5篇
您的检索式：作者名="Xiaowen Lai"
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| 1 | Random packing of tetrahedral particles using the polyhedral discrete element method显示文摘 | Shiwei Zhao Xiaowen Zhou Wenhui Liu Chengguang Lai | 2015 | Particuology2015，13，6： | 7 |
| 2 | Disruption of splicing-regulatory elements using CRISPR/Cas9 to rescue spinal muscular atrophy in human iPSCs and mice显示文摘We here report a genome-editing strategy to correct spinal muscular atrophy(SMA).Rather than directly targeting the pathogenic exonic mutations,our strategy employed Cas9 and guide-sg RNA for the targeted disruption of intronic splicing-regulatory elements.We disrupted intronic splicing silencers(ISSs,including ISS-N1 and ISS+100)of survival motor neuron(SMN)2,a key modifier gene of SMA,to enhance exon 7 inclusion and full-length SMN expression in SMA iPSCs.Survival of splicing-corrected iPSC-derived motor neurons was rescued with SMN restoration.Furthermore,co-injection of Cas9 mRNA from Streptococcus pyogenes(SpCas9)or Cas9 from Staphylococcus aureus(SaCas9)alongside their corresponding sgRNAs targeting ISS-N1 into zygotes rescued 56%and 100%of severe SMA transgenic mice(Smn-/-,SMN2tg/-).The median survival of the resulting mice was extended to>400 days.Collectively,our study provides proof-of-principle for a new strategy to therapeutically intervene in SMA and other RNA-splicing-related diseases. | Jin-Jing Li Xiang Lin Cheng Tang Ying-Qian Lu Xinde Hu Erwei Zuo He Li Wenqin Ying Yidi Sun Lu-Lu Lai Hai-Zhu Chen Xin-Xin Guo Qi-Jie Zhang Shuang Wu Changyang Zhou Xiaowen Shen Qifang Wang Min-Ting Lin Li-Xiang Ma Ning Wang Adrian R.Krainer Linyu Shi Hui Yang Wan-Jin Chen | 2020 | National Science Review2020，7，1： | 1 |
| 3 | A glassy carbon electrode modified with a polyaniline doped with silicotungstic acid and carbon nanotubes for the sensitive amperometric determination of ascorbic acid显示文摘 | Zhang Xiaowen Lai Guosong Yu Aimin | 2013 | Microchim Acta2013，180，5： | 1 |
| 4 | Potassium pre-inserted K1.04Mn8O16 as cathode materials for aqueous Li-ion and Na-ion hybrid capacitors显示文摘For the applications of aqueous Li-ion hybrid capacitors and Na-ion hybrid capacitors,potassium ions are pre-inserted into MnO2 tunnel structure,the as-prepared K1.04Mn8 O16 materials consist of nanoparticles and nanorods were prepared by facile high-temperature solid-state reaction.The as-prepared materials were well studied and they show outstanding electrochemical behavior.We assembled hybrid supercapacitors with commercial activated carbon(YEC-8 A)as anode and K1.04Mn8 O16 as cathode.It shows high energy and power densities.Li-ion capacitors reach a high energy density of 127.61 Wh kg-1 at the power density of 99.86 W kg-1 and Na-ion capacitor obtains 170.96 Wh kg-1 at 133.79 W kg-1.In addition,the hybrid supercapacitors demonstrate excellent cycling performance which maintain 97%capacitance retention for Li-ion capacitor and 85%for Na-ion capacitor after 10,000 cycles. | Yamin Zhang Lina Chen Chongyang Hao Xiaowen Zheng Yixuan Guo Long Chen Kangrong Lai Yinghe Zhang Lijie Ci | 2020 | Journal of Energy Chemistry2020，29，7： | 1 |
| 5 | 让抛硬币更环保、更生态的“藻类硬币”显示文摘在很多东方和西方文化中,当人们祈祷好运时,习惯在水体中投掷硬币。然而,这些硬币对那些误以为是食物的动物来说,是个灾难。例如,水生动物有时会将硬币误认为是食物,因此有成千上万的海龟和鱼类因为试图吃硬币而窒息至死。这款“藻类硬币”让人们抛币祈福更环保、更生态。许愿币被扔进水中时,它会自然地分解并喂养水生动植物,成为水生动植物的营养,而不是破坏环境。人与自然的双赢,才能带来好运! | Shengyan Gao Xiaowen Lai Jiongjie Wang | 2023 | 工业设计2023，，8： | 0 |
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