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| 1 | Chemical mechanical polishing: Theory and experiment显示文摘For several decades,chemical mechanical polishing(CMP)has been the most widely used planarization method in integrated circuits manufacturing.The final polishing results are affected by many factors related to the carrier structure,the polishing pad,the slurry,and the process parameters.As both chemical and mechanical actions affect the effectiveness of CMP,and these actions are themselves affected by many factors,the CMP mechanism is complex and has been a hot research area for many years.This review provides a basic description of the development,challenges,and key technologies associated with CMP.We summarize theoretical CMP models from the perspectives of kinematics,empirical,its mechanism(from the viewpoint of the atomic scale,particle scale,and wafer scale),and its chemical-mechanical synergy.Experimental approaches to the CMP mechanism of material removal and planarization are further discussed from the viewpoint of the particle wear effect,chemical-mechanical synergy,and wafer-pad interfacial interaction. | Dewen ZHAO Xinchun LU | 2013 | Friction2013，1，4： | 18 |
| 2 | A method for the production and expedient screening of CRISPR/Cas9-mediated non-transgenic mutant plants显示文摘Developing CRISPR/Cas9-mediated non-transgenic mutants in asexually propagated perennial crop plants is challenging but highly desirable.Here,we report a highly useful method using an Agrobacterium-mediated transient CRISPR/Cas9 gene expression system to create non-transgenic mutant plants without the need for sexual segregation.We have also developed a rapid,cost-effective,and high-throughput mutant screening protocol based on Illumina sequencing followed by high-resolution melting(HRM)analysis.Using tetraploid tobacco as a model species and the phytoene desaturase(PDS)gene as a target,we successfully created and expediently identified mutant plants,which were verified as tetra-allelic mutants.We produced pds mutant shoots at a rate of 47.5%from tobacco leaf explants,without the use of antibiotic selection.Among these pds plants,17.2%were confirmed to be non-transgenic,for an overall non-transgenic mutation rate of 8.2%.Our method is reliable and effective in creating non-transgenic mutant plants without the need to segregate out transgenes through sexual reproduction.This method should be applicable to many economically important,heterozygous,perennial crop species that are more difficult to regenerate. | Longzheng Chen Wei Li Lorenzo Katin-Grazzini Jing Ding Xianbin Gu Yanjun Li Tingting Gu Ren Wang Xinchun Lin Ziniu Deng Richard J.McAvoy Frederick G.Gmitter Jr. Zhanao Deng Yunde Zhao Yi Li | 2018 | Horticulture Research2018，5，1： | 12 |
| 3 | The SOC1-like gene BoMADS50 is associated with the flowering of Bambusa oldhamii显示文摘Bamboo is known for its edible shoots and beautiful texture and has considerable economic and ornamental value.Unique among traditional flowering plants,many bamboo plants undergo extensive synchronized flowering followed by large-scale death,seriously affecting the productivity and application of bamboo forests.To date,the molecular mechanism of bamboo flowering characteristics has remained unknown.In this study,a SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1(SOC1)-like gene,BoMADS50,was identified from Bambusa oldhamii.BoMADS50 was highly expressed in mature leaves and the floral primordium formation period during B.oldhamii flowering and overexpression of BoMADS50 caused early fl owering in transgenic rice.Moreover,BoMADS50 could interact with APETALA1/FRUITFULL(AP1/FUL)-like proteins(BoMADS 14-1/2,BoMADS15-1/2)in vivo,and the expression of BoMADS50 was signi ficantly promoted by BoMADS14-1,further indicating a synergistic effect between BoMADS50 and BoAP1/FUL-like proteins in regulating B.oldhamii flowering.We also identi fi ed four additional transcripts of BoMADS50(BoMADS50-1/2/3/4)with different nucleotide variations.Although the protein-CDS were polymorphic,they had flowering activation functions similar to those of BoMADS50.Yeast one-hybrid and transient expression assays subsequently showed that both BoMADS50 and BoMADS50-1 bind to the promoter fragment of itself and the SHORT VEGETATIVE PHASE(SVP)-like gene BoSVP,but only BoMADS50-1 can positively induce their transcription.Therefore,nucleotide variations likely endow BoMADS50-1 with strong regulatory activity.Thus,BoMADS50 and BoMADS50-1/2/3/4 are probably important positive flowering regulators in B.oldhamii.Moreover,the functional conservatism and speci ficity of BoMADS50 and BoMADS50-1 might be related to the synchronized and sporadic flowering characteristics of B.oldhamii. | Dan Hou Ling Li Tengfei Ma Jialong Pei Zhongyu Zhao Mengzhu Lu Aimin Wu Xinchun Lin | 2021 | Horticulture Research2021，8，1： | 4 |
| 4 | Contact stress non-uniformity of wafer surface for multi-zone chemical mechanical polishing process显示文摘A finite element analysis(FEA)model is developed for the chemical-mechanical polishing(CMP)process on the basis of a 12-in five-zone polishing head.The proposed FEA model shows that the contact stress non-uniformity is less dependent on the material property of the membrane and the geometry of the retaining ring.The larger the elastic modulus of the pad,the larger contact stress non-uniformity of the wafer.The applied loads on retaining ring and zone of the polishing head significantly affect the contact stress distribution.The stress adjustment ability of a zone depends on its position.In particular,the inner-side zone has a high stress adjustment ability,whereas the outer-side zone has a low stress adjustment ability.The predicted results by the model are shown to be consistent with the experimental data.Analysis results have revealed some insights regarding the performance of the multi-zone CMP. | WANG TongQing LU XinChun ZHAO DeWen HE YongYong | 2013 | Science China(Technological Sciences)2013，56，8： | 3 |
| 5 | Identification of an E3 ligase-encoding gene RFWD3 in non-small cell lung cancer显示文摘In order to unveil ubiquitin pathway genes (UPGs) that are essential for non-small cell lung cancer (NSCLC) cell proliferation,we recently conducted a siRNA screening experiment to knockdown the expression of 696 UPGs found in the human genome in A549 and H1975 NSCLC cells.We found that silencing of one of the candidates,RFWD3 that encodes an E3 ubiquitin ligase essential for the repair of DNA interstrand cross-links inresponse to DNA damage,led to dramatic inhibition of NSCLC cell proliferation with significant Z-scores.Knockdown of RFWD3 suppressed colony forming activity of NSCLC cells.We further evaluated the significance of RFWD3 in NSCLCs and found that this gene was more elevated in tumor samples than in paired normal lung tissues and was inversely associated with the clinical outcome of patients with NSCLC.Moreover,RFWD3 expression was significantly higher in smokers than in non-smokers.These results show for the first time that RFWD3 is required for NSCLC cell proliferation and may have an important role in lung carcinogenesis. | Yanfei Zhang Xinchun Zhao Yongchun Zhou Min Wang Guangbiao Zhou | 2020 | Frontiers of Medicine2020，14，3： | 3 |
| 6 | Genetic diversity analysis of Sinojackia microcarpa, a rare tree species endemic in China, based on simple sequence repeat markers显示文摘Although most Sinojackia species are endangered, they contribute greatly to the biodiversity of local ecosystems. Sinojackia microcarpa, an endangered species, is distributed only in three provinces of eastern China. Determining the genetic diversity of S. microcarpa provides key information for germplasm evaluation and species conservation. Here we used simple sequence repeat (SSR) markers to investigate the genetic diversity of eight natural populations of S. microcarpa. Leaf samples were collected from 144 individuals in 8 wild populations. The 156 bands were generated from 14 pairs of informative SSR primers, with an average percentage of polymorphic bands of 45.67%. The average values of Nei’s genetic diversity (He) and Shannon’s diversity index (I) were 0.1007 and 0.1658, respectively. The total genetic variation of S. microcarpa existed mainly within the eight populations, rather than among populations, and reached 86.41%. A cluster analysis showed that the eight wild populations of S. microcarpa could be classified into four groups, at a threshold of 4.0, based on an analysis of the SSR genotypes. Furthermore, there was a significant association between the phylogenetic relationships and the geographic locations of the S. microcarpa populations. In particular, populations from Fuyang, Jiande, and Lin’an in Zhejiang Province had close phylogenetic relationships and geographic distances. In addition, these three populations had the highest genetic diversity and the most individuals, suggesting that these three locations may be the S.microcarpa distribution center. This study serves as a model for studying the genetic diversity of endangered plant species. | Tailin Zhong Guangwu Zhao Yongfeng Lou Xinchun Lin Xiaomin Guo | 2019 | Journal of Forestry Research2019，30，3： | 2 |
| 7 | Identification of a potential tumor suppressor gene, UBL3, in non-small cell lung cancer显示文摘Objective: Oncogenes have been shown to be drivers of non-small cell lung cancer(NSCLC), yet the tumor suppressing genes involved in lung carcinogenesis remain to be systematically investigated. This study aimed to identify tumor suppressing ubiquitin pathway genes(UPGs) that were critical to lung tumorigenesis.Methods: The 696 UPGs were silenced by an siRNA screening in NSCLC cells;the potential tumor suppressing UPGs were analyzed, and their clinical significance was investigated.Results: We reported that silencing of 11 UPGs resulted in enhanced proliferation of NSCLC cells, and four UPGs(UBL3, TRIM22, UBE2 G2, and MARCH1) were significantly downregulated in tumor samples compared to that in normal lung tissues and their expression levels were positively associated with overall survival(OS) of NSCLC patients. Among these genes, UBL3 was the most significant one. UBL3 expression was decreased in tumor samples compared to that in paired normal lung tissues in 59/86(68.6%) NSCLCs, was correlated with TNM stage and sex of NSCLC patients, and was significantly higher in non-smoking patients than in smoking patients. Silencing UBL3 accelerated cell proliferation and ectopic expression of UBL3 suppressed NSCLC in vitro and in vivo.Conclusions: These results showed that UBL3 represented a tumor suppressor in NSCLC and may have potential for use in therapeutics and for the prediction of clinical outcome of patients. | Xinchun Zhao Yongchun Zhou Qian Hu Sanhui Gao Jie Liu Hong Yu Yanfei Zhang Guizhen Wang Yunchao Huang Guangbiao Zhou | 2020 | Cancer Biology & Medicine2020，17，1： | 2 |
| 8 | The selective deposition of Fe species inside ZSM-5 for the oxidation of cyclohexane to cyclohexanone显示文摘The design of efficient iron-based catalysts remains a great challenge for selective cyclohexane oxidation to cyclohexanone under mild conditions.Because of the complex distribution of iron location on the support,the selectivity is always low.Here,we report a general strategy to selectively deposit highly-dispersed FeO_(x) into the micropore of ZSM-5 by atomic layer deposition(ALD).The framework of ZSM-5 and the Bronsted acid sites are intact during ALD,and the Fe species are selectively deposited onto the defect and Lewis acid sites of ZSM-5.Besides,more Fe–O–Si bonds are formed over FeO_(x)/ZSM-5 with a low loading of Fe,while FeO_(x) nanoparticles are generated at high Fe loading.They cannot be realized by the traditional solution method.The obtained FeO_(x)/ZSM-5 catalysts perform high selectivity of cyclohexanone(92%–97%),and ALD cycle numbers of FeO_(x) control the activity.Compared with the Fe nanoparticles,the Fe–O–Si species performs higher turnover frequency and stability in the oxidation reaction. | Liming Zhai Bin Zhang Haojie Liang Huibin Wu Xinchun Yang Gen Luo Shichao Zhao Yong Qin | 2021 | Science China Chemistry2021，64，7： | 2 |
| 9 | A Computed torque controller for uncertain robotic manipulator systems: Fuzzy approach 显示文摘 | Song Zuoshi Yi Jianqiang Zhao Dongbin Li Xinchun | 2005 | Fuzzy Sets and Systems2005，154，2： | 1 |
| 10 | Application of wind profiler data to rainfall analyses in Tazhong Oilfield region,Xinjiang,China显示文摘To improve the level of meteorological service for the Oilfield region in the Taklimakan Desert,the Urumqi Institute of Desert Meteorology of the China Meteorological Administration(CMA) conducted a detection experiment by means of wind profiling radar(WPR) in Tazhong Oilfield region of Xinjiang,China in July 2010.By using the wind profiler data obtained during the rainfall process on 27 July,this paper analyzed the wind field features and some related scientific issues of this weather event.The results indicated that:(1) wind profiler data had high temporal resolution and vertical spatial resolution,and could be used to analyze detailed vertical structures of rainfall processes and the characteristics of meso-scale systems.Before and after the rain event on 27 July,the wind field showed multi-layer vertical structures,having an obvious meso-scale wind shear line and three airflows from different directions,speeding up the motion of updraft convergence in the lower atmosphere.Besides,the wind directions before and after the rainfall changed inversely with increasing height.Before the rain,the winds blew clockwise,but after the onset of the rain,the wind directions became counterclockwise mainly;(2) the temperature advection derived from wind profiler data can reproduce the characteristics of low-level thermodynamic evolution in the process of rainfall,which is capable to reflect the variation trend of hydrostatic stability in the atmosphere.In the early stage of the precipitation on 27 July,the lower atmosphere was mainly affected by warm advection which had accumulated unstable energy for the rainfall event and was beneficial for the occurrence of updraft motion and precipitation;(3) the 'large-value zone' of the radar reflectivity factor Z was virtually consistent with the onset and end of the rainfall,the height for the formation of rain cloud particles,and precipitation intensity.The reflectivity factor Z during this event varied approximately in the range of 18-38 dBZ and the rain droplets formed mainly at the layer of 3,800-4,500 m. | MinZhong WANG WenShou WEI Qing HE XinChun LIU ZhongJie ZHAO | 2012 | Journal of Arid Land2012，4，4： | 1 |
| 11 | A Computed torque controller for uncertain robotic manipulator systems: Fuzzy approach显示文摘 | Song Zuoshi Yi Jianqiang Zhao Dongbin Li Xinchun | 2005 | Fuzzy Sets and Systems2005，154，2： | 1 |
| 12 | A Computed torque controller for uncertain robotic manipulator systems : Fuzzy approach显示文摘 | Song Zuoshi Yi Jianqiang Zhao Dongbin Li Xinchun | 2005 | Fuzzy Sets and Systems2005，154，2： | 1 |
| 13 | A seepage-stress coupled analysis of seabed deformation induced by the decomposition of gas hydrate显示文摘 | Zhenwei zhao Xinchun shang | 2011 | Intemafional Journal Computational Science and Engineering2011，6，4： | 1 |
| 14 | Y_(2)O_(3) nanosheets as slurry abrasives for chemical-mechanical planarization of copper显示文摘Continued reduction in feature dimension in integrated circuits demands high degree of flatness after chemical mechanical polishing.Here we report using new yttrium oxide(Y_(2)O_(3))nanosheets as slurry abrasives for chemical-mechanical planarization(CMP)of copper.Results showed that the global planarization was improved by 30%using a slurry containing Y_(2)O_(3) nanosheets in comparison with a standard industrial slurry.During CMP,the two-dimensional square shaped Y_(2)O_(3) nanosheet is believed to induce the low friction,the better rheological performance,and the laminar flow leading to the decrease in the within-wafer-non-uniformity,surface roughness,as well as dishing.The application of the two-dimensional nanosheets as abrasive in CMP would increase the manufacturing yield of integrated circuits. | Xingliang HE Yunyun CHEN Huijia ZHAO Haoming SUN Xinchun LU Hong LIANG | 2013 | Friction2013，1，4： | 1 |
| 15 | Carcinogens that induce the A:T 〉 T:A nucleotide substitutions in the genome显示文摘 | Guangbiao Zhou Xinchun Zhao | 2018 | Frontiers of Medicine2018，12，2： | 1 |
| 16 | A Computed torque controller for uncertain robotic manipulator systems: Fuzzy approach 显示文摘 | Sortg Zuoshi Yi Jianqiang Zhao Dongbin Li Xinchun | 2005 | Fuzzy Sets and Systems2005，154，2： | 1 |
| 17 | Flatness maintenance and roughness reduction of silicon mirror in chemical mechanical polishing process显示文摘As an important optical component in laser system,silicon mirror surface is required to have micron-level flatness and subnanometer-level roughness.The research concentrates on how to improve roughness as far as possible while maintaining flatness of silicon mirror surface during chemical mechanical polishing(CMP)process.A polishing edge effect model is established to explain the reason of flatness deterioration,and a roughness theoretical model is set up to get the limit of perfect surface roughness.Based on the models above,a polishing device is designed to maintain the surface flatness,and the optimized polishing process parameters are obtained by orthogonal tests to get a near-perfect surface roughness.Finally the maintenance of flatness and the improvement of roughness can be achieved at the same time in one step of CMP process.This work can be a guide for silicon mirror manufacture to improve optical reflection performance significantly. | JIANG BoCheng ZHAO DeWen WANG BingQuan ZHAO HuiJia LIU YuHong LU XinChun | 2020 | Science China(Technological Sciences)2020，63，1： | 1 |
| 18 | A Computed torque controller for uncertain robotic manipulator systems: Fuzzy approach 显示文摘 | Song Zuoshi Yi Jianqiang Zhao Dongbin Li Xinchun | 2005 | Fuzzy Sets and Systems2005，154，2： | 1 |
| 19 | A Computed torque controller for uncertain robotic manipulator systems : Fuzzy approach显示文摘 | Song Zuoshi Yi Jianqiang Zhao Dongbin Li Xinchun | 2005 | Fuzzy Sets and Systems2005，154，2： | 1 |
| 20 | Analysis for temperature and pressure fields in process of hydrate dissociation by depressurization 显示文摘 | Zhenwei Zhao Xinchun Shang | 2010 | International Journal for Numerical and Analytical Methods in Geomechanics2010，，3： | 1 |
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