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| 1 | Wnt and BMP signaling crosstalk in regulating dental stem cells:Implications in dental tissue engineering显示文摘Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling.Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance,essential oral functions and the quality of life.Regenerative dentistry holds great promise in treating oral/dental disorders.The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells,along with the signaling mechanisms governing stem cell self-renewal and differentiation.In this review,we first summarize the biological characteristics of seven types of dental stem cells,including dental pulp stem cells,stem cells from apical papilla,stem cells from human exfoliated deciduous teeth,dental follicle precursor cells,periodontal ligament stem cells,alveolar bone-derived mesenchymal stem cells(MSCs),and MSCs from gingiva.We then focus on how these stem cells are regulated by bone morphogenetic protein(BMP)and/or Wnt signaling by examining the interplays between these pathways.Lastly,we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways.We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications.Thus,we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade. | Fugui Zhang Jinlin Song Hongmei Zhang Enyi Huang Dongzhe Song Viktor Tollemar Jing Wang Jinhua Wang Maryam Mohammed Qiang Wei Jiaming Fan Junyi Liao Yulong Zou Feng Liu Xue Hu Xiangyang Qu Liqun Chen Xinyi Yu Hue H.Luu Michael J.Lee Tong-Chuan He Ping Ji | 2016 | Genes & Diseases2016，3，4： | 16 |
| 2 | Temperature and velocity dependent friction of a microscale graphite-DLC heterostructure显示文摘One of the promising approaches to achieving large scale superlubricity is the use of junctions between existing ultra-flat surface together with superlubric graphite mesas.Here we studied the frictional properties of microscale graphite mesa sliding on the diamond-like carbon,a commercially available material with a ultra-flat surface.The interface is composed of a single crystalline graphene and a diamond-like carbon surface with roughness less than I nm.Using an integrated approach,which includes Argon plasma irradiation of diamond-like carbon surfaces,X-ray photoelectron spectroscopy analysis and Langmuir adsorption modeling,we found that while the velocity dependence of friction follows a thermally activated sliding mechanism,its temperature dependence is due to the desorption of chemical groups upon heating.These observations indicate that the edges have a significant contribution to the friction.Our results highlight potential factors affecting this type of emerging friction junctions and provide a novel approach for tuning their friction properties through ion irradiation. | Yujie GONGYANG Wengen OUYANG Cangyu QU Michael URBAKH Baogang QUAN Ming MA Quanshui ZHENG | 2020 | Friction2020，8，2： | 5 |
| 3 | Genome-wide association study and genomic prediction of Fusarium ear rot resistance in tropical maize germplasm显示文摘Fusarium ear rot(FER)is a destructive maize fungal disease worldwide.In this study,three tropical maize populations consisting of 874 inbred lines were used to perform genomewide association study(GWAS)and genomic prediction(GP)analyses of FER resistance.Broad phenotypic variation and high heritability for FER were observed,although it was highly influenced by large genotype-by-environment interactions.In the 874 inbred lines,GWAS with general linear model(GLM)identified 3034 single-nucleotide polymorphisms(SNPs)significantly associated with FER resistance at the P-value threshold of 1×10^(-5),the average phenotypic variation explained(PVE)by these associations was 3%with a range from 2.33%to 6.92%,and 49 of these associations had PVE values greater than 5%.The GWAS analysis with mixed linear model(MLM)identified 19 significantly associated SNPs at the P-value threshold of 1×10^(-4),the average PVE of these associations was 1.60%with a range from 1.39%to 2.04%.Within each of the three populations,the number of significantly associated SNPs identified by GLM and MLM ranged from 25 to 41,and from 5 to 22,respectively.Overlapping SNP associations across populations were rare.A few stable genomic regions conferring FER resistance were identified,which located in bins 3.04/05,7.02/04,9.00/01,9.04,9.06/07,and 10.03/04.The genomic regions in bins 9.00/01 and 9.04 are new.GP produced moderate accuracies with genome-wide markers,and relatively high accuracies with SNP associations detected from GWAS.Moderate prediction accuracies were observed when the training and validation sets were closely related.These results implied that FER resistance in maize is controlled by minor QTL with small effects,and highly influenced by the genetic background of the populations studied.Genomic selection(GS)by incorporating SNP associations detected from GWAS is a promising tool for improving FER resistance in maize. | Yubo Liu Guanghui Hu Ao Zhang Alexander Loladze Yingxiong Hu Hui Wang Jingtao Qu Xuecai Zhang Michael Olsen Felix San Vicente Jose Crossa Feng Lin Boddupalli M.Prasanna | 2021 | The Crop Journal2021，9，2： | 3 |
| 4 | Comparative glycemic control, safety and patient ratings for a new 4?mm? × ?32G insulin pen needle in adults with diabetes显示文摘 | Laurence J. Hirsch Michael A. Gibney John Albanese Shankang Qu Kenneth Kassler-Taub Leslie J. Klaff Timothy S. Bailey | 2010 | Current Medical Research & Opinion2010，，6： | 2 |
| 5 | Stereotactic Hypofractionated Radiation Therapy as a Bridge to Transplantation for Hepatocellular Carcinoma: Clinical Outcome and Pathologic Correlation显示文摘 | Alan W. Katz Sheema Chawla Zhenhong Qu Randeep Kashyap Michael T. Milano Aram F. Hezel | 2012 | International Journal of Radiation Oncology Biology Physics2012，，3： | 2 |
| 6 | Fast and accurate surface normal integration on non-rectangular domains显示文摘The integration of surface normals for the purpose of computing the shape of a surface in 3D space is a classic problem in computer vision. However,even nowadays it is still a challenging task to devise a method that is flexible enough to work on non-trivial computational domains with high accuracy, robustness,and computational efficiency. By uniting a classic approach for surface normal integration with modern computational techniques, we construct a solver that fulfils these requirements. Building upon the Poisson integration model, we use an iterative Krylov subspace solver as a core step in tackling the task. While such a method can be very efficient, it may only show its full potential when combined with suitable numerical preconditioning and problem-specific initialisation. We perform a thorough numerical study in order to identify an appropriate preconditioner for this purpose.To provide suitable initialisation, we compute this initial state using a recently developed fast marching integrator. Detailed numerical experiments illustrate the benefits of this novel combination. In addition, we show on real-world photometric stereo datasets that the developed numerical framework is flexible enough to tackle modern computer vision applications. | Martin Bahr Michael Breuβ Yvain Quéau Ali Sharifi Boroujerdi Jean-Denis Durou | 2017 | Computational Visual Media2017，3，2： | 1 |
| 7 | Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion显示文摘 | Chenell Donadee Nicolaas J.H. Raat Tamir Kanias Jesús Tejero Janet S. Lee Eric E. Kelley Xuejun Zhao Chen Liu Hannah Reynolds Ivan Azarov Sheila Frizzell E. Michael Meyer Albert D. Donnenberg Lirong Qu Darrel Triulzi Daniel B. Kim-Shapiro Mark T. Gladwin | 2011 | Circulation2011，，： | 1 |
| 8 | What Wilt it Take for China to Become a Competitive Force in offshore Outsourcing? An Analysis of the Role of Transaction Costs in Supplier Selection 显示文摘 | Zhonghua Qu Michael Brocklehurst | 2003 | Journal of Information Technology2003，，18： | 1 |
| 9 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 10 | What will it take for China to become a competitive force in offshore outsourcing? An analysis of the role of transaction costs in supplier selection显示文摘 | Zhonghua Qu Michael Brocklehurst | 2003 | Journal of Information Technology2003，，18： | 1 |
| 11 | Self-aligned Cu–Si core–shell nanowire array as a high-performance anode for Li-ion batteries显示文摘 | Jun Qu Huaqing Li John J. Henry Surendra K. Martha Nancy J. Dudney Hanbing Xu Miaofang Chi Michael J. Lance Shannon M. Mahurin Theodore M. Besmann Sheng Dai | 2011 | Journal of Power Sources2011，，： | 1 |
| 12 | Human Mesenchymal Stem Cells as a Gene Delivery System to Create Cardiac Pacemakers显示文摘 | Irina Potapova Alexei Plotnikov Zhongju Lu Peter Danilo Virginijus Valiunas Jihong Qu Sergey Doronin Joan Zuckerman Iryna N. Shlapakova Junyuan Gao Zongming Pan Alan J. Herron Richard B. Robinson Peter R. Brink Michael R. Rosen Ira S. Cohen | 2004 | Circulation Research: Journal of the American Heart Association2004，，7： | 1 |
| 13 | Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy显示文摘 | Sophie Pattingre Amina Tassa Xueping Qu Rita Garuti Xiao Huan Liang Noboru Mizushima Milton Packer Michael D. Schneider Beth Levine | 2005 | Cell2005，，6： | 1 |
| 14 | Population-based Risk Factors for Elevated Alanine Aminotransferase in a South Texas Mexican–American Population显示文摘 | Hui-Qi Qu Quan Li Megan L. Grove Yang Lu Jen-Jung Pan Anne R. Rentfro Perry E. Bickel Michael B. Fallon Craig L. Hanis Eric Boerwinkle Joseph B. McCormick Susan P. Fisher-Hoch | 2012 | Archives of Medical Research2012，，6： | 1 |
| 15 | Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation显示文摘 | Masufumi Takiguchi William E Achanzar Wei Qu Guying Li Michael P Waalkes | 2003 | Experimental Cell Research2003，，2： | 1 |
| 16 | Stereotactic Hypofractionated Radiation Therapy as a Bridge to Transplantation for Hepatocellular Carcinoma: Clinical Outcome and Pathologic Correlation显示文摘 | Alan W. Katz Sheema Chawla Zhenhong Qu Randeep Kashyap Michael T. Milano Aram F. Hezel | 2012 | International Journal of Radiation Oncology Biology Physics2012，，3： | 1 |
| 17 | Cardiac-specific haploinsufficiency of β-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction显示文摘 | Jiaxiang Qu Jibin Zhou Xian Ping Yi Baojun Dong Hanqiao Zheng Lisa M. Miller Xuejun Wang Michael D. Schneider Faqian Li | 2007 | Journal of Molecular and Cellular Cardiology2007，，3： | 1 |
| 18 | What will it take for China to become aCompetitive Force in Offshore Outsourcing? An Analysis of Transaction Costs in Supplier显示文摘 | Zhonghua Qu Michael Brocklehurst | 2003 | Journal of Information Technology2003，，18： | 1 |
| 19 | Chronic Exposure to Methylated Arsenicals Stimulates Arsenic Excretion Pathways and Induces Arsenic Tolerance in Rat Liver Cells显示文摘 | Wei Qu Michael P W | 2006 | Toxicological Sciences2006，91，1： | 1 |
| 20 | Neonatal Necrotizing Enterocolitis: Clinical Considerations and Pathogenetic Concepts显示文摘 | Wei Hsueh Michael S. Caplan Xiao-Wu Qu Xiao-Di Tan Isabelle G. De Plaen F. Gonzalez-Crussi | 2003 | Pediatric and Developmental Pathology2003，，1： | 1 |
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