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| 1 | Petrogenesis of the Neopro-terozoic bimodal volcanic rocks along the western margin of the Yangtze Block:New constraints from Hf isotopes and Fe/Mn ratios显示文摘High-precision major element and Hf isotope data are reported for the Neoproterozoic Suxiong volcanic rocks along the western margin of the Yangtze Block. These volcanic rocks have variable εHf(T) values and Fe/Mn ratios. The relatively primitive basalts have high Fe/Mn ratios and high Hf-Nd isotopic compositions, indicating that they were generated by partial melting of garnet clinopyroxene in mantle plume at high pressure. Thus, the Suxiong basalts are genetically related to the proposed Neoproterozoic super-plume. On the contrary, a few differentiated basalts have low Fe/Mn ratios and low Hf-Nd isotopic compositions. They are likely to experience assimilation-fractional crystallization process. The Suxiong rhyolites have consistent Hf and Nd model ages of 1.3―1.4 Ga. They are likely generated by shallow dehydration melting of pre-existing young arc igne-ous rocks associated with the basaltic underplating/intrusion in a continental rift. | LI Xianhua QI Changshi LIU Ying LIANG Xirong TU Xianglin XlE Liewen YANG Yueheng | 2005 | Chinese Science Bulletin2005，50，21： | 91 |
| 2 | Effects of free ammonia on volatile fatty acid accumulation and process performance in the anaerobic digestion of two typical bio-wastes显示文摘The effect of free ammonia on volatile fatty acid(VFA)accumulation and process instability was studied using a lab-scale anaerobic digester fed by two typical bio-wastes:fruit and vegetable waste(FVW)and food waste(FW)at 35°C with an organic loading rate(OLR)of 3.0 kg VS/(m^3·day). The inhibitory effects of free ammonia on methanogenesis were observed due to the low C/N ratio of each substrate(15.6 and 17.2,respectively). A high concentration of free ammonia inhibited methanogenesis resulting in the accumulation of VFAs and a low methane yield. In the inhibited state,acetate accumulated more quickly than propionate and was the main type of accumulated VFA. The co-accumulation of ammonia and VFAs led to an 'inhibited steady state' and the ammonia was the main inhibitory substance that triggered the process perturbation. By statistical significance test and VFA fluctuation ratio analysis,the free ammonia inhibition threshold was identified as 45 mg/L. Moreover,propionate,iso-butyrate and valerate were determined to be the three most sensitive VFA parameters that were subject to ammonia inhibition. | Xuchuan Shi Jia Lin Jiane Zuo Peng Li Xiaoxia Li Xianglin Guo | 2017 | Journal of Environmental Sciences2017，29，5： | 24 |
| 3 | The late Paleoproterozoic extension event:aulacogens and dyke Swarms in the North China craton显示文摘在北方中国 Craton (NCC ) 的延期结构和构造牵连基于 mafic 塘群和地球年代学在这篇论文被讨论,与 aulacogens 的地球年代学结合。迟了的 Paleoproterozoic 时间是在 NCC 的前寒武纪的进化的重要拐弯处点。延期系统(例如 aulacogens 和塘群) 在 NCC 是普遍的,它与类似于现代的板的僵硬特征标记 NCC 的碳化。当模特儿的 paleostress 地建议塘聚集, aulacogens 是标记超级大陆,不是 synorogenic 的开始的 arogenic 扩展和 postorogenic 扩展。在 NCC 的 mafic 塘群主要从 1.83 ~ 1.77 Ga 。NCC 的延期是很有限的易碎的扩展,平均延期比率仅仅是 0.35% 由 mafic 塘群延期计算给,大多数在 NCC 的扩展被 aulacogens 因此贡献。mafic 塘群在起源与 aulacogens 被联系。 | HOU Guiting LI Jianghai LIU Yulin QIAN Xianglin | 2006 | Progress in Natural Science:Materials International2006，16，2： | 13 |
| 4 | Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial显示文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. | Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying Cheng Jie Li Lu Wen Xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang | 2019 | Cancer Communications2019，39，1： | 8 |
| 5 | Quantification of coarse aggregate shape in concrete显示文摘这研究的目的是为大规模申请为总数形式和角的描述选择索引。为这个目的,为在以前的研究展示的总数形式和角的几个参数被介绍。然后基于这些确定的参数, 200 粗糙石英岩总数被使用图象处理此处分析技术。这篇论文也象在形式和角参数之间的关联一样为总数形式和角分析参数的统计分布。为粗糙的总数的形式或角的参数能被正常分发或木头正常分发在 95% 信心水平适合,这被决定。当使用的方面比率和角构画出斜坡,区域比率和半径角索引,和方面比率时,一些形式参数被变化在角特征影响,角索引分别地独立于对方;并且因而,独立参数能被用来确定为目的总数形式和角在水泥的机械行为上塑造学习总数的影响。而且,源于这深入的调查显示出的研究方面比率和角索引能分别地在具体机械性质上推进粗糙的总数形式和角的效果的理解。最后,有一样的内容,类型和表面质地,而是不同方面比率和角的粗糙的总数索引被用来在水泥的行为上学习粗糙的总数形式和角的影响。这被揭示切开水泥的张力的力量随方面比率或粗糙的总数的角索引的增加增加了。 | Xianglin GU Yvonne TRAN Li HONG | 2014 | Frontiers of Structural and Civil Engineering2014，8，3： | 6 |
| 6 | Multiple Components are Integrated to Determine Leaf Complexity in Lotus japonicus显示文摘Transcription factors and phytohormones have been reported to play crucial roles to regulate leaf complexity among plant species. Using the compound-leafed species Lotus japonicus, a model legume plant with five visible leaflets, we characterized four independent mutants with reduced leaf complexity, proliferating floral meristem (pfm), proliferating floral organ-2 (pfo-2), fused leaflets1 (ful1) and umbrella leaflets (uml), which were further identified as loss-of-function mutants of Arabidopsis orthologs LEAFY (LFY ), UNUSUAL FLORAL ORGANS (UFO), CUP-SHAPED COTYLEDON 2 (CUC2) and PIN-FORMED 1 (PIN1), respectively. Comparing the leaf development of wild-type and mutants by a scanning electron microscopy approach, leaflet initiation and/or dissection were found to be affected in these mutants. Expression and phenotype analysis indicated that PFM/LjLFY and PFO/LjUFO determined the basipetal leaflet initiation manner in L. japonicus. Genetic analysis of ful1 and uml mutants and their double mutants revealed that the CUC2-like gene and auxin pathway also participated in leaflet dissection in L. japonicus, and their functions might influence cytokinin biogenesis directly or indirectly. Our results here suggest that multiple genes were interplayed and played conserved functions in controlling leaf complexity during compound leaf development in L. japonicus. | Zhenhua Wang Jianghua Chen Lin Weng Xin Li Xianglin Cao Xiaohe Hu Da Luo Jun Yang | 2013 | Journal of Integrative Plant Biology2013，55，5： | 6 |
| 7 | Effects of flexibility and strength training on peak hamstring musculotendinous strains during sprinting显示文摘Background:Hamstring injury is one of the most common injuries in sports involving sprinting.Hamstring flexibility and strength are often considered to be modifiable risk factors in hamstring injury.Understanding the effects of hamstring flexibility or strength training on the biomechanics of the hamstring muscles during sprinting could assist in improving prevention strategies and rehabilitation related to these injuries.The purpose of this study was to determine the effects of altering hamstring flexibility or strength on peak hamstring musculotendinous strain during sprinting.Methods:A total of 20 male college students(aged 18-24 years)participated and were randomly assigned to either a flexibility intervention group or a strength intervention group.Each participant executed exercise training 3 times a week for 8 weeks.Flexibility,sprinting,and isokinetic strength testing were performed before and after the 2 interventions.Paired t tests were performed to determine hamstring flexibility or strength intervention effects on optimal hamstring musculotendinous lengths and peak hamstring musculotendinous strains during sprinting.Results:Participants in the flexibility intervention group significantly increased the optimal musculotendinous lengths of the semimembranosus and biceps long head(p<0.026)and decreased peak musculotendinous strains in all 3 bi-articulate hamstring muscles(p<0.004).Participants in the strength-intervention group significantly increased the optimal musculotendinous lengths of all 3 hamstring muscles(p<0.041)and significantly decreased their peak musculotendinous strain during sprinting(p<0.017).Conclusion:Increasing hamstring flexibility or strength through exercise training may assist in reducing the risk of hamstring injury during sprinting for recreational male athletes. | Xianglin Wan Shangxiao Li Thomas M.Best Hui Liu Hanjun Li Bing Yu | 2021 | Journal of Sport and Health Science2021，10，2： | 6 |
| 8 | Hydride vapor phase epitaxy for gallium nitride substrate显示文摘Due to the remarkable growth rate compared to another growth methods for gallium nitride(GaN)growth,hydride vapor phase epitaxy(HVPE)is now the only method for mass product GaN substrates.In this review,commercial HVPE systems and the GaN crystals grown by them are demonstrated.This article also illustrates some innovative attempts to develop homebuilt HVPE systems.Finally,the prospects for the further development of HVPE for GaN crystal growth in the future are also discussed. | Jun Hu Hongyuan Wei Shaoyan Yang Chengming Li Huijie Li Xianglin Liu Lianshan Wang Zhanguo Wang | 2019 | Journal of Semiconductors2019，40，10： | 3 |
| 9 | Honeycomb-patterned films of polystyrene/poly(ethylene glycol): Preparation, surface aggregation and protein adsorption显示文摘Highly ordered honeycomb-patterned polystyrene (PS)/poly(ethylene glycol) (PEG) films were prepared by a water-assisted method using an improved setup, which facilitated the formation of films with higher regularity, better reproducibility, and larger area of honeycomb structures. Surface aggregation of hydrophilic PEG and adsorption of bovine serum albumin (BSA) on the honeycomb-patterned films were investigated. Field emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM) were used to observe the surface morphologies of the films before and after being rinsed with water. As confirmed by the FESEM images and the AFM phase images, PEG was enriched in the pores and could be gradually removed by water. The adsorption of fluorescence-labeled BSA on the films was studied in visual form using laser scanning confocal microscopy. Results clearly demonstrated that the protein-resistant PEG was selectively enriched in the pores. This water-assisted method may be a latent tool to prepare honeycomb-patterned biofunctional surfaces. | WAN LingShu KE BeiBei LI XiaoKai MENG XiangLin ZHANG LuYao XU ZhiKang | 2009 | Science China Chemistry2009，52，7： | 3 |
| 10 | Synergistic effects of ginseng stem and leaf-extracted ginsenoside and choline on improving learning and memory in rats Association verification experiment in animals with multiple learning and memory disorders显示文摘BACKGROUND: Ginsenoside extracted from the stem and leaf of ginseng (GSL) and choline have both been shown to improve learning and memory functions; however,further studies are needed to understand the synergistic effects of a combination of both. OBJECTIVE: To verify the combined improved synergistic effects of GSL and choline on learning and memory disorders in rats. DESIGN: Control observation. SETTING: Taishan Medical College. MATERIALS: A total of 150 male Kunming mice weighing (20±2) g and 40 healthy male Wistar rats weighing (220±20) g were provided by the Experimental Animal Department of Jilin University. Animal experimentation received confirmed consent from the local ethic committee. GSL was provided by the Department of Chemistry,Norman Bethune Medical University,and choline was provided by the Third Experiment Factory,Shanghai. METHODS: This study was performed at the Life Science Institute,Taishan Medical College from October 2006 to February 2007. ① Scopolamine-induced learning and memory disorders in rats: Forty rats were randomly divided into control group,model group,combination group (400 mg/kg GSL + 200 mg/kg choline),GSL (400 mg/kg) group,and choline (200 mg/kg) group,8 rats/group. Rats were perfused and administrated in the morning,once a day for 14 successive days. Rats in the control group and model group were perfused with 20 mL/kg distilled water and underwent Morris water maze spatial resolution test 1 hour after perfusion on the 10th,11th,and 12th days after administration. Rats also underwent passive step-down avoidance test 1 hour after reperfusion on the 13th and 14th days after administration. Thirty minutes prior to experimentation,rats in the remaining three groups were intraperitoneally (i.p) injected with 2 mg/kg scopolamine,and rats in the control group were i.p. injected with 2 mL/kg saline. ② Scopolamine-induced learning disorder and memory acquired disorder in mice: Fifty mice were randomly divided into control group,model group,combination group (400 mg/kg GSL +200 mg/kg choline),GSL (400 mg/kg) group,and choline (200 mg/kg) group,with 10 mice/group. Mice were perfused and administrated in the morning,once a day for 9 successive days. Mice in the control group and model group were perfused with 20 mL/kg distilled water and underwent passive step down avoidance test 1 hour after reperfusion on the 8th and 9th day after administration. Twenty minutes prior to training,mice in the remaining three groups were i.p. injected with 2 mg/kg scopolamine,and mice in the control group were i.p. injected with 10 mL/kg saline. ③ Sodium nitrite-induced memory consolidation disorder in mice: Grouping,administration,and testing were the same as mentioned above. After training,mice in the remaining three groups were immediately subcutaneously injected with 120 mg/kg sodium nitrite,and mice in the control group were subcutaneously injected with 20 mL/kg saline. ④ Ethanol-induced memory reconsolidation disorder in mice: Grouping,administration,and testing were the same as mentioned above. At 24 hours after training and 20 minutes before retraining,mice in the remaining four groups were perfused with 10 mL/kg ethanol (0.3 volume fraction),and mice in the control group were perfused with 10 mL/kg saline. MAIN OUTCOME MEASURES: Synergistic effects of GSL and choline on learning and memory deficits induced by scopolamine,sodium nitrite,and ethanol in experimental animals. RESULTS: All 40 rats and 150 mice were included in the final analysis. ① Synergistic effects of GSL and choline on learning and memory disorders induced by scopolamine in rats: During passive step-down avoidance and Morris water maze spatial resolution tests,the number of error responses and length of maze training in the model group were significantly greater than in the control group (P < 0.01); while the number of error responses and length of maze training in the combination group were significantly less than in the model group,GSL group,and choline group (P < 0.05-0.01). The Q value was > 1 after combining administration,which suggests that the combination of GSL and choline had synergistic effects. ② Synergistic effects of GSL and choline on learning disorder and memory-acquired disorder induced by scopolamine in mice: During passive step-down avoidance test,the number of error responses in the model group were significantly greater than in the control group (P < 0.01); while the number of error responses in the combination group were significantly less than in the model group,GSL group,and choline group (P < 0.05-0.01). The Q value was > 1 after combining administration,which suggests GSL and choline had synergistic effects. ③ Synergistic effects of GSL and choline on memory sodium nitrate-induced consolidation disorder in mice: During passive step down avoidance test,the number of error responses in the model group were significantly less than in the control group (P < 0.01); while the number of error responses in the combination group were significantly less than in the model group,GSL group,and choline group (P < 0.05-0.01). The Q value was > 1 after combined administration,which suggests GSL and choline had synergistic effects. ④ Synergistic effects of GSL and choline on ethanol-induced memory reconsolidation disorder in mice: During passive step down avoidance test,the number of error responses in the model group were significantly greater than in the control group (P < 0.01); while the number of error responses in the combination group were significantly less than in the model group,GSL group,and choline group (P < 0.05-0.01). The Q value was > 1 after combined administration,which suggests GSL and choline had synergistic effects. CONCLUSION: GSL and choline have synergistic effects on learning and memory functions. | Xiaomin Zhao Hongxia GU Qing Li Xianglin Xie Zuoli Xia Hongxin Cai Ling Zhang Dawei Li Xinnong Wang | 2008 | Neural Regeneration Research2008，3，2： | 3 |
| 11 | Construction of 2D/2D Z-scheme MnO_(2-x)/g-C_(3)N_(4) photocatalyst for efficient nitrogen fixation to ammonia显示文摘Reducing nitrogen to ammonia with solar energy has become a wide concern when it comes to photocatalysis research.It is considered to be one of the more promising alternate options for the conventional Haber-Bosch cycle.Herein,2D g-C_(3)N_(4)composites with modifying ultrathin sheet MnO_(2-x)were prepared and used as nitrogen fixation photocatalyst.With the assistance of the nature of MnO_(2-x),the generation rate of NH_(3)reached 225 mmol g^(-1)h^(-1),which is more than twice over the rate of pristine 2D g-C_(3)N_(4)(107 mmol g^(-1)h^(-1)).The presence of ultrathin sheet MnO_(2-x)shortens the gap of the carriers to the surface of photocatalyst.Thus the speed of electron transfer gets increased.Besides,the construction of Z-scheme heterojunction boosts the separation and migration of photogenerated carriers.As a result,the nitrogen reduction reaction(NRR)performance gets enhanced.The work may provide an example of promoting the NRR performance of non-metallic compound. | Limin Yu Zhao Mo Xianglin Zhu Jiujun Deng Fan Xu Yanhua Song Yuanbin She Huaming Li Hui Xu | 2021 | Green Energy & Environment2021，6，4： | 3 |
| 12 | Allotransplantation of adult spinal cord tissues after complete transected spinal cord injury: long-term survival and functional recovery in canines显示文摘Spinal cord injury(SCI), especially complete transected SCI, leads to loss of cells and extracellular matrix and functional impairments. In a previous study, we transplanted adult spinal cord tissues(aSCTs) to replace lost tissues and facilitate recovery in a rat SCI model. However, rodents display considerable differences from human patients in the scale, anatomy and functions of spinal cord systems, and responses after injury. Thus, use of a large animal SCI model is required to examine the repair efficiency of potential therapeutic approaches. In this study, we transplanted allogenic aSCTs from adult dogs to the lesion area of canines after complete transection of the thoracic spinal cord, and investigated the long-term cell survival and functional recovery. To enhance repair efficiency, a growth factor cocktail was added during aSCT transplantation, providing a favorable microenvironment. The results showed that transplantation of a SCTs, in particular with the addition of growth factors, significantly improves locomotor function restoration and increases the number of neurofilament-, microtubule-associated protein2-, 5-hydroxytryptamine-, choline acetyltransferase-and tyrosine hydroxylase-positive neurons in the lesion area at 6 months post-surgery. In addition, we demonstrated that donor neurons in a SCTs can survive for a long period after transplantation. This study showed for the first time that transplanting aSCTs combined with growth factor supplementation facilitates reconstruction of injured spinal cords, and consequently promotes long lasting motor function recovery in a large animal complete transected SCI model, and therefore could be considered as a possible therapeutic strategy in humans. | He Shen Shuyu Wu Xi Chen Bai Xu Dezun Ma Yannan Zhao Yan Zhuang Bing Chen Xianglin Hou Jiayin Li Yudong Cao Xianyong Fu Jun Tan Wen Yin Juan Li Li Meng Ya Shi Zhifeng Xiao Xingjun Jiang Jianwu Dai | 2020 | Science China(Life Sciences)2020，63，12： | 3 |
| 13 | Targeting polarized phenotype of microglia via IL6/JAK2/ STAT3 signaling to reduce NSCLC brain metastasis显示文摘Tumor-associated macrophages have emerged as crucial factors for metastases.Microglia are indispensable components of the brain microenvironment and play vital roles in brain metastasis(BM).However,the underlying mechanism of how activated microglia promote brain metastasis of non-small cell lung cancer(NSCLC)remains elusive. | Yu Jin Yalin Kang Minghuan Wang Bili Wu Beibei Su Han Yin Yang Tang Qianxia Li Wenjie Wei Qi Mei Guangyuan Hu Veronika Lukacs-Kornek Jian Li Kongming Wu Xianglin Yuan Wei Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 3 |
| 14 | Pb, Sr isotopes in organic matter of Lower Tertiary hydrocarbon source rocks in Liaohe Fault Depression显示文摘The Pb, Sr isotopic compositions in organic matters (kerogen and soluble organic matter) of Lower Tertiary hydrocarbon source rock in Liaohe Fault Depression is first reported. There is a great variable rang of Pb isotopic compositions in kerogen, 206Pb/204Pb = 17.488-18.656, 207Pb/204Pb= 15.388-15.692, 208Pb/204Pb = 37.656-37.484. And soluble | Jinglian Zhang Bingquan Zhu Yixian Cheng Xianglin Tu Zhengling Chao Chengjun Zhang Qianhua Xiao Jingyou Li Mingzhi Piao | 1999 | Chinese Science Bulletin1999，44，23： | 3 |
| 15 | Tensile and fatigue behavior of corroded rebars显示文摘 | Weiping Zhang Xiaobin Song Xianglin Gu Shibin Li | 2012 | Construction and Building Materials2012，，： | 2 |
| 16 | Dietary butyrate,lauric acid and stearic acid improve gut morphology and epithelial cell turnover in weaned piglets显示文摘This study was to evaluate the effects of the supplementation of saturated fatty acids with different chain lengths on growth performance,intestinal morphology,epithelial cell proliferation,differentiation and apoptosis in weaned piglets.Thirty-two weaned piglets(Duroc×Landrace×Yorkshire,BW=7.81±0.26 kg)were weaned at 21 d and randomly assigned to 1 of 4 experimental treatments:(1)a basal diet(control);(2)control+0.3% butyrate(BT);(3)control+0.3%lauric acid(LA);(4)control+0.3% stearic acid(SA).All piglets were then slaughtered for tissue sampling after having been fed experimental diets for 28 d after weaning.Supplementation of BT increased the gain-to-feed ratio(G:F)(P<0.05)compared to piglets fed the control diet from 14 to 28 d.In addition,the villus height(VH)to crypt depth(CD)ratio(VH:CD ratio)of the ileum were higher in the BT and LA diets than that of the control diet(P<0.05).The SA-supplemented diet increased ileal VH(P<0.05),whereas the BT-supplemented diet increased jejunal CD(P<0.05).Compared to the control,diets supplemented with BT,LA,or SA all tended to increase jejunal proliferation(Ki67/crypt positive cells)(P=0.190);diets supplemented with BT or SA significantly increased the number of ki67-positive cells in the ileal crypt(P<0.05).Furthermore,in the jejunum,the protein expression of activated caspase 3 and villin were increased in piglets fed BT,LA,or SA diets compared to those on the control diet(P<0.05).In the ileum,compared with the control diet,the BT diet tended to increase the protein level of mammalian phosphorylation target of rapamycin(p-m TOR,P<0.10);LA or SA diets significantly increased p-m TOR protein expression(P<0.05).These results show that dietary supplementation of BT,LA,or SA promotes jejunal cell renewal in weaned piglets.At the same time,increased proliferation of ileal crypt cells by promoting p-m TOR expression has beneficial effects on ileal morphology in weaned piglets. | Xianglin Zeng Yuan Yang Junmin Wang Zhaobin Wang Jun Li Yulong Yin Huansheng Yang | 2022 | Animal Nutrition2022，，4： | 2 |
| 17 | Fabrication of Tβ4-Exosome-releasing artificial stem cells for myocardial infarction therapy by improving coronary collateralization显示文摘Currently,stem cell transplantations in cardiac repair are limited owing to disadvantages,such as immunological rejection and poor cell viability.Although direct injection of exosomes can have a curative effect similar to that of stem cell transplantation,high clearance hinders its application in clinical practice.Previous reports suggested that induction of coronary collateralization can be a desired method of adjunctive therapy for someone who had missed the optimal operation time to attenuate myocardial ischemia.In this study,to mimic the paracrine and biological activity of stem cells,we developed artificial stem cells that can continuously release Tβ4-exosomes(Tβ4-ASCs)by encapsulating specific exosomes within microspheres using microfluidics technology.The results show that Tβ4-ASCs can greatly promote coronary collateralization in the periphery of the myocardial infarcted area,and its therapeutic effect is superior to that of directly injecting the exosomes.In addition,to better understand how it works,we demonstrated that the Tβ4-ASC-derived exosomes can enhance the angiogenic capacity of coronary endothelial cells(CAECs)via the miR-17-5p/PHD3/Hif-1αpathway.In brief,as artificial stem cells,Tβ4-ASCs can constantly release functional exosomes and stimulate the formation of collateral circulation after myocardial infarction,providing a feasible and alternative method for clinical revascularization. | Peier Chen Xiaodong Ning Weirun Li Yuxuan Pan Ling Wang Hekai Li Xianglin Fan Jiexin Zhang Tiantian Luo Yaobin Wu Caiwen Ou Minsheng Chen | 2022 | Bioactive Materials2022，7，8： | 2 |
| 18 | A cellular response protein induced during HSV-1 infection inhibits viral replication by interacting with ATF5显示文摘Studies of herpes simplex virus type 1(HSV-1)infection have shown that many known and unknown cellular molecules involved in viral proliferation are up-regulated following HSV-1 infection.In this study,using two-dimensional polyacrylamide gel electrophoresis,we found that the expression of the HSV-1 infection response repressive protein(HIRRP,GI 16552881)was up-regulated in human L02 cells infected with HSV-1.HIRRP,an unknown protein,was initially localized in the cytoplasm and then translocated into the nucleus of HSV-1-infected cells.Further analysis showed that HIRRP represses HSV-1proliferation by inhibiting transcription of the viral genome by interacting with the cellular transcription factor,ATF5,via its N-terminal domain.ATF5 represses the transcription of many host genes but can also act as an activator of genes containing a specific motif.We found that ATF5 promotes the proliferation of HSV-1 via a potential mechanism by which ATF5 enhances the transcription of viral genes during the course of an HSV-1 infection;HIRRP then induces feedback repression of this transcription by interacting with ATF5. | WU LianQiu ZHANG XueMei CHE YanChun ZHANG Ying TANG SongQing LIAO Yun NA RuiXiong XIONG XiangLin LIU LongDing LI QiHan | 2013 | Science China(Life Sciences)2013，56，12： | 2 |
| 19 | National Alveolar Echinococcosis Distribution--China, 2012−2016显示文摘What is already known about this topic?Both alveolar echinococcosis(AE)and cystic echinococcosis are endemic in China,among which alveolar echinococcosis has a very high mortality rate.What is added by this report?The survey results showed the prevalence and scope of AE in China and identified high-risk groups including children,monks,herdsmen and illiterate people.At the same time,all the cases found in the survey(more than 90%of the patients did not go to the hospital for diagnosis and treatment before survey)were promptly diagnosed and treated.What are the implications for public health practice?This study provides information for the development of a plan for AE prevention and control and for the implementation of interventions targeted to high-risk populations. | Canjun Zheng Chuizhao Xue Shuai Han Zhongjie Li Hu Wang Liying Wang Ying Wang Qian Wang Yu Feng Yanyan Hou Xiao Ma Junying Ma Xiumin Han Gongsang Quzhen Xiaofeng Jiang Weidong Guo Xianglin Wu Yaming Yang Lei Cao Fanka Li Weiqi Chen Xinliu Yan Shicheng Yu Meihua Fu Qing Yu Ning Xiao Jiangping Cao Jun Yan Weiping Wu Xiao-nong Zhou | 2020 | China CDC weekly2020，2，1： | 2 |
| 20 | Highly stableβ‑ketoenamine‑based covalent organic frameworks(COFs):synthesis and optoelectrical applications显示文摘Covalent organic frameworks(COFs)are one class of porous materials with permanent porosity and regular channels,and have a covalent bond structure.Due to their interesting characteristics,COFs have exhibited diverse potential applications in many felds.However,some applications require the frameworks to possess high structural stability,excellent crystallinity,and suitable pore size.COFs based onβ-ketoenamine and imines are prepared through the irreversible enol-to-keto tautomerization.These materials have high crystallinity and exhibit high stability in boiling water,with strong resistance to acids and bases,resulting in various possible applications.In this review,we frst summarize the preparation methods for COFs based onβ-ketoenamine,in the form of powders,flms and foams.Then,the efects of diferent synthetic methods on the crystallinity and pore structure of COFs based onβ-ketoenamine are analyzed and compared.The relationship between structures and diferent applications including fuorescence sensors,energy storage,photocatalysis,electrocatalysis,batteries and proton conduction are carefully summarized.Finally,the potential applications,large-scale industrial preparation and challenges in the future are presented. | Yaqin Li Maosong Liu Jinjun Wu Junbo Li Xianglin Yu Qichun Zhang | 2022 | Frontiers of Optoelectronics2022，15，3： | 2 |
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