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| 1 | Safety and efficacy of ciprofol vs.propofol for sedation in intensive care unit patients with mechanical ventilation:a multi-center,open label,randomized,phase 2 trial显示文摘Background:Ciprofol(HSK3486;Haisco Pharmaceutical Group Co.,Ltd.,Chengdu,China),developed as a novel 2,6-disubstituted phenol derivative showed similar tolerability and efficacy characteristics as propofol when applicated as continuous intravenous infusion for 12 h maintenance sedation in a previous phase 1 trial.The phase 2 trial was designed to investigate the safety,efficacy,and pharmacokinetic characteristics of ciprofol for sedation of patients undergoing mechanical ventilation.Methods:In this multicenter,open label,randomized,propofol positive-controlled,phase 2 trial,39 Chinese intensive care unit patients receiving mechanical ventilation were enrolled and randomly assigned to a ciprofol or propofol group in a 2:1 ratio.The ciprofol infusion was started with a loading infusion of 0.1-0.2 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 0.30 mg·kg^(-1)·h^(-1),which could be adjusted to an infusion rate of 0.06 to 0.80 mg·kg^(-1)·h^(-1),whereas for propofol the loading infusion dose was 0.5-1.0 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 1.50 mg·kg^(-1)·h^(-1),which could be adjusted to 0.30-4.00 mg·kg^(-1)·h^(-1)to achieve-2 to+1 Richmond Agitation-Sedation Scale sedation within 6-24 h of drug administration.Results:Of the 39 enrolled patients,36 completed the trial.The median(min,max)of the average time to sedation compliance values for ciprofol and propofol were 60.0(52.6,60.0)min and 60.0(55.2,60.0)min,with median difference of 0.00(95%confidence interval:0.00,0.00).In total,29(74.4%)patients comprising 18(69.2%)in the ciprofol and 11(84.6%)in the propofol group experienced 86 treatment emergent adverse events(TEAEs),the majority being of severity grade 1 or 2.Drug-and sedation-related TEAEs were hypotension(7.7%vs.23.1%,P=0.310)and sinus bradycardia(3.8%vs.7.7%,P=1.000)in the ciprofol and propofol groups,respectively.The plasma concentration-time curves for ciprofol and propofol were similar.Conclusions:ciprofol is comparable to propofol with good tolerance and efficacy for sedation of Chinese intensive care unit patients undergoing mechanical ventilation in the present study setting.Trial registration:ClinicalTrials.gov,NCT04147416. | Yongjun Liu Xiangyou Yu Duming Zhu Jun Zeng Qinhan Lin Bin Zang Chuanxi Chen Ning Liu Xiao Liu Wei Gao Xiangdong Guan | 2022 | Chinese Medical Journal2022，，9： | 19 |
| 2 | A Novel Immunosensor Based on Au Nanoparticles and Polyaniline/Multiwall Carbon Nanotubes/Chitosan Nanocomposite Film Functionalized Interface显示文摘A novel multilayer film based on Au nanoparticles(AuNPs) and polyaniline/carboxylated multiwall carbon nanotubes-chitosan nanocomposite(PANI/MWCNTs/CS) was exploited to fabricate a highly sensitive immunosensor for detecting chlorpyrifos. PANI-coated MWCNTs were prepared by in situ chemical polymerization and carboxylated MWCNTs played an important role in obtaining the thin and uniform coating of PANI resulting in the improved immunosensor response. Au NPs were used as a linker to immobilize chlorpyrifos antibody. The performance of the immunosensor was characterized by means of cyclic voltammetry(CV), electrochemical impedance spectroscopy(EIS) and scanning electron microscopy(SEM), respectively. All variables involved in the preparation process and analytical performance of the immunosensor were optimized.Under optimal conditions(antibody concentration: 5 μg/mL, working buffer pH: 6.5, incubation time: 40 min,incubation temperature: 25℃), the immunosensor exhibited a wide linear range from 0.1 to 40× 10^(-6)mg/mL and from 40 × 10^(-6)mg/mL to 500 × 10^(-6)mg/mL, and with a detection limit of 0.06 × 10^(-6)mg/mL, which provided a valuable tool for the chlorpyrifos detection in real samples. | Xia Sun Lu Qiao Xiangyou Wang | 2013 | Nano-Micro Letters2013，5，3： | 6 |
| 3 | Analysis of heat transfer of loop heat pipe used to cool high power LED显示文摘A novel loop heat pipe(LHP)cooling device for high power LED is developed.The thermal capabilities, including startup performance,temperature uniformity and thermal resistance of the loop heat pipe under different heat loads and incline angles have been investigated experimentally.The obtained results indicate that the thermal resistance of the heat pipe heat sink is in the range of 0.19―3.1 K/W,the temperature uniformity in the evaporator is controlled within 1.5℃,and the junction temperature of high power LED can be controlled steadily under 100℃for a heat load of 100 W. | LU XiangYou HUA ZeZhao LIU MeiJing CHENG YuanXia | 2009 | Science China(Technological Sciences)2009，52，12： | 5 |
| 4 | DOUBLE WAVE DESCRIPTION OF SINGLE PARTICLE IN AN INFINITELY DEEP SQUARE POTENTIAL WELL显示文摘Recently we have suggested that the state of a single particle should be jointly defined by two wave functions.In this letter we use this suggestion to discuss the motion of a single particle in an infinitely deep square potential well;the results obiained in the classical limit correctly describe the motion of the single particle with clarity. | HUANG Xiangyou QIAN Shangwu LIU Quanhui HE Zuoxiu | 1990 | Chinese Physics Letters1990，7，4： | 3 |
| 5 | Electrochemical Aptasensor Based on Prussian Blue-Chitosan-Glutaraldehyde for the Sensitive Determination of Tetracycline显示文摘In this paper, a novel and sensitive electrochemical aptasensor for detecting tetracycline(TET)with prussian blue(PB) as the label-free signal was fabricated. A PB-chitosan-glutaraldehyde(PB-CS-GA)system acting as the signal indicator was developed to improve the sensitivity of the electrochemical aptasensor.Firstly, the PB-CS-GA was fixed onto the glass carbon electrode surface. Then, colloidal gold nanoparticles(Au NPs) were droped onto the electrode to immobilize the anti-TET aptamer for preparation of the aptasensor.The stepwise assembly process of the aptasensor was characterized by cyclic voltammetry(C-V) and scanning electron microscope(SEM). The target TET captured onto the electrode induced the current response of the electrode due to the non-conducting biomoleculars. Under the optimum operating conditions, the response of differential pulse voltammetry(DPV) was used for detecting the concentration of TET. The proposed aptasensor showed a high sensitivity and a wide linear range of 109-~ 105-M and 105-~ 102-M with the correlation coefficients of 0.994 and 0.992, respectively. The detection limit was 3.2×1010-M(RSD 4.12%). Due to its rapidity, sensitivity and low cost, the proposed aptasensor could be used as a pre-scanning method in TET determination for the analysis of livestock products. | Guanghui Shen Yemin Guo Xia Sun Xiangyou Wang | 2014 | Nano-Micro Letters2014，6，2： | 2 |
| 6 | Recruited CD68^(+)CD206^(+)macrophages orchestrate graft immune tolerance to prompt xenogeneic-dentin matrix-based tooth root regeneration显示文摘Successful regenerative medicine strategies of xenogeneic extracellular matrix need a synergistic balance among inflammation,fibrosis,and remodeling process.Adaptive macrophage subsets have been identified to modulate inflammation and orchestrate the repair of neighboring parenchymal tissues.This study fabricated PPARγ-primed CD68+CD206+M2 phenotype(M2γ),and firstly verified their anti-inflammatory and tissue-regenerating roles in xenogeneic bioengineered organ regeneration.Our results showed that Th1-type CD3^(+)CD8^(+)T cell response to xenogeneic-dentin matrix-based bioengineered root complex(xeno-complex)was significantly inhibited by M2γmacrophage in vitro.PPARγactivation also timely recruited CD68^(+)CD206^(+)tissue macrophage polarization to xeno-complex in vivo.These subsets alleviated proinflammatory cytokines(TNF-α,IFN-γ)at the inflammation site and decreased CD3^(+)CD8^(+)T lymphocytes in the periphery system.When translated to an orthotopic nonhuman primate model,PPARγ-primed M2 macrophages immunosuppressed IL-1β,IL-6,TNF-α,MMPs to enable xeno-complex to effectively escape immune-mediated rejection and initiate graft-host synergistic integrity.These collective activities promoted the differentiation of odontoblast-like and periodontal-like cells to guide pulp-dentin and cementum-PDLs-bone regeneration and rescued partially injured odontogenesis such as DSPP and periostin expression.Finally,the regenerated root showed structure-biomechanical and functional equivalency to the native tooth.The timely conversion of M1-to-M2 macrophage mainly orchestrated odontogenesis,fibrogenesis,and osteogenesis,which represents a potential modulator for intact parenchymal-stromal tissue regeneration of targeted organs. | Hui Li Jingjing Sun Hefeng Yang Xue Han Xiangyou Luo LiJun Liao Bo Yang Tian Zhu Fangjun Huo Weihua Guo Weidong Tian | 2021 | Bioactive Materials2021，6，4： | 2 |
| 7 | Effects of circular beam oscillation technique on formability and solidification behaviour of selective laser melted Inconel 718:From single tracks to cuboid samples显示文摘The inherent drawbacks of selective laser melting technique including serious micro-pore and element microsegregation problems destroy the mechanical property of the component.To overcome this problem,a new approach,circular beam oscillation,was successfully applied in the SLMed Inconel 718 samples including single tracks,thin walls and cuboid samples.On one hand,circular beam oscillation reduces the micro-pores in molten pools and cuboid samples,increasing the relative density of the cuboid sample to 99.95%.On the other hand,circular beam oscillation suppresses the element microsegregation,reducing the formation of Laves phases in SLMed Inconel 718 samples.Moreover,circular beam oscillation enhances the<001>texture of thin walls and the<101>texture of cuboid samples.The improvement of formability and microstructure of the SLMed samples with oscillation is closely related to cooling rate,thermal gradient and stirring effect during the solidification process.Therefore,circular beam oscillation shows the possibility to overcome the key bottlenecks of the traditional SLM technology and to realize a further industrial application of SLM technology. | Huihui Yang Guanyi Jing Piao Gao Zemin Wang Xiangyou Li | 2020 | Journal of Materials Science & Technology2020，47，16： | 2 |
| 8 | Growth Pattern and Its Indication of Spheroidal Nano-Micro Crystal Aggregates of Pyrite in the Baiyunpu Pb-Zn Polymetallic Deposit, Central Hunan显示文摘The Baiyunpu deposit lies in the southwest plunging Dachengshan anticline in central Hunan, which is a large Pb-Zn polymetallic deposit. The orebodies were surrounded by the Qiziqiao Formation limestone in the Middle Devonian, and its geological occurrence is consistent with the wall rocks. A large number of spheroidal pyrite aggregates are found unevenly distributed in the ores. The spheroidal aggregates are made up of kernels and concentric rings. The kernels are composed of approximately epigranular pyrite nanocrystals, while the rings are composed of accumulated pyrite microcrystals growing along the radial direction. The spheroidal pyrite aggregate and its outer zones can be divided into five areas(A–E). The results of electron probe micro analysis(EPMA) show that from the zone A1 to B, Co/Ni <1, the sum of Co and Ni is 0.08%–0.26%, S/Fe increases from 2.06 to 2.15. While from the zone C to E, Ni cannot be detected and S/Fe decreases from 2.22 to 2.08. Powder X-ray diffraction(XRD) analysis in the micro zone shows obvious crystalline characteristics in the aggregates. Moving from the inside outwards, the maximum diffraction peak intensity of the(111) and(220) crystal planes of pyrite increases, and the crystallinity improves. The degree of change in the(111) plane is the most prominent. Considering the theory of crystal growth along with the geologic features of the depositional environment where the spheroidal pyrite aggregates developed, we confirm that the spheroidal aggregates are the result of nano-micro crystalline gathering and growth occurring by the following sequence of processes:nano-crystalline nucleation and growth, gathering into a ball, oriented growth of microcrystals, continuous accumulation, and adjustment of grain boundaries. The formation of the spheroidal pyrite aggregates in the late Qiziqiao Formation of the Middle Devonian occurred in a neutral to weak alkaline and reductive sedimentary environment in the normal oxygen-rich shallowwater carbonate platform edge. The variations in the S/Fe ratio and crystallisation characteristics indicate that during pyrite crystal growth, the sulphur fugacity was high locally and rose constantly, the degree of supersaturation decreased locally and the growth environment was stable relatively. | GAO Shang HUANG Fei GU Xiangping LI Xiangyou MENG Lin LIU Rui SUN Li GAO Wenyuan YU Huantao | 2014 | Acta Geologica Sinica(English Edition)2014，88，6： | 2 |
| 9 | Effect of high oxygen modified atmosphere on post-harvest physiology and sensorial qualities of mushroom显示文摘 | Liu Zhanli Wang Xiangyou Zhu Jiying | 2010 | International Journal of Food Science and Technology2010，45，6： | 1 |
| 10 | Acetyl cholinesterase biosensor based on Prussian blue-modied electrode for detecting or- ganophosphorous pesticides显示文摘 | Xia Sun Xiangyou Wang | 2010 | Biosensors and Bioelec- tronics2010，25，： | 1 |
| 11 | Fabrication of micro heater by laser micro cladding electronic paste显示文摘 | Cai Zhixiang Li Xiangyou Hu Qianwu | | 0，，1： | 1 |
| 12 | Multiwall carbon nanotube-based acetylcholinesterase biosensor 显示文摘 | SUN Xia WANG Xiangyou ZHAO Wenping | 2010 | Sens Lett2010，8，2： | 1 |
| 13 | Multiwall carbon nanotube-based acetylcholinesterase biosensor for detecting organophosphorous pesficides显示文摘 | SUN Xia WANG Xiangyou ZHAO Wenping | 2010 | Sens Lett2010，8，2： | 1 |
| 14 | Characterization and formation mechanism of laser-welded Mg and A1 alloys using Ti inter layer显示文摘 | GAO Ming MEI Shuwen LI Xiangyou | 2012 | ScriptaMaterial2012，67，： | 1 |
| 15 | 查看详情显示文摘 | Liao Li Wang Xiangyou Luo Xufang | | 0，，01： | 1 |
| 16 | Conductive line prep- aration on resin surfaces by laser micro - cladding conductive pastes 显示文摘 | Xiangyou Li Huiling Li Jingwe Liu | 2004 | Applied surface science2004，233，： | 1 |
| 17 | Effects of the Postharvest Storage Temperature and its Fluctuations on the Keeping Quality of Agaricus Bisporus 显示文摘 | Jiying Zhu Xiangyou Wang Yingchao Xu | 2006 | International Journal of Food Engineering2006，2，1： | 1 |
| 18 | Studies on the oxygen reduction catalyst for zinc-air battery electrode显示文摘 | Wang Xiangyou Sebastian P J Mascha A Smit | 2003 | J Power Sources2003，124，1： | 1 |
| 19 | MOPA pulsed fiber laser for silicon scribing 显示文摘 | LI XIANGYOU ZENG XIAOYAN LIU YONG | 2016 | Optics2016，2016，80： | 1 |
| 20 | Polypyrrole carbon aerogel con-tposite materials for supercapacitor显示文摘 | An Hongfang Wang Ying Wang Xiangyou | 2010 | Journal of Power Sources2010，195，： | 1 |
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