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| 1 | FGF23 and Phosphate Wasting Disorders显示文摘A decade ago,only two hormones,parathyroid hormone and 1,25(OH)2D,were widely recognized to direct-ly affect phosphate homeostasis.Since the discovery of fibroblast growth factor 23(FGF23) in 2000(1),our understanding of the mechanisms of phosphate homeostasis and of bone mineralization has grown exponentially.FGF23 is the link between intestine,bone,and kidney together in phosphate regulation.However,we still do not know the complex mechanism of phosphate homeostasis and bone mineralization.The physiological role of FGF23 is to regulate serum phosphate.Secreted mainly by osteocytes and osteo-blasts in the skeleton(2-3),it modulates kidney handling of phosphate reabsorption and calcitriol produc-tion.Genetic and acquired abnormalities in FGF23 structure and metabolism cause conditions of either hyper-FGF23 or hypo-FGF23.Hyper-FGF23 is related to hypophosphatemia,while hypo-FGF23 is related to hyperphosphatemia.Both hyper-FGF23 and hypo-FGF23 are detrimentalto humans.In this review,we will discuss the pathophysiology of FGF23 and hyper-FGF23 related renal phosphate wasting disorders(4). | Xianglan Huang Yan Jiang Weibo Xia | 2013 | Bone Research2013，1，2： | 9 |
| 2 | Concerted regulation on vertical orientation and film quality of two-dimensional ruddlesden-popper perovskite layer for efficient solar cells显示文摘Recently,the two-dimensional(2D)ruddlesden-popper(RPP)perovskite has been successfully attracting great attention owing to their excellent electronic property and superior ambient stability.But 2D perovskite solar cells(PVSCs)with insulating large cations show a worse performance than three-dimensional(3D)PVSCs in general because of the worse charge transportation.In this work,dimethyl sulfoxide(DMSO)and KI were incorporated simultaneously to produce a synergistic effect on both film quality and orientation of 2D perovskite.With this strategy,a cavity-free 2D perovskite film was formed with vertically oriented crystal,and high quality film was obtained with decreased defects and increased crystallinity.Besides,profitable multiple phases were obtained for better spontaneous carrier separation and transportation.The 2D PVSCs based on(PEA)2(MA)n−1PbnI3n+1(n=5)delivered a higher power conversion efficiency(PCE)of 13.4%.In addition,the perovskite with KI and DMSO contained more stable low-dimension phase at the bottom of perovskite film,which could act as a barrier to prevent moisture from further eroding internal perovskites.The optimized 2D PVSCs remained 90%of the PCE after being exposed in air(50%–60%humidity,room temperature)with a continuous illumination for 300 h. | Xianglan Tang Xueying Wang Ting Hu Qingxia Fu Xiaotian Hu Zengqi Huang Shuqin Xiao Yiwang Chen | 2020 | Science China Chemistry2020，63，11： | 1 |
| 3 | The novel peptide Nb PPI1 identified from Nicotiana benthamiana triggers immune responses and enhances resistance against Phytophthora pathogens显示文摘In plants, recognition of small secreted peptides, such as damage/danger-associated molecular patterns(DAMPs), regulates diverse processes,includingstressandimmune responses. Here, we identified an SGPS(Ser-Gly-Pro-Ser) motif-containing peptide, Nicotiana tabacum NtPROPPI, and its two homologs in Nicotiana benthamiana, NbPROPPI1 and NbPROPPI2. Phytophthora parasitica infection and salicylic acid(SA) treatment induced NbPROPPI1/2 expression. Moreover, SignalP predicted that the 89-amino acid NtPROPPI includes a 24-amino acid N-terminal signal peptide and NbPROPPI1/2-GFP fusion proteins were mainly localized to the periplasm. Transient expression of NbPROPPI1/2 inhibited P.parasiticacolonization,andNbPROPPI1/2 knockdown rendered plants more susceptible to P. parasitica. An eight-amino-acid segment in the NbPROPPI1 C-terminus was essential for its immune function and a synthetic 20-residue peptide, NbPPI1, derived from the C-terminus of NbPROPPI1 provoked significant immune responses in N. benthamiana. These responses led to enhanced accumulation of reactive oxygen species, activation of mitogen-activated protein kinases, and up-regulation of the defense genes Flg22-induced receptor-like kinase(FRK) and WRKY DNA-binding protein 33(WRKY33). The NbPPI1-induced defense responses require Brassinosteroid insensitive1-associated receptor kinase 1(BAK1). These results suggest that NbPPI1 functions as a DAMP in N. benthamiana;this novel DAMP provides a potentially useful target for improving plant resistance to Pytophthora pathogens. | Qujiang Wen Manli Sun Xianglan Kong Yang Yang Qiang Zhang Guiyan Huang Wenqin Lu Wanyue Li Yuling Meng Weixing Shan | 2021 | Journal of Integrative Plant Biology2021，63，5： | 1 |
| 4 | On the monolayer dispersion behavior of Co_(3)O_(4)on HZSM-5 support:designing applicable catalysts for selective catalytic reduction of nitrogen oxides by ammonia显示文摘Based on monolayer dispersion theory,Co_(3)O_(4)/ZSM-5 catalysts with different loadings have been prepared for selective catalytic reduction of nitrogen oxides by ammonia.Co_(3)O_(4)can spontaneously disperse on HZSM-5 support with a monolayer dispersion threshold of 0.061 mmol 100 m^(-2),equaling to a weight percentage around 4.5%.It has been revealed that the quantities of surface active oxygen(O_(2)^(-))and acid sites are crucial for the reaction,which can adsorb and activate NO_(x)and NH_(3)reactants effectively.Below the monolayer dispersion threshold,Co_(3)O_(4)is finely dispersed as sub-monolayers or monolayers and in an amorphous state,which is favorable to generate the two kinds of active sites,hence promoting the performance of ammonia selective catalytic reduction of nitrogen oxide.However,the formation of crystalline Co_(3)O_(4)above the capacity is harmful to the reaction performance.4%Co_(3)O_(4)/ZSM-5,the catalyst close to the monolayer dispersion capacity,possesses the most abundant active O_(2)^(-)species and acidic sites,thereby demonstrating the best reaction performance in all the samples.It is proposed the optimal Co_(3)O_(4)/ZSM-5 catalyst can be prepared by loading the capacity amount of Co_(3)O_(4)onto HZSM-5 support. | Yufeng Yang Lihong Zhang Tao Song Yixing Huang Xianglan Xu Junwei Xu Xiuzhong Fang Qing Wang Haiming Liu Xiang Wang | 2023 | Frontiers of Chemical Science and Engineering2023，17，11： | 0 |
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