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| 1 | APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells显示文摘APOBEC3 protein families, a DNA cytidine deaminase, were up-regulated in multiple tumors. However, the relationship between Hepatocellular carcinoma(HCC) and APOBEC3B(A3B) remains unknown. It has been confirmed that interleukin-6(IL-6)has significant impacts on oncogenesis of HCC. Here, we reported that the expression of IL-6 was substantially up-regulated by A3 B in HepG2 cells. A3 B induced IL-6 expression through relocating HuR to enhance the IL-6 mRNA stability. Further analysis indicated that IL-6 also increased the expression of A3 B through JAK1/STAT3 signaling pathway, which formed a positive feedback to maintain the continuous expression of A3 B and IL-6, and thereby promoted the prolonged non-resolving inflammation. Collectively, these findings suggest that A3 B is essential for oncogenesis of HCC, and is a potential target for preventive intervention. | Shuran Li Xueyang Bao Duowei Wang Linjun You Xianjing Li Hongbao Yang Jinsong Bian Yun Wang Yong Yang | 2017 | Science China(Life Sciences)2017，60，6： | 2 |
| 2 | Aseismic safety analysis of a prestressed concrete containment vessel for CPR1000 nuclear power plant显示文摘The containment vessel of a nuclear power plant is the last barrier to prevent nuclear reactor radiation.Aseismic safety analysis is the key to appropriate containment vessel design.A prestressed concrete containment vessel(PCCV) model with a semi-infinite elastic foundation and practical arrangement of tendons has been established to analyze the aseismic ability of the CPR1000 PCCV structure under seismic loads and internal pressure.A method to model the prestressing tendon and its interaction with concrete was proposed and the axial force of the prestressing tendons showed that the simulation was reasonable and accurate.The numerical results show that for the concrete structure, the location of the cylinder wall bottom around the equipment hatch and near the ring beam are critical locations with large principal stress.The concrete cracks occurred at the bottom of the PCCV cylinder wall under the peak earthquake motion of 0.50 g, however the PCCV was still basically in an elastic state.Furthermore, the concrete cracks occurred around the equipment hatch under the design internal pressure of 0.4MPa, but the steel liner was still in the elastic stage and its leak-proof function soundness was verified.The results provide the basis for analysis and design of containment vessels. | Yi Ping Wang Qingkang Kong Xianjing | 2017 | Earthquake Engineering and Engineering Vibration2017，16，1： | 1 |
| 3 | Spatiotemporal controlof gene expression by a light-switchable transgene system显示文摘 | Wang Xue Chen Xianj un Yang Yi | 2012 | Nature Methods2012，9，3： | 1 |
| 4 | A Highly Sensitive and Selective Fluorescence Chemosensor for Cu^2+ and Zn^2+ Based on Solvent Effect显示文摘1 能基于(R)-binaphthyl-salen 展出的新奇荧光 chemosensor 向由“转弯”的 Cu2+ 的高度敏感、选择的识别回答荧光由“刺激”在 THF/H2O,和 Zn2+ 熄灭类型在 CHCl3/CH3CN 的荧光改进类型分别地,建议溶剂能戏剧性地影响基于 salen 的 chemosensor 的应答的性质。另外,没有溶剂的影响, Cu2+ 能导致 CD 系列的最显著的变化,它显示这客气的 chemosensor 能也基于 CD 系列被用作一根唯一的 Cu2+ 探针。 | Xiaobo Huang Qian Miao Lu Wang Jieming Jiao Xianjing He Yixiang Cheng | 2013 | Chinese Journal of Chemistry2013，31，2： | 0 |
| 5 | Development levels of pediatric palliative care teams and the extent of palliative care understanding and implementation among pediatric oncologists in China显示文摘Importance:Pediatric palliative care(PPC)is an interdisciplinary collaboration that focuses on the prevention and relief of patient suffering.PPC has emerged as a critical field of medical expertise and practice.However,no information is available regarding the progress of PPC in the Chinese mainland.Objective:This study investigated the geographic distribution,team structure,and services of PPC teams in the Chinese mainland.It also investigated the level of understanding and implementation among pediatric oncologists regarding PPC.Methods:The PPC subspecialty group of the Pediatrics Society of the Chinese Medical Association included 45 PPC teams.The team structure and services were investigated using questionnaires mailed to the team leader of each PPC team.In addition,we sent questionnaires regarding the level of PPC understanding and implementation of PPC practices to 170 pediatric oncologists in 11 hospitals.Results:The geographical distribution of PPC teams is uneven in China.Most PPC teams are concentrated in the eastern provincial capital of China.Most PPC teams had limited staff and services.The level of PPC understanding was considerably limited across all demographics;most pediatric oncologists reported“some understanding”(n=71,41.8%)or“poor understanding”(n=50,29.4%).Only 62.9%of pediatric oncologists had experience providing advice to family members regarding PPC matters.Interpretation:China is currently experiencing a critical shortage of PPC resources.Most pediatric oncologists had a limited understanding of PPC and reported limited practical implementation of PPC,which leads to underutilization of PPC resources. | Siyu Cai Qiaohong Guo Xianjing Wang Ruixin Wang Peiyi Yang Yuchen Zhou Yanhui Luo Xuan Zhou Xiaoxia Peng | 2021 | Pediatric Investigation2021，5，4： | 0 |
| 6 | Intrinsic superconducting transport properties of ultra-thin Fe_(1+y)Te_(0:6)Se_(0:4) microbridges显示文摘We investigated the superconducting properties of Fe_(1+y)Te_(0:6)Se_(0:4) single-crystalline microbridges with a width of 4 m and thicknesses ranging from 20.8 to 136.2 nm. The temperature-dependent in-plane resistance of the bridges exhibited a type of metalinsulator transition in the normal state. The critical current density(J_c) of the microbridge with a thickness of 136.2 nm was82.3 kA/cm^2 at 3K and reached 105 kA/cm^2 after extrapolation to T = 0 K. The current versus voltage characteristics of the microbridges showed a Josephson-like behavior with an obvious hysteresis. These results demonstrate the potential application of ultra-thin Fe-based microbridges in superconducting electronic devices such as bolometric detectors. | HanCong Sun YangYang Lv DaChuan Lu ZhiBao Yang XianJing Zhou LuYao Hao XiangZhuo Xing Wei Zou Jun Li ZhiXiang Shi WeiWei Xu HuaBing Wang PeiHeng Wu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，11： | 0 |
| 7 | Fabrication of Al/AlO_x/Al Josephson junctions on silicon and sapphire substrates using a cold-development technique显示文摘In order to obtain high-quality superconducting qubits, we employed a cold-development technique, using temperatures down to-20°C, to fabricate Al/AlOx/Al Josephson junctions. Cold development greatly reduced the sensitivity of the electron-beam resist to the developer, eliminated molecules of the electron-beam resist at trench edges, and improved the repeatability and reliability of the nanopatterning process. The fabricated samples have well-defined geometries and increased dose margins, with lateral sizes of 100 nm×100 nm on both silicon and sapphire substrates. Together with the bridge-free fabrication method we used in these experiments, we believe that the cold-development technique can play an important role in quantum information technology that employs superconducting qubits. | Wei Chen JiaZheng Pan ZuYu Xu YangYang Lv XianJing Zhou XueCou Tu Jun Li GuoZhu Sun HuaBing Wang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，6： | 0 |
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