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| 1 | Correlation of radiotherapy with prognosis of elderly patients with hormone receptor-positive breast cancer according to immunohistochemical subtyping显示文摘Objective: The present study examined the effect of radiotherapy on recurrence and survival in elderly patients with hormone receptor-positive early breast cancer.Methods: A retrospective analysis of 327 patients aged ≥65 years, with stage I-II, hormone receptor-positive breast cancer who underwent breast-conserving surgery and received endocrine therapy(ET) or radiotherapy plus endocrine therapy(ET+RT) was performed. Both groups were divided into luminal A type and luminal B type subgroups. Evaluation criteria were 5-year disease-free survival(DFS), local relapse rate(LRR), overall survival(OS), and distant metastasis rate(DMR).Results: There were significant differences in 5-year DFS [hazard ratio(HR)=1.59, 95% confidence interval(95% CI), 1.15-2.19;P=0.005] and LRR(HR=3.33, 95% CI, 1.51-7.34;P=0.003), whereas there were no significant differences in OS and DMR between ET group and ET+RT group. In luminal A type, there was no significant difference in 5-year DFS, LRR, OS and DMR between ET group and ET+RT group. In luminal B type,there were statistically significant differences in 5-year DFS(HR=2.19, 95% CI, 1.37-3.49;P=0.001), LRR(HR=5.45, 95% CI, 1.65-17.98;P=0.005), and OS(HR=1.75, 95% CI, 1.01-3.05;P=0.048) between ET group and ET+RT group. In the ET group, there were significant differences between luminal A type and luminal B type in5-year DFS(HR=1.84, 95% CI, 1.23-2.75;P=0.003) and OS(HR=1.76, 95% CI, 1.07-2.91;P=0.026).Conclusions: After breast-conserving surgery, radiotherapy can reduce the LRR and improve the DFS and OS of luminal B type elderly patients, whereas luminal A type elderly patients do not benefit from radiotherapy.Without radiotherapy, luminal A type patients have better DFS and OS than luminal B type patients. | Xiangcheng Zhi Xiaonan Yang Teng Pan Jingjing Liu Xiao Chen Liping Lou Zhendong Shi Jin Zhang | 2019 | Chinese Journal of Cancer Research2019，31，3： | 2 |
| 2 | Oligomers from the Synthetic Polymers:Another Potential Iceberg of New Pollutants显示文摘Pollution generated by synthetic polymers,particularly plastics,has become a significant global environmental problem.However,when compared to polymer-derived products like microplastics,oligomers have not received the attention they deserve.Oligomers are by-products of polymer production and intermediates of degradation.Despite the industrial advancements leading to an exponential increase in the production of new polymers,a majority of oligomers have remained inadequately researched.While the exposure and toxic effects of polylactic acid oligomers have been documented,the structures and fundamental properties of oligomers derived from most polymers are still poorly understood.This knowledge gap presents challenges in establishing effective analytical methods.Considering the potential of oligomers to act as new pollutants,it is imperative to investigate their environmental behavior,as well as their absorption,distribution,metabolism,excretion,and toxicity(ADMET)properties.This perspective highlights the research gap concerning oligomers. | Changzhi Shi Mengjing Wang Zimeng Wang Guangbo Qu Wei Jiang Xiangcheng Pan Mingliang Fang | 2023 | Environment & Health2023，1，4： | 0 |
| 3 | Application of Stone Landscape Materials in Liberation Park of Wuhan显示文摘With the continuous development of landscape design,landscape materials are also constantly enriched.The application and development of stone as an ancient material is constantly developing with the human’s increasing understanding on landscapes.Through investigating the application of stone materials in the landscape industry,this paper finds that the application of stone is mostly in the field of architecture and that the standard reference for the field of landscape garden is not perfect.Therefore,this paper takes Liberation Park in Wuhan for example to investigate and study the application of stone in landscape design,which can provide useful guidance for more scientific and rational selection of stone materials in the process of landscape design and construction. | ZHANG Xinyang PAN Xiangcheng HU Xinyue | 2019 | Journal of Landscape Research2019，11，5： | 0 |
| 4 | Photocatalytic Metal-Free Radical Hydrosilylation for Polymer Functionalization显示文摘Comprehensive Summary,Post-modification of polymers offers a route to prepare functionalized polymers through efficient chemical reactions,and hydrosilylation is one of the most effective strategies.Silane-functionalized polymers have found a wide range of potential applications,such as adhesives,rubbers,and drug delivery agents.For decades,the hydrosilylation for the post-modification of polymers has typically used transition metals as catalysts.Metal-free hydrosilylation strategies that can avoid metal residues in polymers are largely lacking in this field.Herein,we report the photocatalytic metal-free radical hydrosilylation strategy for the post-modification of polymers bearing pendant vinyl groups using the organic photocatalyst and hydrogen atom transfer(HAT)catalyst under blue light irradiation.We used monofunctional silanes to functionalize polymers and the bis(silane)s as crosslinkers to prepare crosslinked polymers. | Zhujun Huang Kaiwen Liu Mingyuan Liu Jie Yun Jin Dong Zhe Chen Zhikang Xie Xiangcheng Pan | 2023 | Chinese Journal of Chemistry2023，41，18： | 0 |
| 5 | High-throughput screening and evaluation of repurposed drugs targeting the SARS-CoV-2 main protease显示文摘Dear editor,To date,a number of clinically approved drugs have been evaluated for potential to treat coronavirus disease 2019(COVID-19),such as lopinavir/ritonavir,hydroxychloroquine,cobicistat,and darunavir.Some of these drugs have been proven to be effective in vitro;however,clinical trials showed that none of these compounds led to a significant improvement in symptoms or length of hospitalization.Thus,it is essential and more reliable to start from a defined target to ide ntify can didate drugs. | Yan Li Jinyong Zhang Zilei Duan Ning Wang Xiangcheng Sun Yanjing Zhang Li Fu Kaiyun Liu Yongjun Yang Shulei Pan Yun Shi Hao Zeng Gang Guo Ren Lai Quanming Zou | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
| 6 | Feasibility of Improving Unmanned Aerial Vehicle-Based Seeding Efficiency by Using Rice Varieties with Low Seed Weight显示文摘Unmanned aerial vehicle(UAV)has offered a promising platform for rice direct seeding that can substantially reduce labor input in the crop establishment process.However,the insufficient payload capacity of UAV-based seeders is currently limiting its intensive and large-scale use for rice direct seeding.This study indicated a large variation in seed weight across varieties,ranging from 15.0 to 36.5 mg and 14.0 to 31.3 mg for inbred and hybrid varieties,respectively,with average seed weights of 25.3 mg for inbred and 24.7 mg for hybrid varieties.Seed weights of 160 out of 4106 inbred varieties and 17 out of 311 hybrid varieties ranged from 15.0 to 20.0 mg. | WANG Xinyu YANG Guodong PAN Xiangcheng XIANG Hongshun PENG Shaobing XU Le | 2022 | Rice science2022，29，4： | 0 |
| 7 | Galerkin-based quasi-smooth manifold element(QSME)method for anisotropic heat conduction problems in composites with complex geometry显示文摘The accurate and efficient analysis of anisotropic heat conduction problems in complex composites is crucial for structural design and performance evaluation. Traditional numerical methods, such as the finite element method(FEM), often face a trade-off between calculation accuracy and efficiency. In this paper, we propose a quasi-smooth manifold element(QSME) method to address this challenge, and provide the accurate and efficient analysis of two-dimensional(2D) anisotropic heat conduction problems in composites with complex geometry. The QSME approach achieves high calculation precision by a high-order local approximation that ensures the first-order derivative continuity.The results demonstrate that the QSME method is robust and stable, offering both high accuracy and efficiency in the heat conduction analysis. With the same degrees of freedom(DOFs), the QSME method can achieve at least an order of magnitude higher calculation accuracy than the traditional FEM. Additionally, under the same level of calculation error, the QSME method requires 10 times fewer DOFs than the traditional FEM. The versatility of the proposed QSME method extends beyond anisotropic heat conduction problems in complex composites. The proposed QSME method can also be applied to other problems, including fluid flows, mechanical analyses, and other multi-field coupled problems, providing accurate and efficient numerical simulations. | Pan WANG Xiangcheng HAN Weibin WEN Baolin WANG Jun LIANG | 2024 | Applied Mathematics and Mechanics(English Edition)2024，45，1： | 0 |
| 8 | Organoboron chemistry towards controlled and precise polymer synthesis显示文摘Organoboron reagents have garnered considerable attention due to their distinct properties. In recent years, boronic acids and boronate esters have been important intermediates for cross-coupling reactions and other functional group construction and are often used to synthesize small organic molecules, drugs, and bioactive substances. In this feature article, we encapsulate the strategy of harnessing the unique properties of organoboron reagents to overcome challenges encountered in conventional polymer synthesis. We delve into the synthesis of boron-containing monomers and polymer materials, unraveling the unique attributes of these newfound polymers while offering innovative insights into their application within recyclable or reprocessable materials. We develop organoboron-based photocatalysts, employing their inner-sphere electron transfer(ISET) mechanisms to initiate controlled radical polymerization. We utilize alkylborane to initiate controlled radical polymerization and further designed B-alkylcatecholboranes to prepare ultra-high molecular weight polymers. Notably, we also propose a liquid-phase synthesis method based on organoboron tags and apply it to the precise synthesis of sequence-controlled conjugated polymers.These advancements open up new frontiers in the realm of polymer science, and the versatility and potential of organoboron reagents in polymer synthesis continue to inspire exciting research endeavors. | Yuxuan Du Jin Dong Chaoran Xu Xiangcheng Pan | 2023 | Science China Chemistry2023，66，12： | 0 |
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