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| 1 | Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells显示文摘Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL)is a rare hereditary cerebrovascular disease caused by a NOTCH3 mutation.However,the underlying cellular and molecular mechanisms remain unidentified.Here,we generated non-integrative induced pluripotent stem cells(iPSCs)from fibroblasts of a CADASIL patient harboring a heterozygous NOTCH3 mutation(c.3226C>T,p.R1076C).Vascular smooth muscle cells(VSMCs)differentiated from CADASIL-specific iPSCs showed gene expression changes associated with disease phenotypes,including activation of the NOTCH and NF-kB signaling pathway,cytoskeleton disorganization,and excessive cell proliferation.In comparison,these abnormalities were not observed in vascular endothelial cells(VECs)derived from the patients iPSCs.Importantly,the abnormal upregulation of NF-kB target genes in CADASIL VSMCs was diminished by a NOTCH pathway inhibitor,providing a potential therapeutic strategy for CADASIL.Overall,using this iPSCbased disease model,our study identified clues for studying the pathogenic mechanisms of CADASIL and developing treatment strategies for this disease. | Chen Ling Zunpeng Liu Moshi Song Weiqi Zhang Si Wang Xiaoqian Liu Shuai Ma Shuhui Sun Lina Fu Qun Chu Juan Carlos Izpisua Belmonte Zhaoxia Wang Jing Qu Yun Yuan Guang-Hui Liu | 2019 | Protein & Cell2019，10，4： | 7 |
| 2 | Origin of strong solid solution strengthening in the CrCoNi-W medium entropy alloy显示文摘Solid solution strengthening is one of the most conventional strategies for optimizing alloys strength,while the corresponding mechanisms can be more complicated than we traditionally thought specifically as heterogeneity of microstructure is involved.In this work,by comparing the change of chemical distribution,dislocation behaviors and mechanical properties after doping equivalent amount of tungsten(W)atoms in CrCoNi alloy and pure Ni,respectively,it is found that the alloying element W in CrCoNi alloy resulted in much stronger strengthening effect due to the significant increase of heterogeneity in chemical distribution after doping trace amount of W.The large atomic scale concentration fluctuation of all elements in CrCoNi-3W causes dislocation motion via strong nanoscale segment detrapping and severe dislocation pile up which is not the case in Ni-3W.The results revealed the high sensitivity of elements distribution in multi-principle element alloys to composition and the significant consequent influence in tuning the mechanical properties,giving insight for complex alloy design. | Yujie Chen Yan Fang Xiaoqian Fu Yiping Lu Sijing Chen Hongbin Bei Qian Yu | 2021 | Journal of Materials Science & Technology2021，，14： | 5 |
| 3 | Reconstruction of sub cross-correlation cancellation technique for unambiguous acquisition of BOC(kn, n) signals显示文摘In order to solve the problem of ambiguous acquisition of BOC signals caused by its property of multiple peaks,an unambiguous acquisition algorithm named reconstruction of sub cross-correlation cancellation technique(RSCCT)for BOC(kn,n)signals is proposed.In this paper,the principle of signal decomposition is combined with the traditional acquisition algorithm structure,and then based on the method of reconstructing the correlation function.The method firstly gets the sub-pseudorandom noise(PRN)code by decomposing the local PRN code,then uses BOC(kn,n)and the sub-PRN code cross-correlation to get the sub cross-correlation function.Finally,the correlation peak with a single peak is obtained by reconstructing the sub cross-correlation function so that the ambiguities of BOC acquisition are removed.The simulation shows that RSCCT can completely eliminate the side peaks of BOC(kn,n)group signals while maintaining the narrow correlation of BOC,and its computational complexity is equivalent to sub carrier phase cancellation(SCPC)and autocorrelation side-peak cancellation technique(ASPeCT),and it reduces the computational complexity relative to BPSK-like.For BOC(n,n),the acquisition sensitivity of RSCCT is 3.25 dB,0.81 dB and 0.25 dB higher than binary phase shift keying(BPSK)-like,SCPC and ASPeCT at the acquisition probability of 90%,respectively.The peak to average power ratio is 1.91,3.0 and 3.7 times higher than ASPeCT,SCPC and BPSK-like at SNR=–20 dB,respectively.For BOC(2n,n),the acquisition sensitivity of RSCCT is 5.5 dB,1.25 dB and 2.69 dB higher than BPSK-like,SCPC and ASPeCT at the acquisition probability of 90%,respectively.The peak to average power ratio is 1.02,1.68 and 2.12 times higher than ASPeCT,SCPC and BPSK-like at SNR=–20 dB,respectively. | JI Yuanfa CHEN Xiaoqian FU Qiang SUN Xiyan ZHEN Weimin | 2019 | Journal of Systems Engineering and Electronics2019，30，5： | 5 |
| 4 | siRNA targeting stathmin inhibits invasion and enhances chemotherapy sensitivity of stem cells derived from glioma cell lines显示文摘Glioma 高度是大多数之一 angiogenic 肿瘤,和 glioma 干细胞(GSC ) 为到化疗和放射疗法的抵抗负责,以及在操作以后的复发。Stathmin 为有丝分裂是实质的并且在导出 glioma 的 endothelial 房间的增长和移植起一个重要作用。然而,在 stathmin 和 GSC 之间的关系不完全地被理解。这里,我们从 glioma 房间线 U87MG 和 U251 孤立 GSC,然后使用了为 silencing 指向 stathmin 的 siRNA。我们证明 stathmin 的 silencing 压制了增长,增加了 apoptosis 率,并且逮捕了在在 GSC 的 G2/M 阶段的房间周期。在 GSC 的 stathmin 的 Silencing 也导致了禁止了迁居 / 侵略以及 vasculogenic 的能力模仿。到 temozolomide 的 GSC 的危险性被 stathmin silencing 也提高。我们的调查结果为 glioma 处理在 GSC 作为一个潜在的目标建议 stathmin。 | Yuwen Song Luyan Mu Xuezhe Han Xiaoqian Liu Songbin Fu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 4 |
| 5 | Effect of stagger angle on capillary performance of microgroove structures with reentrant cavities显示文摘Aluminum-based microgroove surfaces with reentrant cavities (MSRCs) were fabricated by two staggered ploughing/extrusion processes to meet the requirements of lightweight phase change heat transfer devices.Five MSRCs with different stagger angles between cavities and microgrooves (MGs) were fabricated to study the effect of stagger angle on capillary performance.Capillary rise and permeability tests were performed on all MSRCs and the results were compared with MGs having the same processing parameters.It was found that MSRCs with smaller stagger angles have higher capillary height,and the maximum enhancement maintained by MSRC45 was about 54.84%.However,MSRCs with larger stagger angles were found to have higher permeability.Therefore,the capillary parameter K·ΔP_(cap)was used as a comprehensive index to evaluate these wicks.MSRC90 and MSRC75 obtained the largest K·ΔP_(cap)values without and with the effect of gravity considered,respectively.Although all MSRCs had a higher capillary rise height than MGs,smaller stagger angles (≤60°) seriously reduced the permeability of MSRCs and even resulted in smaller K·ΔP_(cap)value than that of MGs when calculated considering the effect of gravity.Therefore,MSRCs with larger stagger angles (≥75°) may be the optimum wicks due to the good balance between capillary pressure and permeability. | SUN YaLong LIANG FuYe TANG Yong TANG Heng XI XiaoQian YANG Shu FU Ting | 2021 | Science China(Technological Sciences)2021，64，7： | 2 |
| 6 | Effects of NEA GaN photocathode performance parameters on quantum efficiency显示文摘 | Du Yujie Chang Benkang Fu Xiaoqian | 2012 | OPTIK2012，123，9： | 1 |
| 7 | Electronic structure and optical properties of zinc-blende GaN显示文摘 | Du Yujie Chang Benkang Fu Xiaoqian | 2012 | OPTIK2012，123，24： | 1 |
| 8 | Study of Quality Stan- dards on Chinese Angelica显示文摘 | Fu Xintong Liu Ying Zhang Xiaoqian | 2003 | Chinese Journal of Information on Traditional Chinese Medicine2003，08，： | 1 |
| 9 | In-situ transformed Mott-Schottky heterointerface in silver/manganese oxide nanorods boosting oxygen reduction,oxygen evolution,and hydrogen evolution reactions显示文摘The development of non-platinum group metal(non-PGM)and efficient multifunctional electrocatalysts for oxygen reduction reaction(ORR),oxygen evolution reaction(OER),and hydrogen evolution reaction(HER)with high activity and stability remains a great challenge.Herein,by in-situ transforming silver manganese composite oxide heterointerface into boosted Mott-Schottky heterointerface through a facile carbon reduction strategy,a nanorod-like silver/manganese oxide with superior multifunctional catalytic activities for ORR,OER and HER and stability was obtained.The nanorod-like silver/manganese oxide with Mott-Schottky heterointerface(designated as Ag/Mn_(3)O_(4))exhibits an ORR half-wave potential of 0.831 V(vs.RHE)in 0.1 M KOH,an OER overpotential of 338 mV and a HER overpotential of 177 mV at the current density of 10 mA·cm^(-2)in 1 M KOH,contributing to its noble-metal benchmarks comparable performance in aqueous aluminum-air(Al-air)battery and laboratorial overall water splitting electrolytic cell.Moreover,in-situ electrochemical Raman and synchrotron radiation spectroscopic measurements were conducted to further illustrate the catalytic mechanism of Ag/Mn_(3)O_(4)Mott-Schottky heterointerface towards various electrocatalytic reactions.At the heterointerface,the Ag phase serves as the electron donor and the active phase for ORR and HER,while the Mn_(3)O_(4)phase serves as the electron acceptor and the active phase for OER,respectively.This work deepens the understanding of the Mott-Schottky effect on electrocatalysis and fills in the gap in fundamental physical principles that are behind measured electrocatalytic activity,which offers substantial implications for the rational design of cost-effective multifunctional electrocatalysts with Mott-Schottky effect. | Ruiqi Cheng Kaiqi Li Huanxin Li Fengzhan Sun Xiaoqian He Tianshuo Zhao Jiao Zhang Chaopeng Fu | 2024 | Nano Research2024，17，5： | 0 |
| 10 | Function identification of miR159a,a positive regulator during poplar resistance to drought stress显示文摘Drought seriously affects the growth and development of plants.MiR159 is a highly conserved and abundant microRNA family that plays a crucial role in plant growth and stress responses.However,studies of its function in woody plants are still lacking.Here,the expression of miR159a was significantly upregulated after drought treatment in poplar,and the overexpression of miR159a(OX159a)significantly reduced the open area of the stomata and improved water-use efficiency in poplar.After drought treatment,OX159a lines had better scavenging ability of reactive oxygen species and damage of the membrane system was less than that in wild-type lines.MYB was the target gene of miR159a,as verified by psRNATarget prediction,RT-qPCR,degradome sequencing,and 5′rapid amplification of cDNA ends(5′RACE).Additionally,miR159a-short tandem target mimic suppression(STTM)poplar lines showed increased sensitivity to drought stress.Transcriptomic analysis comparing OX159a lines with wild-type lines revealed upregulation of a series of genes related to response to water deprivation and metabolite synthesis.Moreover,drought-responsive miR172d and miR398 were significantly upregulated and downregulated respectively in OX159a lines.This investigation demonstrated that miR159a played a key role in the tolerance of poplar to drought by reducing stomata open area,increasing the number and total area of xylem vessels,and enhancing water-use efficiency,and provided new insights into the role of plant miR159a and crucial candidate genes for the molecular breeding of trees with tolerance to drought stress. | Tiantian Fu Chun Wang Yuzhang Yang Xiaoqian Yang Jing Wang Lichun Zhang Zeqi Wang Yanwei Wang | 2023 | Horticulture Research2023，10，12： | 0 |
| 11 | Geographical distribution of Aspergillus flavus in peanut harvest period in China显示文摘In order to grasp the distribution of Aspergillus flavus in the soil of peanut production areas in China,A.flavus biomarkers were tested on 555 soil samples from 37 sampling points in 17 provinces,peanut fields in four agroecological zones(Southern area,Yangtze River Basin,Northern area,Northeast area).The results showed that(1)the cultivation amount of A.flavus per gram of soil in the Yangtze River Basin is 1.30 times that of the southern area,1.56 times that of the northern area,and 6.20 times that of the northeast area,with obvious regional characteristics.(2)In the Yangtze River basin,the change of longitude in the east-west direction has no direct impact on the cultivation amount of A.flavus per gram of soil.(3)In the east coast,the A.flavus cultivated per gram of soil increased first and then decreased with the increase of latitude from south to north.(4)A.flavus can be isolated in the soil samples above 1000 m.Field pollution is an important source of aflatoxin contamination in peanut.The study on the distribution of A.flavus in soil in China could provide theoretical support for the early warning and prevention and control measures of aflatoxin contamination in peanut. | Xiaohan Liu Jiayun Fu Mingbo Wen Haohua Gu Pingping Ji Xiaofeng Yue Xiaoqian Tang Meijuan Liang Yang Zhou Qi Zhang Peiwu Li | 2023 | Oil Crop Science2023，8，2： | 0 |
| 12 | Vertical microbial profiling of water column reveals prokaryotic communities and distribution features of Antarctic Peninsula显示文摘Prokaryotic diversity and community composition in the water column of eight stations(63 samples) around the Antarctic Peninsula of the Southern Ocean were investigated. Through pyrosequencing of the V3–V4hypervariable regions of the 16S ribosomal RNA gene, we characterized 4 720 089 valid reads representing 48 188operational taxonomic units(OTUs, 97% similarity). The community was dominated by the phyla Pseudomonadota(original name: Proteobacteria, 47%), Oxyphotobacteria(26%), and Bacteroidota(original name: Bacteroidetes, 18%), which comprised an average of 91% of the total OTUs in all samples. The prokaryotic community composition varied vertically within the water column. Water column prokaryotic communities exhibited a clear depth profile, with higher microbial richness and higher diversity observed with increasing water depth. Cluster analysis of the community composition of water column samples exhibited a similar trend with depth. Correlation with environmental factors suggested distinct variation in prokaryotic community composition with changes in depth, salinity, temperature and dissolved oxygen levels. Functional prediction showed presence of active nitrogen, sulphur and methane metabolic cycles along the vertical transect of the studied region. These results will improve our knowledge of prokaryotic diversity and community composition at different depth of water column for better understanding of the microbial ecology and nutrient cycles in Antarctic Peninsula region of the Southern Ocean. | Jiang Li Luying Zhao Xiaoqian Gu Chengxuan Li Qian Zhang Liping Fu Ao Zhang | 2023 | Acta Oceanologica Sinica2023，42，9： | 0 |
| 13 | High strength and deformation stability achieved in CrCoNi alloy containing deformable oxides显示文摘Hard secondary phases usually strengthen alloys at the expense of ductility.In this work,we made a dual-phase CrCoNi-O alloy containing a face centered cubic matrix and chromium oxide.On one side,the dispersed chromium oxide nano-particles impeded dislocation movement and increased the strength of the alloy.On another side,the spreading lattice distortion in CrCoNi-O high entropy solution locally relieved the severe interfacial mismatch and led to nanoscale variation of interfacial strain at the matrix-oxide interface,which facilitated dislocations’transmission from one phase to another.Consequently,unlike the strong but brittle oxide nanoparticles used before,the oxide phase here can afford significant dislocation activities during material’s plastic deformation.Comparing the mechanical properties of CrCoNi-O alloys with and without chromium oxide particles,it was found that the yield strength of the dual-phase samples was twice of the single phase CrCoNi-O alloy and strong strain hardening was obtained with ultra-high deformation stability.High density of nanotwins formed in dual-phase samples under high stress,resulting in significant strain hardening according to the well-known twinning-induced plasticity(TWIP)effect.Our results shed light on optimizing the combination of strength and plasticity of compounds by modulating the variation of interfacial strain field based on the spreading lattice distortion. | Jiawei Zou Xiaoqian Fu Yajing Song Tianxin Li Yiping Lu Ze Zhang Qian Yu | 2023 | Journal of Materials Science & Technology2023，，3： | 0 |
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