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| 1 | Effect of Protein Kinase C on Proliferation and Apoptosis of T Lymphocytes in Idiopathic Thrombocytopenic Purpura Children显示文摘It is well-documented that T lymphocyte proliferation and apoptosis are abnormal in idiopathic thrombocytopenic purpura (ITP) children. However, the underlying regulation mechanisms especially in terms of signal transduction remain unknown. In this paper, we reported the changes of protein kinase C (PKC) activity in peripheral blood T lymphocytes and the effect of PKC on T lymphocyte proliferation and apoptosis. We demonstrated that in ITP children, the activator (PMA) and inhibitor (H-7) of PKC affected on T lymphocyte proliferation and apoptosis dramatically, but they altered little in healthy children. PKC activity was significantly enhanced in ITP children together with an increased expression of FasL on CD3+ T, CD4+ T and CD8+T cells, resulting in a positive correlation between PKC activity and the expression of FasL on T cells. While the PKC activity and the platelet count were negatively correlated. Taken together, our findings suggest that the PKC activation may enhance T lymphocytes activity, suppress T cell apoptosis and be involve in thrombocytes damage as a mechanism related to immune pathogenesis of ITP. | Changlin Wu~(1,2) Fang Liu~1 Xuemin Zhou~1 Zhengwei Cheng~1 Xiaomeng Yang~1 Hong Xiao~1 Qun Chen~1 Kangrong Cai~1 ~1Department of Microbiology and Immunology,Guangdong Medical College,Zhanjiang,Guangdong,524023,China ~2Corresponding to:Dr.Changlin Wu,Department of Microbiology and Immunology,Guangdong Medical College,2 Wen-Ming East Road,Zhanjiang,Guangdong,524023,China. | 2005 | Cellular & Molecular Immunology2005，2，3： | 12 |
| 2 | Effect of pyrolytic carbon interphase on mechanical properties of mini T800-C/SiC composites显示文摘The effect of pyrolytic carbon(PyC) thickness on the tensile property of mini T800 carbon fiber reinforced SiC matrix composites(C/SiC) was studied. PyC interphase was prepared by chemical vapor infiltration(CVI) process using C3H6–Ar as gas source, the PyC thickness was adjusted from 0 to 400 nm, and then the SiC matrix was prepared by CVI process using methyltrichlorosilane(MTS)–H2–Ar as precursor and gas source. The results showed that the tensile strength of mini T800-C/SiC increased first and then decreased with the increase of the PyC thickness. When the thickness of PyC was 100 nm, the average strength reached the maximum value of 393 ± 70 MPa. The Weibull modulus increased from 2.0 to 8.06 with the increase of PyC thickness, and the larger the Weibull modulus, the smaller the dispersion, which indicated that the regulation of PyC thickness was conducive to improve tensile properties. | Donglin Zhao Tong Guo Xiaomeng Fan Chao Chen Yue Ma | 2021 | Journal of Advanced Ceramics2021，10，2： | 6 |
| 3 | PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus显示文摘地岬在许多细胞的活动起一个枢轴的作用,并且它的 subcellular 区分提供空间、时间的选择。这里,我们报导由二高度相应的蛋白质 PAQR10 和孕激素和 AdipoQ 受体家庭的 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个模式。PAQR10 和 PAQR11 在 Golgi 仪器是只局部性的。PAQR10/PAQR11 的 Overexpression 刺激基础、导致 EGF 的英皇家空军之阶级最低之兵 phosphorylation 并且以一种剂量依赖者方式增加英皇家空军之阶级最低之兵目标基因的表示。PAQR10/PAQR11 的 Overexpression 显著地提高 HRas, NRas 和 KRas4A 的 Golgi 本地化,然而并非 KRas4B。PAQR10 和 PAQR11 罐头也与 HRas, NRas 和 KRas4A 交往,然而并非 KRas4B。在由 PAQR10/PAQR11 的 overexpression 的 Golgi 仪器的增加的地岬蛋白质处于一个活跃状态。一致地, PAQR10 和 PAQR11 还原剂击倒在 Golgi 仪器的刺激 EGF 的英皇家空军之阶级最低之兵 phosphorylation 和地岬激活。有趣地, PAQR10 和 PAQR11 能与 RasGRP1,地岬的 guanine 核苷酸交换蛋白质,和 RasGRP1 的增加 Golgi 本地化交往。RasGRP1 的 C1 领域为和 PAQR10/PAQR11 的 RasGRP1 的相互作用必要、足够。由 overexpressed PAQR10/PAQR11 的英皇家空军之阶级最低之兵 phosphorylation 的模拟被 RasGRP1 的 downregulation 废除。而且, PC12 房间的区别被 PAQR10/PAQR11 的 overexpression 显著地提高。一起,这研究揭开由 PAQR10 和 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个新范例。 | Ting Jin Qiurong Ding Heng Huang Daqian Xu Yuhui Jiang Ben Zhou Zhenghu Li Xiaomeng Jiang Jing He Weizhong Liu Yixuan Zhang Yi Pan Zhenzhen Wang Walter G Thomas Yan Chen | 2012 | Cell Research2012，22，4： | 6 |
| 4 | Polarization and Apoptosis of T Cell Subsets in Idiopathic Thrombocytopenic Purpura显示文摘It is well-known that idiopathic thrombocytopenic purpura (ITP) is an acquired organ-specific autoimmune hemorrhagic disease and dysfunctional cellular immunity is considered important in the pathophysiology of ITP. However, polarization patterns and apoptosis profiles of T lymphocytes remain unclear. In this study, we investigated the polarization of T cell subsets, the expressions of apoptotic proteins Fas/FasL on the subsets and the level of anti-apoptotic gene bcl-2 and bax mRNA. It was demonstrated that the ratios of Th1/Th2 and Tc1/Tc2 in ITP children were increased obviously and that the average percentages were increased clearly for Th1 and Th2,but not for Tc1 and Tc2. In ITP children, the enhancing expressions were detected for FasL on Th1 and Tc1 and for Fas on Th2 and Tc2. With increasing level of bcl-2 mRNA and decreasing expression of bax mRNA in ITP children, the ratio of bcl-2/bax mRNA was improved obviously, which was positive correlated with the ratio of Th1/Th2. Taken together, our findings indicate that ITP is a Th1 predominant disease. This polarization pattern of T cell subsets might be related to the high ratio of bcl-2/bax mRNA and the abnormal expressions of Fas and FasL on T cell subsets. Cellular & Molecular Immunology. | Fang Liu~(1,2) Changlin WU~1 Xiaomeng Yang~1 Hong Xiao~1 Xuemin Zhuo~1 Zhengwei Cheng~1 Qun Chen~1 ~1Department of Microbiology and Immunology,Guangdong Medical College,Zhanjiang,Guangdong 524023,China ~2Department of Microbiology and Immunology,Guangdong Medical College,No.2 Wen-ming East Road,Zhanjiang,Guangdong 524023,China. | 2005 | Cellular & Molecular Immunology2005，2，5： | 5 |
| 5 | Construction of Co_(2)NiO_(4)@MnCo_(2)O_(4.5)nanoparticles with multiple hetero-interfaces for enhanced electromagnetic wave absorption显示文摘Nanocomposites with heterogeneous structures and magneto-electric synergistic losses have broad prospects for improving electromagnetic wave(EMW)absorption performance.In this study,we synthesized Co_(2)NiO_(4)@MnCo_(2)O_(4.5)nanoparticles with abundant hetero-interfaces and multiple magnetoelectric loss mechanisms by a facile hydrothermal method.The excess 0.5 oxygen atoms in MnCo_(2)O_(4.5) produce more vacancies and contribute to the enhancement of electrical conductivity.Sequential nanoneedle clusters facilitate multiple reflections and absorption of EMW in the materials,which are accompanied by an abundance of heterogeneous interfaces to improve the dielectric loss.The Co_(2)NiO_(4)@MnCo_(2)O_(4.5)composites showed a minimum reflection loss(RLmin)of30.01 dB and a superior effective absorption bandwidth(EAB)of 6.12 GHz(11.88 GHze18 GHz)at a thickness of 2.00 mm.Computer Simulation Technology(CST)revealed that the obtained particles show very low radar crosssection(RCS)values and almost full coverage angles.The maximum reduction of RCS at vertical incidence reaches 19.98 dB m2.The Co_(2)NiO_(4)@MnCo_(2)O_(4.5)nanoparticles exhibit outstanding radar attenuation properties,which can effectively inhibit the reflection and scattering of EMW.Therefore,the prepared Co_(2)NiO_(4)@MnCo_(2)O_(4.5)absorbers have great application potential in the field of EMW absorption. | Yi Zhang Shujuan Tan Zhuoting Zhou Xiaomeng Guan Yu Liao Chen Li Guangbin Ji | 2023 | Particuology2023，，10： | 5 |
| 6 | High-precision regulation synthesis of Fe-doped Co_(2)P nanorod bundles as efficient electrocatalysts for hydrogen evolution in all-pH range and seawater显示文摘The hydrogen evolution reaction(HER)via water electrolysis has gained immense research attention.Seawater electrolysis provides great opportunities for sustainable energy production,but is extremely challenging.Transition metal phosphides are promising candidate electrocatalysts.Herein,we prepared a novel Fe-Co_(2)P bundle of nanorods(BNRs)for catalyzing the HER in seawater electrolysis and over the entire p H range.Cobalt phosphides with different crystal phases and morphologies were obtained by varying the Fe doping amount.The Co:Fe molar ratio of 1:0.5 was found to be optimum.The Fe doping improved the HER performance of Co_(2)P over the entire p H range by providing favorable electronic properties and morphology,lattice distortion,and special coordination environment.The Fe-Co_(2)P BNRs showed higher catalytic activity than 20%Pt/C in seawater at high potentials.The density functional theory calculations revealed that the Fe doping reduced the hydrogen binding strength of Co_(2)P to efficiently accelerate the HER kinetics and produce a favorable charge density.This study provides valuable insights into the design and development of high-efficiency HER catalysts for large-scale seawater electrolysis. | Yan Lin Kaian Sun Xiaomeng Chen Chen Chen Yuan Pan Xiyou Li Jun Zhang | 2021 | Journal of Energy Chemistry2021，30，4： | 4 |
| 7 | Multichannel Financing Reduces Economic Burden and Improves the Medical Security Level for Tuberculosis Patients显示文摘Tuberculosis(TB)is one of the main infectious diseases to simultaneously cause poverty and be caused by poverty.Reducing the economic burden of TB patients in China is essential to improving patient compliance and reducing the impact of the TB epidemic.In accordance with the national reform of the medical and health system and the current status of the country’s TB prevention and treatment service system,representatives of the government proposed the concept of a multichannel financing mechanism. | Fei Huang Ni Wang You Li Hui Zhang Yanli Yuan Xiaomeng Wang Xiaolin Wang Shitong Huan Lixia Wang Mingting Chen Yanlin Zhao | 2020 | China CDC weekly2020，2，12： | 3 |
| 8 | Expert consensus on perioperative management of liver transplantation in adults with acute-on-chronic liver failure显示文摘Acute-on-chronic liver failure(ACLF)is a syndrome in which acute liver failure with extrahepatic organ failure occurs on chronic liver disease.Recently,liver transplantation is the only effective treatment for ACLF.There is still room for discussion on the optimal surgery timing for ACLF,perioperative infection prevention and control,and maintenance of nutrition and organ function.The Transplantation Immu-nology Committee of Branch of Organ Transplantation Physician of Chinese Medical Doctor Association and Enhanced Recovery of Liver Transplantation Group of Enhanced Recovery after Surgery Committee of Chinese Research Hospital Association invited relevant experts to discuss the perioperative management of ACLF liver transplantation in areas including surgery timing,organ protection,nutritional support,infection prevention and control,rehabilitation exercises,regulation of the internal environment,etc.An expert consensus was developed as reference for clinicians. | Transplantation Immunology Committee of Branch of Organ Transplantation Physician of Chinese Medical Doctor Association Enhanced Recovery of Liver Transplantation Group of Enhanced Recovery after Surgery Committee of Chinese Research Hospital Society Guihua Chen Yang Yang Huimin Yi Jianrong Liu Pinglan Lu Lijuan Li Mingming Fan Xiaomeng Yi Haijin Lv Xuxia Wei | 2021 | Liver Research2021，5，2： | 3 |
| 9 | Multi-state autonomous drilling for lunar exploration显示文摘Due to the lack of information of subsurface lunar regolith stratification which varies along depth, the drilling device may encounter lunar soil and lunar rock randomly in the drilling process. To meet the load safety requirements of unmanned sampling mission under limited orbital resources, the control strategy of autonomous drilling should adapt to the indeterminable lunar environments. Based on the analysis of two types of typical drilling media(i.e., lunar soil and lunar rock), this paper proposes a multi-state control strategy for autonomous lunar drilling. To represent the working circumstances in the lunar subsurface and reduce the complexity of the control algorithm, lunar drilling process was categorized into three drilling states: the interface detection, initiation of drilling parameters for recognition and drilling medium recognition. Support vector machine(SVM) and continuous wavelet transform were employed for the online recognition of drilling media and interface, respectively. Finite state machine was utilized to control the transition among different drilling states. To verify the effectiveness of the multi-state control strategy, drilling experiments were implemented with multi-layered drilling media constructed by lunar soil simulant and lunar rock simulant. The results reveal that the multi-state control method is capable of detecting drilling state variation and adjusting drilling parameters timely under vibration interferences.The multi-state control method provides a feasible reference for the control of extraterrestrial autonomous drilling. | Chen Chongbin Quan Qiquan Shi Xiaomeng Deng Zongquan Tang Dewei Jiang Shengyuan | 2016 | Chinese Journal of Aeronautics2016，29，5： | 3 |
| 10 | Ligand effects on arsenite removal by zero-valent iron/O2: Dissolution, corrosion, oxidation and coprecipitation显示文摘Ligands may increase the yields of reactive oxygen species(ROS)in zero-valent iron(ZVI)/O2 systems.To clarify the relationship between the properties of ligands and their effects on the oxidative removal of contaminants,five common ligands(formate,acetate,oxalate,ethylenediaminetetraacetic acid(EDTA),and phosphate)as well as acetylacetone(AA)were investigated with arsenite(As(III))as the target contaminant at three initial p H values(3.0,5.0,and 7.0).The addition of these ligands to the ZVI/O2 system resulted in quite different effects on As(III)removal.EDTA enhanced the oxidation of As(III)to arsenate(As(V))but inhibited the removal of As(V).Oxalate was the only ligand in this work that accelerated both the removal of As(III)and As(V).By analyzing the ligand effects from the four aspects:dissolution of surface iron(hydr)oxides,corrosion of ZVI,reaction with ROS,and interference with precipitation,the following properties of ligands were believed to be important:ability to provide dissociable protons,complexation ability with iron,and reactivity with ROS.The complexation ability is a double-edged sword.It could enhance the generation of ROS by reducing the reduction potential of the Fe(III)/Fe(II)redox couple,but also could inhibit the removal of arsenic by coprecipitation.The elucidated relationship between the key property parameters of ligands and their effects on the ZVI/O2 system is helpful for the rational design of effective ZVI/ligand/O2 systems. | Xiaojie Song Chen Zhang Bingdang Wu Xiaomeng Wang Zhihao Chen Shujuan Zhang | 2019 | Journal of Environmental Sciences2019，31，12： | 3 |
| 11 | In-situ doping-induced lattice strain of NiCoP/S nanocrystals for robust wide pH hydrogen evolution electrocatalysis and supercapacitor显示文摘Developing high-efficiency multifunctional nanomaterials is promising for wide p H hydrogen evolution reaction(HER) and energy storage but still challenging. Herein, a novel in-situ doping-induced lattice strain strategy of NiCoP/S nanocrystals(NCs) was proposed through using seed crystal conversion approach with NiCo_(2)S_(4) spinel as precursor. The small amount of S atoms in NiCoP/S NCs perturbed the local electronic structure, leading to the atomic position shift of the nearest neighbor in the protocell and the nanoscale lattice strain, which optimized the H* adsorption free energy and activated H_(2)O molecules, resulting the dramatically elevated HER performance within a wide p H range. Especially, the NiCoP/S NCs displayed better HER electrocatalytic activity than comical 20% Pt/C at high current density in 1 M KOH and natural seawater: it only needed 266 m V vs. reversible hydrogen electrode(RHE) and660 m V vs. RHE to arrive the current density of 350 m A cm^(-2) in 1 M KOH and natural seawater, indicating the application prospect for industrial high current. Besides, NiCoP/S NCs also displayed excellent supercapacitor performance: it showed high specific capacity of 2229.9 F g^(-1) at 1 A g^(-1) and energy density of87.49 Wh kg^(-1), when assembled into an all-solid-state flexible device, exceeding performance of most transition metal phosphides. This work provides new insights into the regulation in electronic structure and lattice strain for electrocatalytic and energy storage applications. | Yan Lin Xiaomeng Chen Yongxiao Tuo Yuan Pan Jun Zhang | 2022 | Journal of Energy Chemistry2022，31，7： | 2 |
| 12 | Demonstration of epitaxial growth of strain-relaxed GaN films on graphene/SiC substrates for long wavelength light-emitting diodes显示文摘Strain modulation is crucial for heteroepitaxy such as GaN on foreign substrates.Here,the epitaxy of strain-relaxed GaN films on graphene/SiC substrates by metal-organic chemical vapor deposition is demonstrated.Graphene was directly prepared on SiC substrates by thermal decomposition.Its pre-treatment with nitrogen-plasma can introduce C–N dangling bonds,which provides nucleation sites for subsequent epitaxial growth.The scanning transmission electron microscopy measurements confirm that part of graphene surface was etched by nitrogen-plasma.We study the growth behavior on different areas of graphene surface after pre-treatment,and propose a growth model to explain the epitaxial growth mechanism of GaN films on graphene.Significantly,graphene is found to be effective to reduce the biaxial stress in GaN films and the strain relaxation improves indium-atom incorporation in InGaN/GaN multiple quantum wells(MQWs)active region,which results in the obvious red-shift of light-emitting wavelength of InGaN/GaN MQWs.This work opens up a new way for the fabrication of GaN-based long wavelength light-emitting diodes. | Ye Yu Tao Wang Xiufang Chen Lidong Zhang Yang Wang Yunfei Niu Jiaqi Yu Haotian Ma Xiaomeng Li Fang Liu Gaoqiang Deng Zhifeng Shi Baolin Zhang Xinqiang Wang Yuantao Zhang | 2021 | Light(Science & Applications)2021，10，7： | 2 |
| 13 | High-operating-temperature mid-infrared photodetectors via quantum dot gradient homojunction显示文摘Due to thermal carriers generated by a narrow mid-infrared energy gap,cooling is always necessary to achieve ideal photodetection.In quantum dot(QD),the electron thermal generation should be reduced with quantum confinement in all three dimensions.As a result,there would be a great potential to realize high-operating-temperature(HOT)QD mid-IR photodetectors,though not yet achieved.Taking the advantages of colloidal nanocrystals’solution processability and precise doping control by surface dipoles,this work demonstrates a HOT mid-infrared photodetector with a QD gradient homojunction.The detector achieves background-limited performance with D^(*)=2.7×1011 Jones on 4.2μm at 80 K,above 10^(11) Jones until 200 K,above 10^(10 )Jones until 280 K,and 7.6×10^(9) Jones on 3.5μm at 300 K.The external quantum efficiency also achieves more than 77%with responsivity 2.7 A/W at zero bias.The applications such as spectrometers,chemical sensors,and thermal cameras,are also approved,which motivate interest in low-cost,solution-processed and high-performance mid-infrared photodetection beyond epitaxial growth bulk photodetectors. | Xiaomeng Xue Menglu Chen Yuning Luo Tianling Qin Xin Tang Qun Hao | 2023 | Light(Science & Applications)2023，12，3： | 2 |
| 14 | From China’s Heavy Precipitation in 2020 to a “Glocal” Hydrometeorological Solution for Flood Risk Prediction显示文摘The prolonged mei-yu/baiu system with anomalous precipitation in the year 2020 has swollen many rivers and lakes,caused flash flooding,urban flooding and landslides,and consistently wreaked havoc across large swathes of China,particularly in the Yangtze River basin.Significant precipitation and flooding anomalies have already been seen in magnitude and extension so far this year,which have been exerting much higher pressure on emergency responses in flood control and mitigation than in other years,even though a rainy season with multiple ongoing serious flood events in different provinces is not that uncommon in China.Instead of delving into the causes of the uniqueness of this year’s extreme precipitation-flooding situation,which certainly warrants in-depth exploration,in this article we provide a short view toward a more general hydrometeorological solution to this annual nationwide problem.A“glocal”(global to local)hydrometeorological solution for floods(GHS-F)is considered to be critical for better preparedness,mitigation,and management of different types of significant precipitation-caused flooding,which happen extensively almost every year in many countries such as China,India and the United States.Such a GHS-F model is necessary from both scientific and operational perspectives,with the strength in providing spatially consistent flood definitions and spatially distributed flood risk classification considering the heterogeneity in vulnerability and resilience across the entire domain.Priorities in the development of such a GHS-F are suggested,emphasizing the user’s requirements and needs according to practical experiences with various flood response agencies. | Huan WU Xiaomeng LI Guy J.-P.SCHUMANN Lorenzo ALFIERI Yun CHEN Hui XU Zhifang WU Hong LU Yamin HU Qiang ZHU Zhijun HUANG Weitian CHEN Ying HU | 2021 | Advances in Atmospheric Sciences2021，38，1： | 1 |
| 15 | Subdivision Surface-Based Isogeometric Boundary Element Method for Steady Heat Conduction Problems with Variable Coefficient显示文摘The present work couples isogeometric analysis(IGA)and boundary element methods(BEM)for three dimensional steady heat conduction problems with variable coefficients.The Computer-Aided Design(CAD)geometries are built by subdivision surfaces,and meantime the basis functions of subdivision surfaces are employed to discretize the boundary integral equations for heat conduction analysis.Moreover,the radial integration method is adopted to transform the additional domain integrals caused by variable coefficients to the boundary integrals.Several numerical examples are provided to demonstrate the correctness and advantages of the proposed algorithm in the integration of CAD and numerical analysis. | Xiuyun Chen Xiaomeng Yin Kunpeng Li Ruhui Cheng Yanming Xu Wei Zhang | 2021 | Computer Modeling in Engineering & Sciences2021，，10： | 1 |
| 16 | Lattice gas simulation and experiment study of evacuation dynamics 显示文摘 | Li Xiaomeng Chen Tao Pan Lili | 2008 | Physica A2008，387，： | 1 |
| 17 | Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer显示文摘Reversal of cancer drug resistance remains a critical challenge in chemotherapy.Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer.To overcome the intrinsic limitations in conventional mitochondrial targeting strategies,we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin(DOX)resistance in lung cancer.Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors.As a consequence,thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice.This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance. | Lifo Ruan Jun Chen Chuanchao Du Huiru Lu Jiayu Zhang Xiaomeng Cai Rui Dou Wenchu Lin Zhifang Chai Guangjun Nie Yi Hu | 2022 | Bioactive Materials2022，7，7： | 1 |
| 18 | Central sensibility of human cases with different body mass during oral glucose tolerance test using functional magnetic resonance imaging显示文摘BACKGROUND: Because of the limitation of technique, there are few researches on regulating function o central hypothalamus by metabolism, especially the researches on real-time function. OBJECTIVE: To evaluate the response of hypothalamus to oral glucose tolerance test (OGTT) in differen body-weighted subjects by using functional magnetic resonance imaging (fMRI) so as to investigate th relationship between the sensitivity of hypothalamus in glycoregulation and disturbance of carbohydrat metabolism. DESIGN: Paired design. SETTING: Department of Radiology and Beijing Geriatrics Institute, Beijing Hospital, National Publi Health Bureau. PARTICIPANTS: A total of twenty healthy volunteers were selected from Beijing Geriatrics Institute National Public Health Bureau, including 10 subjects with obesity (5 males and 5 females; body mass > 28.0 kg/m2) and 10 subjects with normal body mass (5 males and 5 females; body mass from 18.5 to 23.9 kg/m2). All subjects gave written informed consent before participating in the study. METHODS: fMRI study was performed on GE 1.5 T Signa Twinspeed Infinity with Excite. Each voluntee was ingested of glucose during the fMRI scan. T2* images were acquired using a single-shot gradient echo (EPI) technique. The parameters of EPI included: TR 3 000 ms, TE 40 ms, Flip angle 90°, field of view (FOV) 24 cm × 24 cm, thickness 5 mm, gap 0 mm, matrix 64 × 64, number of excitation 1. All 10 subjects with normal body mass underwent a repeat fMRI scan after consuming an equivalent amount o water without glucose on a separate day. The procedure for the fMRI scan with water intake was the same a for glucose ingestion. fMRI data were processed with Intensity Averaging Method. MAIN OUTCOME MEASURES: The central response of hypothalamus and feedback orientation during OGTT in different body-weighted subjects. RESULTS: An acute transient decrease of fMRI intensity in posterior inferior and anterior inferior o hypothalamus was observed in all subjects within 2 minutes after oral glucose intake. This decrease wa followed by a recovery to the baseline. However, obese subjects had a delayed intensity decrease [(1.96± 1.06) minutes vs. (1.04±0.71) minutes, t =2.14, P < 0.05] and longer recovery time [(26.62±7.35 minutes vs. (16.29±6.42) minutes, t =3.67, P < 0.01] as compared with normal body-weight subjects Furthermore, decreased fMRI intensity was significant different from baseline intensity [(5.7±2.5)% vs (14.3±5.5)%, t =2.56, P < 0.05] in obese subjects, but not in normal body-weight subjects. The area o hypothalamus in normal body-weight volunteers demonstrated no significant signal change before and afte oral water ingestion (P > 0.05). CONCLUSION: Hypothalamus response to glucose loading is different in normal body-weighted and obes subjects. This suggests that fMRI is a useful tool to evaluate the central regulation of glucose metabolism. | Min Chen Yunting Zhang Tiemei Zhang Cheng Zhou Xiaomeng Wu Kui Cai Zhenghan Yang Wenchao Wang Weifeng Zhao Saying Li Zhi Wang Guozhen Li | 2007 | Neural Regeneration Research2007，2，9： | 1 |
| 19 | Preparation of PLGA-collagen hybrid scaffolds with controlled pore structures for cartilage tissue engineering显示文摘Scaffolds used for cartilage tissue engineering should have high mechanical strength and well-controlled pore structure to provide suitable microenvironments for functional tissue regeneration. In this study, hybrid scaffolds which had open and interconnected pore structure and high mechanical property were prepared by hybridization of PLGA mesh and collagen using ice particulates as porogen templates. Embossing ice particulates template was used to form open pore structures on the scaffold surfaces. Free ice particulates were used to generate interconnected bulk pores in the scaffolds. Hybridization with PLGA mesh provided the scaffolds with high mechanical property. Bovine articular chondrocytes were cultured in the hybrid scaffolds. The unique pore structures facilitated the homogeneous distribution of chondrocytes and cartilaginous matrices throughout the scaffolds. Subcutaneous implantation demonstrated cartilage-like tissue regeneration. The hybrid scaffolds should have a high potential for cartilage tissue engineering. | Nur Rofiqoh Eviana Putri Xiuhui Wang Ying Chen Xiaomeng Li Naoki Kawazoe Guoping Chen | 2020 | Progress in Natural Science:Materials International2020，30，5： | 1 |
| 20 | Machine Learning Enhanced Boundary Element Method:Prediction of Gaussian Quadrature Points显示文摘This paper applies a machine learning technique to find a general and efficient numerical integration scheme for boundary element methods.A model based on the neural network multi-classification algorithmis constructed to find the minimum number of Gaussian quadrature points satisfying the given accuracy.The constructed model is trained by using a large amount of data calculated in the traditional boundary element method and the optimal network architecture is selected.The two-dimensional potential problem of a circular structure is tested and analyzed based on the determined model,and the accuracy of the model is about 90%.Finally,by incorporating the predicted Gaussian quadrature points into the boundary element analysis,we find that the numerical solution and the analytical solution are in good agreement,which verifies the robustness of the proposed method. | Ruhui Cheng Xiaomeng Yin Leilei Chen | 2022 | Computer Modeling in Engineering & Sciences2022，，4： | 1 |
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