joint diagonalization tructure of multiple fourth order cumulant matrices显示文摘 | ZENG Wenjun LI Xilin ZHANG Xianda | 2009 | IEEE Transactions on Signal Processing2009，6，3： | 1 |
| 13 | The Regulatory Effect of Braided Silk Fiber Skeletons with Differential Porosities on In Vivo Vascular Tissue Regeneration and Long-Term Patency显示文摘The development of small-diameter vascular grafts that can meet the long-term patency required for implementation in clinical practice presents a key challenge to the research field.Although techniques such as the braiding of scaffolds can offer a tunable platform for fabricating vascular grafts,the effects of braided silk fiber skeletons on the porosity,remodeling,and patency in vivo have not been thoroughly investigated. | Xili Ding Weirong Zhang Peng Xu Wentao Feng Xiaokai Tang Xianda Yang Lizhen Wang Linhao Li Yan Huang Jing Ji Diansheng Chen Haifeng Liu Yubo Fan | 2023 | Research2023，，2： | 0 |
| 14 | Analysis on Meteorological Conditions of Winter Cold Injury of Sugar Orange Industry in Guilin显示文摘Yield and quality of sugar orange are closely related to meteorological conditions,especially the low temperature and cold injury in mature period of fruit. To study the influence of winter cold injury on sugar orange industry of Guilin,the chilling injury weather in each county of Guilin planting sugar orange is analyzed,and the disastrous cold weather and its defense measures are studied. Frost,freezing and cold wave happen in Guilin winter sometimes,and the disastrous weather could seriously harm maturing sugar orange or that in the tree,causing peel coke,dehiscent fruit,fruit drop and quality decline. It can effectively reduce the loss by chilling injury and guarantee excellent quantity and high yield of sugar orange by timely understanding weather change information,scientifically managing water and fertilizer,and doing film cover well. | Liao Rongshun Wu Xiulian Li Zhongbo Wang Ling Su Hangzhou Bai Xianda | 2017 | Meteorological and Environmental Research2017，8，3： | 0 |
| 15 | miR-30a-5p/PHTF2 axis regulates the tumorigenesis and metastasis of lung adenocarcinoma显示文摘Background:Lung adenocarcinoma is a very pervasive histological form of lung cancers,and inhibiting metastasis is crucial for effective treatment.In this investigation,we explored the functional interaction of miR-30a-5p and the putative transcription factor 2 of the homeodomain(PHTF2)in dictating the aggressiveness and metastasis of lung adenocarcinoma.Method:We collected clinical samples to evaluate the expression patterns of miR-30a-5p and PHTF2 in lung adenocarcinoma along with normal tissues.Cellular experiments including cell count kit(CCK)-8 growth assay,apoptosis analysis,migration and invasion examinations were performed to assess the aggressiveness of lung adenocarcinoma cells.Furthermore,we examined tumorigenesis and metastasis in a nude mouse model.Results:MiR-30a-5p exhibited downregulation pattern in lung adenocarcinoma samples.Transfection of miR-30a-5p mimic in lung adenocarcinoma cells resulted in the suppression of malignant characteristics.Notably,the administration of miR-30a-5p mimic also curbed tumorigenesis and metastasis of lung adenocarcinoma cells in animal model.Moreover,PHTF2 was found to be a molecular target of miR-30a-5p.Upregulating PHTF2 counteracted the tumor-suppressive effect of the miR-30a-5p mimic.Conclusion:miR-30a-5p functions as a tumor-suppressive molecule while PHTF2 acts as an oncogenic factor in the development and metastasis of lung adenocarcinoma.Therefore,targeting miR-30a-5p and PHTF2 could be developed into a promising therapeutic approach for inhibiting metastasis in lung adenocarcinoma. | LIJUAN ZHANG QINGYIN MENG LI ZHUANG QUAN GONG XIANDA HUANG XUEQIN LI SHIJUAN LI GUOQIN WANG XICAI WANG | 2024 | BIOCELL2024，48，4： | 0 |
| 16 | Effects of Dietary Picria felterrae Lour Extracts on Serum Biochemical Indexes and Immune Function of Guangxi Partridge Chickens显示文摘[Objective] This trial was to investigate the effect of dietary Picria felterrae Lour extracts on serum biochemical indexes and immune function of Guangxi Partridge chickens. [Method] Totally 500 individuals of 1-day-old Guangxi Partridge chickens were randomly divided into five groups, five replicates each group and 20 chicks each replicate. Groups A, B and C were treatment groups supplemented with 0.70%, 0.35% and0.175% P. felterrae extracts in the basal diet, respectively; group D was a medical control group supplemented with 0.01% colistin sulfate premix in the basal diet; and group E was a control group with basal diet. Serum samples were collected from 10 chickens in each group at 21, 35 and 49 days of age, to analyze the biochemical and immune indexes. [Result] It had no significant impact on serum TP and GLU contents of chickens by adding different levels of P. felterrae extracts in the basal diet(P >0.05). However, at 21 and 35 days of age, the TBILI content of chickens in groups A, B and C were extremely lower or significantly lower than that in group E( P<0.01; P<0.05). At 35 days of age, the serum AKP activities in groups A, B and C were extremely higher than that in group E(P<0.01), and the serum GOT activities at 21 and 35 days of age in group C were significantly higher than that in group E(P<0.05). At 49 days of age, the serum Ig G content in groups A, B and C and the IL-2 content in group B and group C were significantly lower or extremely lower than that in group E( P<0.05; P<0.01); the T-AOC content in group B was significantly higher than that in group E(P<0.05); the GSH content in groups A, B and C were significantly higher than that in group E( P<0.05). Adding different levels of P. felterrae extracts in the diet significantly decreased the TBILI content, reduced the Ig G, IL-2 and IL-6 contents, and improved the AKP and GOT activities and the T-AOC and GSH contents of Guangxi Partridge chicken. [Conclusion] Adding 0.35% P. felterrae extracts in the basal diet received the best effort. | Yang Cui Bi Xianda Hu Tingjun Yang Jian Huang Hongye Tan Honglian Peng Jianbo Luo Wenjuan Li Lu Li Chunjie Liao Yuying Yang Jiahuang | 2018 | Animal Husbandry and Feed Science2018，10，1： | 0 |
| 17 | Blind Equalization Based on Evolution Strategies显示文摘BlindEqualizationBasedonEvolutionStrategiesSongYuZhangXiandaLiYanda(DeptAutomation,TsinghuaUniversity,Beijing100084)AbstractC... | Song Yu Zhang Xianda Li Yanda (Dept Automation,Tsinghua University, Beijing 100084) | 1997 | 通信学报1997，18，3： | 0 |
| 18 | Free-walking:Pedestrian inertial navigation based on dual foot-mounted IMU显示文摘The inertial navigation system(INS),which is frequently used in emergency rescue operations and other situations,has the benefits of not relying on infrastructure,high positioning frequency,and strong real-time performance.However,the intricate and unpredictable pedestrian motion patterns lead the INS localization error to significantly diverge with time.This paper aims to enhance the accuracy of zero-velocity interval(ZVI)detection and reduce the heading and altitude drift of foot-mounted INS via deep learning and equation constraint of dual feet.Aiming at the observational noise problem of low-cost inertial sensors,we utilize a denoising autoencoder to automatically eliminate the inherent noise.Aiming at the problem that inaccurate detection of the ZVI detection results in obvious displacement error,we propose a sample-level ZVI detection algorithm based on the U-Net neural network,which effectively solves the problem of mislabeling caused by sliding windows.Aiming at the problem that Zero-Velocity Update(ZUPT)cannot suppress heading and altitude error,we propose a bipedal INS method based on the equation constraint and ellipsoid constraint,which uses foot-to-foot distance as a new observation to correct heading and altitude error.We conduct extensive and well-designed experiments to evaluate the performance of the proposed method.The experimental results indicate that the position error of our proposed method did not exceed 0.83% of the total traveled distance. | Qu Wang Meixia Fu Jianquan Wang Lei Sun Rong Huang Xianda Li Zhuqing Jiang Yan Huang Changhui Jiang | 2024 | Defence Technology(防务技术)2024，33，3： | 0 |
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