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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 3 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 4 | Synthesis and electrochemical performance of YF_3-coated LiMn_2O_4 cathode materials for Li-ion batteries显示文摘Spinel LiMn2O4 cathodes were coated with 1 mol% YF3.X-ray diffraction(XRD) analyses showed that Y and/or F did not enter the lattice of the LiMn2O4 crystal.Transmission electron microscopy(TEM) showed that a compact YF3 layer of 5-20 nm in thickness was coated onto the surface of LiMn2O4 particles.Scanning electron microscopy(SEM) observation showed that the YF3 coating caused the agglomeration of LiMn2O4 particles.The cycling test demonstrated that the YF3 coating can improve the electrochemical performance of LiMn2O4 at both 20 and 55°C.Moreover,YF3-coated LiMn2O4 exhibited an improved rate capability compared with the uncoated one at high rates over 5C.The immersion test in electrolytes showed that YF3-coated LiMn2O4 is more erosion resistant than the uncoated one. | CAO Jina CAO Gaoshao YU Hongming XIE Jian ZHAO Xinbing | 2011 | Rare Metals2011，30，1： | 7 |
| 5 | N-doped carbon nanocages: Bifunctional electrocatalysts for the oxygen reduction and evolution reactions显示文摘为氧进化反应(OER ) 和氧减小反应(ORR ) 的高度有效的没有金属的、基于碳的、双性人功能的 electrocatalysts 在电气化学的精力变换系统为使用吸引了增加的注意,由于他们的低费用和高活动。在这个工作,有多孔的 self-supported 体系结构和高特定的表面区域的做 N 的碳 nanocages (N-CCs ) 被一个灵巧的界面的集会综合合成线路。材料被扫描电子显微镜学,传播电子显微镜学,氮吸附解吸附作用实验, X 光检查衍射,和 X 光检查光电子光谱学包括地描绘。周期的 voltammetry, chronoamperometry,并且线性打扫 voltammetry 证明同样准备的 N-CC 能在碱的媒介为 ORR 与优秀催化活动,长期的操作耐久性,和优秀甲醇忍耐用作有效没有金属的 electrocatalyst。面对 3 公里甲醇,一半为 ORR 的 N-CCs 的波浪潜力是 190 mV;这比商业 Pt/C electrocatalyst 的更积极。同时, N-CCs 也显示出比得上商业 Ru/C electrocatalyst 的一项 OER 活动,揭示他们的 bifunctional 性质。 | Nan Jia Qiang Weng Yaru Shi Xinyan Shi Xinbing Chen Pei Chen Zhongwei An Yu Chen | 2018 | Nano Research2018，11，4： | 6 |
| 6 | Preparation, characterization, pharmacokinetics and anticancer effects of PEGylated β-elemene liposomes显示文摘Objective:This study aimed to develop a new polyethylene glycol(PEG)ylatedβ-elemene liposome(PEG-Lipo-β-E)and evaluate its characterization,pharmacokinetics,antitumor effects and safety in vitro and in vivo.Methods:The liposomes were prepared by ethanol injection and high-pressure micro-jet homogenization.Characterization of the liposomes was conducted,and drug content,entrapment efficiency(EE),in vitro release and stability were studied by ultra-fast liquid chromatography(UFLC)and a liquid surface method.Blood was drawn from rats to establish the pharmacokinetic parameters.The anticancer effect was evaluated in a KU-19-19 bladder cancer xenograft model.Histological analyses were performed to evaluate safety.Results:The PEG-Lipo-β-E showed good stability and was characterized as 83.31±0.181 nm in size,0.279±0.004 in polydispersity index(PDI),-21.4±1.06 mV in zeta potential,6.65±0.02 in pH,5.024±0.107 mg/mL inβ-elemene(β-E)content,and 95.53±1.712%in average EE.The Fourier transform infrared spectroscopy(FTIR)and differential scanning calorimetry(DSC)indicated the formation of PEG-Lipo-β-E.Compared to elemene injection,PEG-Lipo-β-E demonstrated a 1.75-fold decrease in clearance,a 1.62-fold increase in half-life,and a 1.76-fold increase in area under the concentration-time curves(AUCs)from 0 hour to 1.5 hours(P<0.05).PEG-Lipo-β-E also showed an enhanced anticancer effect in vivo.Histological analyses showed that there was no evidence of toxicity to the heart,kidney,liver,lung or spleen.Conclusions:The present study demonstrates PEG-Lipo-β-E as a new formulation with ease of preparation,high EE,good stability,improved bioavailability and antitumor effects. | Bingtao Zhai Qibiao Wu Wengang Wang Mingming Zhang Xuemeng Han Qiujie Li Peng Chen Xiaying Chen Xingxing Huang Guohua Li Qin Zhang Ruonan Zhang Yu Xiang Shuiping Liu Ting Duan Jianshu Lou Tian Xie Xinbing Sui | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 7 | An ATF24 peptide-functionalized β-elemene-nanostructured lipid carrier combined with cisplatin for bladder cancer treatment显示文摘Objective:In this study,we aimed to develop an amino-terminal fragment(ATF)peptide-targeted liposome carryingβ-elemene(ATF24-PEG-Lipo-β-E)for targeted delivery into urokinase plasminogen activator receptor-overexpressing bladder cancer cells combined with cisplatin(DDP)for bladder cancer treatment.Methods:The liposomes were prepared by ethanol injection and high-pressure microjet homogenization.The liposomes were characterized,and the drug content,entrapment efficiency,andin vitro release were studied.The targeting efficiency was investigated using confocal microscopy,ultra-fast liquid chromatography,and an orthotopic bladder cancer model.The effects of ATF24-PEG-Lipo-β-E combined with DDP on cell viability and proliferation were evaluated by a Cell Counting Kit-8(CCK-8)assay,a colony formation assay,and cell apoptosis and cell cycle analyses.The anticancer effects were evaluated in a KU-19-19 bladder cancer xenograft model.Results:ATF24-PEG-Lipo-β-E had small and uniform sizes(~79 nm),high drug loading capacity(~5.24 mg/mL),high entrapment efficiency(98.37±0.95%),and exhibited sustained drug release behavior.ATF24-PEG-Lipo-β-E had better targeting efficiency and higher cytotoxicity than polyethylene glycol(PEG)ylatedβ-elemene liposomes(PEG-Lipo-β-E).DDP,combined with ATF24-PEG-Lipo-β-E,exerted a synergistic effect on cellular apoptosis and cell arrest at the G2/M phase,and these effects were dependent on the caspase-dependent pathway and Cdc25C/Cdc2/cyclin B1 pathways.Furthermore,thein vivo antitumor activity showed that the targeted liposomes effectively inhibited the growth of tumors,using the combined strategy.Conclusions:The present study provided an effective strategy for the targeted delivery ofβ-elemene(β-E)to bladder cancer,and a combined strategy for bladder cancer treatment. | Bingtao Zhai Peng Chen Wengang Wang Shuiping Liu Jiao Feng Ting Duan Yu Xiang Ruonan Zhang Mingming Zhang Xuemeng Han Xiaying Chen Qiujie Li Guohua Li Ying Liu Xingxing Huang Wenzheng Zhang Ting Pan Lili Yan Ting Jin Tian Xie Xinbing Sui | 2020 | Cancer Biology & Medicine2020，17，3： | 5 |
| 8 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 9 | Doping Effects on Electronic Conductivity and Electrochemical Performance of LiFePO_4显示文摘Olivine-structured pure LiFePO4 and doped Li(M, Fe)PO4 (M=La, Ce, Nd, Mn, Co, Ni) have been synthesized by a solvothermal method. X-ray diffraction and field emission scanning electron microscopy analyses indicate that the as-prepared LiFePO4 is well-crystallized nanopowders without any detectable impurity phases. The electronic conductivity of LiFePO4 is enhanced by around 1-3 orders by doping. It was found that doping alone is not suffcient for the high-rate performance of LiFePO4 and surface coating with such as carbon should be needed. The best dopant for LiFePO4 is Nd among those studied in the present work. Accordingly, doping with 1 mol fraction Nd leads to an increase in 70 mAh/g at 0.1 C for the hydrothermally synthesized sample and 50 mAh/g at 1.0 C after carbon-coating in comparison with the undoped samples. | Jiezi Hu Jian Xie Xinbing Zhao Hongming Yu Xin Zhou Gaoshao Cao Jiangping Tu | 2009 | Journal of Materials Science & Technology2009，25，3： | 2 |
| 10 | Preparation of Nano-structured LiFe_xMn_(1-x)PO_4(x=0,0.2,0.4) by Reflux Method and Research on the Influences of Fe(Ⅱ) Substitution显示文摘Nano structured LiFexMn1-xPO4(x=0,0.2,0.4) materials were successfully prepared by one-step reflux method in a water/PEG400 mixed solvent, and were coated by carbon using glucose as the precursor. The materials were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). The electrochemical properties of the materials were investigated by galvanostatic cycling, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). It was found that the materials consisted of nanorods with a diameter of 50 nm and a length of 500 nm. Galvanostatic cycling showed that the capacity of LiMnPO 4 could be largely increased by Fe2+ substitution. At a current rate of C/20, the capacity of the three samples (x=0,0.2,0.4) were 47, 107 and 150 mA·h·g-1 , respectively. CV result showed that the Fe2+ substitution could decrease the polarization during charging/discharging, accelerating the electrochemical process. EIS result showed that the Fe2+ substitution could decrease the charge transfer resistance between the electrode and electrolyte, | Zhao Yang Hongming Yu Chunyang Wu Gaoshao Cao Jian Xie Xinbing Zhao | 2012 | Journal of Materials Science & Technology2012，28，9： | 2 |
| 11 | Multiradio channel allocation in muhihop wireless networks 显示文摘 | Gao Lin Wang Xinbing Yu Youyun | 2009 | IEEE Trans on Mobile Compu- ting2009，8，11： | 1 |
| 12 | A compact high-voltage pulse generator based on pulse transfotaner withclosed magnetic core 显示文摘 | ZHANG Yu LIU Jinliang CHENG Xinbing | 2010 | Review of Science lnstrmncnt2010，81，03： | 1 |
| 13 | Output characteristics of a kind of high-voltage pulse transformer with closed magnetic core显示文摘 | Zhang Yu Liu Jinliang Cheng Xinbing | 2010 | IEEE Transactions onPlasma Science2010，38，4： | 1 |
| 14 | Rho-Associated Coiled-Coil-Containing Kinase 2 Deficiency in Bone Marrow–Derived Cells Leads to Increased Cholesterol Efflux and Decreased Atherosclerosis显示文摘 | Qian Zhou Yu Mei Takuhito Shoji Xinbing Han Karol Kaminski Goo Taeg Oh Pat P. Ongusaha Kunzhong Zhang Hannah Schmitt Martin Moser Christoph Bode James K. Liao | 2012 | Circulation2012，，18： | 1 |
| 15 | Reverse vaccinology approach identify an Echinococcus granulosus tegumental membrane protein enolase as vaccine candidate显示文摘 | Wenjia Gan Guoxiong Zhao Hongxu Xu Weihua Wu Wuying Du Jiang Huang Xinbing Yu Xuchu Hu | 2010 | Parasitology Research2010，，4： | 1 |
| 16 | Identification, expression, characterization, and immunolocalization of lactate dehydrogenase from Taenia asiatica显示文摘 | Jiang Huang Yan Huang Xuan Wu Wuying Du Xinbing Yu Xuchu Hu | 2009 | Parasitology Research2009，，2： | 1 |
| 17 | Effect of a transition section between the Blumlein line and a load on the output voltage of gigawatt intense electron-beam accelerators显示文摘 | Cheng Xinbing LiuJinliang Zhang Yu | 2009 | Phys Rev ST Accel Beams2009，12，11： | 1 |
| 18 | Molecular cloning and characterization of eDNA encoding a ubiquitin-conjugating enzyme from clonorchis sinensis 显示文摘 | SONG Linxia CHEN Shouyi YU Xinbing | 2004 | Parasitol Res2004，94，： | 1 |
| 19 | Output characteristics of a kind of high-voltage pulse transformer with closed magnetic core显示文摘 | ZHANG Yu LIU Jinliang CHENG Xinbing | 2010 | IEEE Transactions on Plas- ma Science2010，38，4： | 1 |
| 20 | The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer显示文摘Accumulating evidence suggests that chronic inflammation may play a critical role in various malignancies,including bladder cancer.This hypothesis stems in part from inflammatory cells observed in the urethral microenvironment.Chronic inflammation may drive neoplastic transformation and the progression of bladder cancer by activating a series of in-flammatory molecules and signals.Recently,it has been shown that the microbiome also plays an important role in the development and progression of bladder cancer,which can be mediated through the stimulation of chronic inflammation.In effect,the urinary microbiome can play a role in establishing the inflammatory urethral microenvironment that may facilitate the development and progression of bladder cancer.In other words,chronic inflammation caused by the urinary microbiome may promote the initiation and progression of bladder cancer.Here,we provide a detailed and comprehensive account of the link between chronic inflammation,the microbiome and bladder cancer.Finally,we highlight that targeting the urinary microbiome might enable the development of strategies for bladder cancer prevention and personalized treatment. | Xingxing Huang Ting Pan Lili Yan Ting Jin Ruonan Zhang Bi Chen Jiao Feng Ting Duan Yu Xiang Mingming Zhang Xiaying Chen Zuyi Yang Wenzheng Zhang Xia Ding Tian Xie Xinbing Sui | 2021 | Genes & Diseases2021，8，6： | 1 |
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