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| 1 | Threonine 32 (Thr32) of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells显示文摘转变生长因素 --(TGF-) 在恶意的细胞的各种各样的类型上施加 apoptotic 效果,包括肝癌症细胞。然而, TGF- 由导致 apoptosis 的精确机制仍然保持糟糕已知。在现在的学习,我们显示出那 threonine 32 (Thr32 ) FoxO3 的残余是批评的让 TGF- 在 hepatocarcinoma Hep3B 房间经由 Bim 导致 apoptosis。我们的数据证明 TGF- 在 Thr32 通过特定的 de-phosphorylation 导致了 FoxO3 激活。TGF -- 激活的 FoxO3 与 Smad2/3 合作了调停 Bim 起来规定和 apoptosis。在 Thr32 的 FoxO3 (de ) phosphorylation 被酷蛋白 kinase 调整我 --(CKI-) 。由小分子 D4476 的 CKI 抑制能废除 TGF -- 导致的 FoxO/Smad 激活,反向的 Bim 起来规定,和块顺序的 apoptosis。更重要地, CKI- 和 p32FoxO3 的 deregulated 层次在人的恶意的肝纸巾被发现。一起拿,我们的调查结果建议可能有 FoxO3 的 Thr32 为 TGF 是枢轴的一台 CKI-FoxO/Smad-Bim 在引擎 -- 导致的 apoptosis,为肝癌症治疗使它成为一个潜在的治疗学的目标。 | Xiangxuan Zhao Yong Liu Lei Du Leya He Biyun Ni Junbo Hu Dahai Zhu Quan Chen | 2015 | Protein & Cell2015，6，2： | 3 |
| 2 | Absorption properties of carbon black/silicon carbide microwave absorbers 显示文摘 | Liu Xiangxuan Zhang Zeyang Wu Youpeng | 2011 | composites : part B2011，42，： | 1 |
| 3 | The effect of cerium (III) on the chlorophyll formation in spinach显示文摘 | Fashui Hong Ling Wang Xiangxuan Meng Zheng Wei Guiwen Zhao | 2002 | Biological Trace Element Research2002，，3： | 1 |
| 4 | Polymerization of bismaleimide and maleimide monomers catalyzed by nanometersized Na^+/TiO2 显示文摘 | Xiangxuan Liu Daoyong Chert Xin Wang | 2000 | European Polymer Journal2000，36，10： | 1 |
| 5 | Double-layer microwave absorber based on CoFe2O4 ferrite and earbonl iron composites显示文摘 | LIU Yuan LIU Xiangxuan WANG Xuaniun | 2014 | Journal of Alloys and Compounds2014，584，： | 1 |
| 6 | The effect of cerium(Ill) on the chlorophyll formation in spinach显示文摘 | Hong Fashui Wang Ling Meng Xiangxuan | 2002 | Biol Trace Elem Res2002，89，3： | 1 |
| 7 | GABA Signaling Pathway-associated Gene PLCL1 Rare Variants May be Associated with Autism Spectrum Disorders显示文摘Dear Editor,Autism spectrum disorders(ASDs)are neurodevelopmen-tal disorders with phenotypic and genetic heterogeneity,and are among the most heritable of neurodevelopmental disorders[1].Rare single nucleotide variants(SNVs)of genes and/or rare copy number variants(CNVs)involving gene variants and/or genomic imbalances play an important role in ASD,but their molecular pathogenic mechanisms remain indistinct[2].Over the decades,genetic and neurobiological studies mainly involving severe ASD comorbid with intellectual disability(ID)or developmental delay(DD)have indicated that loss of function affects neural development[3]. | Fengyun Zheng Guoyuan Liu Ting Dang Qiaowen Chen Yu An Meng Wu Xiangxuan Kong Zilong Qiu Bai-Lin Wu | 2021 | Neuroscience Bulletin2021，37，8： | 1 |
| 8 | Effect of Nd–Co substitution on magnetic and microwave absorption properties of SrFe 12 O 19 hexaferrites显示文摘 | Zeyang Zhang Xiangxuan Liu Xuanjun Wang Youpeng Wu Rong Li | 2012 | Journal of Alloys and Compounds2012，，： | 1 |
| 9 | The effect of cerium (III) on the chlorophyll formation in spinach显示文摘 | Fashui Hong Ling Wang Xiangxuan Meng Zheng Wei Guiwen Zhao | 2002 | Biological Trace Element Research2002，，3： | 1 |
| 10 | Activity origin and design principles for atomic vanadium anchoring on phosphorene monolayer for nitrogen reduction reaction显示文摘Conversion of inert N2 molecules into NH3 via electrochemical methods is an environmentally friendly alternative to replace the traditional Haber-Bosch process.However,the development of highly efficient catalyst is still challenging.Herein,we report a density functional theory(DFT)based high-throughput screening to investigate the potential of 23 atomic transition metals(Sc,Ti,V,Cr,Mn,Fe,Co,Ni,Cu,Zn,Y,Zr,Nb,Mo,Tc,Ru,Rh,Pd,Ag,Cd,W,Pt and Au)supported on phosphorene monolayer as electrocatalyst for nitrogen reduction reaction(NRR).Our theoretical results demonstrate that V single atom anchoring on phosphorene monolayer exhibits good thermal stability,selectivity and excellent catalytic activity with a low overpotential of 0.18 V.Importantly,rational design principles and electronic descriptor between the intrinsic electronic properties and activation barrier have been developed.Our work offers a new promising noble metal-free catalyst for NRR and reveals profound insights into the activity origin to guide further design. | Xiongyi Liang Xiangxuan Deng Chen Guo Chi-Man Lawrence Wu | 2020 | Nano Research2020，13，11： | 1 |
| 11 | The effect of cerium (III) on the chlorophyll formation in spinach显示文摘 | Fashui Hong Ling Wang Xiangxuan Meng Zheng Wei Guiwen Zhao | 2002 | Biological Trace Element Research2002，，3： | 1 |
| 12 | The effect of cerium (III) on the chlorophyll formation in spinach显示文摘 | Fashui Hong Ling Wang Xiangxuan Meng Zheng Wei Guiwen Zhao | 2002 | Biological Trace Element Research2002，，3： | 1 |
| 13 | Water Environmental Impact Assessment and Analysis of Foshan Brewery Project显示文摘In recent years, the beer industry is a biological food industry that consumes a lot of water, and it has developed rapidly in China. The sewage discharged from the mass production of beer poses a huge threat to the environment. In order to evaluate and better solve the possible environmental impacts of beer treatment engineering projects, a brewery project in Foshan City is taken as an example to investigate the water pollution generation links of the engineering process including surface water and groundwater. According to the relevant technical methods and standards, water pollution factors are screened, and concentration and discharge are monitored. Through comprehensive analysis, predictive evaluation is obtained. It is confirmed that the project meets the requirements of national laws and regulations and environmental protection standards. | Jianqiao QIN Jierong CHEN Donghang JIANG Tianxian TANG Xiangxuan WU Huiling WANG Yingli JIE Zemin ZHENG Haojia XU Xiaoxiao LIAO | 2023 | Meteorological and Environmental Research2023，14，2： | 0 |
| 14 | Ecological Remediation Technology of Urban Landscape Water Body显示文摘Urban landscape water body is not only an important part of urban landscape construction,but also an important way to maintain landscape diversity and biodiversity,carrying the beautiful yearning of urban residents for natural life.A good state of urban landscape water body is crucial to the ecological environment of the city.However,due to the poor kinetic energy of urban landscape water body and the influence of various human factors,the quality of urban landscape water body often declines,and urban population is threatened by water security problems.Through the study of several water body ecological remediation technologies,relevant suggestions are put forward,in order to provide a reference for water pollution restoration and treatment in urban human settlement environment. | SUN Xiangxuan XIONG Qingqing XIAO Shizhen | 2024 | Journal of Landscape Research2024，16，1： | 0 |
| 15 | The Contextual Dynamics of Internet of Things Applications in Smart Public Bike Sharing Services显示文摘The past decade has witnessed the emergence of Internet of Things(IoT)technologies in public service innovation.As the technical characteristics of IoT technologies are rather identical around the globe,one might wonder whether the location still matters for their adoptions.Smart public bike sharing(PBS)scheme is one of the world’s most widespread public IoT applications.Prior studies of smart PBS schemes find the positive effects on the host city’s image and sustainable mobility.However,less attention has been paid to the impact of the host city’s context on the evolution of their service characteristics.The paper proposes a model that explicitly includes the contextual dynamics of public service innovations that utilize IoT.Then the model is used to analyze two empirical cases from Sweden and China,respectively.The results reveal that public motives,user preferences,and governance can impact the evolution of the service characteristics of smart PBS schemes,which is important for smart PBS planners,operators,and policymakers to consider.The best PBS scheme is the one that adapts to the characters of the host city and the changing needs of the users.Moreover,the study reflects the new complexities that arise for digital public services,such as the protection of data and privacy. | XU Xiangxuan | 2017 | Chinese Journal of Urban and Environmental Studies2017，5，2： | 0 |
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