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| 1 | Relationship between Expression of CEA,E-cadherin and Liver Metastasis in Colorectal Cancer显示文摘OBJECTIVE To investigate the expression of E-cadherin andCEA in serum in colorectal carcinoma and their relationship withliver metastasis.METHODS CEA level was measured post-operativelyby radioimmunoassay of 60 patients with colorectal cancer.Immunohistochemical analysis was used to evaluate theexpression of E-cadherin.RESULTS In liver metastasis group,24 patients (24/26,92.3%)were high level of CEA,but only 9 patients in non-liver metastasisgroup.The difference is significant (P=0.004).Expression ofE-cadherin significantly correlated with differentiation,but wasnot associated with Tstage or N stage.Liver metastatic rate innegative expression was higher than that in positive expression.And the survival analysis showed that time of liver metastasis wassignificant different in two groups (P<0.05).CONCLUSION The expression of CEA in serum can be usedto predict liver mestatasis of colorectal cancer after operation.E-cadherin,associated with tumor differentiation,is also a hopefulindicator for the prediction of liver metastasis in patients withcolorectal cancer. | Ning Li Xiaobing Chen Xiangbin Wan Suxia Luo Lili Han Mengqiang Zhou Dengwen Yin Li Zhang | 2008 | Chinese Journal of Clinical Oncology2008，5，6： | 2 |
| 2 | Loss-of-function of KMT5B leads to neurodevelopmental disorder and impairs neuronal development and neurogenesis显示文摘Autism spectrum disorder(ASD)is a group of neurodevelopmental disorders that cause severe social,communication,and behavioral problems.Recent studies show that the variants of a histone methyltransferase gene KMT5B cause neurodevelopmental disorders(NDDs),including ASD,and the knockout of Kmt5b in mice is embryonic lethal.However,the detailed genotype-phenotype correlations and functional effects of KMT5B in neurodevelopment are unclear.By targeted sequencing of a large Chinese ASD cohort,analyzing published genome-wide sequencing data,and mining literature,we curated 39 KMT5B variants identified from NDD individuals.A genotype-phenotype correlation analysis for 10 individuals with KMT5B pathogenic variants reveals common symptoms,including ASD,intellectual disability,languages problem,and macrocephaly.In vitro knockdown of the expression of Kmt5b in cultured mouse primary cortical neurons leads to a decrease in neuronal dendritic complexity and an increase in dendritic spine density,which can be rescued by expression of human KMT5B but not that of pathogenic de novo missense mutants.In vivo knockdown of the Kmt5b expression in the mouse embryonic cerebral cortex by in utero electroporation results in decreased proliferation and accelerated migration of neural progenitor cells.Our findings reveal essential roles of histone methyltransferase KMT5B in neuronal development,prenatal neurogenesis,and neuronal migration. | Guodong Chen Lin Han Senwei Tan Xiangbin Jia Huidan Wu Yingting Quan Qiumeng Zhang Bin Yu Zhengmao Hu Kun Xia Hui Guo | 2022 | Journal of Genetics and Genomics2022，49，9： | 1 |
| 3 | Influence of Sc Addition on Precipitation Behavior and Properties of Al-Cu-Mg Alloy显示文摘In this study, the Al-5.10Cu-0.65 Mg alloys without and with 0.2 wt% Sc addition were prepared to unveil the effect of Sc on the precipitate behavior and properties by atomic-scale scanning transmission electron microscopy. The results show that addition of Sc is able to significantly suppress the formation of the peak-hardening θ’ and S precipitates but in favor of stabilizing Guinier–Preston–Bagaryatsky(GPB) zones during isothermal aging at 180 ℃. The generation of unique GPB precursors dictating the evolution of the subsequent peak-hardening GPB zones is highly correlated with the insufficient vacancies and dragging effect of Sc to Cu in the Al-Cu-Mg-Sc alloy, thereby restricting the nucleation of θ′ and S precipitates owing to the decreased available Cu solutes. In property, 0.2 wt% Sc addition can not only enhance the corrosion resistance but also the electrical conductivity of the peak-hardening alloy. In addition, the peak-hardening Al-Cu-Mg-Sc alloy is also featured with increased strength without losing the ductility compared to its solid solution state. Further analyses indicate that the improved properties are essentially attributed to the formation of densely distributed strain-free GPB zones and smaller precipitate-free zones. The obtained results could provide a potential design strategy of high-performance alloys by Sc addition. | Xiangbin Han Shuangbao Wang Bo Wei Shuai Pan Guizhen Liao Weizhou Li Yuezhou Wei | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，6： | 1 |
| 4 | Fe-based amorphous coating prepared using high-velocity oxygen fuel and its corrosion behavior in static lead-bismuth eutectic alloy显示文摘The Fe_(949.7)Cr_(18)Mn_(1.9)Mo_(7.4)W_(1.6)B_(15.2)C_(3.8)Si_(2) amorphous coating was deposited on T91 steel substrate by using the high-velocity oxygen fuel(HVOF)spray technique to enhance the corrosion resistance of T91 stainless steel in liquid lead-bismuth eutectic(LBE).The corrosion behavior of the T91 steel and coating exposed to oxygen-saturated LBE at 400℃ for 500 h was investigated.Results showed that the T91 substrate was severely corroded and covered by a homogeneously distributed dual-layer oxide on the interface contacted to LBE,consisting of an outer magnetite layer and an inner Fe-Cr spinel layer.Meanwhile,the amorphous coating with a high glass transition temperature(Tg=550℃)and crystallization temperature(T_(x)=600℃)exhibited dramatically enhanced thermal stability and corrosion resistance.No visible LBE penetration was observed,although small amounts of Fe_(3)O_(4),Cr_(2)O_(3),and PbO were found on the coating surface.In addition,the amorphicity and interface bonding of the coating layer remained unchanged after the LBE corrosion.The Fe-based amorphous coating can act as a stable barrier layer in liquid LBE and have great application potential for long-term service in LBE-cooled fast reactors. | Xiangyang Peng Yuhai Tang Xiangbin Ding Zhichao Lu Shuo Hou Jianming Zhou Shuyin Han Zhaoping Lü Guangyao Lu Yuan Wu | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，11： | 1 |
| 5 | Corrosion and irradiation behavior of Fe-based amorphous coating in lead-bismuth eutectic liquids显示文摘Lead-bismuth eutectics (LBE) have considerable potential as a candidate material for accelerator-driven sub-critical systems(ADS).However,LBE corrosion and irradiation damage are two urgent challenges remaining to be solved for impellers of primary pumps.In this study,we have explored the possibility of using Fe-based amorphous coatings to overcome LBE corrosion and concurrently to sustain irradiation damage.Specifically,the Fe_(54)Cr_(18)Mo_(2)Zr_(8)B_(18)amorphous coating was prepared by high-velocity oxygen-fuel (HVOF) spraying on 316L steel and exposed to saturated oxygen static LBE for 500 h at 400℃.The coating with high thermal stability (T_(g)=615℃ and T_(x)=660℃) effectively prevented the substrate steel from being corroded by LBE owing to its unique long-range disordered atomic packing.The coating also exhibited strong irradiation resistance when being subjected to 45 dpa (displacement per atom) Au ion irradiation at room temperature,with no sign of crystallization even at the maximum implantation depth of 300 nm.Consequently,the hardness of the coatings before and after irradiation increased slightly.The current findings shed new insights into understanding corrosion mechanism and irradiation behavior of amorphous solids in LBE and expand the application range of amorphous materials. | LU ZhiChao PENG Xiang Yang TANG YuHai HAN ShuYin WU Yuan FU EnGang DING XiangBin HOU Shuo LU GuangYao CAO PeiPei ZHANG YiBo LIU XiongJun MA Dong WANG Hui JIANG SuiHe LU ZhaoPing | 2022 | Science China(Technological Sciences)2022，65，2： | 1 |
| 6 | Outcomes of Self-Expanding Transcatheter Pulmonary Valves:Extended Follow-Up of a Prospective Trial显示文摘Background:The Venus-P valve was the first self-expanding valve used world-wide for transcatheter pulmonary valve replacement(TPVR)in patients with severe pulmonary regurgitation(PR).We intended to report the extended follow-up results from the prospective trial(No.NCT02590679).Methods:A total of 38 patients with severe PR(mean age 24.2±13.2)were included.Follow-up data were obtained after implanted at 1,6,and 12 months and yearly after.The frame geometry was assessed on post-implant computer tomography(CT)scanning by calculating the non-circularity[circularity ratio(minimum diameter/maximum diameter)<0.9]and under-expansion[expansion ratio(derived external valve area/nominal external valve area)<0.9).Adverse events(all-cause mortality,reintervention,valve dysfunction,stent fracture and endocarditis)were recorded.Results:All valves were implanted successfully with normal function at discharge.Geometric CT analysis showed underexpanded valve was detected in 22 patients(63%)and non-circular valve was seen in 16 patients(46%).During a median follow-up of 4.8 years(range 0.3-8.1),there were 1 death and 1 surgical explant,both resulting from endocarditis.Five-year freedom from valve dysfunction and stent fracture were 84.8%(95%CI 74.8-94.7)and 83.5%(95%CI 73.8-93.2).Endocarditis occurred in 3 patients at a median time of 7 months.Stent fracture was more common in patients with non-circularity stents.Conclusion:TPVR using Venus-P valve is associated with favorable outcomes at 5 years.Non-circular shapes in the valve level may have a higher risk of stent fracture. | Jingnan Zhang Junyi Wan Yihang Li Yu Han Jiahua Pan Fang Fang Shiliang Jiang Xiangbin Pan Gejun Zhang | 2023 | Congenital Heart Disease2023，18，2： | 0 |
| 7 | Rare inherited missense variants of POGZ associate with autism risk and disrupt neuronal development显示文摘Excess de novo likely gene-disruptive and missense variants within dozens of genes have been identified in autism spectrum disorder(ASD)and other neurodevelopmental disorders.However,many rare inherited missense variants of these high-risk genes have not been thoroughly evaluated.In this study,we analyzed the rare missense variant burden of POGZ in a large cohort of ASD patients from the Autism Clinical and Genetic Resources in China(ACGC)and further dissected the functional effect of diseaseassociated missense variants on neuronal development.Our results showed a significant burden of rare missense variants in ASD patients compared to the control population(P=4.6×10-5,OR=3.96),and missense variants in ASD patients showed more severe predicted functional outcomes than those in controls.Furthermore,by leveraging published large-scale sequencing data of neurodevelopmental disorders(NDDs)and sporadic case reports,we identified 8 de novo missense variants of POGZ in NDD patients.Functional analysis revealed that two inherited,but not de novo,missense variants influenced the cellular localization of POGZ and failed to rescue the defects in neurite and dendritic spine development caused by Pogz knockdown in cultured mouse primary cortical neurons.Significantly,L1CAM,an autism candidate risk gene,is differentially expressed in POGZ deficient cell lines.Reduced expression of L1cam was able to partially rescue the neurite length defects caused by Pogz knockdown.Our study showed the important roles of rare inherited missense variants of POGZ in ASD risk and neuronal development and identified the potential downstream targets of POGZ,which are important for further molecular mechanism studies. | Wenjing Zhao Jieqiong Tan Tengfei Zhu Jianjun Ou Ying Li Lu Shen Huidan Wu Lin Han Yanling Liu Xiangbin Jia Ting Bai Honghui Li Xiaoyan Ke Jingping Zhao Xiaobing Zou Zhengmao Hu Hui Guo Kun Xia | 2019 | Journal of Genetics and Genomics2019，46，5： | 0 |
| 8 | Command filter-based I&I adaptive control for MIMO uncertain systems with input saturation and disturbances显示文摘This paper develops a control strategy based on immersion and invariance(I&I)adaptive methodology for a class of multi-input multi-output(MIMO)systems in the presence of parametric uncertainty,input saturation,and external disturbance.To avoid the analytic calculation in the backstepping process,a highgain auxiliary system is constructed to compensate for the effect of command filter error.The first-order command filters are also employed in the construction procedure of the I&I adaptive law to simplify its design and remove the structural conditions on the regressors.A filter-based disturbance observer is developed to counteract the effect of the external disturbance produced by a partially known exogenous system.To overcome the input saturation nonlinearity,a smooth function is introduced to approximate the input saturation with an extended state and a bounding estimation law.Stringent analysis guarantees the stability of closed-loop system.Finally,simulated examples confirm the effectiveness of the suggested method. | Qi Han Zhitao Liu Hongye Su Xiangbin Liu | 2023 | Science China(Information Sciences)2023，66，12： | 0 |
| 9 | Effect of Shoot-Fruit Ratio on Grape Yield,Quality and Storage Nutrient显示文摘With the grape variety ' Summer Black' as the test material,the effects of different shoot-fruit ratios on grape yield,fruit quality and grapevine storage nutrient were investigated for 2 consecutive years,so as to determine the optimized load for Summer Black grapes in Shandong. The results showed that the grapes with shoot-fruit ratio of 1∶ 1 had the highest soluble solid content,vitamin C content and grapevine storage nutrient. Based on the comprehensive analysis,the shootfruit ratio of 1∶ 1 was the optimized load for Summer Black grapes in Tai'an of Shandong Province,and the yield was 1 179. 37-1 288. 63 kg per 667 m^2. | Zhen HAN Xiujie LI Qingtian ZHANG Xiangbin SHI Haibo WANG Bo LI | 2018 | Agricultural Biotechnology2018，7，5： | 0 |
| 10 | The sex determination gene doublesex is required during adulthood to maintain sexual orientation显示文摘Gender differences in behavior are prevalent among animal kingdoms. The causal links among a particular gene, neural circuitry, and gendered behaviors have long been of particular interest in neuroscience. The fruit fly, Drosophila melanogaster, is a wonderful animal model with fruitful genetic tools to tackle these questions(Guo et al., 2019). It has been found that two sex determination genes,fruitless(fru) and doublesex(dsx), jointly govern the sex differences in the nervous system that regulate the male-specific courtship behavior(Burtis and Baker, 1989;Ito et al., 1996;Ryner et al. | Qionglin Peng Jiangtao Chen Xiangbin Su Rong Wang Caihong Han Yufeng Pan | 2022 | Journal of Genetics and Genomics2022，49，2： | 0 |
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