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| 1 | Fegeneration of functional alveoli by adult human SOX9^+ airway basal cell transplantation显示文摘 | Qiwang Ma Yu Ma Xiaotian Dai Tao Ren Yingjie Fu Wenbin Liu Yufei Han Yingchuan Wu Yu Cheng Ting Zhang Wei Zuo | 2018 | Protein & Cell2018，9，3： | 20 |
| 2 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 3 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 4 | Composites of small Ag clusters confined in the channels of well-ordered mesoporous anatase TiO2 and their excellent solar-light-driven photocatalytic performance显示文摘 | Wei Zhou Ting Li Jianqiang Wang Yang Qu Kai Pan Ying Xie Guohui Tian Lei Wang Zhiyu Ren Baojiang Jiang Honggang Fu | 2014 | Nano Research2014，7，5： | 17 |
| 5 | Effects of maize-soybean relay intercropping on crop nutrient uptake and soil bacterial community显示文摘Maize-soybean relay intercropping is an effective approach to improve the crop yield and nutrient use efficiency,which is widely practiced by farmers in southwest of China.To elucidate the characteristics of different planting patterns on crop nutrient uptake,soil chemical properties,and soil bacteria community in maize-soybean relay intercropping systems,we conducted a field experiment in 2015–2016 with single factor treatments,including monoculture maize(MM),monoculture soybean(MS),maize-soybean relay intercropping(IMS),and fallow(CK).The results showed that the N uptake of maize grain increased in IMS compared with MM.Compared with MS,the yield and uptake of N,P,and K of soybean grain were increased by 25.5,24.4,9.6,and 22.4%in IMS,respectively,while the N and K uptakes in soybean straw were decreased in IMS.The soil total nitrogen,available phosphorus,and soil organic matter contents were significantly higher in IMS than those of the corresponding monocultures and CK.Moreover,the soil protease,soil urease,and soil nitrate reductase activities in IMS were higher than those of the corresponding monocultures and CK.The phyla Proteobacteria,Acidobacteria,Chloroflexi,and Actinobacteria dominated in all treatments.Shannon’s index in IMS was higher than that of the corresponding monocultures and CK.The phylum Proteobacteria proportion was positively correlated with maize soil organic matter and soybean soil total nitrogen content,respectively.These results indicated that the belowground interactions increased the crop nutrient(N and P)uptake and soil bacterial community diversity,both of which contributed to improved soil nutrient management for legume-cereal relay intercropping systems. | FU Zhi-dan ZHOU Li CHEN Ping DU Qing PANG Ting SONG Chun WANG Xiao-chun LIU Wei-guo YANG Wen-yu YONG Tai-wen | 2019 | Journal of Integrative Agriculture2019，18，9： | 17 |
| 6 | Idiopathic inflammatory demyelinating diseases of the central nervous system in patients following allogeneic hematopoietic stem cell transplantation: a retrospective analysis of incidence, risk factors and survival显示文摘 | ZHANG Xiao-hui HUANG Xiao-jun LIU Kai-yan XU Lan-ping LIU Dai-hong CHEN Huan HAN Wei CHEN Yu-hong WANG Feng-rong WANG Jing-zhi WANG Yu ZHAO Ting CHEN Yao FU Hai-xia WANG Min | 2013 | Chinese Medical Journal2013，，6： | 12 |
| 7 | Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for photothermal/photodynamic therapy显示文摘氯 e6-pHLIP <候补选手class=“ a-plus-plus ”> ss -AuNRs,金使nanorod具有感光性结合包含 pH (低)有给予细胞外的 pH 的一张二硫化物契约的插入肽( pHLIP )( pH <候补选手class=“ a-plus-plus ”> e )-driven 肿瘤指向能力,成功地为光力学的 bimodal 和 photothermal 治疗被开发了。在这 bimodal 治疗,氯 e6 (Ce6 ) ,第二代的 photosensitizer (PS ) ,被用于光力学的治疗(太平洋夏季时间) 。金 nanorods (AuNRs ) 作为 Ce6 的 nanocarrier 和 quencher 为 photothermal 治疗(PTT ) 并且也被用作一个过高热代理人。pHLIPss 作为一根驾驶 pHe 的指向探针被设计在低 pH 在癌症房间提高 Ce6 和 AuNRs 的累积。在 Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs, Ce6 接近并且由 AuNRs 熄灭了,引起小太平洋夏季时间效果。当暴露了到正常生理的 pH 时 7.4, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 泛泛地与房间膜联系。然而,曾经暴露了到酸的 pH 6.2, pHLIP 活跃地插入到房间膜,和 conjugates 是进房间的 translocated。当这发生时, Ce6 由于二硫化物与 AuNRs 分开细胞内部的谷胱甘肽(GSH ) 引起的契约劈开,和汗衫氧在光之上为太平洋夏季时间被生产照耀。作为单个 PTT 代理人,另外, AuNRs 能由提高的浸透和保留(EPR ) 效果在肿瘤提高 PS 的累积。因此由我们的数据显示了当暴露了到酸的 pH 时, Ce6-pHLIP < 潜水艇 class= “ a-plus-plus ” > ss -AuNRs 能为癌症治疗完成 synergistic PTT/PDT bimodality。 | Nannan Wang Zilong Zhao Yifan Lv Huanhuan Fan Huarong Bai Hongmin Meng Yuqian Long Ting Fu Xiaobing Zhang Weihong Tan | 2014 | Nano Research2014，7，9： | 11 |
| 8 | Adipocytokines and breast cancer risk显示文摘许多研究建议了的背景肥胖增加了乳癌,而是机制的风险,这当前是未知的。Adipocytokines 可能调停关系。我们的学习被瞄准调查在 resistin, adiponectin 和 leptin 的浆液层次之间的关系,胸 cancer.Methods 血样品的发作,侵略和转移来自 80 最新诊断的、组织学地证实的乳癌病人和 50 匹配年龄的健康控制是镇定的。resistin, adiponectin 和 leptin 的浆液层次被连接酶的 immunosorbent 试金(ELISA ) 决定; fasting 血葡萄糖( FBG ),类脂化合物,身体团索引( BMI ),并且腰圆周( WC )是 adiponectin 的 assayed simultaneously.Results 浆液层次(( 8.60 ?????????????€ ?┴??????????????????┴?? | HOU Wei-kai XU Yu-xin YU Ting ZHANG Li ZHANG Wen-wen FU Chun-li SUN Yu WU Qing CHEN Li | 2007 | Chinese Medical Journal2007，，18： | 10 |
| 9 | Evaluation of cracking potential for concrete arch dam based on simulation feedback analysis显示文摘It is still very difficult for researchers and engineers to implement the simulation analysis including a complete process and a full model with the complicated arch dam and the foundation, and to evaluate the cracking potential in the construction and service periods. To take Xiaowan project of China for an example, a practical system of simulation feedback analysis, a specific cracking criterion, and a resolution for the conflicting requirements of temperature and stress/strain simulation are presented, which are put into a successful practice. The simulation results of temperature, stress, and cracking are identical well with the monitor data. A modified temperature control measure is propounded, and the significant effect is gained by adopting the new scheme. | FU ShaoJun HE Ting WANG GuoJin ZHANG ShiHu ZOU LiChun CHEN ShengHong | 2011 | Science China(Technological Sciences)2011，54，3： | 10 |
| 10 | Metal-Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications显示文摘Investigation of metal–organic frameworks(MOFs)for biomedical applications has attracted much attention in recent years.MOFs are regarded as a promising class of nanocarriers for drug delivery owing to well-defined structure,ultrahigh surface area and porosity,tunable pore size,and easy chemical functionalization.In this review,the unique properties of MOFs and their advantages as nanocarriers for drug delivery in biomedical applications were discussed in the first section.Then,state-ofthe-art strategies to functionalize MOFs with therapeutic agents were summarized,including surface adsorption,pore encapsulation,covalent binding,and functional molecules as building blocks.In the third section,the most recent biological applications of MOFs for intracellular delivery of drugs,proteins,and nucleic acids,especially aptamers,were presented.Finally,challenges and prospects were comprehensively discussed to provide context for future development of MOFs as efficient drug delivery systems. | Yujia Sun Liwei Zheng Yu Yang Xu Qian Ting Fu Xiaowei Li Zunyi Yang He Yan Cheng Cui Weihong Tan | 2020 | Nano-Micro Letters2020，12，8： | 10 |
| 11 | lyperoside induces both autophagy and apoptosis in non-small cell lung cancer cells in vitro显示文摘瞄准:Hyperoside (quercetin-3-O-β -D-galactopyranoside) 是在类 Hypericum 和 Crataegus 的植物发现的黄酮醇 glycoside,它展出 anticancer,抗氧化剂,和反煽动性的活动。在这研究,我们调查了 autophagy 是否在 vitro.Methods 在人的非小的房间肺癌症房间涉及 hyperoside 的 anticancer 机制:人的非小的房间肺癌症房间线 A549 被测试,并且人的支气管的上皮的房间线 BEAS-2B 被用于比较。LC3-II, apoptotic 和发信号的蛋白质的表示用西方的弄污被测量。Autophagosomes 与 MDC 染色, LC3 immunocytochemistry,和 GFP-LC3 熔化蛋白质技术被观察。房间生存能力用 MTT assay.Results 被估计:Hyperoside (0.5, 1, 2 mmol/L ) dose-dependently 在 A549 房间增加了 LC3-II 和 autophagosome 数字的表示,但是没在 BEAS-2B 房间有如此的效果。而且, hyperoside dose-dependently 禁止了 Akt, mTOR, p70S6K 和 4E-BP1 的 phosphorylation,但是在 A549 房间增加了 ERK1/2 的 phosphorylation。胰岛素(200 nmol/L ) 显著地提高了 Akt 的 phosphorylation 并且减少在 A549 房间的 LC3-II 表示,被预告的处理与 hyperoside 颠倒,而 MEK1/2 禁止者 U0126 (20 μ mol/L ) 堵住的导致 hyperoside 的 LC3-II 表示。最后, hyperoside dose-dependently 压制了房间生存能力并且在 A549 房间导致了 apoptosis,它被预告的处理显著地与 autophagy 禁止者 3-methyladenine (2.5 mmol/L ) 稀释 .Conclusion:Hyperoside 在 vitro 在人的非小的房间肺癌症房间导致 autophagy 和 apoptosis。autophagy 通过禁止 Akt/mTOR/p70S6K 信号小径被导致,它贡献 hyperoside 的 anticancer 行动。 | Ting FU Ling WANG Xiang-nan JIN Hai-juan SUI Zhou LIU Ying JIN | 2016 | Acta Pharmacologica Sinica2016，37，4： | 10 |
| 12 | Current asthma control predicts future risk of asthma exacerbation: a 12-month prospective cohort study显示文摘 | WEI Hua-hua ZHOU Ting WANG Lan ZHANG Hong-ping FU Juan-juan WANG Lei JI Yu-lin WANG Gang | 2012 | Chinese Medical Journal2012，，17： | 9 |
| 13 | Influence of blood glucose on the expression of glucose transporter proteins 1 and 3 in the brain of diabetic rats显示文摘到大脑的从血的葡萄糖的交货包含的背景它越过血大脑障碍(BBB ) 的 endothelial 房间的经过,它被 facilitative 葡萄糖 transporter 蛋白质调停 1 (GLUT1 ) ,然后越过神经房间膜,它被 GLUT3 调停。试图在这些的表示上评估多糖症的动态影响的这研究由在糖尿病的一个老鼠模型在不同的血葡萄糖层次在大脑测量他们的表示充斥。这可能帮助决定在糖尿病的 apoplexy.Methods 糖尿病 mellitus 的治疗的合适的血葡萄糖阀值水平在 30 只老鼠与 streptozotocin (STZ ) 被导致。老鼠随机被划分成 3 个组:没有血葡萄糖控制(组 DM1 ) 的糖尿病的组,与低剂量胰岛素(组 DM2 ) 对待的糖尿病的老鼠,和与高度对待的糖尿病的老鼠开胰岛素(组 DM3 ) 。GLUT1 和 GLUT3 的 mRNA 和蛋白质层次是由反向的 transcriptase 聚合酶链反应(RT-PCR ) 和 immunohistochemistry 的 assayed, respectively.Results 与正常控制老鼠相比, GLUT1 mRNA 被 46.08% 减少, 29.80% ,(P0.01 )19.22% 分别地在 DM1, DM2,和 DM3 组织;并且 GLUT3 mRNA 被 75.00% , 46.75% ,和 17.89% 减少(P0.01 ) 分别地在 DM1, DM2,和 DM3 组织。许多 GLUT1 和 GLUT3 蛋白质与血葡萄糖水平(P0.01 ) 有否定关联。在糖尿病的老鼠的大脑的 microvessels 的密度没与在 mRNA 和蛋白质的长期的多糖症 downregulates GLUT1 和 GLUT3 表示在老鼠大脑铺平的正常 rats.Conclusions 相比显著地变化,它不由于 microvessels 的密度的减少。GLUT1 和 GLUT3 表示的 downregulation 可能是身体的适应反应阻止过多的葡萄糖进入可以导致房间损坏的房间。 | HOU Wei-kai XIAN Yu-xin ZHANG Li LAI Hong HOU Xin-guo XU Yu-xin YU Ting XU Fu-yu FU Chun-li ZHANG Wen-wen CHEN Li | 2007 | Chinese Medical Journal2007，，19： | 8 |
| 14 | Combined prednisone and levothyroxine improve treatment of severe thrombocytopenia in hepatitis B with compensatory cirrhosis accompanied by subclinical and overt hypothyroidism显示文摘The aim of the present study was to investigate the relationship between hypothyroidism and thrombocytopenia in hepatitis Brelated compensatory liver cirrhosis and to determine whether treatment with levothyroxine and prednisone is superior in a multicenter, open-label, observational study in China. In total, 125 consecutive hepatitis B-related compensated liver cirrhosis patients with severe thrombocytopenia accompanied by hypothyroidism were included. The patients were divided into four groups according to treatment strategy: a control group(n=29), a prednisone group(n=25), a levothyroxine group(n=32) and a prednisone plus levothyroxine group(n=39). Severe thrombocytopenia was more prevalent in hepatitis B-associated compensatory liver cirrhosis patients with hypothyroidism than in euthyroid patients(29.6% vs. 14.7%, P<0.05). Combination treatment with prednisone and levothyroxine decreased the risk of bleeding and improved platelet recovery compared to control treatment and treatment with either prednisone or levothyroxine alone. The platelet count before therapy, serum thyroid stimulating hormone and combination treatment with prednisone and levothyroxine were associated with bleeding events. Therefore, the present study suggests that hypothyroidism is associated with severe thrombocytopenia in hepatitis B-associated compensatory liver cirrhosis. Treatment with prednisone plus levothyroxine may present a novel approach in these patients. | Jing Xue Ru Feng Haixia Fu Qian Jiang Hao Jiang Jing Lu Hui Liu Jingwen Wang Ting Niu Xin Wang YANDi Xie Hao Wang Lanping Xu Kaiyan Liu Xiaojun Huang Xiaohui Zhang | 2018 | Science China(Life Sciences)2018，61，8： | 8 |
| 15 | Crystalline Silica Promotes Rat Fibrocyte Differentiation in Vitro,and Fibrocytes Participate in Silicosis in Vivo显示文摘Objective The aim of this study was to investigate the effects of Si O2 on fibrocytes and whether fibrocytes participate in silicosis in vivo. Methods A macrophagocyte(AM)/fibrocyte coculture system was established, and AMs were treated with 100 μg/mL SiO 2. Flow cytometry was used to detect the number of fibrocytes. Real‐time PCR was performed to measure the expression of collagen I, collagen III, and α‐SMA mR NA. The levels of collagen I, collagen III, and TGF‐β1 protein were determined by ELISA. Immunohistochemical staining was performed to measure α‐SMA protein expression. A rat silicosis model was induced by intratracheal instillation of SiO 2. Lung histopathological evaluation was conducted using HE and Masson's trichrome staining after 1 and 9 weeks. The number of fibrocytes in peripheral blood or lung tissue of rat was detected by flow cytometry. Double‐color immunofluorescence was applied to identify fibrocytes in the lung tissue. Results Peripheral blood monocytes were found to differentiate into fibrocytes in vitro in a time‐dependent manner, and exposure to crystalline silica might potentiate fibrocyte differentiation. In addition, fibrocytes were able to migrate from peripheral blood to the lung tissue, and the number of fibrocytes was increased after SiO 2 exposure. Conclusion Silica exposure potentiates fibrocyte differentiation, and fibrocytes may participate in silicosis in vivo. | LI Juan YAO Wu HOU Jian Yong Zhang Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao HAO Chang Fu | 2017 | Biomedical and Environmental Sciences2017，30，9： | 7 |
| 16 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 17 | Advances in lithium niobate photonics:development status and perspectives显示文摘Lithium niobate(LN)has experienced significant developments during past decades due to its versatile properties,especially its large electro-optic(EO)coefficient.For example,bulk LN-based modulators with high speeds and a superior linearity are widely used in typical fiber-optic communication systems.However,with everincreasing demands for signal transmission capacity,the high power and large size of bulk LN-based devices pose great challenges,especially when one of its counterparts,integrated silicon photonics,has experienced dramatic developments in recent decades.Not long ago,high-quality thin-film LN on insulator(LNOI)became commercially available,which has paved the way for integrated LN photonics and opened a hot research area of LN photonics devices.LNOI allows a large refractive index contrast,thus light can be confined within a more compact structure.Together with other properties of LN,such as nonlinear/acousto-optic/pyroelectric effects,various kinds of high-performance integrated LN devices can be demonstrated.A comprehensive summary of advances in LN photonics is provided.As LN photonics has experienced several decades of development,our review includes some of the typical bulk LN devices as well as recently developed thin film LN devices.In this way,readers may be inspired by a complete picture of the evolution of this technology.We first introduce the basic material properties of LN and several key processing technologies for fabricating photonics devices.After that,various kinds of functional devices based on different effects are summarized.Finally,we give a short summary and perspective of LN photonics.We hope this review can give readers more insight into recent advances in LN photonics and contribute to the further development of LN related research. | Guanyu Chen Nanxi Li Jun Da Ng Hong-Lin Lin Yanyan Zhou Yuan Hsing Fu Lennon Yao Ting Lee Yu Yu Ai-Qun Liu Aaron J.Danner | 2022 | Advanced Photonics2022，4，3： | 6 |
| 18 | New Record of Palaeoscolecids from the Early Cambrian of Yunnan,China显示文摘摘要:新 palaeoscolecid, Guanduscolex 次要的胡,罗 et Fu 情报。et sp。nov,与内向的人和肠的保存软部分来自云南的更低的寒武纪的 Guanshan 动物志,华南。扫描电子显微镜学(SEM ) 揭示的表皮的微结构细节证明每个环忍受三排盘子,每个盘子忍受 910 边缘并且 45 个中央节点。这发现在关系和 palaeoscolecids 和另外的早 priapulids 的进化小径上打开新灯。 | HU Shixue LI Yong LUO Huilin FU Xiaoping YOU Ting PANG Jiyuan LIU Qi Michael STEINER | 2008 | Acta Geologica Sinica(English Edition)2008，82，2： | 6 |
| 19 | Prehospital system delay in patients with ST-segment elevation myocardial infarction in Singapore显示文摘BACKGROUND: Timely reperfusion in ST-segment elevation myocardial infarction(STEMI)improves outcomes. System delay is that between first medical contact and reperfusion therapy,comprising prehospital and hospital components. This study aimed to characterize prehospital system delay in Singapore.METHODS: A retrospective chart review was performed for 462 consecutive STEMI patients presenting to a tertiary hospital from December 2006 to April 2008. Patients with cardiac arrest secondarily presented were excluded. For those who received emergency medical services(EMS),ambulance records were reviewed. Time intervals in the hospital were collected prospectively. The patients were divided into two equal groups of high/low prehospital system delay using visual binning technique.RESULTS: Of 462 patients, 76 received EMS and 52 of the 76 patients were analyzed. The median system delay was 125.5 minutes and the median prehospital system delay was 33.5minutes(interquartile range [IQR]=27.0, 42.0). Delay between call-received-by-ambulance and ambulance-dispatched was 2.48 minutes(IQR=1.47, 16.55); between ambulance-dispatch and arrival-at-patient-location was 8.07 minutes(IQR=1.30, 22.13); between arrival-at- and departurefrom-patient-location was 13.12 minutes(IQR=3.12, 32.2); and between leaving-patient-location to ED-registration was 9.90 minutes(IQR=1.62, 32.92). Comparing patients with prehospital system delay of less than 35.5 minutes versus more showed that the median delay between ambulancedispatch and arrival-at-patient-location was shorter(5.75 vs. 9.37 minutes, P<0.01). The median delay between arrival-at-patient-location and leaving-patient-location was also shorter(10.78 vs.14.37 minutes, P<0.01).CONCLUSION: Prehospital system delay in our patients was suboptimal. This is the first attempt at characterizing prehospital system delay in Singapore and forms the basis for improving efficiency of STEMI care. | Andrew Fu Wah Ho Pin Pin Pek Stephanie Fook-Chong Ting Hway Wong Yih Yng Ng Aaron Sung Lung Wong Marcus Eng Hock Ong | 2015 | World Journal of Emergency Medicine2015，6，4： | 6 |
| 20 | Vehicle Motion Prediction at Intersections Based on the Turning Intention and Prior Trajectories Model显示文摘Intersections are quite important and complex traffic scenarios,where the future motion of surrounding vehicles is an indispensable reference factor for the decision-making or path planning of autonomous vehicles.Considering that the motion trajectory of a vehicle at an intersection partly obeys the statistical law of historical data once its driving intention is determined,this paper proposes a long short-term memory based(LSTM-based)framework that combines intention prediction and trajectory prediction together.First,we build an intersection prior trajectories model(IPTM)by clustering and statistically analyzing a large number of prior traffic flow trajectories.The prior trajectories model with fitted probabilistic density is used to approximate the distribution of the predicted trajectory,and also serves as a reference for credibility evaluation.Second,we conduct the intention prediction through another LSTM model and regard it as a crucial cue for a trajectory forecast at the early stage.Furthermore,the predicted intention is also a key that is associated with the prior trajectories model.The proposed framework is validated on two publically released datasets,next generation simulation(NGSIM)and INTERACTION.Compared with other prediction methods,our framework is able to sample a trajectory from the estimated distribution,with its accuracy improved by about 20%.Finally,the credibility evaluation,which is based on the prior trajectories model,makes the framework more practical in the real-world applications. | Ting Zhang Wenjie Song Mengyin Fu Yi Yang Meiling Wang | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，10： | 6 |
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