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| 1 | UV/H2O2 oxidation of tri(2-chloroethyl) phosphate: Intermediate products, degradation pathway and toxicity evaluation显示文摘Tri(2-chloroethyl) phosphate(TCEP) with the initial concentration of 5 mg/L was degraded by UV/H2O2 oxidation process. The removal rate of TCEP in the UV/H2O2 system was 89.1% with the production of Cl-and PO4^3- of 0.23 and 0.64 mg/L. The removal rate of total organic carbon of the reaction was 48.8% and the pH reached 3.3 after the reaction. The oxidative degradation process of TCEP in the UV/H2O2 system obeyed the first order kinetic reaction with the apparent rate constant of 0.0025 min^-1( R^2 = 0.9788). The intermediate products were isolated and identified by gas chromatography-mass spectrometer. The addition reaction of HO · and H2O and the oxidation reaction with H2O2 were found during the degradation pathway of 5 mg/L TCEP in the UV/H2O2 system. For the first time, environment risk was estimated via the 'ecological structure activity relationships' program and acute and chronic toxicity changes of intermediate products were pointed out. The luminescence inhibition rate of photobacterium was used to evaluate the acute toxicity of intermediate products. The results showed that the toxicity of the intermediate products increased with the increase of reaction time, which may be due to the production of chlorine compounds. Some measures should be introduced to the UV/H2O2 system to remove the highly toxic Cl-containing compounds, such as a nanofiltration or reverse osmosis unit. | Qiuyi Ji Huan He Zhanqi Gao Xiaohan Wang Shaogui Yang Cheng Sun Shiyin Li Yong Wang Limin Zhang | 2020 | Journal of Environmental Sciences2020，32，12： | 4 |
| 2 | Preparation of WO3/C Composite and Its Application in Oxidative Desulfurization of Fuel显示文摘The WO_3/C composite was successfully prepared by calcination of a mixture of WO_3 and g-C_3N_4 at 520 ℃. The as-synthesized samples were analyzed by X-ray diffraction(XRD), electronic differential system(EDS), scanning electron microscopy(SEM), infrared spectrometry(IR) and the Brunner-Emmet-Teller(BET) techniques. The WO_3/C composite, in comparison with the WO_3 and C_3N_4, features smaller particle size, bigger surface area and higher desulphurization performance. The influence of the reaction temperature, the catalyst dosage, the reaction time, the oxidant dosage, the sulfide type and the extractant dose on desulfurization reaction was studied. The results showed that the WO_3/C composite revealed a higher desulfurization activity than the WO_3. The desulfurization rate could reach up to 95.8% under optimal conditions covering a catalyst dosage of 0.02 g, a H_2O_2 amount of 0.2 mL, a 1-ethyl-3-methylimidazolium ethyl sulfate(EMIES) amount of 1.0 mL, a reaction temperature of 70 ℃ and a reaction time of 180 min. After five recycles, the desulfurization activity of catalyst did not significantly decline. | Zhao Rongxiang Li Xiuping Su Jianxun Shi Weiwei Gao Xiaohan | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，2： | 4 |
| 3 | A rapid real-time recombinase polymerase amplification assay for diagnosis of acute hepatopancreatic necrosis disease in shrimp显示文摘Acute hepatopancreatic necrosis disease(AHPND)is an emerging disease in the shrimp farming industry with a high mortality rate that causes serious economic losses in Asia,Africa,and America[1].AHPND is also known as early mortality syndrome because of its early onset of the disease at 5-30 days of shrimp postlarvae stocking and a high mortality rate up to 100%.Symptoms of AHPND include lighter hepatopancreas,atrophy,jejunal empty stomach,softened carapace,and loss of vitality.AHPND is caused by infection of special strains of Vibrio parahaemolyticus(referred to VPAHPND in this study)containing the 69-kb pVA1 plasmid with the binary toxic Photorhabdus insect-related genes PirA and PirB(referred to PirAB in this study)[2].In January 2016,the World Organization for Animal Health(OIE)added AHPND to the OIE List of Aquatic Animal Diseases.Rapid,sensitive,and reliable diagnosis assays for AHPND are demanded by the shrimp farming industry to prevent the disease and reduce economic loss. | Haiyi Yu Xiaohan Yang Juan Zhang Haitao Yang Panpan Zhao Hui Shen Ge Jiang Jing Ji Jingquan Dong Song Gao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 2 |
| 4 | Inactivation of Cipc alters the expression of Per1 but not circadian rhythms in mice显示文摘Circadian clocks are comprised of self-sustained transcriptional/translational feedback loops, which regulate the rhythms of physiology and behavior in mammals. CLOCK-interacting protein, Circadian(CIPC), has been indicated as an additional negative-feedback regulator of the circadian clock in vitro, although its physiological roles in circadian clock are unknown. Here, we generated Cipc homozygous knockout(Cipc-/-) mice and assessed the resultant circadian phenotypes. Surprisingly, the m RNA expression profiles of core clock genes in the liver of Cipc-/- mice showed no significant differences from that in wild-type mice except for Per1. Cipc-/- mice displayed normal locomotor rhythm and entrained activity pattern in both 12:12 light-dark cycle and constant dark cycle. Furthermore, deletion of Cipc in lungs and adipose tissues did not influence their peripheral clock. The results from this work provided more conclusive data suggesting that CIPC is not critically required for basic clock function. | QU ZhiPeng WANG XiaoHan LIU DongChuan GAO Xiang XU Ying | 2015 | Science China(Life Sciences)2015，58，4： | 2 |
| 5 | Colonization of Penicillium oxalicum SL2 in Pb-contaminated paddy soil and its immobilization effect on soil Pb显示文摘Penicillium oxalicum SL2(SL2) is a previously screened Pb-tolerant fungus that can promote crops growth. The relationship between SL2 colonization and Pb immobilization was studied to provide a theoretical basis for microbial remediation of Pb-contaminated paddy soil.In this study, green fluorescent protein(GFP) labeled SL2 was inoculated into different Pbcontaminated paddy soils(S1-S6). The Pb extracted from the soil by HNO, EDTA and CaClwere used to characterize the available Pb. The results showed that the colonization of SL2was divided into lag phase(0-7 days), growth phase(7-30 days), and mortality phase(30-90days). SL2 colonized well in sandy soils rich in clay and total phosphorus with initial p H of 4.5-7.0. In addition, SL2 increased soil p H and decreased soil Eh, which was beneficial to immobilize Pb. In different soils, the highest percentages of CaCl-Pb, EDTA-Pb, and HNO3-Pb immobilized by SL2 were 34.34%-40.53%, 17.05%-20.11%, and 7.39%-15.62%, respectively.Pearson correlation analysis showed that the percentages of CaCl-Pb and EDTA-Pb immobilized by SL2 were significantly positively correlated with the number of SL2 during the growth phase. SL2 mainly immobilized Pb in the growth phase and a higher peak number of SL2 was beneficial to the immobilization of Pb. | Yu Gao Xiaohan Jiang Hanxin Wu Jianhao Tong Xinyue Ren Jiayu Ren Qianhua Wu Jien Ye Chunhui Li Jiyan Shi | 2022 | Journal of Environmental Sciences2022，34，10： | 1 |
| 6 | MAGED1: Molecular insights and clinical implications显示文摘 | Xiaohan Wang Xiang Gao Ying Xu | 2011 | Annals of Medicine2011，，5： | 1 |
| 7 | The Oxygen Activated by the Active Vanadium Species for the Selective Oxidation of Benzene to Phenol显示文摘 | Gao Xiaohan Xu Jie | | 0，，3： | 1 |
| 8 | Genomic diversity and post-admixture adaptation in the Uyghurs显示文摘Population admixture results in genome-wide combinations of genetic variants derived from different ancestral populations of distinct ancestry, thus providing a unique opportunity for understanding the genetic determinants of phenotypic variation in humans. Here, we used whole-genome sequencing of 92 individuals with high coverage(30–60×) to systematically investigate genomic diversity in the Uyghurs living in Xinjiang, China(XJU), an admixed population of both European-like and East-Asian-like ancestry.The XJU population shows greater genetic diversity, especially a higher proportion of rare variants,compared with their ancestral source populations, corresponding to greater phenotypic diversity of XJU.Admixture-induced functional variants in EDAR were associated with the diversity of facial morphology in XJU. Interestingly, the interaction of functional variants between SLC24A5 and OCA2 likely influences the diversity of skin pigmentation. Notably, selection has seemingly been relaxed or canceled in several genes with significantly biased ancestry, such as HERC2–OCA2. Moreover, signatures of post-admixture adaptation in XJU were identified, including genes related to metabolism(e.g. CYP2D6), digestion(e.g.COL11A1), olfactory perception(e.g. ANO2) and immunity(e.g. HLA). Our results demonstrated population admixture as a driving force, locally or globally, in shaping human genetic and phenotypic diversity as well as in adaptive evolution. | Yuwen Pan Chao Zhang Yan Lu Zhilin Ning Dongsheng Lu Yang Gao Xiaohan Zhao Yajun Yang Yaqun Guan Dolikun Mamatyusupu Shuhua Xu | 2022 | National Science Review2022，9，3： | 1 |
| 9 | Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers显示文摘 | Jian Shu Chen Wu Yetao Wu Zhiyuan Li Sida Shao Wenhui Zhao Xing Tang Huan Yang Lijun Shen Xiaohan Zuo Weifeng Yang Yan Shi Xiaochun Chi Hongquan Zhang Ge Gao Youmin Shu Kehu Yuan Weiwu He Chao Tang Yang Zhao Hongkui Deng | 2013 | Cell2013，，5： | 1 |
| 10 | Preparation of Bi2WO6 and Its Ultra-Deep Oxidative Desulfurization Performance in Ionic Liquids显示文摘The micro-spheric Bi_2WO_6 was synthesized by a simple one-step hydrothermal method. Bi_2WO_6 crystals were characterized using XRD, SEM, EDS and BET techniques. Bi_2WO_6, H_2O_2 and [HMIM][BF_4] served as catalyst, oxidant and extracting agent in the oxidative desulfurization system(ODS), respectively. The influence of extraction agent type, oxidant usage, catalyst dosage, temperature, sulfur compound type and other factors on the oxidative desulfurization was studied in the present work. The experimental results demonstrate that Bi_2WO_6 possesses high activity for desulfurization of dibenzothiophene(DBT) and benzothiophene(BT). The desulfurization rate of DBT and BT in model oil could reach 98.1% in 80 minutes and 96.2% in 120min at 70℃, respectively. Moreover, the desulfurization performance of catalyst for DBT hardly changed after being recycled for 10 times. | Xing Pengfei Zhao Rongxiang Li Xiuping Gao Xiaohan | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，1： | 1 |
| 11 | Milk fat globule membrane supplementation protects againstβ-lactoglobul-ininduced food allergy in mice via upregulation of regulatory T cells and enhancement of intestinal barrier in a microbiota-derived short-chain fatty acids manner显示文摘Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and immunomodulation.The aim of this study was to evaluate the protective effects and possible underlying mechanisms of MFGM on cow’s milk allergy(CMA)in aβ-lactoglobulin(BLG)-induced allergic mice model.MFGM was supplemented to allergic mice induced by BLG at a dose of 400 mg/kg body weight.Results demonstrated that MFGM alleviated food allergy symptoms,decreased serum levels of lipopolysaccharide,pro-inflammatory cytokines,immunoglobulin(Ig)E,Ig G1,and Th2 cytokines including interleukin(IL)-4,while increased serum levels of Th1 cytokines including interferon-γand regulatory T cells(Tregs)cytokines including IL-10 and transforming growth factor-β.MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice,as evidenced by decreased relative abundance of Desulfobacterota,Rikenellaceae,Lachnospiraceae,and Desulfovibrionaceae,while increased relative abundance of Bacteroidetes,Lactobacillaceae and Muribaculaceae,and enhanced expressions of tight junction proteins including Occludin,Claudin-1 and zonula occludens-1.Furthermore,MFGM increased fecal short-chain fatty acids(SCFAs)levels,which elevated G protein-coupled receptor(GPR)43 and GPR109A expressions.The increased expressions of GPR43 and GPR109A induced CD103+dendritic cells accumulation and promoted Tregs differentiation in mesenteric lymph node to a certain extent.In summary,MFGM alleviated CMA in a BLG-induced allergic mice model through enhancing intestinal barrier and promoting Tregs differentiation,which may be correlated with SCFAs-mediated activation of GPRs.These findings suggest that MFGM may be useful as a promising functional ingredient against CMA. | Han Gong Tiange Li Dong Liang Jingxin Gao Xiaohan Liu Xueying Mao | 2024 | Food Science and Human Wellness2024，13，1： | 1 |
| 12 | A new application of clay- supported vanadium oxide catalyst to selective hydroxylation of benzene to phenol显示文摘 | GAO Xiaohan XU ]ie | 2006 | Applied Clay Science2006，33，1： | 1 |
| 13 | Crosstalk between PC 12 cells and endothelial cells in an artificial neurovascular niche constructed by a dual-functionalized selfassembling peptide nanofiber hydrogel显示文摘The coordination between neurogenesis and angiogenesis plays an important role in nerve tissue development and regeneration.Recently,using bioactive materials to drive neurogenic and angiogenic responses has gained increasing attention.Understanding the neurovascular link between regulatory cues offers valuable insight into the mechanisms underlying nerve regeneration and the design of new bioactive materials.In this study,we utilized a dual-functionalized peptide nanofiber hydrogel presenting the brain-derived neurotrophic factor and vascular endothelial growth factor mimetic peptides RGIDKRHWNSQ(RGI)and KLTWQELYQLKYKGI(KLT)to construct an artificial neurovascular microenvironment.The dual-functionalized peptide nanofiber hydrogel enhanced the neurite outgrowth of pheochromocytoma(PC12)cells and tube-like structures formation of human umbilical vein endothelial cells(HUVECs)in vitro,and promoted rapid lesion infiltration of neural and vascular cells in a rat brain injury model.Using indirect co-culture models,we found that the dual-functionalized peptide hydrogel effectively mediated neurovascular crosstalk by regulating secretion of paracrine factors from PC12 cells and HUVECs.When the two cells types were directly co-cultured on the dua卜functionalized peptide hydrogel,the efficiency of cell-cell communication was enhanced,which further accelerated the differentiation and maturation of PC12 cells with an increased number of pseudopodia and spread morphology,and HUVECs tube-like structure formation.In summary,the dual-functionalized peptide nanofiber hydrogel successfully formed an artificial neurovascular niche to directly regulate the behaviors of neural and vascular cells and promote their neurovascular crosstalk through paracrine signaling and direct cell-cell contact. | Zhe Zhang Yi Chai He Zhao Shuhui Yang Wei Liu Zihui Yang Weilong Ye Chenlong Wang Xiaohan Gao Xiangdong Kong Xiaodan Sun Lingyun Zhao Tuoyu Chen Yuqi Zhang Jiaju Lu Xiumei Wang | 2022 | Nano Research2022，15，2： | 0 |
| 14 | Structure and immunomodulatory activity of Lentinus edodes polysaccharides modified by probiotic fermentation显示文摘Plant-based fermentations provide an untapped source for novel biotechnological applications.In this study,a probiotic named Lactobacillus fermentum 21828 was introduced to ferment Lentinus edodes.Polysaccharides were extracted from fermented and non-fermented L.edodes and purified via DEAE-52 and Sephadex G-100.The components designated F-LEP-2a and NF-LEP-2a were analyzed by FT-IR,HPGPC,HPAEC,SEM,GC-MS and NMR.The results revealed that probiotic fermentation increased the molecular weight from 1.16×10^(4) Da to 1.87×10^(4) Da and altered the proportions of glucose,galactose and mannose,in which glucose increased from 45.94%to 48.16%.Methylation analysis and NMR spectra indicated that F-LEP-2a and NF-LEP-2a had similar linkage patterns.Furthermore,their immunomodulatory activities were evaluated with immunosuppressive mice.NF-LEP and F-LEP improved immune organ indices,immunoglobulin(Ig G and Ig M)and cytokines concentrations;restored the antioxidation capacity of liver;and maintained the balance of gut microbiota.F-LEP displayed better moderating effects on the spleen index,immunoglobulin,cytokines and the diversity of gut microbiota than NF-LEP(200,400 mg/kg).Our study provides an efficient and environment-friendly way for the structural modification of polysaccharides,which helps to enhance their biological activity and promote their wide application in food,medicine and other fields. | Jingjing Liang Meina Zhang Xiaohan Li Yuan Yue Xiaowei Wang Mengzhen Han Tianli Yue Zhouli Wang Zhenpeng Gao | 2024 | Food Science and Human Wellness2024，13，1： | 0 |
| 15 | Serrin-Type Overdetermined Problem in H^(n)显示文摘In this paper,we prove the symmetry of the solution to overdetermined problem for the equationσ_(k)(D^(2)u-ul)=C^(k)_(n)in hyperbolic space.Our approach is based on establishing a Rellich-Pohozaev type identity and using a P function.Our result generalizes the overdetermined problem for Hessian equation in Euclidean space. | GAO Zhenghuan JIA Xiaohan YAN Jin | 2023 | Journal of Partial Differential Equations2023，36，1： | 0 |
| 16 | Recent advances for liquid metals:Synthesis,modification and bio-applications显示文摘Considering the application requirements for modern biomedicine,research into novel biomaterials with unusual functions is highly desired.As an alternative,liquid metals(LMs),a nontraditional family of metal materials,have piqued the interest of biomedical researchers and made significant advances in biomed-ical areas,owing to their shape transformability,self-healing capability,excellent electrical,and thermal conductivities.In particular,many functionalized strategies for the preparation and modification of LMs or LMs-based composites to achieve extended biomedical applications have been investigated in recent years.These findings provided inspiring while constructive reference for the fabrication and engineering of novel LMs-based composites.Herein,in this topic review,we elaborate on the recent advances of LMs-based functional materials,with particular focuses on the synthesis,modification,and bio-applications,especially in antitumor therapy,antibacterial,contrast agent for imaging,bone repair,electronic skin sen-sor,and nerve connection agent.Further on,the current challenges and future prospects of LMs-based composites are carefully discussed. | Zhenhu Guo Xiaohan Gao Jingsong Lu Wanling Xu Jielin Ye Ying Li Wensheng Xie Lingyun Zhao | 2023 | Journal of Materials Science & Technology2023，，12： | 0 |
| 17 | Low genetic diversity in the endangered marine alga Silvetia siliquosa(Ochrophyta:Fucaceae)and the implication to conservation显示文摘Although signifi cant research eff orts have been targeted toward conservation and management of endangered terrestrial fl ora and fauna,attempts have been limited to conserve threatened seaweeds.Silvetia siliquosa is an ecologically and commercially vital brown alga that is uniquely distributed in the Yellow-Bohai Sea and along the southwest coast of Korea.A massive decline in its distribution range and biomass from the mid-1990s onward indicates that this species has become endangered.In the present study,we used nuclear internal transcribed spacer and concatenated mitochondrial cytochrome oxidase I subunit+intergenic spacer to estimate the genetic diversity,population connectivity,and degree of genetic diff erentiation of S.siliquosa in China and Korea.The molecular results exhibited strikingly low levels of haplotype/ribotype and nucleotide diversity in S.siliquosa populations,with only three mitochondrial haplotypes and nuclear ribotypes detected in 136 and 143 specimens,respectively.The analysis of molecular variance revealed 85%-95%of genetic variance among populations.Population diff erentiation coeffi cient(F_(ST))and gene fl ow(N_(m))suggested that two populations(JIN and GWA)along the southern coast of Korea are highly divergent from the others,with weak genetic exchange.No signifi cant genetic diff erentiation was observed among populations either in China or along the geographically proximate west coast of Korea.Thus,four independent management units were designated for sustainable management:the LII and RUS populations in China,the YEO and CHA populations along the west coast of Korea,and each of the GWA and JIN populations along the south coast of Korea.We suggest that artifi cial cultivation and transplantation of S.siliquosa are the eff ective approaches for restoration and conservation. | Yanshuo LIANG Jie ZHANG Xiaohan SONG Han-Gil CHOI Xu GAO Delin DUAN Zi-min HU | 2022 | Journal of Oceanology and Limnology2022，40，1： | 0 |
| 18 | Maillard reaction-derived laser lithography for printing functional inorganics显示文摘Photopolymerization-based additive printing of functional inorganics has drawn great attention in recent years and one important challenge is the photoresin loading with diverse inorganics. Here, we introduce a Maillard reaction-derived laser lithography strategy for an unprecedented direct printing of diverse inorganic compounds. The sugar-assisted laser lithography(SLL) is powerful to carry choice metal ions and versatile for the generation of patterned inorganic materials comprising metal oxides,metal sulfides, and metal nitrides, characterized by ferroelectric, magnetic, semiconductivity, superconductivity, or other properties. The material architecture is flexibly manipulated by the laser intensity, power, printing speed, precursor solution, and computer-aided design to satisfy the practical requirements. This work demonstrates a new possibility for the further development of laser lithography in the directly printing of feature-rich inorganic materials and devices. | Xiao Dai Yining Jiang Xiaohan Wang Fengnan Chen Liang Gao Xiaofeng Li Guifu Zou | 2022 | Science China Chemistry2022，65，7： | 0 |
| 19 | Thoracic interstitial injection of drug-liposomes in mice for treating atherosclerosis显示文摘Intervaginal space injection(ISI)is a novel mode of administration investigated over the last decade.After injecting nanoparticles into the intervaginal space,they can be transported along low flow resistance channels into the interstitial space.This transport has a certain delivery direction,and site-specific injection can work on specific organs or tissues.In this study,the thorax,a new ISI site in the interstitial surrounding the internal thoracic artery named the thoracic interstitial injection(tISI)was investigated.To prove the targeting ability of the tISI,two sizes of gold nanoparticles(AuNPs)(47 and 87 nm)were administered to mice.After 1 h,the biodistribution of AuNPs in the tissues was measured via single particle inductively coupled plasma mass spectrometry(spICP-MS).The results showed that the concentration of AuNPs in the aorta after tISI injection was significantly higher than that after intravenous injection.Moreover,fewer nanoparticles with larger particle sizes were observed to have entered the blood and were better targeted to the aorta.Thereafter,tanshinone IIa sodium sulfonate liposomes were administered for the treatment of aortic atherosclerosis.The proportion of aortic plaques in atherosclerotic Apoe-/-mice administered via tISI was significantly lower than that in other model animals(P<0.001).Furthermore,the proteoglycan content and CD68-positive cell count in the plaques were significantly reduced.The vascular elastic fibers at the plaque site were thickened,and fractures were reduced.tISI was,therefore,determined to be an effective strategy for the treatment of atherosclerotic aortic plaques. | Tun Yan Huizhen Sun Yahong Shi Ya Gao Xi Lu Kai Li Yuting Zhu Qiang Zhang Tingting Li Zhongxian Li Xiaohan Zhou Yuting Guo Yinglu Ji Xiaoli Shi Dong Han | 2023 | Nano Research2023，16，4： | 0 |
| 20 | Construction of a General Standard Molecule for the Qualitative Detection in Different Transgenic Foodcrops显示文摘Now every laboratory is facing a common problem that is seriously lacking in the standard reference molecule in the GMC detecting research center. Constructing the recombinant plasmid is the urgent demand. In order to overcome this problem, this study respectively cloned Cry1A(B), BAR, CP4-EPSPS, PAT and RBCL genes into PMD18-T vector. This constructed plasmid could be used as the standard reference molecule in the qualitative detecting of the exogenous CP4-EPSPS gene, Cry1A(B) gene, BAR gene and PAT gene. Identification by double restriction endonuclease digestion and identification by PCR proved that the test result was positive. All of these indicated that the established reference molecules in this study were suitable for the qualitative analysis standard of this GMC detection. | AO Jinxia GAO Xuejun YU Yanbo QU Bo YUAN Xiaohan LIU Ying GUO Shicheng | 2009 | Journal of Northeast Agricultural University(English Edition)2009，16，2： | 0 |
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