|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pooled Plasmid Sequencing Reveals the Relationship Between Mobile Genetic Elements and Antimicrobial Resistance Genes in Clinically Isolated Klebsiella pneumoniae显示文摘Plasmids remain important microbial components mediating the horizontal gene transfer(HGT)and dissemination of antimicrobial resistance.To systematically explore the relationship between mobile genetic elements(MGEs)and antimicrobial resistance genes(ARGs),a novel strategy using single-molecule real-time(SMRT)sequencing was developed.This approach was applied to pooled conjugative plasmids from clinically isolated multidrug-resistant(MDR)Klebsiella pneumoniae from a tertiary referral hospital over a 9-month period.The conjugative plasmid pool was obtained from transconjugants that acquired antimicrobial resistance after plasmid conjugation with 53 clinical isolates.The plasmid pool was then subjected to SMRT sequencing,and 82 assembled plasmid fragments were obtained.In total,124 ARGs(responsible for resistance to b-lactam,fluoroquinolone,and aminoglycoside,among others)and 317 MGEs[including transposons(Tns),insertion sequences(ISs),and integrons]were derived from these fragments.Most of these ARGs were linked to MGEs,allowing for the establishment of a relationship network between MGEs and/or ARGs that can be used to describe the dissemination of resistance by mobile elements.Key elements involved in resistance transposition were identified,including IS26,Tn3,IS903 B,ISEcp1,and ISKpn19.As the most predominant IS in the network,a typical IS26-mediated multi-copy composite transposition event was illustrated by tracing its flanking 8-bp target site duplications(TSDs).The landscape of the pooled plasmid sequences highlights the diversity and complexity of the relationship between MGEs and ARGs,underpinning the clinical value of dominant HGT profiles. | Yan Jiang Yanfei Wang Xiaoting Hua Yue Qu Anton Y.Peleg Yunsong Yu | 2020 | Genomics, Proteomics & Bioinformatics2020，18，5： | 1 |
| 2 | Polyoxometalate-Based Ionic Frameworks for Highly Selective CO_(2) Capture and Separation显示文摘During the utilization of structural and functional advantages of polyoxometalates(POMs)for enhanced applications,a suitable assembly of these clusters in framework materials to act as binding nodes represents a promising approach.In contrast to well-developed coordination/covalent combinations,we have developed a convenient strategy to build porous structures of POMs with smaller-sized counterions as bridging ligands via ionic interactions to reinforce their capability in gas adsorption in parallel to metal-organic frameworks(MOFs)/covalent organic frameworks(COFs).With this goal,a series of POMs-based ionic frameworks(IFs)were constructed with triol-ligand modified Anderson-Evans-type clusters as building blocks,and their sodium counter-cations were used as linkers.The three-dimensional(3D)open-frameworks obtained displayed unusually selective CO_(2) capturing capability and efficient separation from their N_(2),H_(2),and CH_(4) mixtures under low pressure at room temperature.Among the synthesized IFs,the cobalt-centered cluster exhibited the best performance for the uptake and selective separation of CO_(2) over N_(2) and CH_(4) in a range of 0-1 bar,while the nickel-centered cluster displayed the highest selectivity over H_(2) at 1 bar.Breakthrough experiments based on real binary gas mixtures demonstrated that the cobalt-containing framework illustrated high performance in the actual gas separation and sustained stability against a simulated operating environment. | Fengxue Duan Xiaoting Liu Di Qu Bao Li Lixin Wu | 2021 | CCS Chemistry2021，3，11： | 1 |
| 3 | The activity of the Ang/Tie-2 system in the brain that suffered acute carbon monoxide poisoning显示文摘 | Wang Suping Liu Zanhua Qu Jing Wang Xiaoting | 2013 | Human and Experimental Toxicology2013，，10： | 1 |
| 4 | Deep learning model improves radiologists'performance in detection and classification of breast lesions显示文摘Objective:Computer-aided diagnosis using deep learning algorithms has been initially applied in the field of mammography,but there is no large-scale clinical application.Methods:This study proposed to develop and verify an artificial intelligence model based on mammography.Firstly,mammograms retrospectively collected from six centers were randomized to a training dataset and a validation dataset for establishing the model.Secondly,the model was tested by comparing 12 radiologists’performance with and without it.Finally,prospectively enrolled women with mammograms from six centers were diagnosed by radiologists with the model.The detection and diagnostic capabilities were evaluated using the freeresponse receiver operating characteristic(FROC)curve and ROC curve.Results:The sensitivity of model for detecting lesions after matching was 0.908 for false positive rate of 0.25 in unilateral images.The area under ROC curve(AUC)to distinguish the benign lesions from malignant lesions was0.855[95%confidence interval(95%CI):0.830,0.880].The performance of 12 radiologists with the model was higher than that of radiologists alone(AUC:0.852 vs.0.805,P=0.005).The mean reading time of with the model was shorter than that of reading alone(80.18 s vs.62.28 s,P=0.032).In prospective application,the sensitivity of detection reached 0.887 at false positive rate of 0.25;the AUC of radiologists with the model was 0.983(95%CI:0.978,0.988),with sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)of94.36%,98.07%,87.76%,and 99.09%,respectively.Conclusions:The artificial intelligence model exhibits high accuracy for detecting and diagnosing breast lesions,improves diagnostic accuracy and saves time. | Yingshi Sun Yuhong Qu Dong Wang Yi Li Lin Ye Jingbo Du Bing Xu Baoqing Li Xiaoting Li Kexin Zhang Yanjie Shi Ruijia Sun Yichuan Wang Rong Long Dengbo Chen Haijiao Li Liwei Wang Min Cao | 2021 | Chinese Journal of Cancer Research2021，33，6： | 1 |
| 5 | Micronuclei Induction in Human Lymphocytes Induced by Carbon Ions Exposure along Penetrate Depth of Ions in Water显示文摘 | Wang Zhuanzi Li Wenjian Xing Xiaoting Qu Yin Jing Xigang | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 0 |
| 6 | Changes in corneal curvature and aberrations after cataract surgery显示文摘Background:Surgically induced astigmatism(SIA)and corneal high-order aberrations(HOAs)are the two main causes of poor visual quality after cataract surgery.Changes in the parameters of corneal HOAs after cataract surgery and their effects on and relationships with changes in corneal curvature have not yet been reported.This study aimed to explore changes in anterior,posterior and total corneal curvature,astigmatism and HOAs after microincision cataract surgery.Methods:Sixty-one age-related cataract patients(61 eyes)were included in this prospective study.The total,anterior and posterior corneal astigmatism and corneal HOAs were analyzed by anterior segment optical coherence tomography(AS-OCT)and iTrace before,one day,one week and three months after 2.2 mm temporal microincision coaxial phacoemulsification to evaluate the changes in anterior,posterior and total corneal curvature,astigmatism and corneal HOAs.Results:The mean J0 and J45 values of anterior,posterior and total corneal curvature obtained by ASOCT showed no statistically significant difference between preoperatively and any postoperative followup.SIA occurred on the anterior,posterior and total corneal surfaces and showed no statistically significant difference at any postoperative follow-up.No significant changes in 3rd-order oblique trefoil,vertical coma or 4th-order spherical aberrations were observed after surgery except for a significant increase in horizontal coma at postoperative day 1(POD1).Conclusions:There were no significant changes in corneal curvature after 2.2 mm temporal microincision coaxial phacoemulsification,and the corneal HOAs were not changed significantly except for the increase in horizontal coma at POD1,which may be one of the main reasons of poor visual quality at POD1 in some cataract patients who have good uncorrected or corrected distance vision. | Ye Dai Xiaoting Ruan Wei Wang Xiaoyun Chen Guangming Jin Lanhua Wang Xiaoxun Gu Bo Qu Jianping Liu Xuhua Tan Enen Zhang Jun Fu Lixia Luo Zhenzhen Liu Yizhi Liu | 2022 | Annals of Eye Science2022，，3： | 0 |
| 7 | Development of Alternative to Animal Testing on Cosmetics by Middle-out Strategy显示文摘 | Shujun Cheng Yu Chen Yihui Ke Xiaoting Qu Yao Qin Jiating Xu | 2016 | China Detergent & Cosmetics2016，1，4： | 0 |
| 8 | Development and Prospect of Process Models and Simulation Methods for Atomic Layer Deposition显示文摘Thin film deposition is one of the most important processes in IC manufacturing. In this paper, several typical models and numerical simulation methods for thin film deposition and atomic layer deposition are introduced. Several modeling methods based on the characteristics of atomic layer deposition are introduced, it includes geometric method, cellular automata and multiscale simulation. The principle of each model and simulation method is explained, and their advantages and disadvantages are analyzed. Finally, the development direction of thin film deposition and atomic layer deposition modeling is prospected, and some modeling ideas are also provided. | Lei Qu Rui Chen Xiaoting Li Jing Zhang Yanrong Wang Shuhua Wei Jiang Yan Yayi Wei | 2019 | Journal of Microelectronic Manufacturing2019，2，2： | 0 |
| 9 | Moisture‑Electric–Moisture‑Sensitive Heterostructure Triggered Proton Hopping for Quality‑Enhancing Moist‑Electric Generator显示文摘Moisture-enabled electricity(ME)is a method of converting the potential energy of water in the external environment into electrical energy through the interaction of functional materials with water molecules and can be directly applied to energy harvesting and signal expression.However,ME can be unreliable in numerous applications due to its sluggish response to moisture,thus sacrificing the value of fast energy harvesting and highly accurate information representation.Here,by constructing a moisture-electric-moisture-sensitive(ME-MS)heterostructure,we develop an efficient ME generator with ultra-fast electric response to moisture achieved by triggering Grotthuss protons hopping in the sensitized ZnO,which modulates the heterostructure built-in interfacial potential,enables quick response(0.435 s),an unprecedented ultra-fast response rate of 972.4 mV s^(−1),and a durable electrical signal output for 8 h without any attenuation.Our research provides an efficient way to generate electricity and important insight for a deeper understanding of the mechanisms of moisture-generated carrier migration in ME generator,which has a more comprehensive working scene and can serve as a typical model for human health monitoring and smart medical electronics design. | Ya’nan Yang Jiaqi Wang Zhe Wang Changxiang Shao Yuyang Han Ying Wang Xiaoting Liu Xiaotong Sun Liru Wang Yuanyuan Li Qiang Guo Wenpeng Wu Nan Chen Liangti Qu | 2024 | Nano-Micro Letters2024，16，3： | 0 |
| 10 | Analysis of Current Research Status of Plasma Etch Process Model显示文摘This paper summarizes the status of the plasma etch process modeling research.It mainly introduces typical etching models employing the analytical method,geometric method,system identification method,basic principle simulation method,as well as empirical model.Each model’s basic principles,application scopes,advantages and disadvantages are discussed.Based on these,the development history of the etch process modeling is summarized,and the development opportunities of the etch model are prospected.This paper provides a brief view for establishment of the plasma etching process model. | Xiaoting Li Rui Chen Lei Qu Xuanmin Zhu Jing Zhang Yanrong Wang Shuhua Wei Jiang Yan Yayi Wei | 2018 | Journal of Microelectronic Manufacturing2018，1，1： | 0 |
| 11 | 人源大麻素受体CB2的晶体结构显示文摘文章简介大麻素受体CB2主要分布在人体的免疫系统,选择性调控大麻素受体CB2对炎症、纤维化及神经退行性疾病等具有较好的治疗潜力,同时可避免由大麻素受体CB1引起的精神活性。本研究报道了大麻素受体CB2与新型拮抗剂AM0257复合物2.8埃分辨率的晶体结构。经结构对比分析,发现同处于拮抗状态的CB2与CB1不但结构差别极大。 | Xiaoting Li Tian Hua Kiran Vemuri Jo-Hao Ho Yiran Wu Lijie Wu Petr Popov Othman Benchama Nikolai Zvonok K’ara Locke Lu Qu Gye Won Han Malliga R.Iyer Resat Cinar Nathan J.Coffey Jingjing Wang Meng Wu Vsevolod Katritch Suwen Zhao George Kunos Laura M.Bohn Alexandros Makriyannis Raymond C.Stevens 刘志杰 | 2020 | 科学新闻2020，，2： | 0 |
| 12 | Rapid report of seismic damage to hospitals in the 2023 Turkey earthquake sequences显示文摘The seismic performance of medical systems is crucial for the seismic resilience of communities.The report summarizes the observed damage to twelve hospital buildings in the area affected by the MW 7.8 and MW 7.5 earthquakes on February 6,2023 in Turkey.They include five base-isolated buildings and seven fixed-base buildings in southcentral Turkey's seven most heavily affected provinces.By relating the post-quake occupancy statuses of the hospitals with the estimated seismic demands during the earthquake doublet,the report offers the following observations:(1)the base-isolated hospital buildings on friction pendulum bearings generally exhibited superior performance of achieving the goal of immediate occupancy and provided better protection for nonstructural elements than fixed-base counterparts did;(2)the fixed-base hospital buildings of reinforced concrete structures constructed after 2001 successfully achieved the goal of collapse prevention even under very high seismic demands;(3)some fixed-base hospitals also remained operational even if they were very close to the fault rupture and were subjected to higher-than-design-level earthquake ground motions. | Zhe Qu Feijian Wang Xiangzhao Chen Xiaoting Wang Zhiguang Zhou | 2023 | Earthquake Research Advances2023，3，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员