|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia显示文摘Microglia 玩在由降级的 A 的清理的一个枢轴的角色他们在 lysosomes,在 Alzheimers 疾病(广告) 阻止淀粉的匾致病。最近的证据建议那个 lysosomal 机能障碍导致有毒的蛋白质总数的不够的消除。我们测试了是否与抄写因素 EB (TFEB ) 提高 lysosomal 功能,必要管理者 modulating lysosomal 小径,将在 microglia 支持一个清理。这里,我们证明 TFEB 的那 microglial 表情便于降级和还原剂扔了的纤丝状的 A (fA ) 淀粉的匾,它被 TFEB 的 deacetylation 进一步提高。用集体 spectrometry 分析,我们第一证实了是的 acetylation 一以前 TFEB 的 unreported 修正并且发现那 SIRT1 直接交往了与并且在离氨酸残余 116 点的 deacetylated TFEB。随后,当 TFEB 被击倒时, SIRT1 overexpression 由 TFEB 下游的目标的 upregulating transcriptional 层次提高了 lysosomal 功能和 fA 降级,它能被禁止。而且,在在 microglia 变异的 K116R 的 deacetylated TFEB 的 overexpression 由刺激 lysosomal 生物的续生说加速了细胞内部的 fA 降级并且极大地在 APP/PS1 转基因的老鼠的大脑片减少了扔的淀粉的匾。我们的调查结果表明 TFEB 的 deacetylation 能调整 lysosomal 生物的续生说和 fA 降级,为 attenuating 使 TFEB 的 microglial 激活成为可能的策略在广告的淀粉的匾免职。 | Jintao Bao Liangjun Zheng Qi Zhang Xinya Li Xuefei Zhang Zeyang Li Xue Bai Zhong Zhang Wei Huo Xuyang Zhao Shujiang Shang Qingsong Wang Chen Zhang Jianguo Ji | 2016 | Protein & Cell2016，7，6： | 10 |
| 2 | Natural selection maintains the transcribed LTR retrotransposons in Nosema bombycis显示文摘Eight intact LTR retrotransposons(Nbr1?Nbr8)have been previously characterized from the genome of Nosema bombycis,a eu-karyotic parasite with a compact and reduced genome.Here we describe six novel transcribed Nbr elements(Nbr9?Nbr14)identified through either cDNA library or RT-PCR.Like previously determined ones,all of them belong to the Ty3/Gypsy superfamily.Retrotransposon diversity and incomplete domains with insertions(Nbr12),deletions(Nbr11)and in-frame stop codons in coding regions(Nbr9)were detected,suggesting that both defective and loss events of LTR retrotransposon have happened in N.bombycis genome.Analysis of selection showed that strong purifying selection acts on all elements except Nbr11.This implies that selective pressure keeps both these Nbrs and their functions in genome.Interestingly,Nbr11 is under positive selection and some positively selected codons were identified,indicating that new functionality might have evolved in the Nbr11 retrotransposon.Unlike other transposable elements,Nbr11 has integrated into a conserved syntenic block and probably resulted in the inversion of both flanking regions.This demonstrates that transposable element is an important factor for the reshuffling and evolution of their host genomes,and may be maintained under natural selection. | Heng Xiang Guoqing Pan Ruizhi Zhang Jinshan Xu Tian Li Wenle Li Zeyang Zhou Zhonghuai Xiang | 2010 | Journal of Genetics and Genomics2010，37，5： | 7 |
| 3 | Interfacial Voids Trigger Carbon-Based, All-Inorganic Cs Pb IBr2 Perovskite Solar Cells with Photovoltage Exceeding 1.33 V显示文摘A novel interface design is proposed for carbon-based,all-inorganic CsPbIBr2 perovskite solar cells(PSCs)by introducing interfacial voids between TiO2 electron transport layer and CsPbIBr2 absorber.Compared with the general interfacial engineering strategies,this design exempts any extra modification layer in final PSC.More importantly,the interfacial voids produced by thermal decomposition of 2-phenylethylammonium iodide trigger three beneficial e ects.First,they promote the light scattering in CsPbIBr2 film and thereby boost absorption ability of the resulting CsPbIBr2 PSCs.Second,they suppress recombination of charge carriers and thus reduce dark saturation current density(J0)of the PSCs.Third,interfacial voids enlarge built-in potential(Vbi)of the PSCs,awarding increased driving force for dissociating photo-generated charge carriers.Consequently,the PSC yields the optimized e ciency of 10.20%coupled with an open-circuit voltage(Voc)of 1.338 V.The Voc achieved herein represents the best value among CsPbIBr2 PSCs reported earlier.Meanwhile,the non-encapsulated PSCs exhibit an excellent stability against light,thermal,and humidity stresses,since it remains^97%or^94%of its initial e ciency after being heated at 85℃for 12 h or stored in ambient atmosphere with relative humidity of 30–40%for 60 days,respectively. | Weidong Zhu Zeyang Zhang Dandan Chen Wenming Chai Dazheng Chen Jincheng Zhang Chunfu Zhang Yue Hao | 2020 | Nano-Micro Letters2020，12，7： | 3 |
| 4 | A kind of double-sided porous anodic alumina membrane fabricated with the three-step anodic oxidation method显示文摘The porous anodic alumina membranes(PAAMs)have been successfully used as templates for the fabrication of functional nano-materials due to their outstanding regularity and physicochemical properties.In this paper,a transparent double-sided anodic alumina membrane with ultra-thin aluminum substrate was fabricated with the three-step anodic oxidation method in the oxalic acid electrolyte.The characters such as the top-surface morphology,membrane thickness,and depth of nanopores of this three-layer(Al2O3-Al-Al2O3)sandwiched nano-structure were controllable through regulating the main anodic oxidation conditions,e.g.,anodic oxidation time of various steps,coating remove process.The experiments data revealed that the aluminum substrate is exponential declined with the oxidation time when it was approximately reduced by a few micrometers.This new double-sided anodic alumina membrane can be used as the high-quality functional field emission materials and templates. | ZHANG Chen WANG KaiGe GAO ZeYang WU JunJun REN JunYing ZHANG LiangLiang GU ChangZhi BAI JinTao | 2014 | Science China(Technological Sciences)2014，57，2： | 2 |
| 5 | Metasurface-enabled augmented reality display: a review显示文摘Augmented reality(AR)display,which superimposes virtual images on ambient scene,can visually blend the physical world and the digital world and thus opens a new vista for human–machine interaction.AR display is considered as one of the next-generation display technologies and has been drawing huge attention from both academia and industry.Current AR display systems operate based on a combination of various refractive,reflective,and diffractive optical elements,such as lenses,prisms,mirrors,and gratings.Constrained by the underlying physical mechanisms,these conventional elements only provide limited light-field modulation capability and suffer from issues such as bulky volume and considerable dispersion,resulting in large size,severe chromatic aberration,and narrow field of view of the composed AR display system.Recent years have witnessed the emerging of a new type of optical elements—metasurfaces,which are planar arrays of subwavelength electromagnetic structures that feature an ultracompact footprint and flexible light-field modulation capability,and are widely believed to be an enabling tool for overcoming the limitations faced by current AR displays.Here,we aim to provide a comprehensive review on the recent development of metasurface-enabled AR display technology.We first familiarize readers with the fundamentals of AR display,covering its basic working principle,existing conventional-optics-based solutions,as well as the associated pros and cons.We then introduce the concept of optical metasurfaces,emphasizing typical operating mechanisms,and representative phase modulation methods.We elaborate on three kinds of metasurface devices,namely,metalenses,metacouplers,and metaholograms,which have empowered different forms of AR displays.Their physical principles,device designs,and the performance improvement of the associated AR displays are explained in details.In the end,we discuss the existing challenges of metasurface optics for AR display applications and provide our perspective on future research endeavors. | Zeyang Liu Danyan Wang Hao Gao Moxin Li Huixian Zhou Cheng Zhang | 2023 | Advanced Photonics2023，5，3： | 2 |
| 6 | Clinical characteristics and risk factors for mortality in cancer patients with COVID-19显示文摘Patients with cancer are at increased risk of severe infections.From a cohort including 3060 patients with confirmed COVID-19,109(3.4%)cancer patients were included in this study.Among them,23(21.1%)patients died in the hospital.Cancer patients,especially those with hematological malignancies(41.6%),urinary carcinoma(35.7%),malignancies of the digestive system(33.3%),gynecological malignancies(20%),and lung cancer(14.3%),had a much higher mortality than patients without cancer.A total of 19(17.4%)cancer patients were infected in the hospital.The clinical characteristics of deceased cancer patients were compared with those of recovered cancer patients.Multivariate Cox regression analysis indicated that a Nutritional Risk Screening(NRS2002)score≥3(adjusted hazard ratio(HR)11.00;95%confidence interval(CI)4.60–26.32;P<0.001),high-risk type(adjusted HR 18.81;95%CI 4.21–83.93;P<0.001),tumor stage IV(adjusted HR 4.26;95%CI 2.34–7.75;P<0.001),and recent adjuvant therapy(<1 month)(adjusted HR 3.16;95%CI 1.75–5.70;P<0.01)were independent risk factors for in-hospital death after adjusting for age,comorbidities,D-dimer,and lymphocyte count.In conclusion,cancer patients showed a higher risk of COVID-19 infection with a poorer prognosis than patients without cancer.Cancer patients with high-risk tumor,NRS2002 score≥3,advanced tumor stage,and recent adjuvant therapy(<1 month)may have high risk of mortality. | Junnan Liang Guannan Jin Tongtong Liu Jingyuan Wen Ganxun Li Lin Chen Wei Wang Yuwei Wang Wei Liao Jia Song Zeyang Ding Xiao-ping Chen Bixiang Zhang | 2021 | Frontiers of Medicine2021，15，2： | 2 |
| 7 | Crystal facet-dependent electrocatalytic performance of metallic Cu in CO_(2)reduction reactions显示文摘Developing high-performance electrocatalysts for CO_(2) reduction reaction(CO_(2)RR)is crucial since it is beneficial for environmental protection and the resulting value-add chemical products can act as an alternative to fossil feedstocks.Nonetheless,the direct reduction of CO_(2) into long-chain hydrocarbons and oxygenated hydrocarbons with high selectivity remains challenging.Copper(Cu)shows a distinctive advantage that it is the only pure metal catalyst for reducing CO_(2) into multi-carbon(C_(2+))products and the certain facets(e.g.,(100),(111),(111))of Cu nanocrystals exhibit relatively low energy barriers for the formation of specific products(e.g.,CO,HCOOH,CH_(4),C_(2)H_(4),C_(2)H_(5)OH,and other C_(2+) products).Therefore,extensive studies have been carried out to explore the relationship between the facets of Cu nanocrystals and corresponding catalytic products.In this review,we will discuss the crystal facet-dependent electrocatalytic CO_(2)RR performance in metallic Cu catalysts,meanwhile,the detailed reaction mechanisms will be systematically summarized.In addition,we will provide a personal perspective for the future research directions in this emerging field.We believe this review is helpful to guide the design of high-selectivity Cu-based electrocatalysts for CO_(2)RR. | Hao Zhang Caihong He Sumei Han Zeyang Du Ling Wang Qinbai Yun Wenbin Cao Bowei Zhang Ya-Hui Tian Qipeng Lu | 2022 | Chinese Chemical Letters2022，33，8： | 2 |
| 8 | The disease resistance potential of Trichoderma asperellum T-Pa2 isolated from Phellodendron amurense rhizosphere soil显示文摘To promote the application of Trichoderma,many countries have collected Trichoderma resources.In the present study,nine isolates were isolated from a rhizosphere soil of Phellodendron amurense and were identified as three species:Trichoderma brevicompactum(one isolate),T.asperellum(two isolates),T.atroviride(six isolates).Dual culture experiments showed that T.asperellum T-Pa2 grew fast and produced the best inhibition rates against six tested pathogens(80.25–91.65%)via competition and mycoparasitism.Populus davidiana×P.alba var.pyramidalis Louche(PdPap poplar)was treated with T-Pa2,which increased the catalase activity,nitrate reductase activity,and content of osmosis molecules significantly(P<0.05).Meanwhile,induction by T-Pa2 increased the resistance of PdPap poplar against Alternaria alternata via modulating the expression of salicylic acid,jasmonic acid,and auxin transduction pathway genes.The results will form the basis for the collection and application of biocontrol agents in forestry. | Zeyang Yu Zhihua Liu Yuzhou Zhang Zhiying Wang | 2022 | Journal of Forestry Research2022，33，1： | 1 |
| 9 | Solution-processable precursor route for fabricating ultrathin silica film for high performance and low voltage organic transistors显示文摘Silica is one of the most commonly used materials for dielectric layer in organic thin-film transistors due to its excellent stability, excellent electrical properties, mature preparation process, and good compatibility with organic semiconductors. However, most of conventional preparation methods for silica film are generally performed at high temperature and/or high vacuum. In this paper, we introduce a simple solution spin-coating method to fabricate silica thin film from precursor route, which possesses a low leakage current, high capacitance, and low surface roughness. The silica thin film can be produced in the condition of low temperature and atmospheric environment. To meet various demands, the thickness of film can be adjusted by means of preparation conditions such as the speed of spin-coating and the concentration of solution. The p-type and n-type organic field effect transistors fabricated by using this film as gate electrodes exhibit excellent electrical performance including low voltage and high performance. This method shows great potential for industrialization owing to its characteristic of low consumption and energy saving, time-saving and easy to operate. | Shujing Guo Zhongwu Wang Zeyang Xu Shuguang Wang Kunjie Wu Shufeng Chen Zongbo Zhang Caihong Xu Wenfeng Qiu Liqiang Li | 2017 | Chinese Chemical Letters2017，28，11： | 1 |
| 10 | Absorption properties of carbon black/silicon carbide microwave absorbers 显示文摘 | Liu Xiangxuan Zhang Zeyang Wu Youpeng | 2011 | composites : part B2011，42，： | 1 |
| 11 | Flow Criterion Research on Fluid in Hydrostatic Bearing from Laminar to Turbulent Transition 显示文摘 | Yanqin Zhang Weiwei Li Zeyang Yu | 2014 | International Journal of Hy- brid Information Technology2014，7，3： | 1 |
| 12 | Influence of Strengthening Rib Location on Temperature Distribution of Heavy Vertical Lathe Worktable 显示文摘 | Yanqin Zhang Yao Chen Zeyang Yu | 2014 | International Journal of u- and e- Service Science and Technology2014，7，1： | 1 |
| 13 | Flow Criterion Researchon Fluid in Hydrostatic Bearing from Laminar to Turbulent Transi- tion 显示文摘 | ZHANG Yanqin LI Weiwei YU Zeyang | 2014 | International Journal of Hybrid Information Technology2014，7，3： | 1 |
| 14 | Influence of Strength- ening Rib Location on Temperature Distribution of Heavy Vertical Lathe Worktable 显示文摘 | ZHANG Yanqin CHEN Yao YU Zeyang | 2014 | International Journal of u-and e-Service Science and Technology2014，7，1： | 1 |
| 15 | Adaptive Quasi Fixed-Time Orbit Control Around Asteroid with Performance Guarantees显示文摘This paper investigates a novel quasi fixed-time orbit tracking control method for spacecraft around an asteroid in the presence of uncertain dynamics and unknown uncertainties.To quantitatively characterize the transient and steady-state responses of orbit tracking error system,a continuous performance function is devised via using a quartic polynomial.Then,integrating backstepping control technique and barrier Lyapunov function leads to a quasi fixed-time convergent orbit tracking controller without using any fractional state information and symbolic functions.Finally,two groups of illustrative examples are employed to test the effectiveness of the proposed orbit control method. | Renyong Zhang Caisheng Wei Zeyang Yin | 2020 | Computer Modeling in Engineering & Sciences2020，，1： | 1 |
| 16 | Effect of Nd–Co substitution on magnetic and microwave absorption properties of SrFe 12 O 19 hexaferrites显示文摘 | Zeyang Zhang Xiangxuan Liu Xuanjun Wang Youpeng Wu Rong Li | 2012 | Journal of Alloys and Compounds2012，，： | 1 |
| 17 | Organ function support in patients with coronavirus disease 2019:Tongji experience显示文摘Coronavirus disease 2019(COVID-19)is a highly contagious disease and a serious threat to human health.COVID-19 can cause multiple organ dysfunction,such as respiratory and circulatory failure,liver and kidney injury,disseminated intravascular coagulation,and thromboembolism,and even death.The World Health Organization reports that the mortality rate of severe-type COVID-19 is over 50%.Currently,the number of severe cases worldwide has increased rapidly,but the experience in the treatment of infected patients is still limited.Given the lack of specific antiviral drugs,multi-organ function support treatment is important for patients with COVID-19.To improve the cure rate and reduce the mortality of patients with severe-and critical-type COVID-19,this paper summarizes the experience of organ function support in patients with severe-and criticaltype COVID-19 in Optical Valley Branch of Tongji Hospital,Wuhan,China.This paper systematically summarizes the procedures of functional support therapies for multiple organs and systems,including respiratory,circulatory,renal,hepatic,and hematological systems,among patients with severe-and critical-type COVID-19.This paper provides a clinical reference and a new strategy for the optimal treatment of COVID-19 worldwide. | Yong Li Fan He Ning Zhou Jia Wei Zeyang Ding Luyun Wang Peng Chen Shuiming Guo Binhao Zhang Xiaoning Wan Wei Zhu 无 Xiaoping Chen Xiaomei Guo Rui Li Shengqing Li Daowen Wang Hui Wang Gang Xu Zhenyu Yin Wenkui Yu Bixiang Zhang Jianping Zhao Jianfeng Zhou | 2020 | Frontiers of Medicine2020，14，2： | 1 |
| 18 | Reflectin基因起源及其蛋白质逐级组装的性质显示文摘文章简介在自然界中,头足纲动物以动态变色和拟态隐形而著称。这其中涉及两种类型的颜色,分别是色素色彩和结构色彩。Reflectin是一类只存在于头足纲动物体内的特殊蛋白质家族,其构成了它们结构色变化的物质基础,然而其基因来源以及如何介导结构色彩变化的分子机理尚不清楚。 | Zhe Guan Tiantian Cai Zhongmin Liu Yunfeng Dou Xuesong Hu Peng Zhang Xin Sun Hongwei Li Yao Kuang Qiran Zhai Hao Ruan Xuanxuan Li Zeyang Li Qihui Zhu Jingeng Mai Qining Wang Luhua Lai Jianguo Ji Haiguang Liu Bin Xia Taijiao Jiang Shu-Jin Luo Hong-Wei Wang 谢灿 | 2018 | 科学新闻2018，0，4： | 0 |
| 19 | BmSE, a SINE family with 3′ ends of (ATTT) repeats in domesticated silkworm (Bombyx mori)显示文摘Short interspersed elements (SINEs), which are mainly composed of Bm1, are abundant in the domesticated silkworm. A 294 bp novel SINE family, designated as BmSE, was identified by mining the database of the complete Bombyx mori genome. A representational BmSE element is flanked by an 11 bp target site duplication sequence posterior poly (A) at the 3′ end and has the sequence motifs of an internal promoter of RNA polymerase III, which are similar to that of Bm1. The repetitive elements of BmSE are widely distributed in all 28 chromosomes of the genome and share the common (ATTT) repeats at the ends. GC-content distribution shows that BmSE tends to accumulate preferably in the region of higher AT content than that of Bm1. A high proportion of the BmSEs are mapped to the coding sequence introns, whereas several elements are also present in the UTR of some transcripts, indicating that BmSEs are indeed exonized with UTRs. Of the 615 identified structural variants (SVs) of BmSE among the 40 domesticated and wild silkworms, only 230 SVs were found in the domesticated silkworms, indicating that many recent SV events of BmSE occurred after domestication, which was probably due to its mobilization. Our analysis might assist in developing BmSE as a potential marker and in understanding the evolutionary roles of SINEs in the domesticated silkworm. | Jinshan Xu Tie Liu Dong Li Ze Zhang Qinyou Xia Zeyang Zhou | 2010 | Journal of Genetics and Genomics2010，37，2： | 0 |
| 20 | Soil seismic analysis for 2D oblique incident waves using exact free-field responses by frequency-based finite/infinite element method显示文摘The seismic analysis of a viscoelastic half-space under two-dimensional(2D)oblique incident waves is carried out by the finite/infinite element method(FIEM).First,the frequency-domain exact solutions for the displacements and stresses of the free field are derived in general form for arbitrary incident P and SV waves.With the present formulation,no distinction needs to be made for SV waves with over-critical incident angles that make the reflected P waves disappear,while no critical angle exists for P waves.Next,the equivalent seismic forces of the earthquake(Taft Earthquake 1952)imposed on the near-field boundary are generated by combining the solutions for unit ground accelerations with the earthquake spectrum.Based on the asymmetric finite/infinite element model,the frequency-domain motion equations for seismic analysis are presented with the key parameters selected.The results obtained in frequency and time domain are verified against those of Wolf’s,Luco and de Barros’and for inversely computed ground motions.The parametric study indicated that distinct phase difference exists between the horizontal and vertical responses for SV waves with over-critical incident angles,but not for under-critical incident angles.Other observations were also made for the numerical results inside the text. | Yeong-Bin Yang Zeyang Zhou Xiongfei Zhang Xiaoli Wang | 2022 | Frontiers of Structural and Civil Engineering2022，16，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员