|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer显示文摘Objective:To compare the efficacy and safety of hyperthermic intravesical chemotherapy(HIVEC)and intravesical chemotherapy(IVEC)in patients with intermediate and high risk nonmuscle-invasive bladder cancer(NMIBC)after transurethral resection.Methods:We included 560 patients diagnosed with primary or recurrent NMIBC between April 2009 and December 2015 at 1 of 6 tertiary centers.We matched 364 intermediate or high risk cases and divided them into 2 groups:the HIVEC+IVEC group[chemohyperthermia(CHT)composed of 3 consecutive sessions followed by intravesical instillation without hyperthermia]and the IVEC group(intravesical instillation without hyperthermia).The data were recorded in the database.The primary endpoint was 2-year recurrence-free survival(RFS)in all NMIBC patients(n=364),whereas the secondary endpoints were the assessment of radical cystectomy(RC)and 5-year overall survival(OS).Results:There was a significant difference in the 2-year RFS between the two groups in all patients(n=364;HIVEC+IVEC:82.42%vs.IVEC:74.18%,P=0.038).Compared with the IVEC group,the HIVEC+IVEC group had a lower incidence of RC(P=0.0274).However,the 5-year OS was the same between the 2 groups(P=0.1434).Adverse events(AEs)occurred in 32.7%of all patients,but none of the events was serious(grades 3–4).No difference in the incidence or severity of AEs between each treatment modality was observed.Conclusions:This retrospective study showed that HIVEC+IVEC had a higher 2-year RFS and a lower incidence of RC than IVEC therapy in intermediate and high risk NMIBC patients.Both treatments were well-tolerated in a similar manner. | Qiang Ruan Degang Ding Bin Wang Chaohong He Xuequn Ren Zhenhua Feng Zhigang Pang Jin Wang Xiangliang Zhang Hongsheng Tang Jiahong Wang Qingjun He Ziying Lei Quanxing Liao Jiali Luo Shuzhong Cui | 2021 | Cancer Biology & Medicine2021，18，1： | 4 |
| 2 | Genetic Transformation of Chinese Cabbage (Brassica rapa pekinensis) with Floral-dip Method显示文摘[Objective] This study is aimed to transform gus gene into Chinese cabbage (Brassica rapa pekinensis) by floral-dip method. [Method] The Chinese cabbage was transformed by floral-dip method for the first time. Then the cabbage seeds were harvested and screened by hygromycin, and the plants with resistance were confirmed by histochemical GUS assay and PCR detection. [Result] The target gene was successfully integrated into the Chinese cabbage genome, and the transformation rate was 0.1%. [Conclusion] This study optimized the genetic transformation system for Chinese cabbage, and laid the foundation for improving the means of genetic transformation of Chinese cabbage. | Yang GAO Xiangliang REN Songlin RUAN Huoxu WANG | 2012 | Agricultural Biotechnology2012，1，4： | 2 |
| 3 | RNA interference mediated knockdown of three putative aminopeptidases N af- fects susceptibility of Spodoptera exigua larvae to Bacillus thuringiensis CrylCa 显示文摘 | Ren Xiangliang Ma Yan Cui Jinjie | 2014 | Journal of Insect Physiology2014，67，： | 1 |
| 4 | Effect of scutellarin on nitric oxide production in early stages of neuron damage induced by hydrogen peroxide 显示文摘 | Hong Liu Xiangliang Yang Ren Tang | 2005 | Pharmacological Research2005，51，3： | 1 |
| 5 | Enhanced anticancer effect of doxorubicin by TPGS-coated liposomes with Bcl-2 siRNA-corona for dual suppression of drug resistance显示文摘Multiple drug resistance(MDR)is a tough problem in developing hepatocellular carcinoma(HCC)therapy.Here,we developed TPGS-coated cationic liposomes with Bcl-2 siRNA corona to load doxorubicin(Dox)i.e.,Bcl-2 siRNA/Dox-TPGS-LPs,to enhance anticancer effect of Dox in HCC-MDR.TPGS i.e.,d-α-tocopheryl polyethylene glycol 1000 succinate,inhibited Pglycoprotein(P-gp)efflux pump and Bcl-2 siRNA suppressed anti-apoptotic Bcl-2 protein.The Bcl-2 siRNA loaded in the liposomal corona was observed under transmission electron microscopy.The stability and hemolysis evaluation demonstrated Bcl-2 siRNA/Dox-TPGSLPs had good biocompatibility and siRNA-corona could protect the liposomal core to avoid the attachment of fetal bovine serum.In drug-resistant cells,TPGS effectively prolonged intracellular Dox retention time and siRNA-corona did improve the internalization of Dox from liposomes.In vitro and in vivo anticancer effect of this dual-functional nanostructure was examined in HCC-MDR Bel7402/5-FU tumor model.MTT assay confirmed the IC50 value of Dox was 20–50 fold higher in Bel7402/5-FU MDR cells than that in sensitive Bel7402 cells.Bcl-2 siRNA corona successfully entered the cytosol of Bel7402/5-FU MDR cells to downregulate Bcl-2 protein levels in vitro and in vivo.Bcl-2 siRNA/Dox-TPGS-LPs showed superior to TPGS-(or siRNA-)linked Dox liposomes in cell apoptosis and cytotoxicity assay in Bel7402/5-FU MDR cells,and 7-fold greater effect than free Dox in tumor growth inhibition of Bel7402/5-FU xenograft nude mice.In conclusion,TPGS-coated cationic liposomes with Bcl-2 siRNA corona had the capacity to inhibit MDR dual-pathways and subsequently improved the anti-tumor activity of the chemotherapeutic agent co-delivered to a level that cannot be achieved by inhibiting a MDR single way. | Yinghuan Li Xi Tan Xuhan Liu Lingyan Liu Yan Fang Rong Rao Yuanyuan Ren Xiangliang Yang Wei Liu | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，5： | 1 |
| 6 | Effect of scutellarin on nitric oxide production in early stages of neuron damage induced by hydrogen peroxide显示文摘 | Liu Hong Yang Xiangliang Ren Tang | 2005 | Pharmacological Research2005，51，3： | 1 |
| 7 | Effects of Erigeron breviscapus ethanol extract on neuronal oxidative injury induced by superoxide radical显示文摘 | Liu Hong Yang Xiangliang Ren Tang | 2005 | Fitoterapia2005，76，78： | 1 |
| 8 | Nickel-decorated TiO2 nanotube arrays as a self-supporting cathode for lithium-sulfur batteries显示文摘Lithium-sulfur batteries are considered to be one of the strong competitors to replace lithium-ion batteries due to their large energy density.However,the dissolution of discharge intermediate products to the electrolyte,the volume change and poor electric conductivity of sulfur greatly limit their further commercialization.Herein,we proposed a self-supporting cathode of nickel-decorated TiO2 nanotube arrays(TiO2 NTs@Ni)prepared by an anodization and electrodeposition method.The TiO2 NTs with large specific surface area provide abundant reaction space and fast transmission channels for ions and electrons.Moreover,the introduction of nickel can enhance the electric conductivity and the polysulfide adsorption ability of the cathode.As a result,the TiO2 NTs@Ni-S electrode exhibits significant improvement in cycling and rate performance over TiO2 NTs,and the discharge capacity of the cathode maintains 719 mA·h·g−1 after 100 cycles at 0.1 C. | Yuming Chen Wenhao Tang Jingru Ma Ben Ge Xiangliang Wang Yufen Wang Pengfei Ren Ruiping Liu | 2020 | Frontiers of Materials Science2020，14，3： | 0 |
| 9 | The immune-chemo-embolization effect of temperature sensitive gold nanomedicines against liver cancer显示文摘Although transcatheter arterial chemo-embolization(TACE)plays a key role on clinical treatment of hepatocellular carcinoma(HCC),it was greatly limited by the poor synergistic effect between chemotherapeutics and physical embolization to tumor-feeding arteries.In the present work,a temperature sensitive polymer poly(N-isopropylacrylamide-b-methacrylic acid)(PNA),which was modified with gold nanoparticles(AuNP@PNA),was successfully used to encapsulate doxorubicin(DOX)by electrostatic binding with their carboxyl groups.The resultant gold nanomedicines(AuNP@PNA/DOX)exhibited temperature responsive sol-gel phase transition,favorable shear thinning effect and X-ray angiography.By in vivo evaluation of vascular embolization on VX2-tumor-bearing rabbits,AuNP@PNA/DOX exhibited far better antitumor efficacy than Lipiodol/DOX,on either tumor growth inhibition,proliferation,apoptosis,necrosis or anti-metastasis.Owing to sufficient embolization to tumor vascular networks,AuNP@PNA/DOX down-regulated the expression levels of HIF-1α,VEGF and MMP-9,and prompted more efficient activation on CD3+/CD8+T cells and the related cytokines,suggesting the synergistic effect between AuNP@PNA and DOX on the improvement of post-operative tumor immunosuppressive microenvironment.With their favorable pharmcokinetics and biocompatibility,AuNP@PNA/DOX is promising to be developed as a multi-functional artery-imaging/embolic agent with immune-chemo-embolization for enhancing TACE efficacy on HCC. | Yiming Liu Dingwen Shi Yanqiao Ren Ling Li Yanbing Zhao Chuansheng Zheng Xiangliang Yang | 2023 | Nano Research2023，16，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员