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| 1 | Analgesic effect of parecoxib and flurbiprofen axetil for patients undergoing laparoscopic cholecystectomy and their influences on platelet aggregation显示文摘当它能也引起时, opioids 生产手术后的痛觉缺失,这被知道当它能也引起时,副作用喜欢恶心,呕吐,便秘,中略,发痒的皮肤,尿保留和因素都有的甚至呼吸的 inhibition.These 极大地为治疗手术后的疼痛限制了它的临床的使用。同时, non-steroidal 反煽动性拖(NSAID ) 在手术后的痛觉缺失起一个日益重要的作用。一些研究建议 NSAIDS 可能是神经的在服的 ischemic conditions.1 Flurbiprofen 保护 axetil,它利用类脂化合物 microsphere 拖交货系统,可以由煽动性的房间支持在煽动性的损害地点和吸收小粒的 flurbiprofen 的累积,有效地帮助到的 2 个两因素指向治疗。 Parecoxib 是为静脉内的注射可得到的第一个选择 cyclooxygenase-2 ( COX-2 )禁止者,它对产生 NSAIDs3 的病人有益,对胃肠的骚乱敏感的那些喜欢穿孔,溃疡,并且 bleeding.4 这调查为经历血小板聚集上的 laparoscopic 胆囊炎和他们的影响以便为诊所实践提供某指导的病人估计 parecoxib 和 flurbiprofen axetil 的止痛效果。 | JI Fu-hai JIN Xin YANG Jian-ping ZAN Li-li | 2010 | Chinese Medical Journal2010，，12： | 29 |
| 2 | Imaging for thinned perforator flap harvest:current status and future perspectives显示文摘With advances in anatomical knowledge and technology,increased interest has been directed towards reconstruction with enhanced aesthetic and functional outcomes.A myriad of thinned perforator flap harvest approaches have been developed for this purpose;however,concerns about jeopardizing their vascularity remain.To ensure optimum reconstructive outcome without hampering the flap’s microcirculation,it is important to make good use of the existing advanced imaging modalities that can provide clear visualization of perforator branches,particularly in the adipose layer,and an accurate assessment of flap perfusion.Therefore,this review will highlight the imaging modalities that have been utilized for harvesting a thinned perforator flap from these two perspectives,along with future insights into creating both functionally and aesthetically satisfying,yet simultaneously safe,thinned perforator flaps for the best reconstructive outcomes for patients. | Yi Min Khoong Xin Huang Shuchen Gu Tao Zan | 2021 | Burns & Trauma2021，9，1： | 3 |
| 3 | Expression analysis,single nucleotide polymorphisms within SIRT4 and SIRT7 genes and their association with body size and meat quality traits in Qinchuan cattle显示文摘Silent information regulator 2(Sir2) proteins, or sirtuins, are nicotine adenine dinucleotide(NAD)-dependent deacetylases that connect metabolism with longevity in lower organisms. In mammals, there are seven Sir2 homologs, namely, silent information regulators(SIRT1–7). SIRT4 and SIRT7 genes play a crucial role in regulating lipid metabolism, cellular growth and metabolism. This suggests that they are potential candidate genes for affecting body size and meat quality traits in animals. Hence, this study aimed to detect genetic variations of both SIRT4 and SIRT7 bovine genes in Qinchuan cattle, and to evaluate the effect of these variations on economically important body size and meat quality traits. Expression analysis using quantitative real-time PCR(q PCR) indicated that SIRT4 and SIRT7 were broadly expressed in all thirteen studied tissues. The expression of SIRT4 was higher in liver, muscle, and in subcutaneous fat tissue. In the case of SIRT7, the expression was higher in lung, abomasum, and subcutaneous fat. Using DNA sequencing, a total of three single nucleotide polymorphisms(SNPs) were identified within SIRT4 and SIRT7 genes in 468 Qinchuan cattle. These included one novel SNP within 3′ untranslated regions(UTR) of SIRT4(SNP1: g.13915A>G) and two novel synonymous substitutions in SIRT7(SNP2: g.3587C>T and SNP3: g.3793T>C). Statistical analyses indicated that all three SNPs could significantly influence some body size and meat quality traits in Qinchuan cattle. These novel findings will provide a background for application of bovine SIRT4 and SIRT7 genes in the selection program of Chinese cattle. | GUI Lin-sheng XIN Xiao-ling WANG Jia-li HONG Jie-yun ZAN Lin-sen | 2016 | Journal of Integrative Agriculture2016，15，12： | 3 |
| 4 | A modified scar model with controlled tension on secondary wound healing in mice显示文摘Pathological scars might cause a distorted appearance and restricted mobility,and the study of scar pathophysiology has been hindered by the absence of a reliable model.In this study,we introduce a model with a modified device to induce controlled tension on a wound healing by secondary intention to overcome the shortcomings of the model generated by Aarabi et al.We investigated and recommend an induction of 0.1 N/mm^(2) tension on day 7 for 14 days to mimic the characteristics of human scars.A 3.5-fold increase in scar tissue and a 2-fold increase in collagen production were induced by the modified model.Histologically,the modified method increased scar thickness.However,no significant difference was found in cell density between the two groups.This modified procedure significantly increased scar tissue,which could be used for further cellular and biomolecular research.The mechanical force applied to the wound became measurable and controllable.This method is more convenient for researchers to observe in realtime and for providing timely adjustments of the tension used in this modified model. | Zi Wang Xin Huang Tao Zan Qingfeng Li Haizhou Li | 2020 | Burns & Trauma2020，8，1： | 2 |
| 5 | Plant species coexistence alleviates the impacts of lead on Zea mays L.显示文摘Whether plant coexistence can reduce the impacts of lead (Pb) on crops in agroecosystems has not been well understood. We conducted a factorial experiment to investigate the effects of weeds coexisting with maize (Zea mays L.) on Pb accumulation in maize and soil microbes at two Pb levels (ambient and 300 mg/kg). Elevated Pb tended to increase the Pb concentration in maize and decreased soil microbial activity (indicated by the average well color development, AWCD), functional group diversity, as well as arbuscular mycorrhizal (AM) colonization and vesicle number of maize. Compared to the monoculture, weeds coexisting with maize reduced the Pb concentrations in the root, leaf, sheath and stem of maize at both seedling and mature stages. In maize-weed mixtures, soil microbial activity and functional group diversity tended to increase for both Pb treatments relative to the monoculture. Furthermore, principal component analysis revealed that the soil microbial community structure changed with the introduction of weeds. The highest Pb accumulation in weeds occurred for the elevated Pb treatment in a three species mixture. The results suggest that multiple plant species coexistence could reduce lead accumulation in crop plants and alleviate the negative impacts on soil microbes in polluted land, thereby highlighting the significance of plant diversity in agroecosystems. | Ruyi Yang Ling Liu Shuting Zan Jianjun Tang Xin Chen | 2012 | Journal of Environmental Sciences2012，24，3： | 2 |
| 6 | CD4+T cells memorize obesity and promote weight regain显示文摘Body weight regain often causes failure of obesity therapies while the underlying mechanism remains largely unknown.In this study,we report that immune cells,especially CD4+T cells,mediate the‘memory’of previous obese status.In a weight gain-loss-regain model,we found that C57BL/6J mice with an obesity history showed a much faster rate of body weight regain.This obesity memory could last for at least 2 months after previously obese mice were kept at the same body weight as non-obese mice.Surprisingly,such obesity memory was abrogated by dexamethasone treatment,whereas immunodeficient Rag1−/−and H2A−/−mice failed to establish such memory.Rag1−/−mice repossessed the obesity memory when immune cells or CD4+T cells isolated from previously obese mice were transferred.Furthermore,depletion of CD4+T cells led to obesity memory ablation.Taken together,we conclude that CD4+T cells mediate obesity memory and promote weight regain. | Jianghuan Zou Beibei Lai Mingzhu Zheng Qin Chen Shujun Jiang Anying Song Zan Huang Peiliang Shi Xin Tu Di Wang Linrong Lu Zhaoyu Lin Xiang Gao | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 7 | A case of scalp avulsion with prolonged ischemic time:indocyanine green angiography can aid in predicting replant survival显示文摘Background:Microsurgical replantation has become the most favorable treatment option for scalp avulsion.However,the accurate prediction of postoperative replant viability remains challenging.Case presentation:In this article,we showed that(indocyanine green angiography,ICGA)can provide a much more precise prediction of replant necrosis than conventional clinical assessment in a rare case of complete scalp avulsion with prolonged ischemia time.Conclusion:Clinical assessment of replant survival may be misleading in cases of complex tissue injuries and prolonged ischemic stress.This case provides insight into the promising utility of ICGA as an important adjuvant tool to better assess tissue perfusion and viability in scalp avulsion and possibly other types of replantation. | Xin Huang Zhichao Wang Caiyue Liu Shuchen Gu Yashan Gao Xiangwen Xu Tao Zan | 2019 | Burns & Trauma2019，7，1： | 2 |
| 8 | Connecting NSF funding to patent innovation in nanotechnology (2001–2004)显示文摘 | Zan Huang Hsinchun Chen Xin Li Mihail C. Roco | 2006 | Journal of Nanoparticle Research2006，，6： | 1 |
| 9 | Variation in community structure of arbuscular mycorrhizal fungi associated with a Cu tolerant plant— Elsholtzia splendens显示文摘 | Ruyi Yang Shuting Zan Jianjun Tang Xin Chen Qian Zhang | 2009 | Applied Soil Ecology2009，，3： | 1 |
| 10 | Quantitative modeling, optimization, and verification of ^(63)Nipowered betavoltaic cells based on three-dimensional ZnO nanorod arrays显示文摘Betavoltaic cells(BCs)are promising self-generating power cells with long life and high power density.However,the low energy conversion efficiency(ECE)has limitations in practical engineering applications.Widebandgap semiconductors(WBGSs)with three-dimensional(3-D)nanostructures are ideal candidates for increasing the ECE of BCs.This paper proposes hydrothermally grown ZnO nanorod arrays(ZNRAs)for ^(63)Ni-powered BCs.A quantitative model was established for simulation using the parameter values of the dark characteristics,which were obtained from the experimental measurements for a simulated BC based on a Ni-incorporated ZNRAs structure.Monte Carlo(MC)modeling and simulation were conducted to obtain the values of the β energy deposited in ZNRAs with different nanorod spacings and heights.Through the simulation and optimization of the 3-D ZNRAs and 2-D ZnO bulk structures,the performance of the ^(63)Ni-powered BCs based on both structures was evaluated using a quantitative model.The BCs based on the 3-D ZNRAs structure and 2-D ZnO bulk structure achieved a maximum ECE of 10.1%and 4.69%,respectively,which indicates the significant superiority of 3-D nanostructured WBGSs in increasing the ECE of BCs. | Zan Ding Tong-Xin Jiang Ren-Rong Zheng Na Wang Li-Feng Zhang Shi-Chao Liu Xin Li Hai-Sheng San | 2022 | Nuclear Science and Techniques2022，33，11： | 1 |
| 11 | Local delivery of superagonist gene based on polymer nanoparticles for cancer immunotherapy显示文摘Cancer is the leading cause that threatens human life expectancy due to the lack of effective therapies.Cancer immunotherapy has been explored to improve the body's immune system against cancer and accompanied by promising results in recent years.Interleukin 15(IL-15),a pleiotropic immunomodulator,is critical for immune cells development and displays great anti-tumor potential in both preclinical and clinical trials.In this study,superagonist IL-15 plasmid(psIL-15)consisting of IL-15Rα-sushi-linker-IL-15 was constructed in order to secret superagonist IL-15(sIL-15)in tumor site.A gene delivery system through self-assembly by methylated polyethylene glycol-b-polylactic acid-b-methylated polyethylene glycol(m PEG-PLA-m PEG)and 1,2-dioleoyl-3-trimethylammonium-propane(DOTAP),named DMAM,was designed to deliver psIL-15.Further study showed that DMAM/psIL-15 could successfully deliver psIL-15 to tumor cells and the supernatants of the tumor cells could further stimulate lymphocytes proliferation as well as activation in vitro.Local delivery of DMAM/psIL-15 in animal models demonstrated significant tumor inhibition through enhancing immune cells responses,reducing angiogenesis,promoting tumor cell apoptosis and inhibiting proliferation,with no evidence of system toxicities.These results indicate that DMAM/psIL-15 may be a promising strategy for cancer immunotherapy. | Zehua Hong Xin Zan Ting Yu Yuzhu Hu Hongfeng Gou Songping Zheng Xiang Gao Peizhi Zhou | 2023 | Chinese Chemical Letters2023，34，3： | 1 |
| 12 | Evaluation of Fbxw7 expression and its correlation with expression ofSREBP-1 in a mouse model of NAFLD显示文摘 | Kangsheng Tu Xin Zheng Guozhi Yin Xianfeng Zan Yingmin Yao Qingguang Liu | 2012 | Molecular Medicine Reports2012，，3： | 1 |
| 13 | Evaluation of Fbxw7 expression and its correlation with the expression of c‐Myc, cyclin E and p53 in human hepatocellular carcinoma显示文摘 | Kangsheng Tu Xin Zheng Xianfeng Zan Shaoshan Han Yingmin Yao Qingguang Liu | 2012 | Hepatology Research2012，，9： | 1 |
| 14 | A novel polymorphism of GDF5 gene and its association with body measurement traits in Bos taurus and Bos indicus breeds显示文摘 | Yong Feng Liu Lin Sen Zan Kui Li Shuan Ping Zhao Ya Ping Xin Qing Lin Wan Qiang Tian Zhi Wei Wang | 2010 | Molecular Biology Reports2010，，1： | 1 |
| 15 | The cryoprotective effects of ascorbic acid supplementation on bovine semen quality显示文摘 | Jian-Hong Hu Wan-Qiang Tian Xian-Lin Zhao Lin-Sen Zan Hui Wang Qing-Wang Li Ya-Ping Xin | 2010 | Animal Reproduction Science2010，，1： | 1 |
| 16 | Population genetic analysis of 6 Y-STR loci in Chinese northwestern Qinchuan yellow cattle breed显示文摘 | Xin Y Zan L Liu Y | 2010 | Molecular Biology Reports2010，37，6： | 1 |
| 17 | Patent citation network in nanotechnology 1976-2004 显示文摘 | Li Xin Chen Hsinchun Huang Zan | 2007 | Journal of Nanoparticle Research2007，9，3： | 1 |
| 18 | Theoretical Investigation on Structures,Stabilities,and Hydrolysis Reactions of Small RuO_(2)Nanoclusters显示文摘The geometric structures and relative stabilities of both neutral and ionic(RuO_(2))_(n)(n=1-5)nanoclusters have been systematically investigated using density functional theory calculations.Differently from the crystal structure,ruthenium tends to adopt a 4-fold coordination with either terminal Ru=O or bridging Ru-O bonds in gas phase clusters.Our calculations show that three-dimensional compact structures are more preferred with the increase of the cluster size.For the low-lying(RuO_(2))_(n)clusters,the cluster formation energy per RuO_(2)unit and the electron af-finity are found to increase whereas the ionization potential is computed to decrease with the cluster size.Based on the optimized lower-energy structures of neutral and cationic(RuO_(2))_(n)(n=1-5),the hydrolysis reactions of these clusters with water molecules have been further explored.The calculated results indicate that the adsorption of wa-ter molecules to the cationic species is much easier than the neutral ones.The overall hydrolysis reaction energies are more exothermic for the cationic clusters than for the neutral clusters.Our calculations indicate that thermody-namically,H_(2)O can be more easily split on the cationic ruthenium oxide clusters than on the neutral clusters. | Hao Dong Zhonghua Zan Xin Zhou | 2014 | Chinese Journal of Chemistry2014，32，6： | 0 |
| 19 | The role of macrophages in the formation of hypertrophic scars and keloids显示文摘Numerous studies have shown that macrophages can orchestrate the microenvironment from the early stage of wound healing to the later stages of scar formation.However,few reviews have highlighted the significance of macrophages during the formation of abnormal scars.The purpose of this reviewwas to outline the polarization of macrophages from early to late stage of pathological scar formation,focusing on spatiotemporal diversity of M1 and M2 macrophages.In this review,the role of macrophages in the formation of hypertrophic scars and keloids is summarized in detail.First,an increased number of M2 cells observed before injuries are significantly associated with susceptibility to abnormal scar pathogenesis.Second,decreased expression of M1 at the early stage and delayed expression of M2 at the late stage results in pathological scar formation.Third,M2 cells are highly expressed at both the margin and the superficial region,which is consistent with the invasive property of keloids.Finally,this review helps to characterize strategies for the prediction and prevention of pathological scar formation. | Xiangwen Xu Shuchen Gu Xin Huang Jieyi Ren Yihui Gu Chengjiang Wei Xiang Lian Haizhou Li Yashan Gao Rui Jin Bin Gu Tao Zan Zhichao Wang | 2020 | Burns & Trauma2020，8，1： | 0 |
| 20 | pIL-12 delivered by polymer based nanovector for anti-tumor genetherapy显示文摘Finding more effective and safe non-viral vectors to transfer genes into cancer cells has become the key of immune gene therapy for cancer.Herein a triblock compound MPEG_(2000)-PDLLA_(4000)-MPEG_(2000) modified by cationic liposome DOTAP was used as a non-viral vector DOTAP/MPEG_(2000)-PDLLA_(4000)-MPEG_(2000)(DMPM)to effectively transfer interleukin(IL)-12 plasmid(pIL-12)into tumor tissue.IL-12 produced by transfected tumor cells successfully inducing lymphocyte proliferation and promoting interferon-γ(IFN-γ)secretion,which resulted in tumor cells death.The ability of DMPM to transfer pIL-12 and the immune effect induced by IL-12 in cells had been explored.The anti-tumor effect,mechanism and safety of pIL-12/DMPM in mice cancer model were investigated in this study.Our results showed that the pIL-12 transferred by DMPM was highly expressed both in CT26 cells and B16-F10 cells.IL-12 expressed in the culture supernatant of transfected tumor cells stimulated lymphocyte proliferation and promoted IFN-γsecretion.The experimental result confirmed that pIL-12/DMPM therapy significantly reduced tumor growth in mice model.We designed the nanocomposite DMPM to deliver pIL-12 for cancer treatment and explored its therapeutic efficacy and the underlying anti-tumor mechanism.Our study suggested pIL-12 loaded by DMPM complex would be an effective strategy for cancer treatment. | Lianbin Wen Xin Zan Qidi Pang Yuzhu Hu Songping Zheng Mengni Ran Xiang Gao Xiang Wang Bilan Wang | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
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