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| 1 | Recent advancement on technical requirements for grid integration of wind power显示文摘The installation of wind energy has experienced rapid development during recent years.As a result,the operation of power system can be greatly affected.Therefore,the operators of different countries have formulated the grid codes which reinforce technical requirements for wind power plants.In this paper,recent grid codes published in different countries have been carefully reviewed.The basic requirements of active power control and reactive power compensation,both of which have particular influence on wind power plants operation,are focused on.Based on this review,it is understood that with the increasing integration of wind energy,there is a worldwide trend to regulate the performance of wind power plants so that they can contribute to the stability and reliability of power system. | Xiaoge LIU Zhao XU Kit Po WONG | 2013 | Journal of Modern Power Systems and Clean Energy2013，1，3： | 19 |
| 2 | Acupuncture at Baihui and Dazhui reduces brain cell apoptosis in heroin readdicts显示文摘Acupuncture at Baihui(GV20) and Dazhui(GV14) reduces neuronal loss and attenuates ultrastructural damage in cerebral ischemic rats. However, whether acupuncture can treat addiction and prevent readdiction through changes to brain cell ultrastructure remains unknown. In this study, cell apoptosis was observed in the hippocampus and frontal lobe of heroin readdicted rats by electron microscopy. Immunohistochemical staining displayed a reduction in Bcl-2 expression and an increase in Bax expression in the hippocampus and frontal lobe. After rats were given acupuncture at Baihui and Dazhui, the pathological damage in the hippocampus and frontal lobe was significantly reduced, Bcl-2 expression was upregulated and Bax expression was downregulated. Acupuncture exerted a similar effect with methadone, a commonly used drug for clinical treatment of drug addiction. Experimental findings suggest that acupuncture at Dazhui and Baihui can prevent brain cell apoptosis in heroin readdicted rats. | Xiaorong Hou Rongjun Zhang Hang Lv Xinghui Cai Guangchuan Xie Xiaoge Song | 2014 | Neural Regeneration Research2014，9，2： | 12 |
| 3 | Analgesic effect of different moxibustion durations in rheumatoid arthritis rats显示文摘OBJECTIVE:To observe the influence of different moxibustion durations on hypothalamic pro-opiomelanocortin(POMC)and prodynorphin(PDYN)mRNA expressions and plasmaβ-endorphin(β-EP)content in rheumatoid arthritis(RA)rats,to understand the mechanism of moxibustion analgesia and its dose-effect relationship.METHODS:Twelve male Wistar rats were randomly selected from 48 male Wistar rats as a normal control group.The RA model was created by raising rats in a windy(blowing with electric fan),cold(6℃±2℃),and wet(80%-90%humidity)environment for 20 days,12 h each day.This was followed byinjectionofFreund'scompleteadjuvant(0.15 mL)into the ankle.Then,rats were randomly divided into a model group,moxibustion groupⅠ,and moxibustion groupⅡ,with 12 rats in each group.In moxibustion groupsⅠandⅡ,moxibustion was given at Shenshu(BL 23)and Zusanli(ST 36)for 20and 40 min,respectively,once daily for 15 days.Hypothalamic POMC and PDYN mRNA expression levels and plasmaβ-EP content were determined.RESULTS:Compared with the normal group,the pressure pain threshold decreased,while the hypothalamic POMC and PDYN mRNA expression levels and plasmaβ-EP content increased in the moxibustion groups(P<0.01).Compared with the model group,the pressure pain threshold,hypothalamic POMC and PDYN mRNA expression levels and plasmaβ-EP content in the moxibustion groups increased significantly(P<0.01).Compared the moxibustion groupⅠ,the pain threshold,hypothalamic POMC and PDYN mRNA expression levels and plasmaβ-EP content in moxibustion groupⅡsignificantly increased(P<0.01).CONCLUSION:Moxibustion has an analgesic effect and increases hypothalamic POMC and PDYN mRNA expression levels and plasmaβ-EP content inRArats.TheanalgesiceffectinmoxibustiongroupⅡisbetterthanthatinmoxibustiongroupⅠ. | Baozhu Zheng Ling Hu Xiaoge Song ZijianWu Ronglin Cai Lu He Cheng Zhang QingYu | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 10 |
| 4 | A targeting black phosphorus nanoparticle based immune cells nanoregulator for photodynamic/photothermal and photo-immunotherapy显示文摘Photo-immunotherapy is a novel therapeutic approach against malignant tumors with minimal invasiveness.Herein,a targeting multifunctional black phosphorus(BP)nanoparticle,modified by PEGylated hyaluronic acid(HA),was designed for photothermal/photodynamic/photo-immunotherapy.In vitro and in vivo assays indicated that HA-BP nanoparticles possess excellent biocompatibility,stability,and sufficient therapeutic efficacy in the combined therapy of photothermal therapy(PTT)and photodynamic therapy(PDT)for cancer therapy.Moreover,the results of in vitro showed that HA-BP down-regulated the expression of CD206(M2 macrophage marker)by 42.3%and up-regulated the ratio of CD86(M1 macrophage marker)by 59.6%,indicating that HABP nanoparticles have functions in remodeling tumor associated macrophages(TAMs)phenotype(from protumor M2 TAMs to anti-tumor M1 macrophages).Fluorescence(FL)and photoacoustic(PA)multimodal imaging confirmed the selective accumulation of HA-BP in tumor site via both CD44^+mediated active targeting and passive EPR effect.In vitro and in vivo studies suggested that the combined therapy of PDT,PTT and immunotherapy using HA-BP could not only significantly inhibit original tumor but also induce immunogenic cell death(ICD)and release Damage-associated molecular patterns(DAMPs),which could induce maturation of dendritic cells(DCs)and activate effector cells that robustly evoke the antitumor immune responses for cancer treatment.This study expands the biomedical application of BP nanoparticles and displays the potential of modified BP as a multifunctional therapeutic platform for the future cancer therapy. | Xiaoge Zhang Junjie Tang Chao Li Yao Lu Lili Cheng Jie Liu | 2021 | Bioactive Materials2021，6，2： | 10 |
| 5 | Experimental investigation of boundary layer transition over a delta wing at Mach number 6显示文摘An experimental study on the boundary layer transition over a delta wing was carried out at Mach number 6 in a quiet wind tunnel.The Nano-tracer-based Planar Laser Scattering(NPLS)and Temperature-Sensitive Paints(TSP)techniques were used to measure the fine flow field structure and the wall Stanton number of the delta wing.The influence of factors such as the angle of attack and the Reynolds number was studied.The following results were obtained.The boundary layer transition between the leading edge and the centerline was dominated by the crossflow instability.At the location of the initial appearance of the traveling crossflow waves,the Stanton number began to rise.The Stanton number reached a maximum when the crossflow waves were broken up to turbulence.Increasing the angle of attack increased the spanwise pressure gradient at the windward side of the delta wing,thereby increasing the crossflow instability and advancing the boundary layer transition front.However,increasing the angle of attack caused the transition front to move backward at the leeward side.In addition,the sensitivity of the boundary layer transition to the Reynolds number varied with the angle of attack and the region. | Haibo NIU Shihe YI Xiaolin LIU Xiaoge LU Dundian GANG | 2020 | Chinese Journal of Aeronautics2020，33，7： | 9 |
| 6 | Combined effects of volume ratio and nitrate recycling ratio on nutrient removal,sludge characteristic and microbial evolution for DPR optimization显示文摘The optimization of volume ratio(V_(An)/V_(A)/V_(0))and nitrate recycling ratio(R)in a two-sludge denitrifying phosphorus removal(DPR)process of Anaerobic Anoxic Oxic-Moving Bed Biofilm Reactor(A^(2)/O-MBBR)was investigated.The results showed that prolonged anaerobic retention time(HRT An:1.25→3.75 hr)exerted favorable effect on chemical oxygen demand(COD)removal(57.26%→73.54%),poly-β-hydroxyalkanoates(PHA)synthesis(105.70→138.12 mg COD/L)and PO_(4)^(3-)release(22.3→38.9 mg/L).However,anoxic retention time(HRT A)and R exhibited positive correlation with PHA utilization(43.87%-81.34%)and denitrifying phosphorus removal(DPR)potential(NO_(3)-/PO^(3-)_(4):0.57-1.34 mg/mg),leading to dramatical TN removal variations from 68.86%to 81.28%.Under the V An/V A/V O ratio of 2:6:0,sludge loss deteriorated nutrient removals but the sludge bioactivity quickly recovered when the oxic zone was recovered.The sludge characteristic and microstructure gradually transformed under the dissolved oxygen(DO)control(1.0-1.5→1.5-2.0 mg/L),in terms of sludge volume index(SVI:194→57 m L/g VSS),median-particle-size(D 50:99.6→300.5μm),extracellular polymeric substances(EPS)(105.62→226.18 mg/g VSS)and proteins/polysaccharides(PN/PS)ratio(1.52→3.46).Fluorescence in situ hybridization(FISH)results showed that phosphorus accumulation organisms(PAOs)(mainly Cluster I of Accumulibacter,contribution ratio:91.79%-94.10%)dominated the superior DPR performance,while glycogen accumulating organisms(GAOs)(mainly Competibacter,contribution ratio:82.61%-86.89%)was responsible for deteriorative TN and PO_(4)^(3-)removals.The optimal HRT A and R assembled around 5-6.5 hr and 300%-400%based on the PHA utilization and DRP performance,and the oxic zones also contributed to PO_(4)^(3-)removal although it showed low dependence on DO concentration and oxic retention time(HRT_(0)). | Miao Zhang Jing Gao Yajun Fan Xiaoge Wu Jun Wu Chengda He | 2021 | Journal of Environmental Sciences2021，33，6： | 6 |
| 7 | Improved decadal climate prediction in the North Atlantic using EnOI-assimilated initial condition显示文摘Decadal prediction experiments of Beijing Climate Center climate system model version 1.1(BCCCSM1.1) participated in Coupled Model Intercomparison Project Phase 5(CMIP5) had poor skill in extratropics of the North Atlantic, the initialization of which was done by relaxing modeled ocean temperature to the Simple Ocean Data Assimilation(SODA) reanalysis data. This study aims to improve the prediction skill of this model by using the assimilation technique in the initialization. New ocean data are firstly generated by assimilating the sea surface temperature(SST) of the Hadley Centre Sea Ice and Sea Surface Temperature(Had ISST) dataset to the ocean model of BCC-CSM1.1 via Ensemble Optimum Interpolation(EnOI). Then a suite of decadal re-forecasts launched annually over the period 1961–2005 is carried out with simulated ocean temperature restored to the assimilated ocean data.Comparisons between the re-forecasts and previous CMIP5 forecasts show that the re-forecasts are more skillful in mid-to-high latitude SST of the North Atlantic. Improved prediction skill is also found for the Atlantic multi-decadal oscillation(AMO), which is consistent with the better skill of Atlantic meridional overturning circulation(AMOC) predicted by the re-forecasts. We conclude that the EnOI assimilation generates better ocean data than the SODA reanalysis for initializing decadal climate prediction of BCC-CSM1.1 model. | Min Wei Qingquan Li Xiaoge Xin Wei Zhou Zhenyu Han Yong Luo Zongci Zhao | 2017 | Science Bulletin2017，62，16： | 6 |
| 8 | Evaluation of Cloud Vertical Structure Simulated by Recent BCC_AGCM Versions through Comparison With CALIPSO-GOCCP Data显示文摘The abilities of BCC AGCM2.1 and BCC AGCM2.2 to simulate the annual-mean cloud vertical structure(CVS) were evaluated through comparison with GCM-Oriented CALIPSO Cloud Product(CALIPSO-GOCCP) data. BCC AGCM2.2has a dynamical core and physical processes that are consistent with BCC AGCM2.1, but has a higher horizontal resolution.Results showed that both BCC AGCM versions underestimated the global-mean total cloud cover(TCC), middle cloud cover(MCC) and low cloud cover(LCC), and that BCC AGCM2.2 underestimated the global-mean high cloud cover(HCC).The global-mean cloud cover shows a systematic decrease from BCC AGCM2.1 to BCC AGCM2.2, especially for HCC.Geographically, HCC is significantly overestimated in the tropics, particularly by BCC AGCM2.1, while LCC is generally overestimated over extra-tropical lands, but significantly underestimated over most of the oceans, especially for subtropical marine stratocumulus clouds.The leading EOF modes of CVS were extracted. The BCC AGCMs perform well in reproducing EOF1, but with a larger variance explained. The two models also capture the basic features of EOF3, except an obvious deficiency in eigenvector peaks. EOF2 has the largest simulation biases in both position and strength of eigenvector peaks. Furthermore, we investigated the effects of CVS on relative shortwave and longwave cloud radiative forcing(RSCRF and RLCRF). Both BCC AGCM versions successfully reproduce the sign of regression coefficients, except for RLCRF in PC1. However, the RSCRF relative contributions from PC1 and PC2 are overestimated, while the relative contribution from PC3 is underestimated in both BCC AGCM versions. The RLCRF relative contribution is underestimated for PC2 and overestimated for PC3. | WANG Fang XIN Xiaoge WANG Zaizhi CHENG Yanjie ZHANG Jie YANG Song | 2014 | Advances in Atmospheric Sciences2014，31，3： | 5 |
| 9 | Distribution of Microbial Populations and Their Relationship with Environmental Variables in the North Yellow Sea,China显示文摘In order to understand the large-scale spatial distribution characteristics of picoplankton,nanophytoplankton and virio-plankton and their relationship with environmental variables in coastal and offshore waters,flow cytometry(FCM) was used to ana-lyze microbial abundance of samples collected in summer from four depths at 36 stations in the North Yellow Sea(NYS).The data revealed spatial heterogeneity in microbial populations in the offshore and near-shore waters of the NYS during the summer.For the surface layer,picoeukaryotes were abundant in the near-shore waters,Synechococcus was abundant in the offshore areas,and bacte-rial and viral abundances were high in the near-shore waters around the Liaodong peninsula.In the near-shore waters,no significant vertical variation of picophytoplankton(0.2-2μm) abundance was found.However,the nanophytoplankton abundance was higher in the upper layers(from the surface to 10 m depth) than in the bottom layer.For the offshore waters,both pico-and nanophytoplankton(2-20μm) abundance decreased sharply with depth in the North Yellow Sea Cold Water Mass(NYSCWM).But,for the vertical dis-tribution of virus and bacteria abundance,no significant variation was observed in both near-shore and offshore waters.Autotrophic microbes were more sensitive to environmental change than heterotrophic microbes and viruses.Viruses showed a positive correla-tion with bacterial abundance,suggesting that the bacteriophage might be prominent for virioplankton(about 0.45μm) in summer in the NYS and that viral abundance might play an important role in microbial loop functions. | BAI Xiaoge WANG Min LIANG Yantao ZHANG Zhifeng WANG Fang JIANG Xuejiao | 2012 | Journal of Ocean University of China2012，11，1： | 5 |
| 10 | Thermophysical properties of Sm_2(Zr_(1-x)Ce_x)_2O_7 ceramics显示文摘Sm2(Zr1-xCex)2O7 (x=0.1, 0.2, and 0.3) ceramics were prepared by solid reaction method at 1600°C for 10 h using Sm2O3, ZrO2, and CeO2 as starting reactants. The phase compositions, microstructures, thermal expansion coefficients, and partial thermal conductivities of these materials were investigated. X-ray diffraction (XRD) results reveal that Sm2(Zr0.9Ce0.1)2O7 with pyrochlore structure and Sm2(Zr1-xCex)2O7 (x=0.2 and 0.3) with fluorite structure were synthesized, and scanning electrical microscopy (SEM) images show that the microstructures of these products are very dense. The linear thermal expansion coefficients increase with increasing temperature in the temperature range from ambient to 1200°C, and the thermal expansion coefficients increase with increasing content of doped CeO2. The thermal conductivities of Sm2(Zr0.8Ce0.2)2O7 and Sm2(Zr0.7Ce0.3)2O7 decrease gradually with an increase in temperature. These results show that the synthesized ceramic materials can be explored as novel prospective candidate materials for use in new thermal barrier coating systems in the future. | ZHANG Hongsong SUN Kun XU Qiang WANG Fuchi LIU Ling WEI Yuan CHEN Xiaoge | 2009 | Rare Metals2009，28，3： | 4 |
| 11 | Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system显示文摘In this study, we show that the percutaneous absorption and brain distribution of tetramethylpyrazine(TMP) is enhanced when combined with borneol(BN) in a microemulsionbased transdermal therapeutic system(ME-TTS). The formulation of the TMP and BN microemulsion(TEM-BN-ME) was optimized in skin permeation studies in vitro following a uniform experimental design. Male Sprague-Dawley rats were used for the in vivo pharmacokinetic and tissue distribution studies of TMP-BN-ME-TTS. In the pharmacokinetic study, the TMP-BN-ME-TTS treated rats had significantly higher( P < 0.05) C max and AUC of TMP than the TMP-ME-TTS treated rats, indicating that BN improves the rate and extent of TMP percutaneous absorption. In the tissue distribution study, the AUC of TMP in brain was significantly higher in the TMP-BN-ME-TTS group( P < 0.05), indicating that BN facilitates the distribution of TMP in brain. In summary, BN enhanced the percutaneous absorption and brain distribution of TMP in a microemulsion-based transdermal therapeutic system. | Xiaoge Hu Ning Cheng Jihui Zhao Xianghua Piao Yulu Yan Qibo Zhang Kuan Zhou Yongtai Zhang Nianping Feng | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 4 |
| 12 | Normalization of ventral tegmental area structure following acupuncture in a rat model of heroin relapse显示文摘Drugs can cause obvious damage to the brain. To verify the relationship between acupuncture, neurotrophic factor expression and brain cell structural changes, this study established a rat model of heroin relapse using intramuscular injection of increasing amounts of heroin. During the detoxification period, rat models received acupuncture at Baihui(DU20) and Dazhui(DU14). Electron microscopy demonstrated that the structure of the ventral tegmental area in heroin relapse rats gradually became normalized after acupuncture treatment. Immunohistochemical staining exhibited that the expression of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor increased in the ventral tegmental area following acupuncture. Moreover, the effects were similar to that of methadone, a type of medicine called an opioid. Results suggested that acupuncture at Baihui and Dazhui protected brain neurons against injury in rats with heroin relapse by promoting brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression. | Rongjun Zhang Xinghui Cai Xiaoge Song Chaoyang Dong Xiaorong Hou Lei Lv | 2014 | Neural Regeneration Research2014，9，3： | 4 |
| 13 | Literature study on clinical treatment of facial paralysis in the last 20 years using Web of Science Comparison between rehabilitation, physiotherapy and acupuncture显示文摘BACKGROUND: Facial paralysis is defined as severe or complete loss of facial muscle motor function. OBJECTIVE: The study was undertaken to explore a bibliometric approach to quantitatively assess the research on clinical treatment of facial paralysis using key words rehabilitation, physiotherapy and acupuncture using Web of Science from 1992 to 2011. DESIGN: Bibliometric approach. DATA RETRIEVAL: A bibliometric analysis based on the publications on Web of Science was performed using such as 'facial paralysis', 'rehabilitation', 'physiotherapy' and 'acupuncture'. INCLUSIVE CRITERIA: (1) Research articles on the clinical treatment of facial paralysis using acupuncture or physiotherapy (e.g. exercise, electro-stimulation) and other rehabilitation methods; (2) researches on human and animal fundamentals, clinical trials and case reports; (3) Article types: article, review, proceedings paper, note, letter, editorial material, discussion, book chapter. (4) Publication year: 1992-2011 inclusive. Exclusion criteria: (1) Articles on the causes and diagnosis on facial paralysis; (2) Type of articles: correction; (3) Articles from following databases: all databases related to social science and chemical databases in Web of Science. MAIN OUTCOME MEASURES: (1) Overall number of publications; (2) number of publications annually; (3) number of citations received annually; (4) top cited paper; (5) subject categories of publication; (6) the number of countries in which the article is published; (7) distribution of output in journals. RESULTS: Overall population stands at 3 543 research articles addressing the clinical treatment of facial paralysis in Web of Science during the study period. There is also a markedly increase in the number of publications on the subject 'facial paralysis treatments using rehabilitation' during the first decade of the 21st century, except in 2004 and 2006 when there are perceptible drops in the number of articles published. The only other year during the study period saw such a drop is 1993. Specifically, there are 192 published articles on facial paralysis treated by rehabilitation in the past two decades, far more than the output of physiotherapy treatment. Physiotherapy treatment scored only 25 articles including acupuncture treatment, with over 80% of these written by Chinese researchers and clinicians. Ranked by regions, USA is by far the most productive country in terms of the number of publications on facial paralysis rehabilitation and physiotherapy research. Seeing from another angle, the journals that focus on otolaryngology published the most number of articles in rehabilitation and physiotherapy studies, whereas most acupuncture studies on facial paralysis were published in the alternative and complementary medicine journals. CONCLUSION: Study of facial paralysis remains an area of active investigation and innovation. Further clinical studies in humans addressing the use of growth factors or stem cells continue to successful facial nerve regeneration. | Xiaoge Zhang Ling Feng Liang Du Anxiang Zhang Tian Tang | 2012 | Neural Regeneration Research2012，7，2： | 4 |
| 14 | Acupuncture inhibits cue-induced heroin craving and brain activation显示文摘Previous research using functional MRI has shown that specific brain regions associated with drug dependence and cue-elicited heroin craving are activated by environmental cues. Craving is an important trigger of heroin relapse, and acupuncture may inhibit craving. In this study, we performed functional MRI in heroin addicts and control subjects. We compared differences in brain activation between the two groups during heroin cue exposure, heroin cue exposure plus acupuncture at the Zusanli point (ST36) without twirling of the needle, and heroin cue exposure plus acupuncture at the Zusanli point with twirling of the needle. Heroin cue exposure elicited significant activation in craving-related brain regions mainly in the frontal lobes and callosal gyri. Acupuncture without twirling did not significantly affect the range of brain activation induced by heroin cue exposure, but significantly changed the extent of the activation in the heroin addicts group. Acupuncture at the Zusanli point with twirling of the needle significantly decreased both the range and extent of activation induced by heroin cue exposure compared with heroin cue exposure plus acupuncture without twirling of the needle. These experimental findings indicate that presentation of heroin cues can induce activation in craving-related brain regions, which are involved in reward, learning and memory, cognition and emotion. Acupuncture at the Zusanli point can rapidly suppress the activation of specific brain regions related to craving, supporting its potential as an intervention for drug craving. | Xinghui Cai Xiaoge Song Chuanfu Li Chunsheng Xu Xiliang Li Qi Lu | 2012 | Neural Regeneration Research2012，7，33： | 4 |
| 15 | Wildlife conservation and management in China:achievements,challenges and perspectives显示文摘Dramatic global changes to the environment have wrought unprecedented reductions in biodiversity, with>28%species assessed by the International Union for Conservation of Nature(IUCN) under the threat of extinction[1]. China, as one of the world’s megadiverse countries, plays a critical role in global biodiversity conservation. | Guangping Huang Xiaoge Ping Weihua Xu Yibo Hu Jiang Chang Ronald R.Swaisgood Jiang Zhou Xiangjiang Zhan Zejun Zhang Yonggang Nie Jie Cui Michael Bruford Zhihe Zhang Baoguo Li Li Zhang Zhi Lv Fuwen Wei | 2021 | National Science Review2021，8，7： | 4 |
| 16 | Mechanisms of Traditional Chinese Medicine Bushenantai granules(补肾安胎颗粒) in promoting angiogenesis at the maternal-fetal interface of recurrent spontaneous abortion mice显示文摘OBJECTIVE:To assess the effects of Bushenantai(BSAT)granule(补肾安胎颗粒)on angiogenesis-related factors[E2,P,and vascular endothelial growth factor(VEGF)]at the maternal-fetal interface of recurrent spontaneous abortion(RSA)mice,and to evaluate the role of BSAT in promoting angiogenesis at the maternal-fetal interface by influencing the expression of sex hormones,and VEGF.METHODS:A mouse model with normal pregnancy and another with Clark’s classic RSA were established.The RSA mice were randomly assigned to six groups:normal,model,progesterone,high-doseBSAT granule(BSAT-H),medium-dose-BSAT granule(BSAT-M),and low-dose-BSAT granule(BSAT-L)(n=10 for each group).The embryo loss rate and the histopathological changes in the decidual tissues were measured.Serum levels of estrogen(E2),progesterone(P),and VEGF were detected by enzyme-linked immunosorbent assay.The m RNA and protein expressions of estradiol receptor(ER),progesterone receptor(PR),VEGF,and vascular endothelial growth factor receptor 2(VEGFR2)in the decidual tissues were identified by immunohistochemistry,Western blotting,and quantitative reverse transcription polymerase chain reaction.RESULTS:The embryo loss rate in all groups that received BSAT treatment was reduced,while the number of blood vessels at decidual tissues was increased.The serum levels of E2,P and VEGF were elevated,and the m RNA and protein expressions of ER,PR,VEGF,and VEGFR2 in the decidual tissues were enhanced.CONCLUSION:BSAT can improve angiogenesis at the maternal-fetal interface and reduce the embryo loss rate,which may be associated with its ability to increase the serum levels of estrogen,progesterone,and VEGF,in addition to up-regulation of m RNA and protein expression of ER,PR,VEGF,and VEGFR2 in the decidual tissues. | LI Yuanqi LI Weili YU Xinhui WU Hua WANG Yuanzhong JIN Ya HAO Lele LIU Mingmin SONG Xiaoge | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 3 |
| 17 | CHARACTERIZATIONS OF SEMI-PREQUASI-INVEXITY显示文摘Because of its importance in optimization theory,the concept of convexity has been generalized in various ways.With these generalizations,to seek some practical criteria for them is especially important.In this paper,some criteria are developed for semi-prequasi-invexity,which includes prequasi-invexity as the special case.Mutual characterizations among semi-prequasi-invex functions,strictly semi-prequasi-invex functions,and strongly semi-prequasi-invex functions are presented. | ZHAO Yingxue MENG Xiaoge QIAO Han WANG Shouyang COLADAS URIA Luis | 2014 | Journal of Systems Science & Complexity2014，27，5： | 3 |
| 18 | MiR-214-3p promotes proliferation and inhibits estradiol synthesis in porcine granulosa cells显示文摘Background: Granulosa cells(GCs) proliferation and estradiol synthesis significantly affect follicular development.The miR-214-3p expression in the ovarian tissues of high-yielding sows is higher than that in low-yielding sows,indicating that miR-214-3p may be involved in sow fertility. However, the functions and mechanisms of miR-214-3p on GCs are unclear. This study focuses on miR-214-3p in terms of the effects on GCs proliferation and estradiol synthesis.Results: Our findings revealed that miR-214-3p promotes proliferation and inhibits estradiol synthesis in porcine GCs. MiR-214-3p can increase the percentage of S-phase cells, the number of EdU labeled positive cells, and cell viability. However, E2 concentration was reduced after miR-214-3p agomir treatment. We also found that miR-214-3p up-regulates the expression of cell cycle genes including cell cycle protein B(Cyclin B), cell cycle protein D(Cyclin D), cell cycle protein E(Cyclin E), and cyclin-dependent kinase 4(CDK4) at the transcription and translation levels, but down-regulates the mRNA and protein levels of cytochrome P450 family 11 subfamily A member 1(CYP11A1), cytochrome P450 family 19 subfamily A member 1(CYP19A1), and steroidogenic acute regulatory protein(StAR)(i.e., the key enzymes in estradiol synthesis). On-line prediction, bioinformatics analysis, a luciferase reporter assay, RT-qPCR, and Western blot results showed that the target genes of miR-214-3p in proliferation and estradiol synthesis are Mfn2 and NR5A1, respectively.Conclusions: Our findings suggest that miR-214-3 p plays an important role in the functional regulation of porcine GCs and therefore may be a target gene for regulating follicular development. | Shengjie Shi Xiaoge Zhou Jingjing Li Lutong Zhang Yamei Hu Yankun Li Gongshe Yang Guiyan Chu | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 3 |
| 19 | Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer显示文摘 | Jia Wang Shanshan Li Yuying Fan Yan Chen Dan Liu Hairong Cheng Xiaoge Gao Yifa Zhou | 2010 | Journal of Ethnopharmacology2010，，2： | 3 |
| 20 | SciFinder-guided rational design of fluorescent carbon dots for ratiometric monitoring intracellular pH fluctuations under heat shock显示文摘Intracellular pH plays a significant role in various biological processes, including cell proliferation,apoptosis, metabolism, enzyme activity and homeostasis. In this work, a novel design strategy for the preparation of pH responsive carbon dots(CDs-pH) for ratiometric intracellular imaging was reported. By using SciFinder database, fluorescent CDs-pH with the required p Kavalue of 6.84 were rationally designed, which is vital important for precise sensing of intracellular pH. As a result, the synthesized CDspH demonstrated robust ability to test pH fluctuations within the physiological range of 5.4-7.4. The CDspH was further utilized for fluorescent ratiometric imaging of pH in living HeLa cells, effectively avoided the influence of autofluorescence from native cellular species. Moreover, real-time monitoring of intracellular pH fluctuation under heat shock was successfully realized. This SciFinder-guided design strategy is simple and flexible, which has a great potential to be used for the development of other types of CDs for various applications. | Haifang Liu Yuanqiang Sun Zhaohui Li Ran Yang Jie Yang Aaron Albert Aryee Xiaoge Zhang Jia Ge Lingbo Qu Yuehe Lin | 2019 | Chinese Chemical Letters2019，30，9： | 3 |
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