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| 1 | Lactobacillus salivarius alleviates inflammation via NF-κB signaling in ETEC K88-induced IPEC-J2 cells显示文摘Background:Enterotoxigenic Escherichia coli(ETEC)K88 commonly colonize in the small intestine and keep releasing enterotoxins to impair the intestinal barrier function and trigger inflammatory reaction.Although Lactobacillus salivarius(L.salivarius)has been reported to enhance intestinal health,it remains to be seen whether there is a functional role of L.salivarius in intestinal inflammatory response in intestinal porcine epithelial cell line(IPEC-J2)when stimulated with ETEC K88.In the present study,IPEC-J2 cells were first treated with L.salivarius followed by the stimulation of ETEC K88 for distinct time period.ETEC K88 adherent status,pattern recognition receptors(PRRs)mRNA,mitogen-activated protein kinase(MAPK)and nuclear factor-κB(NF-κB)activation,the release of pro-inflammation cytokines and cell integrity were examined.Results:Aside from an inhibited adhesion of ETEC K88 to IPEC-J2 cells,L.salivarius was capable of remarkably attenuating the expression levels of interleukin(IL)-1β,tumor necrosis factor-α(TNF-α),IL-8,Toll-like receptor(TLR)4,nucleotide-binding oligomerization domain(NOD)-like receptor pyrin domain-containing protein(NLRP)3 and NLRP6.This alternation was accompanied by a significantly decreased phosphorylation of p38 MAPK and p65 NF-κB during ETEC K88 infection with L.salivarius pretreatment.Western blot analysis revealed that L.salivarius increased the expression levels of zona occludens 1(ZO-1)and occludin(P<0.05)in ETEC K88-infected IPEC-J2 cells.Compared with ETEC K88-infected groups,the addition of L.salivarius as well as extra inhibitors for MAPKs and NF-κB to ETEC K88-infected IPEC-J2 cells had the capability to reduce pro-inflammatory cytokines.Conclusions:Collectively,our results suggest that L.salivarius might reduce inflammation-related cytokines through attenuating phosphorylation of p38 MAPK and blocking the NF-κB signaling pathways.Besides,L.salivarius displayed a potency in the enhancement of IPEC-J2 cell integrity. | Jiayun Qiao Zeyang Sun Dongmei Liang Haihua Li | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 11 |
| 2 | Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia显示文摘Microglia 玩在由降级的 A 的清理的一个枢轴的角色他们在 lysosomes,在 Alzheimers 疾病(广告) 阻止淀粉的匾致病。最近的证据建议那个 lysosomal 机能障碍导致有毒的蛋白质总数的不够的消除。我们测试了是否与抄写因素 EB (TFEB ) 提高 lysosomal 功能,必要管理者 modulating lysosomal 小径,将在 microglia 支持一个清理。这里,我们证明 TFEB 的那 microglial 表情便于降级和还原剂扔了的纤丝状的 A (fA ) 淀粉的匾,它被 TFEB 的 deacetylation 进一步提高。用集体 spectrometry 分析,我们第一证实了是的 acetylation 一以前 TFEB 的 unreported 修正并且发现那 SIRT1 直接交往了与并且在离氨酸残余 116 点的 deacetylated TFEB。随后,当 TFEB 被击倒时, SIRT1 overexpression 由 TFEB 下游的目标的 upregulating transcriptional 层次提高了 lysosomal 功能和 fA 降级,它能被禁止。而且,在在 microglia 变异的 K116R 的 deacetylated TFEB 的 overexpression 由刺激 lysosomal 生物的续生说加速了细胞内部的 fA 降级并且极大地在 APP/PS1 转基因的老鼠的大脑片减少了扔的淀粉的匾。我们的调查结果表明 TFEB 的 deacetylation 能调整 lysosomal 生物的续生说和 fA 降级,为 attenuating 使 TFEB 的 microglial 激活成为可能的策略在广告的淀粉的匾免职。 | Jintao Bao Liangjun Zheng Qi Zhang Xinya Li Xuefei Zhang Zeyang Li Xue Bai Zhong Zhang Wei Huo Xuyang Zhao Shujiang Shang Qingsong Wang Chen Zhang Jianguo Ji | 2016 | Protein & Cell2016，7，6： | 10 |
| 3 | Simulation and experimental study on lubrication characteristics of vertical hydrostatic guide rails显示文摘In order to improve the cutting stiffness,the paper studies the vertical hydrostatic bearing in the slide when a ram is in feed process.The change of the oil film thickness on hydrostatic guide rail and the curve of the oil film thickness in various cutting forces are calculated and a relation model through theoretical analysis method is derived.The pressure field of the guide rail recess is simulated based on the finite volume method and demonstrated through experiments.The study is of vital theoretical significance for the improvement of machining accuracy of numerical control machines and the entire computer numerical control(CNC) equipment and provides valuable theoretical basis for the design of hydrostatic guide rail in engineering practice. | 张艳芹 Yu Zeyang Chen Yao Shao Junpeng Yu Xiaodong Jiang Hui | 2014 | High Technology Letters2014，20，3： | 8 |
| 4 | Natural selection maintains the transcribed LTR retrotransposons in Nosema bombycis显示文摘Eight intact LTR retrotransposons(Nbr1?Nbr8)have been previously characterized from the genome of Nosema bombycis,a eu-karyotic parasite with a compact and reduced genome.Here we describe six novel transcribed Nbr elements(Nbr9?Nbr14)identified through either cDNA library or RT-PCR.Like previously determined ones,all of them belong to the Ty3/Gypsy superfamily.Retrotransposon diversity and incomplete domains with insertions(Nbr12),deletions(Nbr11)and in-frame stop codons in coding regions(Nbr9)were detected,suggesting that both defective and loss events of LTR retrotransposon have happened in N.bombycis genome.Analysis of selection showed that strong purifying selection acts on all elements except Nbr11.This implies that selective pressure keeps both these Nbrs and their functions in genome.Interestingly,Nbr11 is under positive selection and some positively selected codons were identified,indicating that new functionality might have evolved in the Nbr11 retrotransposon.Unlike other transposable elements,Nbr11 has integrated into a conserved syntenic block and probably resulted in the inversion of both flanking regions.This demonstrates that transposable element is an important factor for the reshuffling and evolution of their host genomes,and may be maintained under natural selection. | Heng Xiang Guoqing Pan Ruizhi Zhang Jinshan Xu Tian Li Wenle Li Zeyang Zhou Zhonghuai Xiang | 2010 | Journal of Genetics and Genomics2010，37，5： | 7 |
| 5 | Analysis of cytochrome P450 genes in silkworm genome (Bombyx mori)显示文摘We have searched the Bombyx mori genome for members of the major enzyme family, the Cytochrome P450s, which carry out multiple reactions to enable organisms to rid themselves of foreign compounds. As a result, 86 putative P450s were discovered in silkworm genome, which are thought to belong to 32 subfamilies. A comparative genomic analysis with Drosophila melanogaster reveals that the two insects have some similar P450 distribution pat-terns but still have some obvious differences. Especially, the diverse distribution exists in 7 p450 subfamilies, which are CYP4A, CYP4C, CYP4D, CYP6A, CYP6AE, CYP6B and CYP9A. Fur-thermore, we collected expression sequence tag (EST) evidence for 49 putative P450s genes, which are expressed at the transcriptional level and more likely to be true P450s. | LI Bin XIA Qingyou LU Cheng ZHOU Zeyang XIANG Zhonghuai | 2005 | Science China(Life Sciences)2005，48，4： | 7 |
| 6 | Histone Deacetylase AtSRT1 Links Metabolic Flux and Stress Response in Arabidopsis显示文摘怎么种新陈代谢的流动,改变基因表示优化植物生长,对应力的反应仍然保持大部分不清楚。这里,我们报导 Arabidopsis thaliana NAD +-dependent histone deacetylase AtSRT1 否定地调整植物公差到应力和 glycolysis,但是刺激 mitochondrial 呼吸。我们发现 AtSRT1 与 Arabidopsis cMyc 有约束力的蛋白质 1 交往(AtMBP-1 ) ,一个 transcriptional 抑压者由 cytosolic glycolytic enolase 基因 LOS2/ENO2 的其他的翻译生产了。我们证明 AtSRT1 能与 AtMBP-1 目标 LOS2/ENO2 和 STZ/ZAT10 的染色质联系,哪个编码关键压力管理者,并且在这些基因减少 H3K9ac 层次镇压他们的抄写。AtSRT1 和 AtMBP-1 的 Overexpression 在 glycolytic 基因的表示上有 synergistic 效果, glycolytic 酶的活动,和 mitochondrial 呼吸。而且,我们发现 AtMBP-1 是 lysine-acetylated 并且对 proteasomal 蛋白质降级脆弱,当 AtSRT1 能移开它的离氨酸 acetylation 并且显著地提高它的稳定性在时 ? vivo。一起拿,这些结果显示 AtSRT1 在 Arabidopsis 由 epigenetic 规定和 AtMBP-1 transcriptional 活动的调整调整主要新陈代谢和压力反应。 | Xiaoyun Liu Wei Wei Wenjun Zhu Lufang Su Zeyang Xiong Man Zhou Yu Zheng and Dao-Xiu Zhou | 2017 | Molecular Plant2017，10，12： | 6 |
| 7 | A review of friction stir joining of SiCp/Al composites显示文摘SiCp/Al composites have excellent comprehensive properties and have been widely used in aerospace,automotive industry and other fields.Due to the huge difference in performance between SiC particles and matrix alloys,traditional fusion welding methods are difficult to meet the join requirements of SiCp/Al composites.Friction stir joining(friction stir welding),as a solid phase joining process,has been proved to be a new technology with fine prospect in joining SiCp/Al composites compared with fusion welding process.Although some progress has been made in recent years,there are still full of challenges.In this paper,the research status of friction stir joining of SiCp/Al composites in recent years is expatiated,including the weldability of SiCp/Al composites,the macrostructure and the microstructure of joints,mechanical properties of joints,and tool wear and monitoring.Furthermore,the existing challenges of friction stir joining of SiCp/Al composites are summarized and the future development directions are prospected. | Lisheng ZUO Xianrui ZHAO Zeyang LI Dunwen ZUO Hongfeng WANG | 2020 | Chinese Journal of Aeronautics2020，33，3： | 6 |
| 8 | Effects of atmospheric pressure fluctuations on hill-side coal fires and surface anomalies显示文摘This paper presents numerical studies on the effects of atmospheric pressure fluctuations on hill-side coal fires and their surface anomalies. Based on the single-particle reaction–diffusion model, a formula to estimate oxygen consumption rate at high temperature controlled by oxygen transport is proposed.Daily fluctuant atmospheric pressure was imposed on boundaries, including the abandoned gallery and cracks. Simulated results show that the effects of atmospheric pressure fluctuations on coal fires and surface anomalies depend on two factors: the fluctuant amplitude and the pressure difference between inlet(s) and outlet(s) of the air ventilation system. If the pressure difference is close to the fluctuant amplitude, atmospheric pressure fluctuations greatly enhance gas flow motion and temperatures of the combustion zone and outtake(s). If the pressure difference is much larger than the fluctuant amplitude, atmospheric pressure fluctuations exert no impact on underground coal fires and surface anomalies. | Song Zeyang Zhu Hongqing Xu Jiyuan Qin Xiaofeng | 2015 | International Journal of Mining Science and Technology2015，25，6： | 4 |
| 9 | Interfacial Voids Trigger Carbon-Based, All-Inorganic Cs Pb IBr2 Perovskite Solar Cells with Photovoltage Exceeding 1.33 V显示文摘A novel interface design is proposed for carbon-based,all-inorganic CsPbIBr2 perovskite solar cells(PSCs)by introducing interfacial voids between TiO2 electron transport layer and CsPbIBr2 absorber.Compared with the general interfacial engineering strategies,this design exempts any extra modification layer in final PSC.More importantly,the interfacial voids produced by thermal decomposition of 2-phenylethylammonium iodide trigger three beneficial e ects.First,they promote the light scattering in CsPbIBr2 film and thereby boost absorption ability of the resulting CsPbIBr2 PSCs.Second,they suppress recombination of charge carriers and thus reduce dark saturation current density(J0)of the PSCs.Third,interfacial voids enlarge built-in potential(Vbi)of the PSCs,awarding increased driving force for dissociating photo-generated charge carriers.Consequently,the PSC yields the optimized e ciency of 10.20%coupled with an open-circuit voltage(Voc)of 1.338 V.The Voc achieved herein represents the best value among CsPbIBr2 PSCs reported earlier.Meanwhile,the non-encapsulated PSCs exhibit an excellent stability against light,thermal,and humidity stresses,since it remains^97%or^94%of its initial e ciency after being heated at 85℃for 12 h or stored in ambient atmosphere with relative humidity of 30–40%for 60 days,respectively. | Weidong Zhu Zeyang Zhang Dandan Chen Wenming Chai Dazheng Chen Jincheng Zhang Chunfu Zhang Yue Hao | 2020 | Nano-Micro Letters2020，12，7： | 3 |
| 10 | A kind of double-sided porous anodic alumina membrane fabricated with the three-step anodic oxidation method显示文摘The porous anodic alumina membranes(PAAMs)have been successfully used as templates for the fabrication of functional nano-materials due to their outstanding regularity and physicochemical properties.In this paper,a transparent double-sided anodic alumina membrane with ultra-thin aluminum substrate was fabricated with the three-step anodic oxidation method in the oxalic acid electrolyte.The characters such as the top-surface morphology,membrane thickness,and depth of nanopores of this three-layer(Al2O3-Al-Al2O3)sandwiched nano-structure were controllable through regulating the main anodic oxidation conditions,e.g.,anodic oxidation time of various steps,coating remove process.The experiments data revealed that the aluminum substrate is exponential declined with the oxidation time when it was approximately reduced by a few micrometers.This new double-sided anodic alumina membrane can be used as the high-quality functional field emission materials and templates. | ZHANG Chen WANG KaiGe GAO ZeYang WU JunJun REN JunYing ZHANG LiangLiang GU ChangZhi BAI JinTao | 2014 | Science China(Technological Sciences)2014，57，2： | 2 |
| 11 | Metasurface-enabled augmented reality display: a review显示文摘Augmented reality(AR)display,which superimposes virtual images on ambient scene,can visually blend the physical world and the digital world and thus opens a new vista for human–machine interaction.AR display is considered as one of the next-generation display technologies and has been drawing huge attention from both academia and industry.Current AR display systems operate based on a combination of various refractive,reflective,and diffractive optical elements,such as lenses,prisms,mirrors,and gratings.Constrained by the underlying physical mechanisms,these conventional elements only provide limited light-field modulation capability and suffer from issues such as bulky volume and considerable dispersion,resulting in large size,severe chromatic aberration,and narrow field of view of the composed AR display system.Recent years have witnessed the emerging of a new type of optical elements—metasurfaces,which are planar arrays of subwavelength electromagnetic structures that feature an ultracompact footprint and flexible light-field modulation capability,and are widely believed to be an enabling tool for overcoming the limitations faced by current AR displays.Here,we aim to provide a comprehensive review on the recent development of metasurface-enabled AR display technology.We first familiarize readers with the fundamentals of AR display,covering its basic working principle,existing conventional-optics-based solutions,as well as the associated pros and cons.We then introduce the concept of optical metasurfaces,emphasizing typical operating mechanisms,and representative phase modulation methods.We elaborate on three kinds of metasurface devices,namely,metalenses,metacouplers,and metaholograms,which have empowered different forms of AR displays.Their physical principles,device designs,and the performance improvement of the associated AR displays are explained in details.In the end,we discuss the existing challenges of metasurface optics for AR display applications and provide our perspective on future research endeavors. | Zeyang Liu Danyan Wang Hao Gao Moxin Li Huixian Zhou Cheng Zhang | 2023 | Advanced Photonics2023，5，3： | 2 |
| 12 | Electromagnetic scattering characteristics of coaxial helicopter based on dynamic transformation method显示文摘With the development of coaxial rotors and high-speed helicopters, the electromagnetic scattering characteristics of coaxial helicopters have gradually become a research hotspot. In order to deal with the Radar Cross-Section(RCS) of high-speed rotating rotors or coaxial main rotors, a Dynamic Scattering Method(DSM) based on dynamic process simulation and grid coordinate transformation is presented. Instantaneous electromagnetic scattering from rotors and helicopters is solved using Physical Optics(PO) and Physical Theory of Diffraction(PTD). Important factors are analyzed and discussed in detail, including individual rotor rotation, azimuth, elevation angle,fuselage, pitch angle, and roll angle. The results show that the electromagnetic scattering characteristics of rotor-type components are dynamic and periodic. The dynamic RCS period of a single rotor is related to the dynamic RCS period of the coaxial main rotor. Choosing different observation angles and attitude angles has a great impact on the static and dynamic RCS of the helicopter.The presented DSM is effective and efficient to analyze and determine the dynamic electromagnetic scattering characteristics of conventional helicopters or coaxial helicopters. | Zeyang ZHOU Jun HUANG Jinjun WANG | 2021 | Chinese Journal of Aeronautics2021，34，2： | 2 |
| 13 | Clinical characteristics and risk factors for mortality in cancer patients with COVID-19显示文摘Patients with cancer are at increased risk of severe infections.From a cohort including 3060 patients with confirmed COVID-19,109(3.4%)cancer patients were included in this study.Among them,23(21.1%)patients died in the hospital.Cancer patients,especially those with hematological malignancies(41.6%),urinary carcinoma(35.7%),malignancies of the digestive system(33.3%),gynecological malignancies(20%),and lung cancer(14.3%),had a much higher mortality than patients without cancer.A total of 19(17.4%)cancer patients were infected in the hospital.The clinical characteristics of deceased cancer patients were compared with those of recovered cancer patients.Multivariate Cox regression analysis indicated that a Nutritional Risk Screening(NRS2002)score≥3(adjusted hazard ratio(HR)11.00;95%confidence interval(CI)4.60–26.32;P<0.001),high-risk type(adjusted HR 18.81;95%CI 4.21–83.93;P<0.001),tumor stage IV(adjusted HR 4.26;95%CI 2.34–7.75;P<0.001),and recent adjuvant therapy(<1 month)(adjusted HR 3.16;95%CI 1.75–5.70;P<0.01)were independent risk factors for in-hospital death after adjusting for age,comorbidities,D-dimer,and lymphocyte count.In conclusion,cancer patients showed a higher risk of COVID-19 infection with a poorer prognosis than patients without cancer.Cancer patients with high-risk tumor,NRS2002 score≥3,advanced tumor stage,and recent adjuvant therapy(<1 month)may have high risk of mortality. | Junnan Liang Guannan Jin Tongtong Liu Jingyuan Wen Ganxun Li Lin Chen Wei Wang Yuwei Wang Wei Liao Jia Song Zeyang Ding Xiao-ping Chen Bixiang Zhang | 2021 | Frontiers of Medicine2021，15，2： | 2 |
| 14 | Crystal facet-dependent electrocatalytic performance of metallic Cu in CO_(2)reduction reactions显示文摘Developing high-performance electrocatalysts for CO_(2) reduction reaction(CO_(2)RR)is crucial since it is beneficial for environmental protection and the resulting value-add chemical products can act as an alternative to fossil feedstocks.Nonetheless,the direct reduction of CO_(2) into long-chain hydrocarbons and oxygenated hydrocarbons with high selectivity remains challenging.Copper(Cu)shows a distinctive advantage that it is the only pure metal catalyst for reducing CO_(2) into multi-carbon(C_(2+))products and the certain facets(e.g.,(100),(111),(111))of Cu nanocrystals exhibit relatively low energy barriers for the formation of specific products(e.g.,CO,HCOOH,CH_(4),C_(2)H_(4),C_(2)H_(5)OH,and other C_(2+) products).Therefore,extensive studies have been carried out to explore the relationship between the facets of Cu nanocrystals and corresponding catalytic products.In this review,we will discuss the crystal facet-dependent electrocatalytic CO_(2)RR performance in metallic Cu catalysts,meanwhile,the detailed reaction mechanisms will be systematically summarized.In addition,we will provide a personal perspective for the future research directions in this emerging field.We believe this review is helpful to guide the design of high-selectivity Cu-based electrocatalysts for CO_(2)RR. | Hao Zhang Caihong He Sumei Han Zeyang Du Ling Wang Qinbai Yun Wenbin Cao Bowei Zhang Ya-Hui Tian Qipeng Lu | 2022 | Chinese Chemical Letters2022，33，8： | 2 |
| 15 | A Draft Sequence for the Genome of the Domesticated Silkworm (Bombyx mori)显示文摘 | Xia Qingyou Zhou Zeyang Lu Cheng | 2004 | Science2004，306，： | 1 |
| 16 | The disease resistance potential of Trichoderma asperellum T-Pa2 isolated from Phellodendron amurense rhizosphere soil显示文摘To promote the application of Trichoderma,many countries have collected Trichoderma resources.In the present study,nine isolates were isolated from a rhizosphere soil of Phellodendron amurense and were identified as three species:Trichoderma brevicompactum(one isolate),T.asperellum(two isolates),T.atroviride(six isolates).Dual culture experiments showed that T.asperellum T-Pa2 grew fast and produced the best inhibition rates against six tested pathogens(80.25–91.65%)via competition and mycoparasitism.Populus davidiana×P.alba var.pyramidalis Louche(PdPap poplar)was treated with T-Pa2,which increased the catalase activity,nitrate reductase activity,and content of osmosis molecules significantly(P<0.05).Meanwhile,induction by T-Pa2 increased the resistance of PdPap poplar against Alternaria alternata via modulating the expression of salicylic acid,jasmonic acid,and auxin transduction pathway genes.The results will form the basis for the collection and application of biocontrol agents in forestry. | Zeyang Yu Zhihua Liu Yuzhou Zhang Zhiying Wang | 2022 | Journal of Forestry Research2022，33，1： | 1 |
| 17 | A draft sequence for the genome of the domesticated silkworm (Bombyx mori)显示文摘 | Xia Qingyou Zhou Zeyang Lu Cheng | 2004 | Science2004，306，： | 1 |
| 18 | Theory study on nonlinear control of ventilation network air flow of mine 显示文摘 | Zhu Hongqing Song Zeyang Yao Meiqun | 2011 | Proce- dia Engineering2011，26，： | 1 |
| 19 | Solution-processable precursor route for fabricating ultrathin silica film for high performance and low voltage organic transistors显示文摘Silica is one of the most commonly used materials for dielectric layer in organic thin-film transistors due to its excellent stability, excellent electrical properties, mature preparation process, and good compatibility with organic semiconductors. However, most of conventional preparation methods for silica film are generally performed at high temperature and/or high vacuum. In this paper, we introduce a simple solution spin-coating method to fabricate silica thin film from precursor route, which possesses a low leakage current, high capacitance, and low surface roughness. The silica thin film can be produced in the condition of low temperature and atmospheric environment. To meet various demands, the thickness of film can be adjusted by means of preparation conditions such as the speed of spin-coating and the concentration of solution. The p-type and n-type organic field effect transistors fabricated by using this film as gate electrodes exhibit excellent electrical performance including low voltage and high performance. This method shows great potential for industrialization owing to its characteristic of low consumption and energy saving, time-saving and easy to operate. | Shujing Guo Zhongwu Wang Zeyang Xu Shuguang Wang Kunjie Wu Shufeng Chen Zongbo Zhang Caihong Xu Wenfeng Qiu Liqiang Li | 2017 | Chinese Chemical Letters2017，28，11： | 1 |
| 20 | Sequence structure and expression pattern of a novel anionic defensin-like gene from silkworm (Bombyx mori)显示文摘 | Hongxiu Wen Xiqian Lan Tingcai Cheng Ningjia He Kunihiro Shiomi Zenta Kajiura Zeyang Zhou Qingyou Xia Zhonghuai Xiang Masao Nakagaki | 2009 | Molecular Biology Reports2009，，4： | 1 |
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