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| 1 | Ferroptosis is an autophagic cell death process显示文摘Ferroptosis 是调整坏死的一种铁依赖者形式。它在各种各样的人的疾病被含有,包括 ischemic 机关损坏和癌症。这里,我们报导 autophagy 的关键角色,特别地细胞的铁存储蛋白质(作为 ferritinophagy 知道的一个过程) 的 autophagic 降级,在 ferroptosis。用 RNAi,屏蔽结合了随后的基因分析,我们作为 ferroptosis 的积极管理者识别了多重 autophagy 相关的基因。Ferroptosis 正式就职导致了 autophagy 激活和 ferritin 和 ferritinophagy 货物受体 NCOA4 的作为结果的降级。一致地,由 autophagy 的阻塞的 ferritinophagy 的抑制或废除的 NCOA4 击倒联系 ferroptosis 的细胞的易变的铁的累积和反应的氧种类,以及最终的 ferroptotic 细胞死亡。因此, ferroptosis 是一个 autophagic 房间死亡过程,并且调停 NCOA4 的 ferritinophagy 由控制细胞的铁动态平衡支持 ferroptosis。 | Minghui Gao Prashant Monian Qiuhui Pan Wei Zhang Jenny Xiang Xuejun Jiang | 2016 | Cell Research2016，26，9： | 138 |
| 2 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 3 | Discovery and implications of catenary-bead subaqueous dunes显示文摘Measurements of topography at the segment of bifurcation between the South Channel and North Channel in the Yangtze Estuary were conducted, and a new type of subaqueous dune was discovered. This structure, newly defined as a catenary-bead dune, consists of a catenary dune and its associated elliptical pit bedform. Based on this finding, the nomenclature of 'morphology of dune associated with accompanying bedform' is first proposed. The measured data indicate a mean height and wavelength of 1.29 m and 31.89 m, respectively; wavelength/height ratio(L/H) of 14 to 56; and elliptical pits of mean and maximum depth 0.98 m and 1.98 m, respectively. Flow information was obtained using an Acoustic Doppler Current Profile(ADCP), and the bed material components were gathered with a bottom sampler. The results show mean flood and ebb velocities of 0.27 and 0.78 m s?1, respectively, with shorter duration of flood tide than ebb tide. The silt, very fine sand, and fine sand fractions were within the ranges 21.6–23.4%, 28.2–32.2%, and 39.7–41.6%, respectively, revealing complex bed material composition. Water depth at the study site varies from 13 to 17 m. This finding will enrich the study of dunes and provide important data for geomorphological research. Moreover, the results are significant for engineering applications to estuaries. | ZHENG Shu Wei CHENG He Qin WU Shuai Hu LIU Gao Wei LU XueJun XU WenXiao | 2016 | Science China Earth Sciences2016，59，3： | 5 |
| 4 | Association of the Late Cornified Envelope-3 Genes with Psoriasis and Psoriatic Arthritis:A Systematic Review显示文摘Psoriasis(Ps)and psoriatic arthritis(Ps A)are genetically complex diseases with strong genetic evidence.Recently,susceptibility genes for Ps and Ps A have been identified within the late cornified envelop(LCE)gene cluster,especially the cluster 3(LCE3)genes.It is noteworthy that the deletion of LCE3B and LCE3C(LCE3C_LCE3B-del)is significantly associated with these two diseases.Gene-gene interactions between LCE3 genes and other genes are associated with Ps and Ps A.LCE3 genes also have pleiotropic effect on some autoimmune diseases,such as rheumatoid arthritis,atopic dermatitis and systemic lupus erythematosus.Further studies need to focus on the potential function of LCE3 genes in the pathogenesis of Ps and Ps A in the future. | Changbing Shen Jing Gao Xianyong Yin Yujun Sheng Liangdan Sun Yong Cui Xuejun Zhang | 2015 | Journal of Genetics and Genomics2015，42，2： | 4 |
| 5 | Preparation of one-dimensional nanostructured ZnO显示文摘Rod-like ZnO particles were synthesized via a sol-gel method by adding ethylene diamine(EDA) to the reaction system of Zn(Ac)2·2H2O and H2C2O4·2H2O.The crystal phase and morphology of the products were characterized by XRD(X-ray powder diffractometer) and TEM(transmission electron microscope).Rod-like ZnO belongs to the hexagonal Wurtzite system,with diameters and lengths of about 20-200 nm and 0.2-1.5 m,respectively.Experimental results showed that the morphology of nano-ZnO can be controlled by modulating the quantities of EDA added into the reaction system and that EDA plays an important role in the formation of rod-like ZnO particles.The growth mechanism of the rod-like nanoZnO was briefly discussed.The proposed facile,reproducible,effective and low-cost synthesis promises future large-scale preparation of nanostructured ZnO for application in nanotechnology. | Xiuping Jiang Youzhi Liu Yanyang Gao Xuejun Zhang Lihong Shi | 2010 | Particuology2010，8，4： | 4 |
| 6 | Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana显示文摘Here,we report the identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge,Guyana.In March 2019,14 employees of Chongqing Bosai Mining Company,China,working in a manganese mining of Guyana,had unexplained fever,and two of them died.We obtained lung and brain tissues as well as the blood samples from the two deceased cases(patient No.1 and 2),and bronchoscopy lavages and cerebrospinal fluid samples from one severe case(patient No.3),respectively.All samples were tested by pathological examination,high-throughput sequencing,and real-time PCR.Pathological detection showed the presence of spore-like structures in the lung tissue of patient No.1,indicating a fungal infection in this patient.Nanopore sequencing identified the existing of H.capsulatum in the lung tissue sample within 13 h.Next-generation sequencing identified specific fragments of H.capsulatum in all of the samples tested(lung,brain and blood serum from the deceased cases,and plasma from the severe case).Real-time PCR assays did not reveal any viral infection related to transmission from bat feces.We conclude that H.capsulatum was the causative pathogen of this disease cluster based on epidemiologic,clinical,pathological and nucleic acid evidence. | Ji Wang Weimin Zhou Hua Ling Xiaoping Dong Yi Zhang Jiandong Li Yong Zhang Jingdong Song William J.Liu Yang Li Ruiqing Zhang Wei Zhen Kun Cai Shuangli Zhu Dongyan Wang Jinbo Xiao Yigang Tong Wenli Liu Lihua Song Wei Wu Yang Liu Xiang Zhao Ruihuan Wang Sheng Ye Jing Wang Roujian Lu Baoying Huang Fei Ye Wenwen Lei Rongbao Gao Qi Shi Cao Chen Jun Han Wenbo Xu George F.Gao Xuejun Ma Guizhen Wu | 2019 | Biosafety and Health2019，1，3： | 3 |
| 7 | DNA methylation-based subclassification of psoriasis in the Chinese Han population显示文摘Psoriasis (Ps)is an inflammatory skin disease caused by genetic and environmental factors.Previous studies on DNA methylation (DNAm)found genetic markers that are closely associated with Ps,and evidence has shown that DNAm mediates genetic risk in Ps.In this study,Consensus Clustering was used to analyze DNAm data,and 114Ps patients were divided into three subclassifications.Investigation of the clinical characteristics and copy number variations (CNVs)of DEFB4,IL22,and LCE3C in the three subclassifications revealed no significant differences in gender ratio and in Ps area and severity index (PASI)score.The proportion of late-onset (≥40 years)Ps patients was significantly higher in type I than in types H and III (P =0.035).Type III contained the smallest proportion of smokers and the largest proportion of non-smoking Ps patients (P =0.086).The CNVs of DEFB4and LCE3C showed no significant differences but the CNV oflL22significantly differed among the three subelassifications (P =0.044).This study is the first to profile Ps subclassifications based on DNAm data in the Chinese Han population.These results are useful in the treatment and management of Ps from the molecular and genetic perspectives. | Fusheng Zhou Changbing Shen Yi-Hsiang Hsu Jing Gao Jinfa Dou Randy KO Xiaodong Zheng Liangdan Sun Yong Cui Xuejun Zhang | 2018 | Frontiers of Medicine2018，12，6： | 3 |
| 8 | Separation and Purification of Thrombin-like Enzymes by Affinity Adsorbents显示文摘An affinity adsorbent, benzamidine Sepharose 4B, was used to separate and purify thrombin like enzymes. The p aminobenzamidine as a specific ligand was coupled to the matrix-Sepharose 4B. The recombinant thrombin like enzyme-defibrase was used as a model in order to evaluate the efficiency of this biospecific affinity adsorbent. The homogeneity of the enzyme preparation was comfirmed as one band on sodium dodecyl sulfate polyacrylamide gel electrophoresis. | 杨青 Xu Xiaoming Hu Xuejun Gao Xiaorong Dong Xinyan Su Zhiguo An Lijia | 2001 | High Technology Letters2001，7，4： | 2 |
| 9 | Crystallization Behavior of High Purity Fused Magnesia显示文摘The chemical composition and microstructure of Tibetan microcrystalline magnesite were studied by means of XRF,XRD and FESEM. It is found that the microcrystalline magnesite has uniformly distributed grains,mostly in the range of 2-4 μm,and the MgO content is47. 80%. In fused magnesia,the druses are colorless transparent periclase megacrysts without impurity,while the crust sand is white,with a high MgO content up to97%-99%. The periclase crystals are big,appearing as faced and step-growth morphology. Massive secondary long columnar periclase is crystallized. | LI Xuejun GAO Zhenxin YAN Guanghui ZHANG Wei FU Qiuhua | 2017 | China's Refractories2017，26，2： | 2 |
| 10 | Serum from Acute-on-chronic Liver Failure Patients May Affect Mesenchymal Stem Cells Transplantation by Impairing the Immunosuppressive Function of Cells显示文摘Background and Aims:The safety and efficacy of mesenchymal stem cells(MSCs)in the treatment of acute-onchronic liver failure(ACLF)have been validated.However,the impact of the pathological ACLF microenvironment on MSCs is less well understood.This study was designed to explore the changes in the functional properties of MSCs exposed to ACLF serum.Methods:MSCs were cultured in the presence of 10%,30%and 50%serum concentrations from ACLF patients and healthy volunteers.Then,the cell morphology,phenotype,apoptosis and proliferation of MSCs were evaluated,including the immunosuppressive effects.Subsequently,mRNA sequencing analysis was used to identify the molecules and pathways involved in MSC functional changes in the context of ACLF.Results:In the presence of ACLF serum,MSC morphology significantly changed but phenotype did not.Besides,MSC proliferation activity was weakened,while the apoptosis rate was lightly increased.Most importantly,the immunosuppressive function of MSCs was enhanced in a lowconcentration serum environment but transformed into a proinflammatory response in a high-concentration serum environment.RNA sequencing indicated that 10%serum concentration from ACLF patients mediated the PI3K-Akt pathway to enhance the anti-inflammatory effect of MSCs,while the 50%serum concentration from ACLF patients promoted the conversion of MSCs into a proinflammatory function by affecting the cell cycle.Conclusions:The 50%ACLF serum concentration is more similar to the environment in the human body,which means that direct peripheral blood intravenous infusion of MSCs may reduce the effect of transplantation.Combining treatments of plasma exchange to reduce harmful substances in serum may promote MSCs to exert a stronger anti-inflammatory effect. | Yongyuan Zheng Shu Zhu Xingrong Zheng Wenxiong Xu Xuejun Li Jianguo Li Zhiliang Gao Chan Xie Liang Peng | 2021 | Journal of Clinical and Translational Hepatology2021，9，4： | 2 |
| 11 | Ecological damage of submerged macrophyte Myriophyllum spicatum by cell extracts from microcystin(MC)-and non-MC-producing cyanobacteria,Microcystis显示文摘To explore how decomposed Microcystis-dominant cyanobacterial blooms affect submerged macrophytes,the submerged plant Myriophyllum spicatum was exposed to cell extracts from microcystin(MC)-and non-MC-producing Microcystis strains in a laboratory experiment.Results showed that both Mcracystis cell extracts exerted obvious damages to plant biomass,photosynthesis,primary and secondary metabolism measures,and resistance of plant antioxidant systems,with MC-producing Microcystis having stronger effects due to the presence of MCs.Cyanotoxins other than MCs responsible for the negative effects from both strains needs further identification.The Shannon diversity and Chao1 indices of epiphytic and planktonic bacteria were decreased by the cell extracts from both Microcystis strains.However,epiphytic and planktonic bacterial communities responded differently to cell extracts at the genus level.The dominant genera of planktonic bacteria including Enterobacter,Pseudomonas,and Novosphingobium from phylum Proteobacteria,Chryseobacterium from phylum Bacteroidetes,and Microbacterium from Actinobacteriota in the treatments with cell extracts were previously reported to have strains with algicidal and MC-degrading capabilities.B acterial genes associated with energy production and conversion,amino acid transport and metabolism,and inorganic ion transport and metabolism,were more abundant in both treatments than the control for planktonic bacteria,but less abundant for epiphytic bacteria.We speculate that planktonic bacterial communities have the potential to use and degrade substances derived from Microcystis cell extracts,which may be beneficial for M.spicatum to alleviate damages from Microcystis.Further research is needed to verify the structure and function dynamics of epiphytic and planktonic bacteria in the interaction between cyanobacteria and submerged macrophytes. | Yunni GAO Hui YANG Xiaofei GAO Mei LI Man ZHANG Jing DONG Jingxiao ZHANG Longfei LI Xuejun LI Michele A BURFORD | 2022 | Journal of Oceanology and Limnology2022，40，5： | 2 |
| 12 | Stress - Strain Behaviors Simulation of High Chromium Steel at Elevated Temperatures显示文摘 | Ligang Liu Qiang Li Bo Liao Yukui Gao Yuhui Wang Xuejun Ren and Qingxiang Yang | 2010 | Journal of Ma- terials Engineering and Performance2010，，19： | 1 |
| 13 | Damage evolution of yttria-stabilized zirconia induced by He irradiation显示文摘 | Tengfei Yang Xuejun Huang Yuan Gao Chenxu Wang Yanwen Zhang Jianming Xue Sha Yan Yugang Wang | 2011 | Journal of Nuclear Materials2011，，1： | 1 |
| 14 | Synthesis and surface properties of semi-interpenetrating fluorine-containing polyacrylate and epoxy resin networks显示文摘 | Xuejun Cui Yan Gao Shuangling Zhong Zaihang Zheng Yuxia Cheng Hongyan Wang | 2012 | Journal of Polymer Research2012，，3： | 1 |
| 15 | A multiplex nested PCR assay for the simultaneous detection of genetically modified soybean, maize and rice in highly processed products显示文摘 | Ao Jinxia Li Qingzhang Gao Xuejun Yu Yanbo Li Lu Zhang Minghui | 2011 | Food Control2011，，10： | 1 |
| 16 | Preparation and characterization of emulsifier-free core-shell interpene- trating polymer network-fluorinated polyacrylate latex parti- cles显示文摘 | Cui Xuejun Zhong Shuangling Gao Yan | 2008 | Colloids and Surfaces A: Physicochemical and Engi- neering Aspects2008，324，123： | 1 |
| 17 | Detection of Roundup Ready soy in highly processed products by triplex nested PCR显示文摘 | Minghui Zhang Xuejun Gao Yanbo Yu Jinxia Ao Jun Qin Yonghao Yao Qingzhang Li | 2006 | Food Control2006，，10： | 1 |
| 18 | Immunohistochemical expression oftranscription factor Sp3 during dental enamel development in SD rat tooth germ显示文摘 | Lv Ping Jia HongTi Gao XueJun | 2006 | Eur J Oral Sci2006，114，： | 1 |
| 19 | Effect of Carburization on Residual Stress Field of 20CrMnTi Specimen and Its Numerical Simulation 显示文摘 | Yang Qingxiang Ren Xuejun Gao Yukui | 2005 | Materials Science and Engineering2005，392，12： | 1 |
| 20 | The Pharmacological Research of Fuling Analyze and Its Beginnings Explore on Clinical Application显示文摘 | | 1985 | Chinese Medicinal Herb1985，16，4： | 1 |
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